Raaz, Uwe

[["dc.bibliographiccitation.firstpage","1796"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Arteriosclerosis, Thrombosis, and Vascular Biology"],["dc.bibliographiccitation.lastpage","1805"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Adam, Matti"],["dc.contributor.author","Kooreman, Nigel Geoffrey"],["dc.contributor.author","Jagger, Ann"],["dc.contributor.author","Wagenhäuser, Markus U."],["dc.contributor.author","Mehrkens, Dennis"],["dc.contributor.author","Wang, Yongming"],["dc.contributor.author","Kayama, Yosuke"],["dc.contributor.author","Toyama, Kensuke"],["dc.contributor.author","Raaz, Uwe"],["dc.contributor.author","Schellinger, Isabel N."],["dc.contributor.author","Maegdefessel, Lars"],["dc.contributor.author","Spin, Joshua M."],["dc.contributor.author","Hamming, Jaap F."],["dc.contributor.author","Quax, Paul H.A."],["dc.contributor.author","Baldus, Stephan"],["dc.contributor.author","Wu, Joseph C."],["dc.contributor.author","Tsao, Philip S."],["dc.date.accessioned","2020-12-10T18:37:55Z"],["dc.date.available","2020-12-10T18:37:55Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1161/ATVBAHA.117.310672"],["dc.identifier.eissn","1524-4636"],["dc.identifier.issn","1079-5642"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77136"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Systemic Upregulation of IL-10 (Interleukin-10) Using a Nonimmunogenic Vector Reduces Growth and Rate of Dissecting Abdominal Aortic Aneurysm"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","513"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Circulation Research"],["dc.bibliographiccitation.lastpage","524"],["dc.bibliographiccitation.volume","117"],["dc.contributor.author","Raaz, Uwe"],["dc.contributor.author","Schellinger, Isabel N."],["dc.contributor.author","Chernogubova, Ekaterina"],["dc.contributor.author","Warnecke, Christina"],["dc.contributor.author","Kayama, Yosuke"],["dc.contributor.author","Penov, Kiril"],["dc.contributor.author","Hennigs, Jan K."],["dc.contributor.author","Salomons, Florian"],["dc.contributor.author","Eken, Suzanne"],["dc.contributor.author","Emrich, Fabian C."],["dc.contributor.author","Zheng, Wei H."],["dc.contributor.author","Adam, Matti"],["dc.contributor.author","Jagger, Ann"],["dc.contributor.author","Nakagami, Futoshi"],["dc.contributor.author","Toh, Ryuji"],["dc.contributor.author","Toyama, Kensuke"],["dc.contributor.author","Deng, Alicia"],["dc.contributor.author","Buerke, Michael"],["dc.contributor.author","Maegdefessel, Lars"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Spin, Joshua M."],["dc.contributor.author","Tsao, Philip S."],["dc.date.accessioned","2017-09-07T11:43:37Z"],["dc.date.available","2017-09-07T11:43:37Z"],["dc.date.issued","2015"],["dc.description.abstract","Rationale: Accelerated arterial stiffening is a major complication of diabetes mellitus with no specific therapy available to date. Objective: The present study investigates the role of the osteogenic transcription factor runt-related transcription factor 2 (Runx2) as a potential mediator and therapeutic target of aortic fibrosis and aortic stiffening in diabetes mellitus. Methods and Results: Using a murine model of type 2 diabetes mellitus (db/db mice), we identify progressive structural aortic stiffening that precedes the onset of arterial hypertension. At the same time, Runx2 is aberrantly upregulated in the medial layer of db/db aortae, as well as in thoracic aortic samples from patients with type 2 diabetes mellitus. Vascular smooth muscle cell-specific overexpression of Runx2 in transgenic mice increases expression of its target genes, Col1a1 and Col1a2, leading to medial fibrosis and aortic stiffening. Interestingly, increased Runx2 expression per se is not sufficient to induce aortic calcification. Using in vivo and in vitro approaches, we further demonstrate that expression of Runx2 in diabetes mellitus is regulated via a redox-sensitive pathway that involves a direct interaction of NF-B with the Runx2 promoter. Conclusions: In conclusion, this study highlights Runx2 as a previously unrecognized inducer of vascular fibrosis in the setting of diabetes mellitus, promoting arterial stiffness irrespective of calcification."],["dc.identifier.doi","10.1161/CIRCRESAHA.115.306341"],["dc.identifier.gro","3141842"],["dc.identifier.isi","000360142000007"],["dc.identifier.pmid","26208651"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/1679"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.eissn","1524-4571"],["dc.relation.issn","0009-7330"],["dc.title","Transcription Factor Runx2 Promotes Aortic Fibrosis and Stiffness in Type 2 Diabetes Mellitus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Der Internist"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Raaz, Uwe"],["dc.contributor.author","Schellinger, Isabel N."],["dc.contributor.author","Maegdefessel, Lars"],["dc.contributor.author","Spin, Joshua M."],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Tsao, Philip S."],["dc.date.accessioned","2018-11-07T10:15:54Z"],["dc.date.available","2018-11-07T10:15:54Z"],["dc.date.issued","2016"],["dc.format.extent","S58"],["dc.identifier.isi","000375417500113"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40914"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.issn","1432-1289"],["dc.relation.issn","0020-9554"],["dc.title","MicroRNA miR-29b is a mediator of aortic stiffness and hypertension in a murine model of diabetes mellitus type 2"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","633"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Circulation Research"],["dc.bibliographiccitation.lastpage","644"],["dc.bibliographiccitation.volume","120"],["dc.contributor.author","Eken, Suzanne M."],["dc.contributor.author","Jin, Hong"],["dc.contributor.author","Chernogubova, Ekaterina"],["dc.contributor.author","Li, Yuhuang"],["dc.contributor.author","Simon, Nancy"],["dc.contributor.author","Sun, Changyan"],["dc.contributor.author","Korzunowicz, Greg"],["dc.contributor.author","Busch, Albert"],["dc.contributor.author","Bäcklund, Alexandra"],["dc.contributor.author","Österholm, Cecilia"],["dc.contributor.author","Razuvaev, Anton"],["dc.contributor.author","Renné, Thomas"],["dc.contributor.author","Eckstein, Hans Henning"],["dc.contributor.author","Pelisek, Jaroslav"],["dc.contributor.author","Eriksson, Per"],["dc.contributor.author","González Díez, María"],["dc.contributor.author","Perisic Matic, Ljubica"],["dc.contributor.author","Schellinger, Isabel N."],["dc.contributor.author","Raaz, Uwe"],["dc.contributor.author","Leeper, Nicholas J."],["dc.contributor.author","Hansson, Göran K."],["dc.contributor.author","Paulsson-Berne, Gabrielle"],["dc.contributor.author","Hedin, Ulf"],["dc.contributor.author","Maegdefessel, Lars"],["dc.date.accessioned","2020-12-10T18:37:59Z"],["dc.date.available","2020-12-10T18:37:59Z"],["dc.date.issued","2017"],["dc.description.abstract","Rationale: In the search for markers and modulators of vascular disease, microRNAs (miRNAs) have emerged as potent therapeutic targets. Objective: To investigate miRNAs of clinical interest in patients with unstable carotid stenosis at risk of stroke. Methods and Results: Using patient material from the BiKE (Biobank of Karolinska Endarterectomies), we profiled miRNA expression in patients with stable versus unstable carotid plaque. A polymerase chain reactionbased miRNA array of plasma, sampled at the carotid lesion site, identified 8 deregulated miRNAs (miR-15b, miR29c, miR-30c/d, miR-150, miR-191, miR-210, and miR-500). miR-210 was the most significantly downregulated miRNA in local plasma material. Laser capture microdissection and in situ hybridization revealed a distinct localization of miR-210 in fibrous caps. We confirmed that miR-210 directly targets the tumor suppressor gene APC (adenomatous polyposis coli), thereby affecting Wnt (Wingless-related integration site) signaling and regulating smooth muscle cell survival, as well as differentiation in advanced atherosclerotic lesions. Substantial changes in arterial miR-210 were detectable in 2 rodent models of vascular remodeling and plaque rupture. Modulating miR210 in vitro and in vivo improved fibrous cap stability with implications for vascular disease. Conclusions: An unstable carotid plaque at risk of stroke is characterized by low expression of miR-210. miR-210 contributes to stabilizing carotid plaques through inhibition of APC, ensuring smooth muscle cell survival. We present local delivery of miR-210 as a therapeutic approach for prevention of atherothrombotic vascular events."],["dc.identifier.doi","10.1161/CIRCRESAHA.116.309318"],["dc.identifier.eissn","1524-4571"],["dc.identifier.isi","000394446200016"],["dc.identifier.issn","0009-7330"],["dc.identifier.pmid","27895035"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77157"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1524-4571"],["dc.relation.issn","0009-7330"],["dc.title","MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","E11"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.lastpage","E12"],["dc.bibliographiccitation.volume","133"],["dc.contributor.author","Raaz, Uwe"],["dc.contributor.author","Zöllner, Alexander M."],["dc.contributor.author","Schellinger, Isabel N."],["dc.contributor.author","Toh, Ryuji"],["dc.contributor.author","Nakagami, Futoshi"],["dc.contributor.author","Brandt, Moritz"],["dc.contributor.author","Emrich, Fabian C."],["dc.contributor.author","Kayama, Yosuke"],["dc.contributor.author","Eken, Suzanne"],["dc.contributor.author","Adam, Matti"],["dc.contributor.author","Maegdefessel, Lars"],["dc.contributor.author","Hertel, Thomas"],["dc.contributor.author","Deng, Alicia"],["dc.contributor.author","Jagger, Ann"],["dc.contributor.author","Buerke, Michael"],["dc.contributor.author","Dalman, Ronald L."],["dc.contributor.author","Spin, Joshua M."],["dc.contributor.author","Kuhl, Ellen"],["dc.contributor.author","Tsao, Philip S."],["dc.date.accessioned","2020-12-10T18:38:00Z"],["dc.date.available","2020-12-10T18:38:00Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1161/CIRCULATIONAHA.115.018759"],["dc.identifier.eissn","1524-4539"],["dc.identifier.isi","000367540000006"],["dc.identifier.issn","0009-7322"],["dc.identifier.pmid","26719393"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77164"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1524-4539"],["dc.relation.issn","0009-7322"],["dc.title","Response to Letters Regarding Article, \"Segmental Aortic Stiffening Contributes to Experimental Abdominal Aortic Aneurysm Development\""],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Journal of the American College of Cardiology"],["dc.bibliographiccitation.volume","69"],["dc.contributor.author","Raaz, Uwe"],["dc.contributor.author","Schellinger, Isabel N."],["dc.contributor.author","Mattern, Karin"],["dc.contributor.author","Mattes, Lena"],["dc.contributor.author","Spin, Joshua"],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Maegdefessel, Lars"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Tsao, Philip S."],["dc.date.accessioned","2018-11-07T10:26:06Z"],["dc.date.available","2018-11-07T10:26:06Z"],["dc.date.issued","2017"],["dc.format.extent","2023"],["dc.identifier.isi","000397342302745"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42971"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Elsevier Science Inc"],["dc.publisher.place","New york"],["dc.relation.conference","66th Annual Scientific Session and Expo of the American-College-of-Cardiology (ACC)"],["dc.relation.eventlocation","Washington, DC"],["dc.relation.issn","1558-3597"],["dc.relation.issn","0735-1097"],["dc.title","NON-CODING RNAS COMPREHENSIVELY COUNTERACT ADVERSE ARTERIAL REMODELING AND STIFFENING IN TYPE 2 DIABETES"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]