Hinz, Jose

[["dc.bibliographiccitation.artnumber","39"],["dc.bibliographiccitation.journal","Journal of Cardiothoracic Surgery"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Gehoff, Philipp"],["dc.contributor.author","Schotola, Hanna"],["dc.contributor.author","Hosseini, Morteza Tavakkoli"],["dc.contributor.author","Didilis, Vassilios N."],["dc.contributor.author","Jebran, Ahmad Fawad"],["dc.contributor.author","Gehoff, Anastasia"],["dc.contributor.author","Wiese, Christoph Hermann"],["dc.contributor.author","Schulz, Egbert Godehard"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Popov, Aron Frederik"],["dc.date.accessioned","2018-11-07T09:11:03Z"],["dc.date.available","2018-11-07T09:11:03Z"],["dc.date.issued","2012"],["dc.description.abstract","Background: Peri-operative statin therapy in cardiac surgery cases is reported to reduce the rate of mortality, stroke, postoperative atrial fibrillation, and systemic inflammation. Systemic inflammation could affect the hemodynamic parameters and stability. We set out to study the effect of statin therapy on perioperative hemodynamic parameters and its clinical outcome. Methods: In a single center study from 2006 to 2007, peri-operative hemodynamic parameters of 478 patients, who underwent cardiac surgery with cardiopulmonary bypass, were measured. Patients were divided into those who received perioperative statin therapy (n = 276; statin group) and those who did not receive statin therapy (n = 202; no-statin group). The two groups were compared together using Kolmogorov-Smirnov-Test, Fisher's-Exact-Test, and Student's-T-test. A p value < 0.05 was considered as significant. Results: There was no significant difference in the preoperative risk factors. Onset of postoperative atrial fibrillation was not affected by statin therapy. Extended hemodynamic measurements revealed no significant difference between the two groups, apart from Systemic Vascular Resistance Index (SVRI). The no-statin group had a significantly higher SVRI (882 +/- 206 vs. 1050 +/- 501 dyn s/cm(5)/m(2), p = 0.022). Inotropic support was the same in both groups and no significant difference in the mortality rate was noticed. Also, hemodynamic parameters were not affected by different types and doses of statins. Conclusions: Perioperative statin therapy for patients undergoing on-pump coronary bypass grafting or valvular surgery, does not affect the hemodynamic parameters and its clinical outcome."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2012"],["dc.identifier.doi","10.1186/1749-8090-7-39"],["dc.identifier.isi","000306370800001"],["dc.identifier.pmid","22533985"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8510"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26638"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1749-8090"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Hemodynamic effects of peri-operative statin therapy in on-pump cardiac surgery patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","199"],["dc.bibliographiccitation.journal","Journal of Cardiothoracic Surgery"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Schoendorf, Daniel"],["dc.contributor.author","Bireta, Christian"],["dc.contributor.author","Lipke, Christina"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Bergmann, Ingo"],["dc.contributor.author","Wiese, Christoph Herman"],["dc.contributor.author","Mansur, Ashham"],["dc.contributor.author","Schotola, Hanna"],["dc.contributor.author","Sabashnikov, Anton"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Popov, Aron Frederik"],["dc.date.accessioned","2018-11-07T09:18:28Z"],["dc.date.available","2018-11-07T09:18:28Z"],["dc.date.issued","2013"],["dc.description.abstract","Background: The eNOS 894G/T polymorphism (GG, GT, and TT) is associated with cardiovascular mortality and may influence cardiovascular diseases as a genetic risk factor. Moreover, this polymorphism has an impact on intraoperative hemodynamics during cardiac surgery with cardiopulmonary bypass (CPB). In this study, we analyzed the influence of this gene polymorphism on early clinical outcome in patients who underwent cardiac surgery with CPB. Also, we performed a 5-year follow-up, assessing the impact of this polymorphism on long-term mortality. Method: 500 patients who underwent cardiac surgery with CPB between 2006 and 2007 were included in this prospective single centre study. Genotyping for the eNOS gene polymorphism was performed by polymerase chain reaction amplification. Results: Genotype distribution of 894G/T was: GG 50.2%; GT 42.2%; TT 7.8%. Cardiovascular risk factors were equally distributed between the different genotypes of the eNOS 894G/T polymorphism. No significant difference among the groups was shown regarding Euroscore, SAPS II and APACHE II. Perioperative characteristics were also not affected by the genotypes, except for the consumption of norepinephrine (p = 0.03) and amiodarone (p = 0.01) which was higher in the GT allele carrier. The early postoperative course was quite uniform across the genotypes, except for mean intensive care unit length of stay which was significantly prolonged in GT carriers (p = 0.001). The five-year follow-up was 100% complete and showed no significant differences regarding mortality between the groups. Conclusion: Our results show that the eNOS 894G/T polymorphism is not associated with early and late clinical outcome after cardiac surgery. Thus, this polymorphism can actually not help to identify high risk groups in the heterogeneous population of individuals who undergo cardiac surgery with CPB."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2013"],["dc.identifier.doi","10.1186/1749-8090-8-199"],["dc.identifier.isi","000329216900001"],["dc.identifier.pmid","24161078"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9474"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28420"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1749-8090"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","The eNOS 894G/T gene polymorphism and its influence on early and long-term mortality after on-pump cardiac surgery"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","3"],["dc.bibliographiccitation.journal","Journal of Cardiothoracic Surgery"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Coskun, Sinan Tolga"],["dc.contributor.author","Popov, Aron Frederik"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Bockhorst, Kerstin"],["dc.contributor.author","Stich, Kathrin Monika"],["dc.contributor.author","Koerfer, Reiner"],["dc.date.accessioned","2018-11-07T08:33:34Z"],["dc.date.available","2018-11-07T08:33:34Z"],["dc.date.issued","2009"],["dc.description.abstract","Background: Complications of acute myocardial infarction ( AMI) with mechanical defects are associated with poor prognosis. Surgical intervention is indicated for a majority of these patients. The goal of surgical intervention is to improve the systolic cardiac function and to achieve a hemodynamic stability. In this present study we reviewed the outcome of patients with post infarction ventricular septal defect (PVSD) who underwent cardiac surgery. Methods: We analysed retrospectively the hospital records of 41 patients, whose ages range from 48 to 81, and underwent a surgical treatment between 1990 and 2005 because of PVSD. Results: In 22 patients concomitant coronary artery bypass grafting (CAGB) was performed. In 15 patients a residual shunt was found, this required re-op in seven of them. The time interval from infarct to rupture was 8.7 days and from rupture to surgery was 23.1 days. Hospital mortality in PVSD group was 32%. The mortality of urgent repair within 3 days of intractable cardiogenic shock was 100%. The mortality of patients with an anterior VSD and a posterior VSD was 29.6% vs 42.8%, respectively. All patients who underwent the surgical repair later than day 36 survived. Conclusion: Surgical intervention is indicated for a majority of patients with mechanical complications. Cardiogenic shock remains the most important factor that affects the early results. The surgical repair of PVSD should be performed 4-5 weeks after AMI. To improve surgical outcome and hemodynamics the choice of surgical technique and surgical timing as well as preoperative management should be tailored for each patient individually."],["dc.identifier.doi","10.1186/1749-8090-4-3"],["dc.identifier.isi","000262911700001"],["dc.identifier.pmid","19126196"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/4302"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17608"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1749-8090"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Experiences with surgical treatment of ventricle septal defect as a post infarction complication"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","1"],["dc.bibliographiccitation.journal","Journal of Cardiothoracic Surgery"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Popov, Aron Frederik"],["dc.contributor.author","Baryalei, Mersa Mohammed"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Wiese, Christoph Hermann"],["dc.contributor.author","Raab, Björn"],["dc.contributor.author","Kolat, Philipp"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Seipelt, Ralf G."],["dc.date.accessioned","2018-11-07T08:33:36Z"],["dc.date.available","2018-11-07T08:33:36Z"],["dc.date.issued","2009"],["dc.description.abstract","We report an unusual case of an aortic type A dissection with a corpus alienum which compresses the right ventricle. The patient successfully underwent an aortic root replacement in deep hypothermia with re-implantation of the coronary arteries using a modified Bentall procedure and the resection of the corpus alienum. Intraoperative finding reveals 3 greatly adhered gauze compresses, which were most likely forgotten in the operation 34 years ago."],["dc.identifier.doi","10.1186/1749-8090-4-1"],["dc.identifier.isi","000262911500001"],["dc.identifier.pmid","19121214"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/4303"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17615"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","Najko"],["dc.relation.issn","1749-8090"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Acute aortic dissection type A discloses Corpus alienum"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","83"],["dc.bibliographiccitation.journal","Journal of Cardiothoracic Surgery"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Popov, Aron Frederik"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Giesler, Michael"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Hanekop, Gerd Gunnar"],["dc.contributor.author","Gravenhorst, Verena D."],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Ruschewski, Wolfgang"],["dc.date.accessioned","2018-11-07T09:05:57Z"],["dc.date.available","2018-11-07T09:05:57Z"],["dc.date.issued","2012"],["dc.description.abstract","Background: The arterial switch operation (ASO) has become the surgical approach of choice for d-transposition of the great arteries (d-TGA). There is, however an increased incidence of midterm and longterm adverse sequelae in some survivors. In order to evaluate operative risk and midterm outcome in this population, we reviewed patients who underwent ASO for TGA at our centre. Methods: In this retrospective study 52 consecutive patients with TGA who underwent ASO between 04/1991 and 12/1999 were included. To analyze the predictors for mortality and adverse events (coronary stenoses, distortion of the pulmonary arteries, dilatation of the neoaortic root, and aortic regurgitation), a multivariate analysis was performed. The follow-up time was ranged from 1-10 years (mean 5 years, cumulative 260 patient-years). Results: All over mortality rate was 15.4% and was only observed in the early postoperative period till 1994. The predictors for poor operative survival were low APGAR-score, older age at surgery, and necessity of associated surgical procedures. Late re-operations were necessary in 6 patients (13.6%) and included a pulmonary artery patch enlargement due to supravalvular stenosis (n = 3), coronary revascularisation due to coronary stenosis in a coronary anatomy type E, aortic valve replacement due to neoaortic valve regurgitation (n = 2), and patch-plasty of a pulmonary vein due to obstruction (n = 1). The dilatation of neoaortic root was not observed in the follow up. Conclusions: ASO remains the procedure of choice for TGA with acceptable early and late outcome in terms of overall survival and freedom of reoperation. Although ASO is often complex and may be associated with morbidity, most patients survived without major complications even in a small centre."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2012"],["dc.identifier.doi","10.1186/1749-8090-7-83"],["dc.identifier.isi","000311289900001"],["dc.identifier.pmid","22958234"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8188"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25441"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1749-8090"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Midterm results after arterial switch operation for transposition of the great arteries: a single centre experience"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","20"],["dc.bibliographiccitation.journal","Journal of cardiothoracic surgery"],["dc.bibliographiccitation.lastpage","6"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Popov, Aron Frederik"],["dc.contributor.author","Dorge, Hilmar"],["dc.contributor.author","Hinz, José"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Stojanovic, Tomislav"],["dc.contributor.author","Seipelt, Ralf"],["dc.contributor.author","Didilis, Vassilios"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2019-07-10T08:12:56Z"],["dc.date.available","2019-07-10T08:12:56Z"],["dc.date.issued","2008"],["dc.description.abstract","Background: More than 50% of aortocoronary saphenous vein grafts are occluded 10 years after surgery. Intimal hyperplasia is the initial critical step in the progression toward occlusion. Internal mammary veins, which are physiologically prone to less hydrostatic pressure, may undergo an accelerated progression to intimal hyperplasia and thus be suitable for investigation of the mechanisms of aortocoronary vein graft disease. Methods: Six minipigs underwent aortocoronary bypass grafting using standard cardiopulmonary bypass and cardioplegic arrest. Mammary vein were grafted in a reversed manner from ascending aorta to left anterior descending coronary artery (LAD). The proximal LAD was ligated, rendering the anterior left ventricle vein graft-dependent. Minipigs were killed after 4 weeks, and vein grafts were harvested. Histological and immunohistological investigation were performed with respect to morphometric analysis, endothelial damage/dysfunction (v-Willebrand-factor (vWF)), smooth muscle cells (?-smooth actin) and proliferation rate (proliferation marker Ki 67). Results: Mean intimal area of vein grafts was increased compared to ungrafted mammary veins. Intimal hyperplasia in vein grafts was characterized by massive accumulation of smooth muscle cells with a high proliferation rate and endothelial perturbation. Significant (p = 0.001) intimal hyperplasia of the grafted mammary vein compared to the ungrafted mammary vein was found. These changes were absent in ungrafted mammary veins. Conclusion: The present study demonstrates a pig model of aortocoronary vein graft intimal hyperplasia which is characterized by an accelerated progression within internal mammary veins. The model is suitable to investigate the pathophysiology of aortocoronary vein graft intimal hyperplasia as well as therapeutic approaches."],["dc.identifier.fs","216118"],["dc.identifier.ppn","575639180"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/4332"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61078"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1749-8090"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","617"],["dc.title","Accelerated intimal hyperplasia in aortocoronary internal mammary vein grafts in minipigs"],["dc.title.alternative","Research article"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]