Regen, Tommy

[["dc.bibliographiccitation.firstpage","447"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Cell Science"],["dc.bibliographiccitation.lastpage","458"],["dc.bibliographiccitation.volume","124"],["dc.contributor.author","Fitzner, Dirk"],["dc.contributor.author","Schnaars, Mareike"],["dc.contributor.author","van Rossum, Denise"],["dc.contributor.author","Krishnamoorthy, Gurumoorthy"],["dc.contributor.author","Dibaj, Payam"],["dc.contributor.author","Bakhti, Mostafa"],["dc.contributor.author","Regen, Tommy"],["dc.contributor.author","Hanisch, Uwe-Karsten"],["dc.contributor.author","Simons, Mikael"],["dc.date.accessioned","2018-11-07T08:59:39Z"],["dc.date.available","2018-11-07T08:59:39Z"],["dc.date.issued","2011"],["dc.description.abstract","The transfer of antigens from oligodendrocytes to immune cells has been implicated in the pathogenesis of autoimmune diseases. Here, we show that oligodendrocytes secrete small membrane vesicles called exosomes, which are specifically and efficiently taken up by microglia both in vitro and in vivo. Internalisation of exosomes occurs by a macropinocytotic mechanism without inducing a concomitant inflammatory response. After stimulation of microglia with interferon-gamma, we observe an upregulation of MHC class II in a subpopulation of microglia. However, exosomes are preferentially internalised in microglia that do not seem to have antigen-presenting capacity. We propose that the constitutive macropinocytotic clearance of exosomes by a subset of microglia represents an important mechanism through which microglia participate in the degradation of oligodendroglial membrane in an immunologically 'silent' manner. By designating the capacity for macropinocytosis and antigen presentation to distinct cells, degradation and immune function might be assigned to different subtypes of microglia."],["dc.description.sponsorship","ERC; EMBO YIP; German Research Council [SFB/TR43]"],["dc.identifier.doi","10.1242/jcs.074088"],["dc.identifier.isi","000286223600016"],["dc.identifier.pmid","21242314"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8034"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23953"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Company Of Biologists Ltd"],["dc.relation.issn","0021-9533"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1477"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Glia"],["dc.bibliographiccitation.lastpage","1489"],["dc.bibliographiccitation.volume","58"],["dc.contributor.author","Pukrop, Tobias"],["dc.contributor.author","Dehghani, Faramarz"],["dc.contributor.author","Chuang, Han-Ning"],["dc.contributor.author","Lohaus, Raphaela"],["dc.contributor.author","Bayanga, Kathrin"],["dc.contributor.author","Heermann, Stephan"],["dc.contributor.author","Regen, Tommy"],["dc.contributor.author","van Rossum, Denise"],["dc.contributor.author","Klemm, Florian"],["dc.contributor.author","Schulz, Matthias"],["dc.contributor.author","Siam, Laila"],["dc.contributor.author","Hoffmann, Anja"],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Bechmann, Ingo"],["dc.contributor.author","Hanisch, Uwe-Karsten"],["dc.contributor.author","Binder, Claudia"],["dc.date.accessioned","2018-11-07T08:39:43Z"],["dc.date.available","2018-11-07T08:39:43Z"],["dc.date.issued","2010"],["dc.description.abstract","Although there is increasing evidence that blood-derived macrophages support tumor progression, it is still unclear whether specialized resident macrophages, such as brain microglia, also play a prominent role in metastasis formation. Here, we show that microglia enhance invasion and colonization of brain tissue by breast cancer cells, serving both as active transporters and guiding rails. This is antagonized by inactivation of microglia as well as by the Wnt inhibitor Dickkopf-2. Proinvasive microglia demonstrate altered morphology, but neither upregulation of M2-like cytokines nor differential gene expression. Bacterial lipopolysacharide shifts tumor-educated microglia into a classical M1 phenotype, reduces their proinvasive function, and unmasks inflammatory and Wnt signaling as the most strongly regulated pathways. Histological findings in human brain metastases underline the significance of these results. In conclusion, microglia are critical for the successful colonization of the brain by epithelial cancer cells, suggesting inhibition of proinvasive microglia as a promising antimetastatic strategy. (C) 2010 Wiley-Liss, Inc."],["dc.description.sponsorship","German Research Council (DFG) [For942 BI 703/3-1]"],["dc.identifier.doi","10.1002/glia.21022"],["dc.identifier.isi","000280349900008"],["dc.identifier.pmid","20549749"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6326"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19065"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.relation.issn","0894-1491"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Microglia Promote Colonization of Brain Tissue by Breast Cancer Cells in a Wnt-Dependent Way"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]