Obst, Katrin Ulrike

[["dc.bibliographiccitation.firstpage","63"],["dc.bibliographiccitation.journal","Brain Research"],["dc.bibliographiccitation.lastpage","77"],["dc.bibliographiccitation.volume","1473"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.contributor.author","Keil, Maria"],["dc.contributor.author","Obst, Katrin U."],["dc.contributor.author","Henseler, Ilona"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T09:05:53Z"],["dc.date.available","2018-11-07T09:05:53Z"],["dc.date.issued","2012"],["dc.description.abstract","There is ample evidence of gender differences in neural processes and behavior. Differences in reward-related behaviors have been linked to either temporary or permanent organizational influences of gonadal hormones on the mesolimbic dopamine system and reward-related activation. Still, little is known about the association between biological gender and the neural underpinnings of the ability to resist reward-related impulses. Here we assessed with functional magnetic resonance imaging which neural processes enable men and women to successfully control their desire for immediate reward when this is required by a higher-order goal (i.e., during a 'desire-reason dilemma'; Dielchof and Gruber, 2010). Thirty-two participants (16 females) were closely matched for age, personality characteristics (e.g., novelty seeking) and behavioral performance in the 'desire-reason task'. On the neural level, men and women showed similarities in the general response of the nucleus accumbens and of the ventral tegmental area to predictors of immediate reward, but they differed in additional brain mechanisms that enabled self-controlled decisions against the preference for immediate reward. Firstly, men exhibited a stronger reduction of activation in the ventral pallidum, putamen, temporal pole and pregenual anterior cingulate cortex during the 'desire-reason dilemma'. Secondly, connectivity analyses revealed a significant change in the direction of the connectivity between anteroventral prefrontal cortex and nucleus accumbens during decisions counteracting the reward-related impulse when comparing men and women. Together, these findings support the view of a sexual dimorphism that manifested in the recruitment of gender-specific neural resources during the successful deployment of self-control. (c) 2012 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.brainres.2012.07.010"],["dc.identifier.isi","000309145100008"],["dc.identifier.pmid","22814146"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25429"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0006-8993"],["dc.title","A functional neuroimaging study assessing gender differences in the neural mechanisms underlying the ability to resist impulsive desires"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","557"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","European Archives of Psychiatry and Clinical Neuroscience"],["dc.bibliographiccitation.lastpage","566"],["dc.bibliographiccitation.volume","266"],["dc.contributor.author","Engel, K. R."],["dc.contributor.author","Obst, K."],["dc.contributor.author","Bandelow, B."],["dc.contributor.author","Dechent, P."],["dc.contributor.author","Gruber, O."],["dc.contributor.author","Zerr, I."],["dc.contributor.author","Ulrich, K."],["dc.contributor.author","Wedekind, D."],["dc.date.accessioned","2017-11-28T10:03:35Z"],["dc.date.available","2017-11-28T10:03:35Z"],["dc.date.issued","2015"],["dc.description.abstract","There is evidence that besides limbic brain structures, prefrontal and insular cortical activations and deactivations are involved in the pathophysiology of panic disorder. This study investigated activation response patterns to stimulation with individually selected panic-specific pictures in patients with panic disorder with agoraphobia (PDA) and healthy control subjects using functional magnetic resonance imaging (fMRI). Structures of interest were the prefrontal, cingulate, and insular cortex, and the amygdalo-hippocampal complex. Nineteen PDA subjects (10 females, 9 males) and 21 healthy matched controls were investigated using a Siemens 3-Tesla scanner. First, PDA subjects gave Self-Assessment Manikin (SAM) ratings on 120 pictures showing characteristic panic/agoraphobia situations, of which 20 pictures with the individually highest SAM ratings were selected. Twenty matched pictures showing aversive but not panic-specific stimuli and 80 neutral pictures from the International Affective Picture System were chosen for each subject as controls. Each picture was shown twice in each of four subsequent blocks. Anxiety and depression ratings were recorded before and after the experiment. Group comparisons revealed a significantly greater activation in PDA patients than control subjects in the insular cortices, left inferior frontal gyrus, dorsomedial prefrontal cortex, the left hippocampal formation, and left caudatum, when PA and N responses were compared. Comparisons for stimulation with unspecific aversive pictures showed activation of similar brain regions in both groups. Results indicate region-specific activations to panic-specific picture stimulation in PDA patients. They also imply dysfunctionality in the processing of interoceptive cues in PDA and the regulation of negative emotionality. Therefore, differences in the functional networks between PDA patients and control subjects should be further investigated."],["dc.identifier.doi","10.1007/s00406-015-0653-6"],["dc.identifier.fs","624606"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/10614"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1433-8491"],["dc.relation.issn","0940-1334"],["dc.title","Functional MRI activation in response to panic-specific, non-panic aversive, and neutral pictures in patients with panic disorder and healthy controls"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","300"],["dc.bibliographiccitation.journal","Behavioural Brain Research"],["dc.bibliographiccitation.lastpage","307"],["dc.bibliographiccitation.volume","237"],["dc.contributor.author","Guse, Birgit"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Whalley, Heather"],["dc.contributor.author","Gibson, Lydia"],["dc.contributor.author","Hasan, Alkomiet"],["dc.contributor.author","Obst, Katrin U."],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","McIntosh, Andrew M."],["dc.contributor.author","Suchan, Boris"],["dc.contributor.author","Wobrock, Thomas"],["dc.date.accessioned","2018-11-07T09:29:11Z"],["dc.date.available","2018-11-07T09:29:11Z"],["dc.date.issued","2013"],["dc.description.abstract","In schizophrenia patients negative symptoms and cognitive impairment often persist despite treatment with second generation antipsychotics leading to reduced quality of life and psychosocial functioning. One core cognitive deficit is impaired working memory (WM) suggesting malfunctioning of the dorsolateral prefrontal cortex. High frequency repetitive transcranial magnetic stimulation (rTMS) has been used to transiently facilitate or consolidate neuronal processes. Pilot studies using rTMS have demonstrated improvement of psychopathology in other psychiatric disorders, but a systematic investigation of working memory effects outlasting the stimulation procedure has not been performed so far. The aim of our study was to explore the effect of a 3-week high frequency active or sham 10 Hz rTMS on cognition, specifically on working memory, in schizophrenia patients (n = 25) in addition to antipsychotic therapy and in healthy controls (n = 22). We used functional magnetic resonance imaging (fMRI) to compare activation patterns during verbal WM (letter 2-back task) before and after 3-weeks treatment with rTMS. Additionally, other cognitive tasks were conducted. 10 Hz rTMS was applied over the left posterior middle frontal gyrus (EEG electrode location F3) with an intensity of 110% of the individual resting motor threshold (RMT) over a total of 15 sessions. Participants recruited the common fronto- parietal and subcortical WM network. Multiple regression analyses revealed no significant activation differences over time in any contrast or sample. According to the ANOVAs for repeated measures performance remained without alterations in all groups. This is the first fMRI study that has systematically investigated this topic within a randomized, placebo-controlled, double-blind design, contrasting the effects in schizophrenia patients and healthy controls. (C) 2012 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.bbr.2012.09.034"],["dc.identifier.isi","000312119200041"],["dc.identifier.pmid","23022750"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30959"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0166-4328"],["dc.title","The effect of long-term high frequency repetitive transcranial magnetic stimulation on working memory in schizophrenia and healthy controls-A randomized placebo-controlled, double-blind fMRI study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Psychiatry"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Wedekind, Dirk"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Obst, Katrin U."],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Engel, Kirsten-Rita"],["dc.contributor.author","Ulrich, Kalinke"],["dc.contributor.author","Bandelow, Borwin"],["dc.date.accessioned","2018-11-07T09:01:15Z"],["dc.date.available","2018-11-07T09:01:15Z"],["dc.date.issued","2011"],["dc.identifier.isi","000208641302154"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24376"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier France-editions Scientifiques Medicales Elsevier"],["dc.publisher.place","Paris"],["dc.relation.issn","0924-9338"],["dc.title","FUNCTIONAL MRI ACTIVATION IN RESPONSE TO PANIC-SPECIFIC, NON-PANIC AVERSIVE, AND NEUTRAL IMAGERY IN PATIENTS WITH PANIC DISORDER AND HEALTHY CONTROLS"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","507"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Acta Psychologica"],["dc.bibliographiccitation.lastpage","514"],["dc.bibliographiccitation.volume","139"],["dc.contributor.author","Melcher, Tobias"],["dc.contributor.author","Obst, Katrin U."],["dc.contributor.author","Mann, Andreas"],["dc.contributor.author","Paulus, Christine"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T09:12:36Z"],["dc.date.available","2018-11-07T09:12:36Z"],["dc.date.issued","2012"],["dc.description.abstract","The present behavioral study investigated the influence of negative affect on the neural mechanisms of cognitive control. We expected to find evidence for an antagonistic modulation of cognition by threat-relevant and threat-irrelevant negative affect (i.e. fear and sadness) that should promote bottom-up monitoring and top-down selection, respectively. Subjects performed one of three conflict tasks (Stroop, Flanker, or Simon) that tap distinct control mechanisms of conflict resolution, comprising specific attentional and motor control processes. On each task trial, target stimuli were preceded by a face stimulus exhibiting a fearful, sad, or neutral expression, providing three affect conditions. Our data provides strong evidence for substantially increased selection (attentional and motor selection) after priming of threat-irrelevant negative affect (sadness). Deviating from the results of previous studies, our analysis did not consistently yield increased monitoring after fear priming. We discuss these findings with respect to the effectiveness of different experimental affect priming procedures (i.e. stimuli) and the role of the task context, among others. (C) 2012 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.actpsy.2012.01.012"],["dc.identifier.isi","000302508700015"],["dc.identifier.pmid","22366726"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26974"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1873-6297"],["dc.relation.issn","0001-6918"],["dc.title","Antagonistic modulatory influences of negative affect on cognitive control: Reduced and enhanced interference resolution capability after the induction of fear and sadness"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]