Slotta, Jan Erik

[["dc.bibliographiccitation.firstpage","215"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes"],["dc.bibliographiccitation.lastpage","222"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Schäfer, T."],["dc.contributor.author","Sperling, J."],["dc.contributor.author","Slotta, J. E."],["dc.contributor.author","Kollmar, O."],["dc.contributor.author","Schilling, M. K."],["dc.contributor.author","Menger, M. D."],["dc.contributor.author","Richter, S."],["dc.date.accessioned","2019-07-09T11:40:02Z"],["dc.date.available","2019-07-09T11:40:02Z"],["dc.date.issued","2012"],["dc.description.abstract","BACKGROUND: Hepatic arterial infusion (HAI) has been developed for high-dose regional chemotherapy of unresectable liver metastases or primary liver malignancies. While it is well known that high concentrations of tumor necrosis factor (TNF)-α damage tumor blood perfusion, there is no information on whether autochthonous liver perfusion is affected by HAI with TNF-α. Therefore, we investigated the effects of HAI with TNF-α on hepatic macro- and microvascular perfusion. METHODS: Swabian Hall pigs were randomized into three groups. HAI was performed with either 20 or 40 µg/kg body weight TNF-α (n = 6 each group). Saline-treated animals served as controls (n = 6). Analyses during a 2-hour post-HAI observation period included systemic hemodynamics, portal venous and hepatic arterial blood flow, portal venous pressure, and the blood flow in the hepatic microcirculation. RESULTS: HAI with TNF-α caused a slight decrease of mean arterial blood pressure (p < 0.001), which was compensated by a moderate increase of heart rate (p < 0.001). No further systemic side effects of TNF-α were observed. HAI with TNF-α further caused a slight but not significant decrease of portal venous blood flow (p = 0.737) in both experimental groups, paralleled by an increase of hepatic arterial blood flow (p = 0.023, 20 µg/kg; p = 0.034, 40 µg/kg) resulting in an overall hepatic hyperperfusion. The hepatic hyperperfusion after HAI with 20 µg/kg TNF-α was more pronounced and associated with a 40% decrease of the blood flow in the hepatic microcirculation (p = 0.009). HAI with 40 µg/kg TNF-α was only associated with a temporary and moderate total hepatic hyperperfusion and did not affect the blood flow in the hepatic microcirculation. CONCLUSION: HAI with TNF-α causes a decrease of portal venous flow; however, this is overcompensated by an increased hepatic arterial blood flow, resulting in a total hepatic hyperperfusion. Moderate total hepatic hyperperfusion does not affect the blood flow in the hepatic microcirculation, while a persistent and more pronounced hyperperfusion may cause hepatic microcirculatory disturbances."],["dc.identifier.doi","10.1159/000339306"],["dc.identifier.fs","594196"],["dc.identifier.pmid","22739241"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10601"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58078"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1421-9921"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Blood Pressure"],["dc.subject.mesh","Female"],["dc.subject.mesh","Heart Rate"],["dc.subject.mesh","Hepatic Artery"],["dc.subject.mesh","Liver Circulation"],["dc.subject.mesh","Male"],["dc.subject.mesh","Microcirculation"],["dc.subject.mesh","Portal Vein"],["dc.subject.mesh","Swine"],["dc.subject.mesh","Tumor Necrosis Factor-alpha"],["dc.subject.mesh","Venous Pressure"],["dc.title","Hepatic arterial infusion with tumor necrosis factor-α induces early hepatic hyperperfusion."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","72"],["dc.bibliographiccitation.journal","BMC Oral Health"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Schmalz, Gerhard"],["dc.contributor.author","Kauffels, Anne"],["dc.contributor.author","Kollmar, Otto"],["dc.contributor.author","Slotta, Jan Erik"],["dc.contributor.author","Vasko, Radovan"],["dc.contributor.author","Mueller, Georg Anton"],["dc.contributor.author","Haak, Rainer"],["dc.contributor.author","Ziebolz, Dirk"],["dc.date.accessioned","2018-11-07T10:10:08Z"],["dc.date.available","2018-11-07T10:10:08Z"],["dc.date.issued","2016"],["dc.description.abstract","Background: Aim of this single center cross-sectional study was to investigate oral behavior, dental, periodontal and microbiological findings in patients undergoing hemodialysis (HD) and after kidney transplantation (KT). Methods: Patients undergoing HD for end-stage renal failure and after KT were investigated. Oral health behavior was recorded using a standardized questionnaire, e.g. dental behavior, tooth brushing, oral hygiene aids. Oral investigation included screening of oral mucosa, dental findings (DMF-T) and periodontal situation (Papilla bleeding index [PBI] periodontal probing depth [PPD] and clinical attachment loss [CAL]). Additionally, microbiological analysis of subgingival biofilm samples (PCR) was performed. Statistical analysis: Student's t-test or Mann-Whitney-U-test, Fisher's exact test (a = 5 %). Results: A total of 70 patients (HD: n = 35, KT: n = 35) with a mean age of 56.4 +/- 11.1 (HD) and 55.8 +/- 10.9 (KT) years were included. Lack in use of additional oral hygiene (dental floss, inter-dental brush) was found. KT group presented significantly more gingivial overgrowth (p = 0.01). DMF-T was 19.47 +/- 5.84 (HD) and 17.61 +/- 5.81 (KT; p = 0. 21). Majority of patients had clinically moderate and severe periodontitis; showing a need for periodontal treatment of 57 % (HD) and 71 % (KT; p = 0.30). Significantly higher prevalence of Parvimonas micra and Capnocytophaga species in the HD group were found (p < 0.01). Conclusion: Periodontal treatment need and lack in oral behavior for both groups indicate the necessity of an improved early treatment and prevention of dental and periodontal disease, e.g. in form of special care programs. Regarding microbiological findings, no major differences between KT and HD patients were found."],["dc.identifier.doi","10.1186/s12903-016-0274-0"],["dc.identifier.isi","000381734000003"],["dc.identifier.pmid","27531498"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13871"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39797"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1472-6831"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Oral behavior, dental, periodontal and microbiological findings in patients undergoing hemodialysis and after kidney transplantation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","589"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Surgery"],["dc.bibliographiccitation.lastpage","595"],["dc.bibliographiccitation.volume","154"],["dc.contributor.author","Justinger, Christoph"],["dc.contributor.author","Slotta, Jan Erik"],["dc.contributor.author","Ningel, Sebastian"],["dc.contributor.author","Graeber, Stefan"],["dc.contributor.author","Kollmar, Otto"],["dc.contributor.author","Schilling, Martin Karl"],["dc.date.accessioned","2018-11-07T09:20:40Z"],["dc.date.available","2018-11-07T09:20:40Z"],["dc.date.issued","2013"],["dc.description.abstract","Background. Wound infections after abdominal surgery are still frequent types of nosocomial infections. Suture materials might serve as a vehicle for mechanical transport of bacteria into the surgical wound. To prevent the contamination of suture material in surgical wounds, triclosan-coated suture materials with antibacterial activity was developed. We here report a prospective randomized pathway controlled trial investigating the effect of triclosan impregnation of polydioxanone sutures used for abdominal wall closure on the rate of surgical-site infections. Patients and methods. A total of 856 patients included in this trial underwent a standardized clinical pathway documented abdominal wall closure after abdominal surgery. Patients were randomized to have the fascia closed with either a 2-0 polydioxanone loop or a triclosan impregnated 2-0 polydioxanone loop. The primary outcome was the number of wound infections. Risk factors for poor wound healing were collected prospectively to compare the two groups. Results. When a PDS loop suture for abdominal wall closure was used, 42 (11.3%) patients with wound infections were detected. The number of patients with wound infections decreased significantly to 31 when the PDS plus for abdominal wall closure was used (6.4%, P < .05). Other risk factors for the development of side infections were comparably in the two groups. Conclusion. This clinical pathway facilitated trial shows that triclosan impregnation of a 2-0 polydioxanone closing suture can decrease wound infections in patients having a laparotomy for general and abdominal vascular procedures."],["dc.description.sponsorship","Johnson&Johnson, Summerville, NJ"],["dc.identifier.doi","10.1016/j.surg.2013.04.011"],["dc.identifier.isi","000324085900021"],["dc.identifier.pmid","23859304"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11334"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28931"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mosby-elsevier"],["dc.relation.issn","0039-6060"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Surgical-site infection after abdominal wall closure with triclosan-impregnated polydioxanone sutures: Results of a randomized clinical pathway facilitated trial (NCT00998907)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]