Raaz, Uwe

[["dc.bibliographiccitation.journal","Frontiers in Physiology"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Wagenhäuser, Markus U."],["dc.contributor.author","Schellinger, Isabel N."],["dc.contributor.author","Yoshino, Takuya"],["dc.contributor.author","Toyama, Kensuke"],["dc.contributor.author","Kayama, Yosuke"],["dc.contributor.author","Deng, Alicia"],["dc.contributor.author","Guenther, Sabina P."],["dc.contributor.author","Petzold, Anne"],["dc.contributor.author","Mulorz, Joscha"],["dc.contributor.author","Mulorz, Pireyatharsheny"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Ibing, Wiebke"],["dc.contributor.author","Elvers, Margitta"],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Ramasubramanian, Anand K."],["dc.contributor.author","Adam, Matti"],["dc.contributor.author","Schelzig, Hubert"],["dc.contributor.author","Spin, Joshua M."],["dc.contributor.author","Raaz, Uwe"],["dc.contributor.author","Tsao, Philip S."],["dc.date.accessioned","2020-12-10T18:44:37Z"],["dc.date.available","2020-12-10T18:44:37Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.3389/fphys.2018.01459"],["dc.identifier.eissn","1664-042X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78531"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Chronic Nicotine Exposure Induces Murine Aortic Remodeling and Stiffness Segmentation—Implications for Abdominal Aortic Aneurysm Susceptibility"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","616"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Kidney International"],["dc.bibliographiccitation.lastpage","627"],["dc.bibliographiccitation.volume","91"],["dc.contributor.author","Schellinger, Isabel N."],["dc.contributor.author","Cordasic, Nada"],["dc.contributor.author","Panesar, Julian"],["dc.contributor.author","Buchholz, Bjoern"],["dc.contributor.author","Jacobi, Johannes"],["dc.contributor.author","Hartner, Andrea"],["dc.contributor.author","Klanke, Bernd"],["dc.contributor.author","Jakubiczka-Smorag, Joanna"],["dc.contributor.author","Burzlaff, Nicolai"],["dc.contributor.author","Heinze, Eva"],["dc.contributor.author","Warnecke, Christina"],["dc.contributor.author","Raaz, Uwe"],["dc.contributor.author","Willam, Carsten"],["dc.contributor.author","Tsao, Philip S."],["dc.contributor.author","Eckardt, Kai-Uwe"],["dc.contributor.author","Amann, Kerstin"],["dc.contributor.author","Hilgers, Karl F."],["dc.date.accessioned","2018-11-07T10:26:33Z"],["dc.date.available","2018-11-07T10:26:33Z"],["dc.date.issued","2017"],["dc.description.abstract","Chronic kidney disease (CKD) is associated with increased risk and worse prognosis of cardiovascular disease, including peripheral artery disease. An impaired angiogenic response to ischemia may contribute to poor outcomes of peripheral artery disease in patients with CKD. Hypoxia inducible factors (HIF) are master regulators of angiogenesis and therefore represent a promising target for therapeutic intervention. To test this we induced hind-limb ischemia in rats with CKD caused by 5/6 nephrectomy and administered two different treatments known to stabilize HIF protein in vivo: carbon monoxide and a pharmacological inhibitor of prolyl hydroxylation 2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido) acetate (ICA). Expression levels of proangiogenic HIF target genes (Vegf, Vegf-r1, Vegf-r2, Ho-1) were measured by qRT-PCR. Capillary density was measured by CD31 immunofluorescence staining and HIF expression was evaluated by immunohistochemistry. Capillary density in ischemic skeletal muscle was significantly lower in CKD animals compared to sham controls. Rats with CKD showed significantly lower expression of HIF and all measured pro-angiogenic HIF target genes, including VEGF. Both HIF stabilizing treatments rescued HIF target gene expression in animals with CKD and led to significantly higher ischemia-induced capillary sprouting compared to untreated controls. ICA was effective regardless of whether it was administered before or after induction of ischemia and led to a HIF expression in skeletal muscle. Thus, impaired ischemia-induced angiogenesis in rats with CKD can be improved by HIF stabilization, even if started after onset of ischemia."],["dc.identifier.doi","10.1016/j.kint.2016.09.028"],["dc.identifier.isi","000394921400016"],["dc.identifier.pmid","27927598"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43067"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1523-1755"],["dc.relation.issn","0085-2538"],["dc.title","Hypoxia inducible factor stabilization improves defective ischemia-induced angiogenesis in a rodent model of chronic kidney disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1796"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Arteriosclerosis, Thrombosis, and Vascular Biology"],["dc.bibliographiccitation.lastpage","1805"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Adam, Matti"],["dc.contributor.author","Kooreman, Nigel Geoffrey"],["dc.contributor.author","Jagger, Ann"],["dc.contributor.author","Wagenhäuser, Markus U."],["dc.contributor.author","Mehrkens, Dennis"],["dc.contributor.author","Wang, Yongming"],["dc.contributor.author","Kayama, Yosuke"],["dc.contributor.author","Toyama, Kensuke"],["dc.contributor.author","Raaz, Uwe"],["dc.contributor.author","Schellinger, Isabel N."],["dc.contributor.author","Maegdefessel, Lars"],["dc.contributor.author","Spin, Joshua M."],["dc.contributor.author","Hamming, Jaap F."],["dc.contributor.author","Quax, Paul H.A."],["dc.contributor.author","Baldus, Stephan"],["dc.contributor.author","Wu, Joseph C."],["dc.contributor.author","Tsao, Philip S."],["dc.date.accessioned","2020-12-10T18:37:55Z"],["dc.date.available","2020-12-10T18:37:55Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1161/ATVBAHA.117.310672"],["dc.identifier.eissn","1524-4636"],["dc.identifier.issn","1079-5642"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77136"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Systemic Upregulation of IL-10 (Interleukin-10) Using a Nonimmunogenic Vector Reduces Growth and Rate of Dissecting Abdominal Aortic Aneurysm"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Der Internist"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Schellinger, Isabel N."],["dc.contributor.author","Tsao, Philip S."],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Raaz, Uwe"],["dc.date.accessioned","2018-11-07T10:15:54Z"],["dc.date.available","2018-11-07T10:15:54Z"],["dc.date.issued","2016"],["dc.format.extent","S75"],["dc.identifier.isi","000375417500148"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40915"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.issn","1432-1289"],["dc.relation.issn","0020-9554"],["dc.title","Transcription factor Runx2 is induced in vascular aging and may promote age-related arterial stiffness"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","513"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Circulation Research"],["dc.bibliographiccitation.lastpage","524"],["dc.bibliographiccitation.volume","117"],["dc.contributor.author","Raaz, Uwe"],["dc.contributor.author","Schellinger, Isabel N."],["dc.contributor.author","Chernogubova, Ekaterina"],["dc.contributor.author","Warnecke, Christina"],["dc.contributor.author","Kayama, Yosuke"],["dc.contributor.author","Penov, Kiril"],["dc.contributor.author","Hennigs, Jan K."],["dc.contributor.author","Salomons, Florian"],["dc.contributor.author","Eken, Suzanne"],["dc.contributor.author","Emrich, Fabian C."],["dc.contributor.author","Zheng, Wei H."],["dc.contributor.author","Adam, Matti"],["dc.contributor.author","Jagger, Ann"],["dc.contributor.author","Nakagami, Futoshi"],["dc.contributor.author","Toh, Ryuji"],["dc.contributor.author","Toyama, Kensuke"],["dc.contributor.author","Deng, Alicia"],["dc.contributor.author","Buerke, Michael"],["dc.contributor.author","Maegdefessel, Lars"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Spin, Joshua M."],["dc.contributor.author","Tsao, Philip S."],["dc.date.accessioned","2017-09-07T11:43:37Z"],["dc.date.available","2017-09-07T11:43:37Z"],["dc.date.issued","2015"],["dc.description.abstract","Rationale: Accelerated arterial stiffening is a major complication of diabetes mellitus with no specific therapy available to date. Objective: The present study investigates the role of the osteogenic transcription factor runt-related transcription factor 2 (Runx2) as a potential mediator and therapeutic target of aortic fibrosis and aortic stiffening in diabetes mellitus. Methods and Results: Using a murine model of type 2 diabetes mellitus (db/db mice), we identify progressive structural aortic stiffening that precedes the onset of arterial hypertension. At the same time, Runx2 is aberrantly upregulated in the medial layer of db/db aortae, as well as in thoracic aortic samples from patients with type 2 diabetes mellitus. Vascular smooth muscle cell-specific overexpression of Runx2 in transgenic mice increases expression of its target genes, Col1a1 and Col1a2, leading to medial fibrosis and aortic stiffening. Interestingly, increased Runx2 expression per se is not sufficient to induce aortic calcification. Using in vivo and in vitro approaches, we further demonstrate that expression of Runx2 in diabetes mellitus is regulated via a redox-sensitive pathway that involves a direct interaction of NF-B with the Runx2 promoter. Conclusions: In conclusion, this study highlights Runx2 as a previously unrecognized inducer of vascular fibrosis in the setting of diabetes mellitus, promoting arterial stiffness irrespective of calcification."],["dc.identifier.doi","10.1161/CIRCRESAHA.115.306341"],["dc.identifier.gro","3141842"],["dc.identifier.isi","000360142000007"],["dc.identifier.pmid","26208651"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/1679"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.eissn","1524-4571"],["dc.relation.issn","0009-7330"],["dc.title","Transcription Factor Runx2 Promotes Aortic Fibrosis and Stiffness in Type 2 Diabetes Mellitus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Der Internist"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Raaz, Uwe"],["dc.contributor.author","Schellinger, Isabel N."],["dc.contributor.author","Maegdefessel, Lars"],["dc.contributor.author","Spin, Joshua M."],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Tsao, Philip S."],["dc.date.accessioned","2018-11-07T10:15:54Z"],["dc.date.available","2018-11-07T10:15:54Z"],["dc.date.issued","2016"],["dc.format.extent","S58"],["dc.identifier.isi","000375417500113"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40914"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.issn","1432-1289"],["dc.relation.issn","0020-9554"],["dc.title","MicroRNA miR-29b is a mediator of aortic stiffness and hypertension in a murine model of diabetes mellitus type 2"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","720"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Circulation Research"],["dc.bibliographiccitation.lastpage","730"],["dc.bibliographiccitation.volume","117"],["dc.contributor.author","Riegler, Johannes"],["dc.contributor.author","Tiburcy, Malte"],["dc.contributor.author","Ebert, Antje"],["dc.contributor.author","Tzatzalos, Evangeline"],["dc.contributor.author","Raaz, Uwe"],["dc.contributor.author","Abilez, Oscar J."],["dc.contributor.author","Shen, Qi"],["dc.contributor.author","Kooreman, Nigel G."],["dc.contributor.author","Neofytou, Evgenios"],["dc.contributor.author","Chen, Vincent C."],["dc.contributor.author","Wang, Mouer"],["dc.contributor.author","Meyer, Tim"],["dc.contributor.author","Tsao, Philip S."],["dc.contributor.author","Connolly, Andrew J."],["dc.contributor.author","Couture, Larry A."],["dc.contributor.author","Gold, Joseph D."],["dc.contributor.author","Zimmermann, Wolfram-Hubertus"],["dc.contributor.author","Wu, Joseph C."],["dc.date.accessioned","2017-09-07T11:43:32Z"],["dc.date.available","2017-09-07T11:43:32Z"],["dc.date.issued","2015"],["dc.description.abstract","Rationale: Tissue engineering approaches may improve survival and functional benefits from human embryonic stem cell-derived cardiomyocyte transplantation, thereby potentially preventing dilative remodeling and progression to heart failure. Objective: Assessment of transport stability, long-term survival, structural organization, functional benefits, and teratoma risk of engineered heart muscle (EHM) in a chronic myocardial infarction model. Methods and Results: We constructed EHMs from human embryonic stem cell-derived cardiomyocytes and released them for transatlantic shipping following predefined quality control criteria. Two days of shipment did not lead to adverse effects on cell viability or contractile performance of EHMs (n=3, P=0.83, P=0.87). One month after ischemia/reperfusion injury, EHMs were implanted onto immunocompromised rat hearts to simulate chronic ischemia. Bioluminescence imaging showed stable engraftment with no significant cell loss between week 2 and 12 (n=6, P=0.67), preserving 25% of the transplanted cells. Despite high engraftment rates and attenuated disease progression (change in ejection fraction for EHMs, -6.71.4% versus control, -10.9 +/- 1.5%; n>12; P=0.05), we observed no difference between EHMs containing viable and nonviable human cardiomyocytes in this chronic xenotransplantation model (n>12; P=0.41). Grafted cardiomyocytes showed enhanced sarcomere alignment and increased connexin 43 expression at 220 days after transplantation. No teratomas or tumors were found in any of the animals (n=14) used for long-term monitoring. Conclusions: EHM transplantation led to high engraftment rates, long-term survival, and progressive maturation of human cardiomyocytes. However, cell engraftment was not correlated with functional improvements in this chronic myocardial infarction model. Most importantly, the safety of this approach was demonstrated by the lack of tumor or teratoma formation."],["dc.identifier.doi","10.1161/CIRCRESAHA.115.306985"],["dc.identifier.gro","3141824"],["dc.identifier.isi","000361730700010"],["dc.identifier.pmid","26291556"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/1479"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/93"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C04: Fibroblasten-Kardiomyozyten Interaktion im gesunden und erkrankten Herzen: Mechanismen und therapeutische Interventionen bei Kardiofibroblastopathien"],["dc.relation.eissn","1524-4571"],["dc.relation.issn","0009-7330"],["dc.relation.workinggroup","RG Ebert (Cardiovascular Cell Biology and Systems Medicine)"],["dc.relation.workinggroup","RG Tiburcy (Stem Cell Disease Modeling)"],["dc.relation.workinggroup","RG Zimmermann (Engineered Human Myocardium)"],["dc.title","Human Engineered Heart Muscles Engraft and Survive Long Term in a Rodent Myocardial Infarction Model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","E11"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.lastpage","E12"],["dc.bibliographiccitation.volume","133"],["dc.contributor.author","Raaz, Uwe"],["dc.contributor.author","Zöllner, Alexander M."],["dc.contributor.author","Schellinger, Isabel N."],["dc.contributor.author","Toh, Ryuji"],["dc.contributor.author","Nakagami, Futoshi"],["dc.contributor.author","Brandt, Moritz"],["dc.contributor.author","Emrich, Fabian C."],["dc.contributor.author","Kayama, Yosuke"],["dc.contributor.author","Eken, Suzanne"],["dc.contributor.author","Adam, Matti"],["dc.contributor.author","Maegdefessel, Lars"],["dc.contributor.author","Hertel, Thomas"],["dc.contributor.author","Deng, Alicia"],["dc.contributor.author","Jagger, Ann"],["dc.contributor.author","Buerke, Michael"],["dc.contributor.author","Dalman, Ronald L."],["dc.contributor.author","Spin, Joshua M."],["dc.contributor.author","Kuhl, Ellen"],["dc.contributor.author","Tsao, Philip S."],["dc.date.accessioned","2020-12-10T18:38:00Z"],["dc.date.available","2020-12-10T18:38:00Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1161/CIRCULATIONAHA.115.018759"],["dc.identifier.eissn","1524-4539"],["dc.identifier.isi","000367540000006"],["dc.identifier.issn","0009-7322"],["dc.identifier.pmid","26719393"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77164"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1524-4539"],["dc.relation.issn","0009-7322"],["dc.title","Response to Letters Regarding Article, \"Segmental Aortic Stiffening Contributes to Experimental Abdominal Aortic Aneurysm Development\""],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Journal of the American College of Cardiology"],["dc.bibliographiccitation.volume","69"],["dc.contributor.author","Raaz, Uwe"],["dc.contributor.author","Schellinger, Isabel N."],["dc.contributor.author","Mattern, Karin"],["dc.contributor.author","Mattes, Lena"],["dc.contributor.author","Spin, Joshua"],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Maegdefessel, Lars"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Tsao, Philip S."],["dc.date.accessioned","2018-11-07T10:26:06Z"],["dc.date.available","2018-11-07T10:26:06Z"],["dc.date.issued","2017"],["dc.format.extent","2023"],["dc.identifier.isi","000397342302745"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42971"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Elsevier Science Inc"],["dc.publisher.place","New york"],["dc.relation.conference","66th Annual Scientific Session and Expo of the American-College-of-Cardiology (ACC)"],["dc.relation.eventlocation","Washington, DC"],["dc.relation.issn","1558-3597"],["dc.relation.issn","0735-1097"],["dc.title","NON-CODING RNAS COMPREHENSIVELY COUNTERACT ADVERSE ARTERIAL REMODELING AND STIFFENING IN TYPE 2 DIABETES"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Cardiovascular Medicine"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Schellinger, Isabel N."],["dc.contributor.author","Dannert, Angelika R."],["dc.contributor.author","Mattern, Karin"],["dc.contributor.author","Raaz, Uwe"],["dc.contributor.author","Tsao, Philip S."],["dc.date.accessioned","2021-06-01T09:42:23Z"],["dc.date.available","2021-06-01T09:42:23Z"],["dc.date.issued","2021"],["dc.description.abstract","New technologies have greatly shaped the scientific and medical landscape within the last years. The unprecedented expansion of data and information on RNA biology has led to the discovery of new RNA classes with unique functions and unexpected modifications. Today, the biggest challenge is to transfer the large number of findings in basic RNA biology into corresponding clinical RNA-based therapeutics. Lately, this research begins to yield positive outcomes. RNA drugs advance to the final phases of clinical trials or even receive FDA approval. Furthermore, the introduction of the RNA-guided gene-editing technology CRISPR and advances in the delivery of messenger RNAs have triggered a major progression in the field of RNA-therapeutics. Especially short interfering RNAs and antisense oligonucleotides are promising examples for novel categories of therapeutics. However, several issues need to be addressed including intracellular delivery, toxicity, and immune responses before utilizing RNAs in a clinical setting. In this review, we provide an overview on opportunities and challenges for clinical translation of RNA-based therapeutics, with an emphasis on advances in novel delivery technologies and abdominal aortic aneurysm disease where non-coding RNAs have been shown to play a crucial regulatory role."],["dc.identifier.doi","10.3389/fcvm.2021.571076"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85237"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","2297-055X"],["dc.title","Unresolved Issues in RNA Therapeutics in Vascular Diseases With a Focus on Aneurysm Disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]