Fuchs, Thomas

[["dc.bibliographiccitation.firstpage","37"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","44"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Beutner, Caroline"],["dc.contributor.author","Werchan, Barbora"],["dc.contributor.author","Forkel, Susann"],["dc.contributor.author","Gupta, Sidhi"],["dc.contributor.author","Fuchs, Thomas"],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Buhl, Timo"],["dc.date.accessioned","2021-04-14T08:31:31Z"],["dc.date.available","2021-04-14T08:31:31Z"],["dc.date.issued","2020"],["dc.description.abstract","Summary Background: Sensitization rates to aeroallergens are rising worldwide. The prevalence is increasing, especially in Western countries. We aimed to investigate (1) sensitization rates and (2) cross‐sensitization patterns in skin prick tests (SPTs) for the most relevant inhaled allergens in central Germany over 20 years, adjusted for regional pollen counts. Patients and Methods: This monocentric study evaluated SPTs for tree pollen, grass pollen and house dust mites (HDMs) in 4,315 patients (including children) with suspected airway allergies, from 1998–2017. Results: Sensitization rates to almost all aeroallergens have increased significantly over time, without relevant changes in regional pollen counts. Current sensitization rates in all our symptomatic patients were highest for grass (55.3 %) and rye pollen (59.6 %), with most pronounced increases in HDM sensitization over time (from 37.8 % to the current figure of 50.1 %). However, a low but consistent proportion of tree‐sensitized patients (3.6–7.8 %) showed isolated positive SPTs to alder and/or hazel pollen without sensitization to birch pollen. Conclusions We demonstrate a significant rise in the total number of sensitized patients as well as increases in cross‐sensitization between closely related allergens. Individuals with unusual mono‐sensitization profiles to common inhaled allergens should be studied in more detail, since these patients are currently excluded from clinical trials for allergen immunotherapy."],["dc.identifier.doi","10.1111/ddg.14312"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83619"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes."],["dc.title","Sensitization rates to common inhaled allergens in Germany – increase and change patterns over the last 20 years"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Contact Dermatitis"],["dc.contributor.author","Kreipe, Katharina"],["dc.contributor.author","Forkel, Susann"],["dc.contributor.author","Heinemann, Kim‐Elisabeth"],["dc.contributor.author","Amschler, Katharina"],["dc.contributor.author","Fuchs, Thomas"],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Buhl, Timo"],["dc.date.accessioned","2021-06-01T09:42:01Z"],["dc.date.available","2021-06-01T09:42:01Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract Background The use of disinfectants is part of the everyday life of people, especially in the medical profession. During the coronavirus disease 2019 (COVID‐19) pandemic, the use of disinfectants continues to increase and is of fundamental importance in infection control. Objectives To determine the frequency of sensitization and the value of patch testing to didecyldimethylammonium chloride (DDAC) and the alcohols ethanol, 1‐propanol, and isopropanol. Methods Clinical patch test data of 145 patients with suspected contact allergy to disinfectants were retrospective analysed. Results Among the 145 patients patch tested with the different alcohols, only one nurse was detected with a possible allergy to 1‐propanol. Additional patch testing in 84 patients with DDAC 0.05% resulted in five patients with weakly positive reactions only, without clinical relevance. Patch testing with DDAC 0.03% showed no positive reactions at all on day 3 readings. Conclusions DDAC and alcohols are rarely responsible for allergic contact dermatitis. The accused products of the patients should be checked for other allergens and further additives with skin‐irritating properties. Individual susceptibility and mishandling of the disinfectants should be considered."],["dc.identifier.doi","10.1111/cod.13844"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85112"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.publisher","Blackwell Publishing Ltd"],["dc.relation.eissn","1600-0536"],["dc.relation.issn","0105-1873"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes."],["dc.title","Contact sensitizations to disinfectants containing alcohols or quaternary ammonium compounds are rarely of clinical relevance"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]