Kruss, Sebastian

[["dc.bibliographiccitation.firstpage","9104-9115"],["dc.bibliographiccitation.issue","16"],["dc.bibliographiccitation.journal","Nanoscale"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Meyer, Daniel"],["dc.contributor.author","Telele, Saba"],["dc.contributor.author","Zelená, Anna"],["dc.contributor.author","Gillen, Alice J."],["dc.contributor.author","Antonucci, Alessandra"],["dc.contributor.author","Neubert, Elsa"],["dc.contributor.author","Nißler, Robert"],["dc.contributor.author","Mann, Florian A."],["dc.contributor.author","Erpenbeck, Luise"],["dc.contributor.author","Boghossian, Ardemis A."],["dc.contributor.author","Köster, Sarah"],["dc.contributor.author","Kruss, Sebastian"],["dc.date.accessioned","2020-06-26T11:13:39Z"],["dc.date.available","2020-06-26T11:13:39Z"],["dc.date.issued","2020"],["dc.description.abstract","Cells can take up nanoscale materials, which has important implications for understanding cellular functions, biocompatibility as well as biomedical applications. Controlled uptake, transport and triggered release of nanoscale cargo is one of the great challenges in biomedical applications of nanomaterials. Here, we study how human immune cells (neutrophilic granulocytes, neutrophils) take up nanomaterials and program them to release this cargo after a certain time period. For this purpose, we let neutrophils phagocytose DNA-functionalized single-walled carbon nanotubes (SWCNTs) in vitro that fluoresce in the near infrared (980 nm) and serve as sensors for small molecules. Cells still migrate, follow chemical gradients and respond to inflammatory signals after uptake of the cargo. To program release, we make use of neutrophil extracellular trap formation (NETosis), a novel cell death mechanism that leads to chromatin swelling, subsequent rupture of the cellular membrane and release of the cell's whole content. By using the process of NETosis, we can program the time point of cargo release via the initial concentration of stimuli such as phorbol 12-myristate-13-acetate (PMA) or lipopolysaccharide (LPS). At intermediate stimulation, cells continue to migrate, follow gradients and surface cues for around 30 minutes and up to several hundred micrometers until they stop and release the SWCNTs. The transported and released SWCNT sensors are still functional as shown by subsequent detection of the neurotransmitter dopamine and reactive oxygen species (H2O2). In summary, we hijack a biological process (NETosis) and demonstrate how neutrophils transport and release functional nanomaterials."],["dc.identifier.doi","10.1039/d0nr00864h"],["dc.identifier.pmid","32286598"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66755"],["dc.language.iso","en"],["dc.relation.eissn","2040-3372"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Köster (Cellular Biophysics)"],["dc.rights","CC BY 3.0"],["dc.subject.gro","cellular biophysics"],["dc.title","Transport and programmed release of nanoscale cargo from cells by using NETosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Molecular Neurobiology"],["dc.contributor.author","Noor, Aneeqa"],["dc.contributor.author","Zafar, Saima"],["dc.contributor.author","Shafiq, Mohsin"],["dc.contributor.author","Younas, Neelam"],["dc.contributor.author","Siegert, Anna"],["dc.contributor.author","Mann, Florian A."],["dc.contributor.author","Kruss, Sebastian"],["dc.contributor.author","Schmitz, Matthias"],["dc.contributor.author","Dihazi, Hassan"],["dc.contributor.author","Ferrer, Isidre"],["dc.contributor.author","Zerr, Inga"],["dc.date.accessioned","2021-12-01T09:23:29Z"],["dc.date.available","2021-12-01T09:23:29Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract The molecular determinants of atypical clinical variants of Alzheimer’s disease, including the recently discovered rapidly progressive Alzheimer’s disease (rpAD), are unknown to date. Fibrilization of the amyloid-β (Aβ) peptide is the most frequently studied candidate in this context. The Aβ peptide can exist as multiple proteoforms that vary in their post-translational processing, amyloidogenesis, and toxicity. The current study was designed to identify these variations in Alzheimer’s disease patients exhibiting classical (sAD) and rapid progression, with the primary aim of establishing if these variants may constitute strains that underlie the phenotypic variability of Alzheimer’s disease. We employed two-dimensional polyacrylamide gel electrophoresis and MALDI-ToF mass spectrometry to validate and identify the Aβ proteoforms extracted from targeted brain tissues. The biophysical analysis was conducted using RT-QuIC assay, confocal microscopy, and atomic force microscopy. Interactome analysis was performed by co-immunoprecipitation. We present a signature of 33 distinct pathophysiological proteoforms, including the commonly targeted Aβ 40 , Aβ 42 , Aβ 4-42 , Aβ 11-42 , and provide insight into their synthesis and quantities. Furthermore, we have validated the presence of highly hydrophobic Aβ seeds in rpAD brains that seeded reactions at a slower pace in comparison to typical Alzheimer’s disease. In vitro and in vivo analyses also verified variations in the molecular pathways modulated by brain-derived Aβ. These variations in the presence, synthesis, folding, and interactions of Aβ among sAD and rpAD brains constitute important points of intervention. Further validation of reported targets and mechanisms will aid in the diagnosis of and therapy for Alzheimer’s disease."],["dc.description.abstract","Abstract The molecular determinants of atypical clinical variants of Alzheimer’s disease, including the recently discovered rapidly progressive Alzheimer’s disease (rpAD), are unknown to date. Fibrilization of the amyloid-β (Aβ) peptide is the most frequently studied candidate in this context. The Aβ peptide can exist as multiple proteoforms that vary in their post-translational processing, amyloidogenesis, and toxicity. The current study was designed to identify these variations in Alzheimer’s disease patients exhibiting classical (sAD) and rapid progression, with the primary aim of establishing if these variants may constitute strains that underlie the phenotypic variability of Alzheimer’s disease. We employed two-dimensional polyacrylamide gel electrophoresis and MALDI-ToF mass spectrometry to validate and identify the Aβ proteoforms extracted from targeted brain tissues. The biophysical analysis was conducted using RT-QuIC assay, confocal microscopy, and atomic force microscopy. Interactome analysis was performed by co-immunoprecipitation. We present a signature of 33 distinct pathophysiological proteoforms, including the commonly targeted Aβ 40 , Aβ 42 , Aβ 4-42 , Aβ 11-42 , and provide insight into their synthesis and quantities. Furthermore, we have validated the presence of highly hydrophobic Aβ seeds in rpAD brains that seeded reactions at a slower pace in comparison to typical Alzheimer’s disease. In vitro and in vivo analyses also verified variations in the molecular pathways modulated by brain-derived Aβ. These variations in the presence, synthesis, folding, and interactions of Aβ among sAD and rpAD brains constitute important points of intervention. Further validation of reported targets and mechanisms will aid in the diagnosis of and therapy for Alzheimer’s disease."],["dc.identifier.doi","10.1007/s12035-021-02566-9"],["dc.identifier.pii","2566"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94665"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.relation.eissn","1559-1182"],["dc.relation.issn","0893-7648"],["dc.title","Molecular Profiles of Amyloid-β Proteoforms in Typical and Rapidly Progressive Alzheimer’s Disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Selvaggio, Gabriele"],["dc.contributor.author","Chizhik, Alexey"],["dc.contributor.author","Nißler, Robert"],["dc.contributor.author","Kuhlemann, llyas"],["dc.contributor.author","Meyer, Daniel"],["dc.contributor.author","Vuong, Loan"],["dc.contributor.author","Preiß, Helen"],["dc.contributor.author","Herrmann, Niklas"],["dc.contributor.author","Mann, Florian A."],["dc.contributor.author","Lv, Zhiyi"],["dc.contributor.author","Oswald, Tabea A."],["dc.contributor.author","Spreinat, Alexander"],["dc.contributor.author","Erpenbeck, Luise"],["dc.contributor.author","Großhans, Jörg"],["dc.contributor.author","Karius, Volker"],["dc.contributor.author","Janshoff, Andreas"],["dc.contributor.author","Pablo Giraldo, Juan"],["dc.contributor.author","Kruss, Sebastian"],["dc.date.accessioned","2020-11-05T15:08:10Z"],["dc.date.available","2020-11-05T15:08:10Z"],["dc.date.issued","2020"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2020"],["dc.identifier.doi","10.1038/s41467-020-15299-5"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17352"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/68478"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-352.7"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","2041-1723"],["dc.relation.orgunit","Fakultät für Physik"],["dc.rights","CC BY 4.0"],["dc.rights.uri","http://creativecommons.org/licenses/by/4.0/"],["dc.title","Exfoliated near infrared fluorescent silicate nanosheets for (bio)photonics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","18341"],["dc.bibliographiccitation.issue","33"],["dc.bibliographiccitation.journal","The Journal of Physical Chemistry C"],["dc.bibliographiccitation.lastpage","18351"],["dc.bibliographiccitation.volume","125"],["dc.contributor.author","Spreinat, Alexander"],["dc.contributor.author","Dohmen, Maria M."],["dc.contributor.author","Lüttgens, Jan"],["dc.contributor.author","Herrmann, Niklas"],["dc.contributor.author","Klepzig, Lars F."],["dc.contributor.author","Nißler, Robert"],["dc.contributor.author","Weber, Sabrina"],["dc.contributor.author","Mann, Florian A."],["dc.contributor.author","Lauth, Jannika"],["dc.contributor.author","Kruss, Sebastian"],["dc.date.accessioned","2021-10-01T09:57:41Z"],["dc.date.available","2021-10-01T09:57:41Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1021/acs.jpcc.1c05432"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89894"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-469"],["dc.relation.eissn","1932-7455"],["dc.relation.issn","1932-7447"],["dc.title","Quantum Defects in Fluorescent Carbon Nanotubes for Sensing and Mechanistic Studies"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Selvaggio, Gabriele"],["dc.contributor.author","Preiß, Helen"],["dc.contributor.author","Chizhik, Alexey"],["dc.contributor.author","Nißler, Robert"],["dc.contributor.author","Mann, Florian A."],["dc.contributor.author","Lv, Zhiyi"],["dc.contributor.author","Oswald, Tabea A."],["dc.contributor.author","Spreinat, Alexander"],["dc.contributor.author","Erpenbeck, Luise"],["dc.contributor.author","Großhans, Jörg"],["dc.contributor.author","Giraldo, Juan Pablo"],["dc.contributor.author","Kruss, Sebastian"],["dc.date.accessioned","2020-11-05T15:08:07Z"],["dc.date.available","2020-11-05T15:08:07Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1101/710384"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/68469"],["dc.notes.intern","DOI Import GROB-352.7"],["dc.title","Exfoliated near infrared fluorescent CaCuSi 4 O 10 nanosheets with ultra-high photostability and brightness for biological imaging"],["dc.type","preprint"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","11159"],["dc.bibliographiccitation.issue","23"],["dc.bibliographiccitation.journal","Nanoscale"],["dc.bibliographiccitation.lastpage","11166"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Nißler, Robert"],["dc.contributor.author","Mann, Florian A."],["dc.contributor.author","Preiß, Helen"],["dc.contributor.author","Selvaggio, Gabriele"],["dc.contributor.author","Herrmann, Niklas"],["dc.contributor.author","Kruss, Sebastian"],["dc.date.accessioned","2019-07-15T10:05:29Z"],["dc.date.accessioned","2021-10-27T13:12:41Z"],["dc.date.available","2019-07-15T10:05:29Z"],["dc.date.available","2021-10-27T13:12:41Z"],["dc.date.issued","2019"],["dc.description.abstract","Single-walled carbon nanotubes (SWCNTs) have unique photophysical properties and serve as building blocks for biosensors, functional materials and devices. For many applications it is crucial to use chirality-pure SWCNTs, which requires sophisticated processes. Purification procedures such as wrapping by certain polymers, phase separation, density gradient centrifugation or gel chromatography have been developed and yield distinct SWCNT species wrapped by a specific polymer or surfactant. However, many applications require a different organic functionalization (corona) around the SWCNTs instead of the one used for the purification process. Here, we present a novel efficient and straightforward process to gain chirality pure SWCNTs with tunable functionalization. Our approach uses polyfluorene (PFO) polymers to enrich certain chiralities but the polymer is removed again and finally exchanged to any desired organic phase. We demonstrate this concept by dispersing SWCNTs in poly[(9,9-dioctylfluorenyl-2,7-diyl)-alt-co-(6,6'-{2,2'-bipyridine})] (PFO-BPy), which is known to preferentially solubilize (6,5)-SWCNTs. Then PFO-BPy is removed and recycled, while letting the SWCNTs adsorb/agglomerate on sodium chloride (NaCl) crystals, which act as a toluene-stable but water-soluble filler material. In the last step these purified SWCNTs are redispersed in different polymers, surfactants and ssDNA. This corona phase exchange purification (CPEP) approach was also extended to other PFO variants to enrich and functionalize (7,5)-SWCNTs. CPEP purified and functionalized SWCNTs display monodisperse nIR spectra, which are important for fundamental studies and applications that rely on spectral changes. We show this advantage for SWCNT-based nIR fluorescent sensors for the neurotransmitter dopamine and red-shifted sp3 defect peaks . In summary, CPEP makes use of PFO polymers for chirality enrichment but provides access to chirality enriched SWCNTs functionalized in any desired polymer, surfactant or biopolymer."],["dc.identifier.doi","10.1039/c9nr03258d"],["dc.identifier.pmid","31149692"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16279"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91713"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.eissn","2040-3372"],["dc.relation.issn","2040-3364"],["dc.relation.orgunit","Fakultät für Chemie"],["dc.rights","CC BY 3.0"],["dc.rights.access","openAccess"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.subject","carbon nanotubes; Chirality; CPEP"],["dc.subject.ddc","540"],["dc.title","Chirality enriched carbon nanotubes with tunable wrapping via corona phase exchange purification (CPEP)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","727"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Nature Protocols"],["dc.bibliographiccitation.lastpage","747"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Mann, Florian A."],["dc.contributor.author","Galonska, Phillip"],["dc.contributor.author","Herrmann, Niklas"],["dc.contributor.author","Kruss, Sebastian"],["dc.date.accessioned","2022-04-01T10:02:39Z"],["dc.date.available","2022-04-01T10:02:39Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1038/s41596-021-00663-6"],["dc.identifier.pii","663"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105973"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","1750-2799"],["dc.relation.issn","1754-2189"],["dc.rights.uri","https://www.springer.com/tdm"],["dc.title","Quantum defects as versatile anchors for carbon nanotube functionalization"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","1521"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Sensors (Basel, Switzerland)"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Mann, Florian A."],["dc.contributor.author","Herrmann, Niklas"],["dc.contributor.author","Meyer, Daniel"],["dc.contributor.author","Kruss, Sebastian"],["dc.date.accessioned","2019-07-09T11:43:35Z"],["dc.date.available","2019-07-09T11:43:35Z"],["dc.date.issued","2017-06-28"],["dc.description.abstract","Detection of neurotransmitters is an analytical challenge and essential to understand neuronal networks in the brain and associated diseases. However, most methods do not provide sufficient spatial, temporal, or chemical resolution. Near-infrared (NIR) fluorescent single-walled carbon nanotubes (SWCNTs) have been used as building blocks for sensors/probes that detect catecholamine neurotransmitters, including dopamine. This approach provides a high spatial and temporal resolution, but it is not understood if these sensors are able to distinguish dopamine from similar catecholamine neurotransmitters, such as epinephrine or norepinephrine. In this work, the organic phase (DNA sequence) around SWCNTs was varied to create sensors with different selectivity and sensitivity for catecholamine neurotransmitters. Most DNA-functionalized SWCNTs responded to catecholamine neurotransmitters, but both dissociation constants (Kd) and limits of detection were highly dependent on functionalization (sequence). Kd values span a range of 2.3 nM (SWCNT-(GC)15 + norepinephrine) to 9.4 μM (SWCNT-(AT)15 + dopamine) and limits of detection are mostly in the single-digit nM regime. Additionally, sensors of different SWCNT chirality show different fluorescence increases. Moreover, certain sensors (e.g., SWCNT-(GT)10) distinguish between different catecholamines, such as dopamine and norepinephrine at low concentrations (50 nM). These results show that SWCNTs functionalized with certain DNA sequences are able to discriminate between catecholamine neurotransmitters or to detect them in the presence of interfering substances of similar structure. Such sensors will be useful to measure and study neurotransmitter signaling in complex biological settings."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2017"],["dc.identifier.doi","10.3390/s17071521"],["dc.identifier.pmid","28657584"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14585"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58922"],["dc.language.iso","en"],["dc.notes.intern","DeepGreen Import"],["dc.publisher","MDPI"],["dc.relation.eissn","1424-8220"],["dc.relation.issn","1424-8220"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.rights.access","openAccess"],["dc.subject.ddc","540"],["dc.title","Tuning Selectivity of Fluorescent Carbon Nanotube-Based Neurotransmitter Sensors."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","17732"],["dc.bibliographiccitation.issue","40"],["dc.bibliographiccitation.journal","Angewandte Chemie International Edition"],["dc.bibliographiccitation.lastpage","17738"],["dc.bibliographiccitation.volume","59"],["dc.contributor.author","Mann, Florian A."],["dc.contributor.author","Herrmann, Niklas"],["dc.contributor.author","Opazo, Felipe"],["dc.contributor.author","Kruss, Sebastian"],["dc.date.accessioned","2021-04-14T08:23:42Z"],["dc.date.available","2021-04-14T08:23:42Z"],["dc.date.issued","2020"],["dc.description.abstract","Abstract Single‐walled carbon nanotubes (SWCNTs) are a 1D nanomaterial that shows fluorescence in the near‐infrared (NIR, \\u0026gt;800 nm). In the past, covalent chemistry was less explored to functionalize SWCNTs as it impairs NIR emission. However, certain sp3 defects (quantum defects) in the carbon lattice have emerged that preserve NIR fluorescence and even introduce a new, red‐shifted emission peak. Here, we report on quantum defects, introduced using light‐driven diazonium chemistry, that serve as anchor points for peptides and proteins. We show that maleimide anchors allow conjugation of cysteine‐containing proteins such as a GFP‐binding nanobody. In addition, an Fmoc‐protected phenylalanine defect serves as a starting point for conjugation of visible fluorophores to create multicolor SWCNTs and in situ peptide synthesis directly on the nanotube. Therefore, these quantum defects are a versatile platform to tailor both the nanotube's photophysical properties as well as their surface chemistry."],["dc.description.abstract","Two new quantum defects were incorporated into single‐walled carbon nanotubes (SWCNT) carrying anchor groups for functionalization with biomolecules. The potential and versatility of this approach was demonstrated by the conjugation of a GFP‐binding nanobody as well as the growth of (fluorescent) peptide chains directly on the nanotube's carbon lattice. image"],["dc.description.sponsorship","Volkswagen Foundation (DE)"],["dc.description.sponsorship","Niedersächsisches Ministerium für Wissenschaft und Kultur http://dx.doi.org/10.13039/501100010570"],["dc.identifier.doi","10.1002/anie.202003825"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81019"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1521-3773"],["dc.relation.issn","1433-7851"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited."],["dc.title","Quantum Defects as a Toolbox for the Covalent Functionalization of Carbon Nanotubes with Peptides and Proteins"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","11469"],["dc.bibliographiccitation.issue","33"],["dc.bibliographiccitation.journal","Angewandte Chemie International Edition"],["dc.bibliographiccitation.lastpage","11473"],["dc.bibliographiccitation.volume","58"],["dc.contributor.author","Mann, Florian A."],["dc.contributor.author","Lv, Zhiyi"],["dc.contributor.author","Großhans, Jörg"],["dc.contributor.author","Opazo, Felipe"],["dc.contributor.author","Kruss, Sebastian"],["dc.date.accessioned","2020-12-10T14:05:38Z"],["dc.date.available","2020-12-10T14:05:38Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1002/anie.v58.33"],["dc.identifier.eissn","1521-3773"],["dc.identifier.issn","1433-7851"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/69599"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Nanobody‐Conjugated Nanotubes for Targeted Near‐Infrared In Vivo Imaging and Sensing"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]