Hinz, Jose

[["dc.bibliographiccitation.artnumber","39"],["dc.bibliographiccitation.journal","Journal of Cardiothoracic Surgery"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Gehoff, Philipp"],["dc.contributor.author","Schotola, Hanna"],["dc.contributor.author","Hosseini, Morteza Tavakkoli"],["dc.contributor.author","Didilis, Vassilios N."],["dc.contributor.author","Jebran, Ahmad Fawad"],["dc.contributor.author","Gehoff, Anastasia"],["dc.contributor.author","Wiese, Christoph Hermann"],["dc.contributor.author","Schulz, Egbert Godehard"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Popov, Aron Frederik"],["dc.date.accessioned","2018-11-07T09:11:03Z"],["dc.date.available","2018-11-07T09:11:03Z"],["dc.date.issued","2012"],["dc.description.abstract","Background: Peri-operative statin therapy in cardiac surgery cases is reported to reduce the rate of mortality, stroke, postoperative atrial fibrillation, and systemic inflammation. Systemic inflammation could affect the hemodynamic parameters and stability. We set out to study the effect of statin therapy on perioperative hemodynamic parameters and its clinical outcome. Methods: In a single center study from 2006 to 2007, peri-operative hemodynamic parameters of 478 patients, who underwent cardiac surgery with cardiopulmonary bypass, were measured. Patients were divided into those who received perioperative statin therapy (n = 276; statin group) and those who did not receive statin therapy (n = 202; no-statin group). The two groups were compared together using Kolmogorov-Smirnov-Test, Fisher's-Exact-Test, and Student's-T-test. A p value < 0.05 was considered as significant. Results: There was no significant difference in the preoperative risk factors. Onset of postoperative atrial fibrillation was not affected by statin therapy. Extended hemodynamic measurements revealed no significant difference between the two groups, apart from Systemic Vascular Resistance Index (SVRI). The no-statin group had a significantly higher SVRI (882 +/- 206 vs. 1050 +/- 501 dyn s/cm(5)/m(2), p = 0.022). Inotropic support was the same in both groups and no significant difference in the mortality rate was noticed. Also, hemodynamic parameters were not affected by different types and doses of statins. Conclusions: Perioperative statin therapy for patients undergoing on-pump coronary bypass grafting or valvular surgery, does not affect the hemodynamic parameters and its clinical outcome."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2012"],["dc.identifier.doi","10.1186/1749-8090-7-39"],["dc.identifier.isi","000306370800001"],["dc.identifier.pmid","22533985"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8510"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26638"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1749-8090"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Hemodynamic effects of peri-operative statin therapy in on-pump cardiac surgery patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","199"],["dc.bibliographiccitation.journal","Journal of Cardiothoracic Surgery"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Schoendorf, Daniel"],["dc.contributor.author","Bireta, Christian"],["dc.contributor.author","Lipke, Christina"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Bergmann, Ingo"],["dc.contributor.author","Wiese, Christoph Herman"],["dc.contributor.author","Mansur, Ashham"],["dc.contributor.author","Schotola, Hanna"],["dc.contributor.author","Sabashnikov, Anton"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Popov, Aron Frederik"],["dc.date.accessioned","2018-11-07T09:18:28Z"],["dc.date.available","2018-11-07T09:18:28Z"],["dc.date.issued","2013"],["dc.description.abstract","Background: The eNOS 894G/T polymorphism (GG, GT, and TT) is associated with cardiovascular mortality and may influence cardiovascular diseases as a genetic risk factor. Moreover, this polymorphism has an impact on intraoperative hemodynamics during cardiac surgery with cardiopulmonary bypass (CPB). In this study, we analyzed the influence of this gene polymorphism on early clinical outcome in patients who underwent cardiac surgery with CPB. Also, we performed a 5-year follow-up, assessing the impact of this polymorphism on long-term mortality. Method: 500 patients who underwent cardiac surgery with CPB between 2006 and 2007 were included in this prospective single centre study. Genotyping for the eNOS gene polymorphism was performed by polymerase chain reaction amplification. Results: Genotype distribution of 894G/T was: GG 50.2%; GT 42.2%; TT 7.8%. Cardiovascular risk factors were equally distributed between the different genotypes of the eNOS 894G/T polymorphism. No significant difference among the groups was shown regarding Euroscore, SAPS II and APACHE II. Perioperative characteristics were also not affected by the genotypes, except for the consumption of norepinephrine (p = 0.03) and amiodarone (p = 0.01) which was higher in the GT allele carrier. The early postoperative course was quite uniform across the genotypes, except for mean intensive care unit length of stay which was significantly prolonged in GT carriers (p = 0.001). The five-year follow-up was 100% complete and showed no significant differences regarding mortality between the groups. Conclusion: Our results show that the eNOS 894G/T polymorphism is not associated with early and late clinical outcome after cardiac surgery. Thus, this polymorphism can actually not help to identify high risk groups in the heterogeneous population of individuals who undergo cardiac surgery with CPB."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2013"],["dc.identifier.doi","10.1186/1749-8090-8-199"],["dc.identifier.isi","000329216900001"],["dc.identifier.pmid","24161078"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9474"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28420"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1749-8090"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","The eNOS 894G/T gene polymorphism and its influence on early and long-term mortality after on-pump cardiac surgery"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","3"],["dc.bibliographiccitation.journal","Journal of Cardiothoracic Surgery"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Coskun, Sinan Tolga"],["dc.contributor.author","Popov, Aron Frederik"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Bockhorst, Kerstin"],["dc.contributor.author","Stich, Kathrin Monika"],["dc.contributor.author","Koerfer, Reiner"],["dc.date.accessioned","2018-11-07T08:33:34Z"],["dc.date.available","2018-11-07T08:33:34Z"],["dc.date.issued","2009"],["dc.description.abstract","Background: Complications of acute myocardial infarction ( AMI) with mechanical defects are associated with poor prognosis. Surgical intervention is indicated for a majority of these patients. The goal of surgical intervention is to improve the systolic cardiac function and to achieve a hemodynamic stability. In this present study we reviewed the outcome of patients with post infarction ventricular septal defect (PVSD) who underwent cardiac surgery. Methods: We analysed retrospectively the hospital records of 41 patients, whose ages range from 48 to 81, and underwent a surgical treatment between 1990 and 2005 because of PVSD. Results: In 22 patients concomitant coronary artery bypass grafting (CAGB) was performed. In 15 patients a residual shunt was found, this required re-op in seven of them. The time interval from infarct to rupture was 8.7 days and from rupture to surgery was 23.1 days. Hospital mortality in PVSD group was 32%. The mortality of urgent repair within 3 days of intractable cardiogenic shock was 100%. The mortality of patients with an anterior VSD and a posterior VSD was 29.6% vs 42.8%, respectively. All patients who underwent the surgical repair later than day 36 survived. Conclusion: Surgical intervention is indicated for a majority of patients with mechanical complications. Cardiogenic shock remains the most important factor that affects the early results. The surgical repair of PVSD should be performed 4-5 weeks after AMI. To improve surgical outcome and hemodynamics the choice of surgical technique and surgical timing as well as preoperative management should be tailored for each patient individually."],["dc.identifier.doi","10.1186/1749-8090-4-3"],["dc.identifier.isi","000262911700001"],["dc.identifier.pmid","19126196"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/4302"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17608"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1749-8090"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Experiences with surgical treatment of ventricle septal defect as a post infarction complication"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","E85"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Artificial Organs"],["dc.bibliographiccitation.lastpage","E90"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Popov, Aron Frederik"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Coskun, Sinan Tolga"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Ruschewski, Wolfgang"],["dc.date.accessioned","2018-11-07T08:45:10Z"],["dc.date.available","2018-11-07T08:45:10Z"],["dc.date.issued","2010"],["dc.description.abstract","The optimal treatment of congenital aortic valve lesions is a controversial issue. This study was performed to evaluate the outcome after surgical treatment of aortic valve lesions in congenital aortic valve disease. Between the years of 2000 and 2008, 61 patients (mean age: 12.6 +/- 9.6 years, range: 1 day to 40 years) underwent aortic valve surgery for congenital aortic valve disease. Twenty-four patients had undergone previous cardiovascular operations. Indications for surgery were aortic regurgitation in 14.7% (n = 9), aortic stenoses in 26.2% (n = 16), and mixed disease in 59.1% (n = 36). The Ross procedure was performed in 37.7% (n = 23), aortic valve replacement with biological or mechanical prostheses in 29.5% (n = 18). Concomitant procedures were performed in 91.8% (n = 56) due to associated congenital cardiac defects. The overall mortality rate was 5%. Six patients needed reoperation. Implantation of permanent pacemakers occurred in six patients for permanent atrioventricular block. At the latest clinical evaluation, all survivors are in New York Heart Association class I-II and are living normal lives. Aortic valve surgeries in patients with congenital heart disease have had low mortality and morbidity rates in our series. Surgical technique as well as timing should be tailored for each patient. Aortic valve replacement should be delayed until the implantation of an adult-sized prosthesis is possible."],["dc.identifier.doi","10.1111/j.1525-1594.2009.00958.x"],["dc.identifier.isi","000275725900004"],["dc.identifier.pmid","20447039"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20370"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.publisher.place","Malden"],["dc.relation.conference","5th International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion"],["dc.relation.eventlocation","Dallas, TX"],["dc.relation.issn","0160-564X"],["dc.title","Aortic Valve Surgery in Congenital Heart Disease: A Single-Center Experience"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","1"],["dc.bibliographiccitation.journal","Journal of Cardiothoracic Surgery"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Popov, Aron Frederik"],["dc.contributor.author","Baryalei, Mersa Mohammed"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Wiese, Christoph Hermann"],["dc.contributor.author","Raab, Björn"],["dc.contributor.author","Kolat, Philipp"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Seipelt, Ralf G."],["dc.date.accessioned","2018-11-07T08:33:36Z"],["dc.date.available","2018-11-07T08:33:36Z"],["dc.date.issued","2009"],["dc.description.abstract","We report an unusual case of an aortic type A dissection with a corpus alienum which compresses the right ventricle. The patient successfully underwent an aortic root replacement in deep hypothermia with re-implantation of the coronary arteries using a modified Bentall procedure and the resection of the corpus alienum. Intraoperative finding reveals 3 greatly adhered gauze compresses, which were most likely forgotten in the operation 34 years ago."],["dc.identifier.doi","10.1186/1749-8090-4-1"],["dc.identifier.isi","000262911500001"],["dc.identifier.pmid","19121214"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/4303"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17615"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","Najko"],["dc.relation.issn","1749-8090"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Acute aortic dissection type A discloses Corpus alienum"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","429"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Coronary Artery Disease"],["dc.bibliographiccitation.lastpage","434"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Popov, Aron Frederik"],["dc.contributor.author","Schulz, Egbert Godehard"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Seipelt, Ralf G."],["dc.contributor.author","Koziolek, Michael Johann"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Mueller, Gerhard Anton"],["dc.date.accessioned","2018-11-07T11:09:22Z"],["dc.date.available","2018-11-07T11:09:22Z"],["dc.date.issued","2008"],["dc.description.abstract","Objective Endothelin is the most potent endogenous vasoconstrictor and is involved in several vascular disorders such as arterial hypertension. Its intense interaction with other vasoactive hormone systems revealed the consideration about the endothelin gene as an interesting candidate for influencing the development of essential hypertension and hypertensive endorgan damage. The purpose of this study was to investigate the role of endothelin-1 Lys198Asn polymorphism in patients with severe arterial hypertension as well as associated endorgan damages. Methods In 400 hypertensive patients and 150 normotensive controls we examined the endothelin-1 Lys198Asn polymorphism by DNA sequencing and patients were divided according to their genotype (GG, GT, and TT). Moreover, the frequency of endothelin-1 Lys198Asn polymorphism was investigated with respect to the prevalence of several actual or historical endorgan damages (renal disorder, coronary artery disease, vascular events, vascular damage, and congestive heart failure) in hypertensive patients. Results Genotype distribution for endothelin-1 Lys198Asn polymorphism was 573% (GG), 41.3% (GT), and 11.43% (TT) in normotensive individuals; and in hypertensive individuals was 54.75% (GG), 43% (GT) and 2.25% (TT). Genotype distribution was unaffected in patients with severe hypertension, renal disorder, vascular events, vascular damage, and congestive heart failure. We, however, found a significant difference in hypertensive individuals with coronary artery disease and TT genotype (P=0.004). Conclusion Homozygous TT carrier contributes to a higher prevalence of coronary artery disease, especially for three-vessel disease in hypertensive individuals. Thus, the polymorphism at position 198 could serve as a possibility to differentiate high-risk subgroups in the heterogeneous population of hypertensive patients. Coron Artery Dis 19:429-434 (C) 2008 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins."],["dc.identifier.doi","10.1097/MCA.0b013e32830936e5"],["dc.identifier.isi","000260520400001"],["dc.identifier.pmid","18923236"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52994"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0954-6928"],["dc.title","Impact of endothelin-1 Lys198Asn polymorphism on coronary artery disease and endorgan damage in hypertensives"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","651"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","European Journal of Cardio-Thoracic Surgery"],["dc.bibliographiccitation.lastpage","656"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Popov, Aron Frederik"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Schulz, Egbert Godehard"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Wiese, Christoph Hermann"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Seipelt, Ralf G."],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T11:23:32Z"],["dc.date.available","2018-11-07T11:23:32Z"],["dc.date.issued","2009"],["dc.description.abstract","Objective: Renal dysfunction is one of the most serious complications following cardiac surgery with cardiopulmonary bypass. The causes of renal dysfunction following cardiac surgery are poorly understood. We hypothesised that T-786C endothelial NO synthase (eNOS) polymorphism may lead to an increase in the occurrence of postoperative renal dysfunction following cardiac surgery with cardiopulmonary bypass. Methods: A total of 497 patients undergoing cardiac surgery with cardiopulmonary bypass were included in the study. The T-786C eNOS polymorphism was detected by a polymerase chain reaction. The patients were grouped on the basis of whether they were homozygous or heterozygous for the C allele (TC + CC; n = 289) or only homozygous for the Tallele (TT; n = 208). Results: No significance was demonstrated in the preoperative risk factors, with the exclusion of smoking habits (p = 0.04) for the C-allele carrier. The administration of anti-lipid agents (p = 0.01) and anti-arrhythmics (p = 0.01) was significantly tower in the TC/CC group. The TC + CC genotype group had a significantly greater decrease in creatine clearance (p = 0.024), the lowest creatine clearance (p = 0.004) and more C-allele carriers received acute renal replacement therapy (p = 0.04). The usage of norepinephrine (p = 0.02) and dobutamine (p = 0.02) was significantly higher in C-allele carriers. In the TC + CC genotype group, cross-clamp time (p = 0.02) and administration of red cell transfusion (p = 0.04) achieved statistically significant difference. The overall in-hospital mortality rate was 8.2% for all patients and was not significant between genotypes. Conclusions: The present findings support the hypothesis that the T-786C eNOS polymorphism may play a role in the development of renal dysfunction and increase the occurrence of renal replacement therapy following cardiac surgery with cardiopulmonary bypass. This polymorphism may be useful in stratifying the risk for the development of postoperative renal dysfunction. (C) 2009 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.ejcts.2009.04.049"],["dc.identifier.isi","000270644100008"],["dc.identifier.pmid","19523844"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56217"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1010-7940"],["dc.title","The eNOS 786C/T polymorphism in cardiac surgical patients with cardiopulmonary bypass is associated with renal dysfunction"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1026"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Artificial Organs"],["dc.bibliographiccitation.lastpage","1030"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Popov, Aron Frederik"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Kriebel, Thomas"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Ruschewski, Wolfgang"],["dc.contributor.author","Tirilomis, Theodor"],["dc.date.accessioned","2018-11-07T08:37:19Z"],["dc.date.available","2018-11-07T08:37:19Z"],["dc.date.issued","2010"],["dc.description.abstract","Drowning and near-drowning is often associated with severe hypothermia requiring active core rewarming. We performed rewarming by cardiopulmonary bypass (CPB). Between 1987 and 2007, 13 children (9 boys and 4 girls) with accidental hypothermia were rewarmed by extracorporeal circulation (ECC) in our institution. The average age of the patients was 3.2 years. Resuscitation was started immediately upon the arrival of the rescue team and was continuously performed during the transportation. All patients were intubated and ventilated. Core temperature at admission ranged from 20 to 29 degrees C (mean 25.3 degrees C). Connection to the CPB was performed by thoracic (9 patients) or femoral/iliac means (4 patients). Restoration of circulation was achieved in 11 patients (84.6%). After CPB termination two patients needed an extracorporeal membrane oxygenation system due to severe pulmonary edema. Five patients were discharged from hospital after prolonged hospital stay. During follow-up, two patients died (10 and 15 months, respectively) of pulmonary complications and one patient was lost to follow-up. The two remaining survivors were without neurological deficit. Modes of rewarming, age, sex, rectal temperature, and serum electrolytes did not influence mortality. In conclusion, drowning and near-drowning with severe hypothermia remains a challenging emergency. Rewarming by ECC provides efficient rewarming and full circulatory support. Although nearly half of the children may survive after rewarming by ECC, long-term outcome is limited by pulmonary and neurological complications."],["dc.identifier.doi","10.1111/j.1525-1594.2010.01156.x"],["dc.identifier.isi","000284588300026"],["dc.identifier.pmid","21134219"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18502"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","6th International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion"],["dc.relation.eventlocation","Boston, MA"],["dc.relation.issn","1525-1594"],["dc.relation.issn","0160-564X"],["dc.title","Extracorporeal Circulation for Rewarming in Drowning and Near-Drowning Pediatric Patients"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","83"],["dc.bibliographiccitation.journal","Journal of Cardiothoracic Surgery"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Popov, Aron Frederik"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Giesler, Michael"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Hanekop, Gerd Gunnar"],["dc.contributor.author","Gravenhorst, Verena D."],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Ruschewski, Wolfgang"],["dc.date.accessioned","2018-11-07T09:05:57Z"],["dc.date.available","2018-11-07T09:05:57Z"],["dc.date.issued","2012"],["dc.description.abstract","Background: The arterial switch operation (ASO) has become the surgical approach of choice for d-transposition of the great arteries (d-TGA). There is, however an increased incidence of midterm and longterm adverse sequelae in some survivors. In order to evaluate operative risk and midterm outcome in this population, we reviewed patients who underwent ASO for TGA at our centre. Methods: In this retrospective study 52 consecutive patients with TGA who underwent ASO between 04/1991 and 12/1999 were included. To analyze the predictors for mortality and adverse events (coronary stenoses, distortion of the pulmonary arteries, dilatation of the neoaortic root, and aortic regurgitation), a multivariate analysis was performed. The follow-up time was ranged from 1-10 years (mean 5 years, cumulative 260 patient-years). Results: All over mortality rate was 15.4% and was only observed in the early postoperative period till 1994. The predictors for poor operative survival were low APGAR-score, older age at surgery, and necessity of associated surgical procedures. Late re-operations were necessary in 6 patients (13.6%) and included a pulmonary artery patch enlargement due to supravalvular stenosis (n = 3), coronary revascularisation due to coronary stenosis in a coronary anatomy type E, aortic valve replacement due to neoaortic valve regurgitation (n = 2), and patch-plasty of a pulmonary vein due to obstruction (n = 1). The dilatation of neoaortic root was not observed in the follow up. Conclusions: ASO remains the procedure of choice for TGA with acceptable early and late outcome in terms of overall survival and freedom of reoperation. Although ASO is often complex and may be associated with morbidity, most patients survived without major complications even in a small centre."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2012"],["dc.identifier.doi","10.1186/1749-8090-7-83"],["dc.identifier.isi","000311289900001"],["dc.identifier.pmid","22958234"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8188"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25441"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1749-8090"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Midterm results after arterial switch operation for transposition of the great arteries: a single centre experience"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","20"],["dc.bibliographiccitation.journal","Journal of cardiothoracic surgery"],["dc.bibliographiccitation.lastpage","6"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Popov, Aron Frederik"],["dc.contributor.author","Dorge, Hilmar"],["dc.contributor.author","Hinz, José"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Stojanovic, Tomislav"],["dc.contributor.author","Seipelt, Ralf"],["dc.contributor.author","Didilis, Vassilios"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2019-07-10T08:12:56Z"],["dc.date.available","2019-07-10T08:12:56Z"],["dc.date.issued","2008"],["dc.description.abstract","Background: More than 50% of aortocoronary saphenous vein grafts are occluded 10 years after surgery. Intimal hyperplasia is the initial critical step in the progression toward occlusion. Internal mammary veins, which are physiologically prone to less hydrostatic pressure, may undergo an accelerated progression to intimal hyperplasia and thus be suitable for investigation of the mechanisms of aortocoronary vein graft disease. Methods: Six minipigs underwent aortocoronary bypass grafting using standard cardiopulmonary bypass and cardioplegic arrest. Mammary vein were grafted in a reversed manner from ascending aorta to left anterior descending coronary artery (LAD). The proximal LAD was ligated, rendering the anterior left ventricle vein graft-dependent. Minipigs were killed after 4 weeks, and vein grafts were harvested. Histological and immunohistological investigation were performed with respect to morphometric analysis, endothelial damage/dysfunction (v-Willebrand-factor (vWF)), smooth muscle cells (?-smooth actin) and proliferation rate (proliferation marker Ki 67). Results: Mean intimal area of vein grafts was increased compared to ungrafted mammary veins. Intimal hyperplasia in vein grafts was characterized by massive accumulation of smooth muscle cells with a high proliferation rate and endothelial perturbation. Significant (p = 0.001) intimal hyperplasia of the grafted mammary vein compared to the ungrafted mammary vein was found. These changes were absent in ungrafted mammary veins. Conclusion: The present study demonstrates a pig model of aortocoronary vein graft intimal hyperplasia which is characterized by an accelerated progression within internal mammary veins. The model is suitable to investigate the pathophysiology of aortocoronary vein graft intimal hyperplasia as well as therapeutic approaches."],["dc.identifier.fs","216118"],["dc.identifier.ppn","575639180"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/4332"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61078"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1749-8090"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","617"],["dc.title","Accelerated intimal hyperplasia in aortocoronary internal mammary vein grafts in minipigs"],["dc.title.alternative","Research article"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]