Strik, Herwig Matthias

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Hoffmann, A. L."],["dc.contributor.author","Buhk, Jan-Hendrik"],["dc.contributor.author","Nitsche, M."],["dc.contributor.author","Strik, Herwig Matthias"],["dc.date.accessioned","2018-11-07T11:08:46Z"],["dc.date.available","2018-11-07T11:08:46Z"],["dc.date.issued","2008"],["dc.format.extent","1115"],["dc.identifier.isi","000261695800218"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52865"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Duke Univ Press"],["dc.publisher.place","Durham"],["dc.relation.conference","8th Congress of the European-Association-for-Neuro-Oncology (EANO)"],["dc.relation.eventlocation","Barcelona, SPAIN"],["dc.relation.issn","1522-8517"],["dc.title","LONG TERM STABILIZATION OF LEPTOMENINGEAL AND SOLID CNS METASTASES FROM BREAST CANCER WITH COMBINED INTRATHECAL LIPOSOMAL ARA-C AND SYSTEMIC TEMOZOLOMIDE"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","226"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Folia Neuropathologica"],["dc.bibliographiccitation.lastpage","233"],["dc.bibliographiccitation.volume","52"],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Goldmann, Torben"],["dc.contributor.author","Menke, Jan"],["dc.contributor.author","Strik, Herwig"],["dc.contributor.author","Bock, Hans-Christoph"],["dc.contributor.author","Mohr, Alexander"],["dc.contributor.author","Buhk, Jan-Hendrik"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Knauth, Michael"],["dc.date.accessioned","2018-11-07T09:45:46Z"],["dc.date.available","2018-11-07T09:45:46Z"],["dc.date.issued","2014"],["dc.description.abstract","Introduction: Malignant brain tumors tend to migration and invasion of surrounding brain tissue. Histopathological studies reported malignant cells in macroscopically unsuspicious parenchyma (normal appearing white matter - NAWM) remote from the tumor localization. In early stages, diffuse interneural infiltration with changes of the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) is hypothesized. Material and methods: Patients' ADC and FA values from NAWM of the hemisphere contralateral to a malignant glioma were compared to age- and sex-matched normal controls. Results: Apparent diffusion coefficient levels of the entire contra lateral hemisphere revealed a significant increase and a decrease of FA levels. An even more pronounced ADC increase was found in a region mirroring the glioma location. Conclusions: In patients with previously untreated anaplastic astrocytoma or glioblastoma, an increase of the ADC and a reduction of FA were found in the brain parenchyma of the hemisphere contralateral to the tumor localization. In the absence of visible MRI abnormalities, this may be an early indicator of microstructural changes of the NAWM attributed to malignant brain tumor."],["dc.description.sponsorship","Volkswagen Stiftung [ZN1635, ZN 2193]"],["dc.identifier.doi","10.5114/fn.2014.45563"],["dc.identifier.isi","000342712000002"],["dc.identifier.pmid","25310733"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34702"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1509-572X"],["dc.relation.issn","1641-4640"],["dc.title","Abnormalities in the normal appearing white matter of the cerebral hemisphere contralateral to a malignant brain tumor detected by diffusion tensor imaging"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","15"],["dc.bibliographiccitation.journal","Journal of Clinical Oncology"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Strik, Herwig Matthias"],["dc.contributor.author","Proemmel, Peter"],["dc.contributor.author","Pilgram-Pastor, Sara M."],["dc.contributor.author","Buhk, Jan-Hendrik"],["dc.date.accessioned","2018-11-07T08:29:51Z"],["dc.date.available","2018-11-07T08:29:51Z"],["dc.date.issued","2009"],["dc.identifier.isi","000276606606185"],["dc.identifier.pmid","27963675"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16755"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Clinical Oncology"],["dc.publisher.place","Alexandria"],["dc.relation.conference","45th Annual Meeting of the American-Society-of-Clinical-Oncology"],["dc.relation.eventlocation","Orlando, FL"],["dc.relation.issn","0732-183X"],["dc.title","Neoplastic meningitis-Is MRI as sensitive as CSF cytology?"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","217"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Neuro-Oncology"],["dc.bibliographiccitation.lastpage","222"],["dc.bibliographiccitation.volume","112"],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Goldmann, Torben"],["dc.contributor.author","Menke, Jan"],["dc.contributor.author","Strik, Herwig Matthias"],["dc.contributor.author","Bock, Hans-Christoph"],["dc.contributor.author","Stockhammer, Florian"],["dc.contributor.author","Buhk, Jan-Hendrik"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Knauth, Michael"],["dc.date.accessioned","2018-11-07T09:26:42Z"],["dc.date.available","2018-11-07T09:26:42Z"],["dc.date.issued","2013"],["dc.description.abstract","The most frequent primary brain tumors, anaplastic astrocytomas (AA) and glioblastomas (GBM): tend to invasion of the surrounding brain. Histopathological studies found malignant cells in macroscopically unsuspicious brain parenchyma remote from the primary tumor, even affecting the contralateral hemisphere. In early stages, diffuse interneural infiltration with changes of the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) is suspected. The purpose of this study was to investigate the value of DTI as a possible instrument of depicting evidence of tumor invasion into the corpus callosum (CC). Preoperatively, 31 patients with high-grade brain tumors (8 AA and 23 GBM) were examined by MRI at 3 T, applying a high-resolution diffusion tensor imaging (DTI) sequence. ADC- and FA-values were analyzed in the tumor-associated area of the CC as identified by fiber tracking, and were compared to matched healthy controls. In (MR-)morphologically normal appearing CC the ADC values were elevated in the tumor patients (n = 22; 0.978 x 10(-3) mmA(2)/s) compared to matched controls (0.917 x 10(-3) mmA(2)/s, p < 0.05), and the corresponding relative FA was reduced (rFA: 88 %, p < 0.01). The effect was pronounced in case of affection of the CC visible on MRI (n = 9; 0.978 x 10(-3) mmA(2)/s, p < 0.05; rFA: 72 %, p < 0.01). Changes in diffusivity and anisotropy in the CC can be interpreted as an indicator of tumor spread into the contralateral hemisphere not visible on conventional MRI."],["dc.description.sponsorship","Volkswagen Stiftung [ZN1635, ZN 2193]"],["dc.identifier.doi","10.1007/s11060-013-1049-y"],["dc.identifier.isi","000316755000009"],["dc.identifier.pmid","23344787"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10366"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30361"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0167-594X"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Glioma infiltration of the corpus callosum: early signs detected by DTI"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","805"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Radiology"],["dc.bibliographiccitation.lastpage","812"],["dc.bibliographiccitation.volume","253"],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Bock, Hans-Christoph"],["dc.contributor.author","Helms, Gunther"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Wrede, Arne"],["dc.contributor.author","Buhk, Jan-Hendrik"],["dc.contributor.author","Giese, Alf"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Strik, Herwig"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Knauth, Michael"],["dc.date.accessioned","2018-11-07T11:21:46Z"],["dc.date.available","2018-11-07T11:21:46Z"],["dc.date.issued","2009"],["dc.description.abstract","Purpose: To use localized in vivo proton magnetic resonance (MR) spectroscopy of the contralateral hemisphere in patients with glioblastoma multiforme (GBM) to detect alterations in cerebral metabolites as potential markers of infiltrating GBM cells. Materials and Methods: The study was approved by the ethics committee, and written informed consent was obtained. Twenty-two patients with newly diagnosed and untreated GBM underwent in vivo single-voxel short echo time proton MR spectroscopy with a 3-T MR imaging system. Absolute metabolite concentrations in the hemisphere contralateral to the tumor were compared with data from five patients with low-grade gliomas (LGGs) and from a group of 14 age-matched control subjects by using analysis of variance and subsequent t tests or corresponding nonparametric tests. Results: In the contralateral hemisphere, MR spectroscopy revealed increased concentrations of myo-inositol and glutamine. Mean myo-inositol levels were significantly increased in patients with GBM (3.6 mmol/L +/- 0.8 [standard deviation]) relative to levels in control subjects (3.1 mmol/L +/- 0.6; P = .03) and tended to be higher relative to levels in patients with LGG (2.7 mmol/L +/- 0.8; P = .09). Mean glutamine concentrations in patients with GBM (3.4 mmol/L +/- 0.9) differed significantly from those in control subjects (2.7 mmol/L +/- 0.7; P < .01); mean concentrations in patients with GBM differed from those in patients with LGG (2.4 mmol/L +/- 0.5; P < .01). There were no significant differences between data in patients with LGG and in control subjects. Conclusion: Increased concentrations of myo-inositol and glutamine in the contralateral normal-appearing white matter of GBM patients are consistent with mild astrocytosis and suggest the detectability of early neoplastic infiltration by using proton MR spectroscopy in vivo. (C) RSNA, 2009"],["dc.identifier.doi","10.1148/radiol.2533071654"],["dc.identifier.isi","000272247300028"],["dc.identifier.pmid","19789222"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6268"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55854"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Radiological Soc North America"],["dc.relation.issn","0033-8419"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Untreated Glioblastoma Multiforme: Increased Myo-inositol and Glutamine Levels in the Contralateral Cerebral Hemisphere at Proton MR Spectroscopy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","71"],["dc.bibliographiccitation.journal","Onkologie"],["dc.bibliographiccitation.lastpage","72"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Strik, Herwig Matthias"],["dc.contributor.author","Buhk, Jan-Hendrik"],["dc.contributor.author","Nitsche, M."],["dc.contributor.author","Hoffmann, A. L."],["dc.contributor.author","Giese, A. ."],["dc.contributor.author","Bock, C."],["dc.contributor.author","Baehr, M."],["dc.date.accessioned","2018-11-07T11:18:51Z"],["dc.date.available","2018-11-07T11:18:51Z"],["dc.date.issued","2008"],["dc.identifier.isi","000253372800226"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55134"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","0378-584X"],["dc.title","Rechallenge of malignant gliomas with temozolomide - Can it be effective?"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Strik, Herwig Matthias"],["dc.contributor.author","Buhk, Jan-Hendrik"],["dc.contributor.author","Bock, C."],["dc.contributor.author","Nitsche, M."],["dc.contributor.author","Hoffmann, A. L."],["dc.contributor.author","Wrede, Arne"],["dc.contributor.author","Marosi, Christine"],["dc.contributor.author","Kaiser, U."],["dc.contributor.author","Christmann, M."],["dc.contributor.author","Kaina, Bernd"],["dc.date.accessioned","2018-11-07T11:08:46Z"],["dc.date.available","2018-11-07T11:08:46Z"],["dc.date.issued","2008"],["dc.format.extent","1062"],["dc.identifier.isi","000261695800017"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52864"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Duke Univ Press"],["dc.publisher.place","Durham"],["dc.relation.conference","8th Congress of the European-Association-for-Neuro-Oncology (EANO)"],["dc.relation.eventlocation","Barcelona, SPAIN"],["dc.relation.issn","1522-8517"],["dc.title","TEGWONDO-DEVELOPMENT OF A NOVEL NEAR-CONTINUOUS DOSE-DENSE TEMOZOLOMIDE REGIMEN FOR THE TREATMENT OF RECURRENT GLIOMAS"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Onkologie"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Hoffmann, A. L."],["dc.contributor.author","Buhk, Jan-Hendrik"],["dc.contributor.author","Nitsche, M."],["dc.contributor.author","Strik, Herwig Matthias"],["dc.date.accessioned","2018-11-07T11:18:51Z"],["dc.date.available","2018-11-07T11:18:51Z"],["dc.date.issued","2008"],["dc.format.extent","72"],["dc.identifier.isi","000253372800227"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55135"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","0378-584X"],["dc.title","Long term stabilization of leptomeningeal and solid CNS metastases from breast cancer with combined intrathecal liposomal ARA-C and systemic temozolomide"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Strik, Herwig"],["dc.contributor.author","Buhk, Jan-Hendrik"],["dc.contributor.author","Bock, C.-H."],["dc.contributor.author","Wrede, Arne"],["dc.contributor.author","Marosi, Christine"],["dc.contributor.author","Kaiser, Ulrich"],["dc.contributor.author","Christmann, Markus"],["dc.contributor.author","Kaina, Bernd"],["dc.date.accessioned","2018-11-07T11:21:41Z"],["dc.date.available","2018-11-07T11:21:41Z"],["dc.date.issued","2009"],["dc.identifier.isi","000272974100337"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55835"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","3rd Quadrennial Meeting of the World-Federation-of-Neuro-Oncoloyg/6th Meeting of the Asian-Society-for-Neuro-Oncology"],["dc.relation.eventlocation","Yokohama, JAPAN"],["dc.title","SAFETY AND EFFICACY OF NEAR-CONTINUOUS DOSE-DENSE TEMOZOLOMIDE (TEGWONDO) FOR RECURRENT GLIOMAS"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","5191"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Anticancer Research"],["dc.bibliographiccitation.lastpage","5195"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Hoffmann, A. L."],["dc.contributor.author","Buhk, Jan-Hendrik"],["dc.contributor.author","Strik, Herwig Matthias"],["dc.date.accessioned","2018-11-07T11:21:15Z"],["dc.date.available","2018-11-07T11:21:15Z"],["dc.date.issued","2009"],["dc.description.abstract","Background: Patients with neoplastic meningitis (NM) from breast cancer have a median survival of 4-8 months with specific treatment. Here, good tolerance and long-term stabilization with combined intrathecal liposomal cytarabine (Ara-C), which is probably the most promising drug for intrathecal chemotherapy to date, near-continuous temozolomide and radiotherapy is reported in two patients with leptomeningeal and solid central nervous system (CNS) mefastases from breast cancer. Case Reports: A 42- and a 43-year-old female presented with NM and disseminated CNS metastases from human epidermal growth factor receptor type 2 (Het-2)-positive breast cancer. After irradiation of the symptomatic sites, intrathecal liposomal Ara-C every 2-4 weeks was combined with temozolomide 100 mg/m(2) day 1-5/7. Cerebrospinal fluid (CSF) cytology and neurological symptoms improved in both patients and stabilized for several months. The patients survived 10 and 17 months after diagnosis of NM, without signs of neurological toxicity. Conclusion: Intensive treatment is complicated by extensive pre-treatment and the lack of active CNS-penetrating systemic drugs. The long-term results with up to 17 intrathecal injections of liposomal AraC show that this treatment regimen is feasible and well-tolerated. The stabilization of both patients indicates activity of this combined intrathecal and systemic regimen that is based on long-term exposure of the tumour cells to both Ara-C and temozolomide. The results need to be confirmed prospectively."],["dc.identifier.isi","000273365700040"],["dc.identifier.pmid","20044635"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55730"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Int Inst Anticancer Research"],["dc.relation.issn","0250-7005"],["dc.title","Neoplastic Meningitis from Breast Cancer: Feasibility and Activity of Long-term Intrathecal Liposomal Ara-C Combined with Dose-dense Temozolomide"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]