Hinz, Jose

[["dc.bibliographiccitation.firstpage","S129"],["dc.bibliographiccitation.journal","Journal of Hypertension"],["dc.bibliographiccitation.lastpage","S130"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Popov, A. F."],["dc.contributor.author","Schulz, E.-G."],["dc.contributor.author","Hinz, Jose Maria"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Seipelt, Ralf G."],["dc.contributor.author","Koziolek, Michael Johann"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Mueller, Georg Anton"],["dc.date.accessioned","2018-11-07T11:14:45Z"],["dc.date.available","2018-11-07T11:14:45Z"],["dc.date.issued","2008"],["dc.identifier.isi","000257197000576"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54210"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","18th Scientific Meeting of the European-Society-of-Hypertension/22nd Scientific Meeting of the International-Society-of-Hypertension"],["dc.relation.eventlocation","Berlin, GERMANY"],["dc.relation.issn","0263-6352"],["dc.title","Impact of endothelin-1 Lys198Asn polymorphism for severe essential hypertension and endorgan damage"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","E85"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Artificial Organs"],["dc.bibliographiccitation.lastpage","E90"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Popov, Aron Frederik"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Coskun, Sinan Tolga"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Ruschewski, Wolfgang"],["dc.date.accessioned","2018-11-07T08:45:10Z"],["dc.date.available","2018-11-07T08:45:10Z"],["dc.date.issued","2010"],["dc.description.abstract","The optimal treatment of congenital aortic valve lesions is a controversial issue. This study was performed to evaluate the outcome after surgical treatment of aortic valve lesions in congenital aortic valve disease. Between the years of 2000 and 2008, 61 patients (mean age: 12.6 +/- 9.6 years, range: 1 day to 40 years) underwent aortic valve surgery for congenital aortic valve disease. Twenty-four patients had undergone previous cardiovascular operations. Indications for surgery were aortic regurgitation in 14.7% (n = 9), aortic stenoses in 26.2% (n = 16), and mixed disease in 59.1% (n = 36). The Ross procedure was performed in 37.7% (n = 23), aortic valve replacement with biological or mechanical prostheses in 29.5% (n = 18). Concomitant procedures were performed in 91.8% (n = 56) due to associated congenital cardiac defects. The overall mortality rate was 5%. Six patients needed reoperation. Implantation of permanent pacemakers occurred in six patients for permanent atrioventricular block. At the latest clinical evaluation, all survivors are in New York Heart Association class I-II and are living normal lives. Aortic valve surgeries in patients with congenital heart disease have had low mortality and morbidity rates in our series. Surgical technique as well as timing should be tailored for each patient. Aortic valve replacement should be delayed until the implantation of an adult-sized prosthesis is possible."],["dc.identifier.doi","10.1111/j.1525-1594.2009.00958.x"],["dc.identifier.isi","000275725900004"],["dc.identifier.pmid","20447039"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20370"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.publisher.place","Malden"],["dc.relation.conference","5th International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion"],["dc.relation.eventlocation","Dallas, TX"],["dc.relation.issn","0160-564X"],["dc.title","Aortic Valve Surgery in Congenital Heart Disease: A Single-Center Experience"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","445"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Annals of Thoracic and Cardiovascular Surgery"],["dc.bibliographiccitation.lastpage","447"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Kolat, Philipp"],["dc.contributor.author","Ortmann, Philipp"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Sohns, Christian"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T08:35:58Z"],["dc.date.available","2018-11-07T08:35:58Z"],["dc.date.issued","2010"],["dc.description.abstract","Diffuse atherosclerosis of the anterior descending artery may require unconventional surgical treatment to increase graft flow. A 74-year-old man with severe, diffuse 3-vessel-coronary artery disease was presented to our institution with progredient angina pectoris symptoms. Intraoperatively, the revascularization of the left anterior descending coronary artery (LAD) was technically challenging because of the extremely calcified coronary artery disease; therefore we performed the longest endarterectomy of the LAD that has thus far been described. (Ann Thorac Cardiovasc Surg 2010; 16: 445-447)"],["dc.identifier.isi","000287296500014"],["dc.identifier.pmid","21263430"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18203"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Medical Tribune Inc"],["dc.relation.issn","1341-1098"],["dc.title","CABG Surgery with Long Coronary Endarterectomy of the LAD"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","969"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Artificial Organs"],["dc.bibliographiccitation.lastpage","979"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Heidrich, Florian"],["dc.contributor.author","Sossalla, Samuel T."],["dc.contributor.author","Schotola, Hanna"],["dc.contributor.author","Vorkamp, Tobias"],["dc.contributor.author","Ortmann, Philipp"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Rajab, Taufiek K."],["dc.contributor.author","Friedrich, Martin"],["dc.contributor.author","Sohns, Christian"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.date.accessioned","2018-11-07T08:37:19Z"],["dc.date.available","2018-11-07T08:37:19Z"],["dc.date.issued","2010"],["dc.description.abstract","We established a stable and reproducible animal model of chronic heart failure (CHF) in sheep to investigate biomolecular changes. Therefore, two biomarkers, adenosine monophosphate-activated protein kinase (AMPK) and vascular endothelial growth factor-A (VEGF-A) were examined to reveal their role during chronic ischemic conditions of the heart. AMPK was studied because it plays an important role in cellular energy homeostasis and its upregulation is associated with myocardial ischemia, whereas VEGF-A was studied because it acts as an important signaling protein for neoangiogenesis. We examined 15 juvenile sheep (mean weight, 78 +/- 4 kg; control, n = 3; ShamOP, n = 2; coronary microembolization [CME], n = 10). CHF was induced under fluoroscopic guidance by multiple sequential microembolizations (MEs) through bolus injection of polysterol microspheres (90 mu m, n = 25.000) into the left main coronary artery. CME was repeated up to three times at 2- to 3-week intervals until animals started to develop stable signs of CHF. All animals were followed for 3 months. Phosphorylation of AMPK, marking the activated protein form, was detected by Western blotting. VEGF-A and vascular endothelial growth factor-receptor 2 (VEGF-R2) mRNA were detected by real-time polymerase chain reaction. Glyceraldehyde-3-phosphate-dehydrogenase (GAPDH) was used as a reference housekeeping gene. All 10 CHF animals developed clinical signs of CHF as indicated by a significant decrease of cardiac output, decreased ejection fraction, as well as occurrence of tachycardia and tachypnoea. Western blots showed significant phosphorylation of AMPK in CME animals compared to the control group (phospho-adenosine monophosphate-activated protein kinase a) (GAPDH control: 0.0, CME left ventricle [LV]: 0.39 +/- 0.20, CME right ventricle [RV]: 0.53 +/- 0.30; P < 0.05). VEGF-A and VEGF-R2 expression in CME animal myocardium was within the range of the control group, but this data did not reach statistical significance due to the small size of this group. While microinjection was performed into the left main coronary artery, phosphorylation of AMPK and expression of VEGF-A and VEGF-R2 were significantly higher in the RV than in the LV. Multiple sequential intracoronary MEs can effectively induce myocardial dysfunction with clinical and biomolecular signs of chronic ischemic cardiomyopathy. Quantitative analysis of biomolecular markers showed a significantly higher phosphorylation of AMPK in CHF animals compared with control myocardium."],["dc.identifier.doi","10.1111/j.1525-1594.2010.01121.x"],["dc.identifier.isi","000284588300018"],["dc.identifier.pmid","21092039"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18501"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","6th International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion"],["dc.relation.eventlocation","Boston, MA"],["dc.relation.issn","1525-1594"],["dc.relation.issn","0160-564X"],["dc.title","The Role of Phospho-Adenosine Monophosphate-Activated Protein Kinase and Vascular Endothelial Growth Factor in a Model of Chronic Heart Failure"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","429"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Coronary Artery Disease"],["dc.bibliographiccitation.lastpage","434"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Popov, Aron Frederik"],["dc.contributor.author","Schulz, Egbert Godehard"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Seipelt, Ralf G."],["dc.contributor.author","Koziolek, Michael Johann"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Mueller, Gerhard Anton"],["dc.date.accessioned","2018-11-07T11:09:22Z"],["dc.date.available","2018-11-07T11:09:22Z"],["dc.date.issued","2008"],["dc.description.abstract","Objective Endothelin is the most potent endogenous vasoconstrictor and is involved in several vascular disorders such as arterial hypertension. Its intense interaction with other vasoactive hormone systems revealed the consideration about the endothelin gene as an interesting candidate for influencing the development of essential hypertension and hypertensive endorgan damage. The purpose of this study was to investigate the role of endothelin-1 Lys198Asn polymorphism in patients with severe arterial hypertension as well as associated endorgan damages. Methods In 400 hypertensive patients and 150 normotensive controls we examined the endothelin-1 Lys198Asn polymorphism by DNA sequencing and patients were divided according to their genotype (GG, GT, and TT). Moreover, the frequency of endothelin-1 Lys198Asn polymorphism was investigated with respect to the prevalence of several actual or historical endorgan damages (renal disorder, coronary artery disease, vascular events, vascular damage, and congestive heart failure) in hypertensive patients. Results Genotype distribution for endothelin-1 Lys198Asn polymorphism was 573% (GG), 41.3% (GT), and 11.43% (TT) in normotensive individuals; and in hypertensive individuals was 54.75% (GG), 43% (GT) and 2.25% (TT). Genotype distribution was unaffected in patients with severe hypertension, renal disorder, vascular events, vascular damage, and congestive heart failure. We, however, found a significant difference in hypertensive individuals with coronary artery disease and TT genotype (P=0.004). Conclusion Homozygous TT carrier contributes to a higher prevalence of coronary artery disease, especially for three-vessel disease in hypertensive individuals. Thus, the polymorphism at position 198 could serve as a possibility to differentiate high-risk subgroups in the heterogeneous population of hypertensive patients. Coron Artery Dis 19:429-434 (C) 2008 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins."],["dc.identifier.doi","10.1097/MCA.0b013e32830936e5"],["dc.identifier.isi","000260520400001"],["dc.identifier.pmid","18923236"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52994"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0954-6928"],["dc.title","Impact of endothelin-1 Lys198Asn polymorphism on coronary artery disease and endorgan damage in hypertensives"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","961"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Artificial Organs"],["dc.bibliographiccitation.lastpage","968"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Schulz, Egbert G."],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Tzvetkov, Mladen Vassilev"],["dc.contributor.author","Kazmaier, Stephan"],["dc.contributor.author","Zimmermann, Janna"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Hinz, Jose"],["dc.date.accessioned","2018-11-07T08:37:19Z"],["dc.date.available","2018-11-07T08:37:19Z"],["dc.date.issued","2010"],["dc.description.abstract","Several genetic polymorphisms have been identified to play a role in the occurrence and progression of renal dysfunction after cardiac surgery with cardiopulmonary bypass (CPB). Recently, it was demonstrated that the T allele of SNP rs1617640 in the promoter of the erythropoetin (EPO) gene is significantly associated with proliferative diabetic retinopathy (PDR) and end-stage renal disease (ESRD) due to increased EPO expression. This disease risk-associated gene and its potential pathway mediating severe microvascular complications in T-allele carriers could also play a role on renal dysfunction in patients who underwent cardiac surgery with CPB. We hypothesized that the patients' ability to produce increased EPO concentrations will affect morbidity and mortality after CPB. We conducted a prospective single center study between April 2006 and May 2007. In 481 patients who underwent cardiac surgery with CPB we prospectively examined the SNP rs1617640 in the promoter of the EPO gene by DNA sequencing. The patients were grouped according to their genotype (GG, GT, and TT). The genotype distribution of SNP rs1617640 in the promoter of the EPO gene was 36% (TT), 49% (TG), and 15% (GG). There was no difference in age, body mass index, gender, CPB time, or length of stay in intensive care unit. The hospitalization was irrespective of the patients' genotypes. The baseline creatinine in the TT group was 0.2 points higher than in the other groups; however this was without statistical significance in the multivariate analysis. No significant difference was shown in Euroscore, the Simplified Acute Physiology Score II, the Acute Physiology and Chronic Health Evaluation Score II, Acute Renal Failure Score, or the Risk, Injury, Failure, Loss of Kidney Function Score. The mortality was equal across the genotypes. However, an association between the TT genotype and acute renal replacement therapy (P = 0.03), intraaortic balloon pump usage (P = 0.02), and serum creatine phosphokinase-MB increase (P = 0.03) were observed after cardiac surgery. Our analysis suggests that the risk allele (T) of rs1617640 plays a role in the development of renal dysfunction after cardiac surgery with CPB. Patients with the TT risk allele required more frequent acute renal replacement therapy. Since our result is close to the border of significance, this hypothesis should be investigated in larger prospective studies with long-term follow-up to emphasize this polymorphism as a potential risk factor."],["dc.identifier.doi","10.1111/j.1525-1594.2010.01108.x"],["dc.identifier.isi","000284588300017"],["dc.identifier.pmid","21092038"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18500"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","6th International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion"],["dc.relation.eventlocation","Boston, MA"],["dc.relation.issn","1525-1594"],["dc.relation.issn","0160-564X"],["dc.title","Relation Between Renal Dysfunction Requiring Renal Replacement Therapy and Promoter Polymorphism of the Erythropoietin Gene in Cardiac Surgery"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","915"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Artificial Organs"],["dc.bibliographiccitation.lastpage","921"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Kriebel, Thomas"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Ruschewski, Wolfgang"],["dc.date.accessioned","2018-11-07T11:22:22Z"],["dc.date.available","2018-11-07T11:22:22Z"],["dc.date.issued","2009"],["dc.description.abstract","Due to improved outcome after surgery for congenital heart defects, children, adolescents, and grown-ups with congenital heart defects become an increasing population. In order to evaluate operative risk and early outcome after mechanical aortic valve replacement (AVR) in this population, we reviewed patients who underwent previous repair of congenital heart defects. Between July 2002 and November 2008, 15 (10 male and 5 female) consecutive patients (mean age 14.5 +/- 10.5 years) underwent mechanical AVR. Hemodynamic indications for AVR were aortic stenosis in four (27%), aortic insufficiency in eight (53%), and mixed disease in three (20%) after previous repair of congenital heart defects. All patients had undergone one or more previous cardiovascular operations due to any congenital heart disease. Concomitant cardiac procedures were performed in all of them. In addition to AVR, in two patients, a mitral valve exchange was performed. One patient received a right ventricle-pulmonary artery conduit replacement as concomitant procedure. The mean size of implanted valves was 23 mm (range 17-29 mm). There were neither early deaths nor late mortality until December 2008. Reoperations were necessary in five (33%) and included implantation of a permanent pacemaker due to complete atrioventricular block in two (15%), mitral valve replacement with a mechanical prosthesis due to moderate to severe mitral regurgitation in one (7%), aortocoronary bypass grafting due to stenosis of a coronary artery in one (7%), and in one (7%), a redo subaortic stenosis resection was performed because of a secondary subaortic stenosis. At the latest clinical evaluation, all patients were in good clinical condition without a pathological increased gradient across the aortic valve prosthesis or paravalvular leakage in echocardiography. Mechanical AVR has excellent results in patients after previous repair of congenital heart defects in childhood, even in combination with complex concomitant procedures. Previous operations do not significantly affect postoperative outcome."],["dc.identifier.doi","10.1111/j.1525-1594.2009.00886.x"],["dc.identifier.isi","000272127800007"],["dc.identifier.pmid","19817736"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55984"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.relation.issn","0160-564X"],["dc.title","Mechanical Aortic Valve Replacement in Children and Adolescents After Previous Repair of Congenital Heart Disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","651"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","European Journal of Cardio-Thoracic Surgery"],["dc.bibliographiccitation.lastpage","656"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Popov, Aron Frederik"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Schulz, Egbert Godehard"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Wiese, Christoph Hermann"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Seipelt, Ralf G."],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T11:23:32Z"],["dc.date.available","2018-11-07T11:23:32Z"],["dc.date.issued","2009"],["dc.description.abstract","Objective: Renal dysfunction is one of the most serious complications following cardiac surgery with cardiopulmonary bypass. The causes of renal dysfunction following cardiac surgery are poorly understood. We hypothesised that T-786C endothelial NO synthase (eNOS) polymorphism may lead to an increase in the occurrence of postoperative renal dysfunction following cardiac surgery with cardiopulmonary bypass. Methods: A total of 497 patients undergoing cardiac surgery with cardiopulmonary bypass were included in the study. The T-786C eNOS polymorphism was detected by a polymerase chain reaction. The patients were grouped on the basis of whether they were homozygous or heterozygous for the C allele (TC + CC; n = 289) or only homozygous for the Tallele (TT; n = 208). Results: No significance was demonstrated in the preoperative risk factors, with the exclusion of smoking habits (p = 0.04) for the C-allele carrier. The administration of anti-lipid agents (p = 0.01) and anti-arrhythmics (p = 0.01) was significantly tower in the TC/CC group. The TC + CC genotype group had a significantly greater decrease in creatine clearance (p = 0.024), the lowest creatine clearance (p = 0.004) and more C-allele carriers received acute renal replacement therapy (p = 0.04). The usage of norepinephrine (p = 0.02) and dobutamine (p = 0.02) was significantly higher in C-allele carriers. In the TC + CC genotype group, cross-clamp time (p = 0.02) and administration of red cell transfusion (p = 0.04) achieved statistically significant difference. The overall in-hospital mortality rate was 8.2% for all patients and was not significant between genotypes. Conclusions: The present findings support the hypothesis that the T-786C eNOS polymorphism may play a role in the development of renal dysfunction and increase the occurrence of renal replacement therapy following cardiac surgery with cardiopulmonary bypass. This polymorphism may be useful in stratifying the risk for the development of postoperative renal dysfunction. (C) 2009 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.ejcts.2009.04.049"],["dc.identifier.isi","000270644100008"],["dc.identifier.pmid","19523844"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56217"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1010-7940"],["dc.title","The eNOS 786C/T polymorphism in cardiac surgical patients with cardiopulmonary bypass is associated with renal dysfunction"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","265"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","JOURNAL OF CARDIOVASCULAR SURGERY"],["dc.bibliographiccitation.lastpage","272"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Popov, A. F."],["dc.contributor.author","Henker, Christian"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Wiese, Christoph Hermann"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Danner, Bernhard Christoph"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Quintel, M."],["dc.contributor.author","Hinz, Jose Maria"],["dc.date.accessioned","2018-11-07T08:44:34Z"],["dc.date.available","2018-11-07T08:44:34Z"],["dc.date.issued","2010"],["dc.description.abstract","Aim. The endothelial nitric oxide (eNOS) gene T-786C polymorphism may influence as a genetic risk factor cardiovascular diseases and shows association with cardiovascular mortality. We hypothesized that this polymorphism may lead to increase mortality and morbity after cardiac surgery with cardiopulmonary bypass (CPB). Methods. In 500 patients who underwent cardiac surgery with CPB we investigated the eNOS T-786C polymorphism by DNA-sequencing. The patients were grouped according to their genotype in three groups (TT, TC, and CC). Results. The overall genotype distribution of T-786C polymorphism was TT=41.60/0, TC=51.2%, and CC=7.2% respectively. The groups did not differ in age and gender. No significance was shown in preopertive risk factores, excluding perpheral disease (P=0.03). No difference was shown in Euroscore, APACHE II, and SAPS II. The usage of norepinephrine (P=0.03) and nitroglycerine (P=0.01) was significant higher in TC allele carrier. The mortality was quite uniform across elective and urgent subgroup. However, we found a significant difference concerning mortality and emergency cardiac procedures in homozygous C-allele carrier (P=0.014). Conclusion. The present study demonstrates that this polymorphism contributes to a higher prevalence of postoperative mortality after emergency cardiac surgery. Thus, the eNOS T-786C polymorphism could serve as a possibility to differentiate high risk subgroups in heterogeneous population of individuals with cardiac diseases who need cardiac surgery with CPB."],["dc.identifier.isi","000278822900014"],["dc.identifier.pmid","20354497"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20230"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Edizioni Minerva Medica"],["dc.relation.issn","1827-191X"],["dc.relation.issn","0021-9509"],["dc.title","Clinical relevance of eNOS T-786C polymorphism for hospital mortality and morbidity in cardiac surgical patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","947"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Artificial Organs"],["dc.bibliographiccitation.lastpage","952"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Coskun, Sinan Tolga"],["dc.contributor.author","Ortmann, Philipp"],["dc.contributor.author","Vorkamp, Tobias"],["dc.contributor.author","Heidrich, Florian"],["dc.contributor.author","Sossalla, Samuel T."],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Heuer, J. F."],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Chen, Frederick Yen-Ching"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T11:22:23Z"],["dc.date.available","2018-11-07T11:22:23Z"],["dc.date.issued","2009"],["dc.description.abstract","Although a large variety of animal models for acute ischemia and acute heart failure exist, valuable models for studies on the effect of ventricular assist devices in chronic heart failure are scarce. We established a stable and reproducible animal model of chronic heart failure in sheep and aimed to investigate the hemodynamic changes of this animal model of chronic heart failure in sheep. In five sheep (n = 5, 77 +/- 2 kg), chronic heart failure was induced under flouroscopic guidance by multiple sequential microembolization through bolus injection of polysterol microspheres (90 mu m, n = 25.000) into the left main coronary artery. Coronary microembolization (CME) was repeated up to three times in 2 to 3-week intervals until animals started to develop stable signs of heart failure. During each operation, hemodynamic monitoring was performed through implantation of central venous catheter (central venous pressure [CVP]), arterial pressure line (mean arterial pressure [MAP]), implantation of a right heart catheter {Swan-Ganz catheter (mean pulmonary arterial pressure [PAPmean])}, pulmonary capillary wedge pressure (PCWP), and cardiac output [CO]) as well as pre- and postoperative clinical investigations. All animals were followed for 3 months after first microembolization and then sacrificed for histological examination. All animals developed clinical signs of heart failure as indicated by increased heart rate (HR) at rest (68 +/- 4 bpm [base] to 93 +/- 5 bpm [3 mo] [P < 0.05]), increased respiratory rate (RR) at rest (28 +/- 5 [base] to 38 +/- 7 [3 mo] [P < 0.05]), and increased body weight 77 +/- 2 kg to 81 +/- 2 kg (P < 0.05) due to pleural effusion, peripheral edema, and ascites. Hemodynamic signs of heart failure were revealed as indicated by increase of HR, RR, CVP, PAP, and PCWP as well as a decrease of CO, stroke volume, and MAP 3 months after the first CME. Multiple sequential intracoronary microembolization can effectively induce myocardial dysfunction with clinical and hemodynamic signs of chronic ischemic cardiomyopathy. The present model may be suitable in experimental work on heart failure and left ventricular assist devices, for example, for studying the impact of mechanical unloading, mechanisms of recovery, and reverse remodeling."],["dc.identifier.doi","10.1111/j.1525-1594.2009.00921.x"],["dc.identifier.isi","000272127800012"],["dc.identifier.pmid","19817734"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55985"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.relation.issn","0160-564X"],["dc.title","Hemodynamic Changes in a Model of Chronic Heart Failure Induced by Multiple Sequential Coronary Microembolization in Sheep"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]