Hinz, Jose

[["dc.bibliographiccitation.firstpage","E85"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Artificial Organs"],["dc.bibliographiccitation.lastpage","E90"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Popov, Aron Frederik"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Coskun, Sinan Tolga"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Ruschewski, Wolfgang"],["dc.date.accessioned","2018-11-07T08:45:10Z"],["dc.date.available","2018-11-07T08:45:10Z"],["dc.date.issued","2010"],["dc.description.abstract","The optimal treatment of congenital aortic valve lesions is a controversial issue. This study was performed to evaluate the outcome after surgical treatment of aortic valve lesions in congenital aortic valve disease. Between the years of 2000 and 2008, 61 patients (mean age: 12.6 +/- 9.6 years, range: 1 day to 40 years) underwent aortic valve surgery for congenital aortic valve disease. Twenty-four patients had undergone previous cardiovascular operations. Indications for surgery were aortic regurgitation in 14.7% (n = 9), aortic stenoses in 26.2% (n = 16), and mixed disease in 59.1% (n = 36). The Ross procedure was performed in 37.7% (n = 23), aortic valve replacement with biological or mechanical prostheses in 29.5% (n = 18). Concomitant procedures were performed in 91.8% (n = 56) due to associated congenital cardiac defects. The overall mortality rate was 5%. Six patients needed reoperation. Implantation of permanent pacemakers occurred in six patients for permanent atrioventricular block. At the latest clinical evaluation, all survivors are in New York Heart Association class I-II and are living normal lives. Aortic valve surgeries in patients with congenital heart disease have had low mortality and morbidity rates in our series. Surgical technique as well as timing should be tailored for each patient. Aortic valve replacement should be delayed until the implantation of an adult-sized prosthesis is possible."],["dc.identifier.doi","10.1111/j.1525-1594.2009.00958.x"],["dc.identifier.isi","000275725900004"],["dc.identifier.pmid","20447039"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20370"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.publisher.place","Malden"],["dc.relation.conference","5th International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion"],["dc.relation.eventlocation","Dallas, TX"],["dc.relation.issn","0160-564X"],["dc.title","Aortic Valve Surgery in Congenital Heart Disease: A Single-Center Experience"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","429"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Coronary Artery Disease"],["dc.bibliographiccitation.lastpage","434"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Popov, Aron Frederik"],["dc.contributor.author","Schulz, Egbert Godehard"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Seipelt, Ralf G."],["dc.contributor.author","Koziolek, Michael Johann"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Mueller, Gerhard Anton"],["dc.date.accessioned","2018-11-07T11:09:22Z"],["dc.date.available","2018-11-07T11:09:22Z"],["dc.date.issued","2008"],["dc.description.abstract","Objective Endothelin is the most potent endogenous vasoconstrictor and is involved in several vascular disorders such as arterial hypertension. Its intense interaction with other vasoactive hormone systems revealed the consideration about the endothelin gene as an interesting candidate for influencing the development of essential hypertension and hypertensive endorgan damage. The purpose of this study was to investigate the role of endothelin-1 Lys198Asn polymorphism in patients with severe arterial hypertension as well as associated endorgan damages. Methods In 400 hypertensive patients and 150 normotensive controls we examined the endothelin-1 Lys198Asn polymorphism by DNA sequencing and patients were divided according to their genotype (GG, GT, and TT). Moreover, the frequency of endothelin-1 Lys198Asn polymorphism was investigated with respect to the prevalence of several actual or historical endorgan damages (renal disorder, coronary artery disease, vascular events, vascular damage, and congestive heart failure) in hypertensive patients. Results Genotype distribution for endothelin-1 Lys198Asn polymorphism was 573% (GG), 41.3% (GT), and 11.43% (TT) in normotensive individuals; and in hypertensive individuals was 54.75% (GG), 43% (GT) and 2.25% (TT). Genotype distribution was unaffected in patients with severe hypertension, renal disorder, vascular events, vascular damage, and congestive heart failure. We, however, found a significant difference in hypertensive individuals with coronary artery disease and TT genotype (P=0.004). Conclusion Homozygous TT carrier contributes to a higher prevalence of coronary artery disease, especially for three-vessel disease in hypertensive individuals. Thus, the polymorphism at position 198 could serve as a possibility to differentiate high-risk subgroups in the heterogeneous population of hypertensive patients. Coron Artery Dis 19:429-434 (C) 2008 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins."],["dc.identifier.doi","10.1097/MCA.0b013e32830936e5"],["dc.identifier.isi","000260520400001"],["dc.identifier.pmid","18923236"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52994"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0954-6928"],["dc.title","Impact of endothelin-1 Lys198Asn polymorphism on coronary artery disease and endorgan damage in hypertensives"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","651"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","European Journal of Cardio-Thoracic Surgery"],["dc.bibliographiccitation.lastpage","656"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Popov, Aron Frederik"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Schulz, Egbert Godehard"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Wiese, Christoph Hermann"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Seipelt, Ralf G."],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T11:23:32Z"],["dc.date.available","2018-11-07T11:23:32Z"],["dc.date.issued","2009"],["dc.description.abstract","Objective: Renal dysfunction is one of the most serious complications following cardiac surgery with cardiopulmonary bypass. The causes of renal dysfunction following cardiac surgery are poorly understood. We hypothesised that T-786C endothelial NO synthase (eNOS) polymorphism may lead to an increase in the occurrence of postoperative renal dysfunction following cardiac surgery with cardiopulmonary bypass. Methods: A total of 497 patients undergoing cardiac surgery with cardiopulmonary bypass were included in the study. The T-786C eNOS polymorphism was detected by a polymerase chain reaction. The patients were grouped on the basis of whether they were homozygous or heterozygous for the C allele (TC + CC; n = 289) or only homozygous for the Tallele (TT; n = 208). Results: No significance was demonstrated in the preoperative risk factors, with the exclusion of smoking habits (p = 0.04) for the C-allele carrier. The administration of anti-lipid agents (p = 0.01) and anti-arrhythmics (p = 0.01) was significantly tower in the TC/CC group. The TC + CC genotype group had a significantly greater decrease in creatine clearance (p = 0.024), the lowest creatine clearance (p = 0.004) and more C-allele carriers received acute renal replacement therapy (p = 0.04). The usage of norepinephrine (p = 0.02) and dobutamine (p = 0.02) was significantly higher in C-allele carriers. In the TC + CC genotype group, cross-clamp time (p = 0.02) and administration of red cell transfusion (p = 0.04) achieved statistically significant difference. The overall in-hospital mortality rate was 8.2% for all patients and was not significant between genotypes. Conclusions: The present findings support the hypothesis that the T-786C eNOS polymorphism may play a role in the development of renal dysfunction and increase the occurrence of renal replacement therapy following cardiac surgery with cardiopulmonary bypass. This polymorphism may be useful in stratifying the risk for the development of postoperative renal dysfunction. (C) 2009 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.ejcts.2009.04.049"],["dc.identifier.isi","000270644100008"],["dc.identifier.pmid","19523844"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56217"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1010-7940"],["dc.title","The eNOS 786C/T polymorphism in cardiac surgical patients with cardiopulmonary bypass is associated with renal dysfunction"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1026"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Artificial Organs"],["dc.bibliographiccitation.lastpage","1030"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Popov, Aron Frederik"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Kriebel, Thomas"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Ruschewski, Wolfgang"],["dc.contributor.author","Tirilomis, Theodor"],["dc.date.accessioned","2018-11-07T08:37:19Z"],["dc.date.available","2018-11-07T08:37:19Z"],["dc.date.issued","2010"],["dc.description.abstract","Drowning and near-drowning is often associated with severe hypothermia requiring active core rewarming. We performed rewarming by cardiopulmonary bypass (CPB). Between 1987 and 2007, 13 children (9 boys and 4 girls) with accidental hypothermia were rewarmed by extracorporeal circulation (ECC) in our institution. The average age of the patients was 3.2 years. Resuscitation was started immediately upon the arrival of the rescue team and was continuously performed during the transportation. All patients were intubated and ventilated. Core temperature at admission ranged from 20 to 29 degrees C (mean 25.3 degrees C). Connection to the CPB was performed by thoracic (9 patients) or femoral/iliac means (4 patients). Restoration of circulation was achieved in 11 patients (84.6%). After CPB termination two patients needed an extracorporeal membrane oxygenation system due to severe pulmonary edema. Five patients were discharged from hospital after prolonged hospital stay. During follow-up, two patients died (10 and 15 months, respectively) of pulmonary complications and one patient was lost to follow-up. The two remaining survivors were without neurological deficit. Modes of rewarming, age, sex, rectal temperature, and serum electrolytes did not influence mortality. In conclusion, drowning and near-drowning with severe hypothermia remains a challenging emergency. Rewarming by ECC provides efficient rewarming and full circulatory support. Although nearly half of the children may survive after rewarming by ECC, long-term outcome is limited by pulmonary and neurological complications."],["dc.identifier.doi","10.1111/j.1525-1594.2010.01156.x"],["dc.identifier.isi","000284588300026"],["dc.identifier.pmid","21134219"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18502"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","6th International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion"],["dc.relation.eventlocation","Boston, MA"],["dc.relation.issn","1525-1594"],["dc.relation.issn","0160-564X"],["dc.title","Extracorporeal Circulation for Rewarming in Drowning and Near-Drowning Pediatric Patients"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","638"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Investigative Medicine"],["dc.bibliographiccitation.lastpage","643"],["dc.bibliographiccitation.volume","62"],["dc.contributor.author","Mansur, Ashham"],["dc.contributor.author","Hinz, José"],["dc.contributor.author","Hillebrecht, Bronja"],["dc.contributor.author","Bergmann, Ingo"],["dc.contributor.author","Popov, Aron Frederik"],["dc.contributor.author","Ghadimi, Michael"],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Beissbarth, Tim"],["dc.contributor.author","Mihm, Sabine"],["dc.date.accessioned","2021-06-01T10:48:39Z"],["dc.date.available","2021-06-01T10:48:39Z"],["dc.date.issued","2014"],["dc.description.abstract","Background Sepsis is a life-threatening condition. Programmed cell death 1 protein (PD-1), a negative costimulatory molecule, is suggested to be involved in pathogenesis as mortality is associated with high expression and as neutralizing antibodies improve survival in a mouse model. The PD-1 gene harbors an intronic single-nucleotide polymorphism, rs11568821, which is located in a transcription factor-binding site and supposed to affect PD-1 transcription. Objective This study aimed at investigating whether mortality (90-day) among patients with sepsis associates with PD-1 rs11568821 genotypes. Methods Adult white patients with sepsis from the surgical intensive care units of a university medical center were followed up for 90 days, and mortality was recorded as primary outcome variable. Blood samples were taken for PD-1 rs11568821 genotyping. Sequential Organ Failure Assessment scores increased at enrollment and during the observation period to monitor morbidity. Results Two hundred nineteen critically ill patients with sepsis were enrolled in this investigation. Ninety-day mortality was significantly higher among G homozygotes than among A allele carriers (P = 0.0032). During intensive care unit stay, G homozygotes experienced higher Sequential Organ Failure Assessment scores (P < 0.001) and a higher demand of vasopressor therapy (P = 0.0107). Conclusions Data provide first associative evidence for PD-1 rs11568821 as a prognostic indicator in patients with sepsis."],["dc.identifier.doi","10.2310/JIM.0000000000000059"],["dc.identifier.isi","000332039500006"],["dc.identifier.pmid","24463978"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86007"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.eissn","1708-8267"],["dc.relation.issn","1081-5589"],["dc.title","Ninety-Day Survival Rate of Patients With Sepsis Relates to Programmed Cell Death 1 Genetic Polymorphism rs11568821"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]