Rave-Fränk, Margret

[["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.volume","181"],["dc.contributor.author","Hermann, H. R."],["dc.contributor.author","Fest, J."],["dc.contributor.author","Christiansen, H."],["dc.contributor.author","Rave-Fraenk, Margret"],["dc.contributor.author","Grundker, Carsten"],["dc.contributor.author","Viereck, Volker"],["dc.contributor.author","Schmidberger, Heinz"],["dc.date.accessioned","2018-11-07T11:06:46Z"],["dc.date.available","2018-11-07T11:06:46Z"],["dc.date.issued","2005"],["dc.format.extent","37"],["dc.identifier.isi","000229590600132"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52393"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.conference","11th Annual Congress of the German-Society-for-Radiooncology"],["dc.relation.eventlocation","Karlsruhe, GERMANY"],["dc.relation.issn","0179-7158"],["dc.title","The soya-isoflavon genistein and estradiol increases the radiosensitivity of bronchial cancer cells in dependancy on TP53 status in vitro"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","667"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.lastpage","672"],["dc.bibliographiccitation.volume","179"],["dc.contributor.author","Schmidberger, Heinz"],["dc.contributor.author","Rave-Fraenk, Margret"],["dc.contributor.author","Kim, S."],["dc.contributor.author","Hille, Andrea"],["dc.contributor.author","Pradier, Olivier"],["dc.contributor.author","Hess, C. F."],["dc.date.accessioned","2018-11-07T10:36:01Z"],["dc.date.available","2018-11-07T10:36:01Z"],["dc.date.issued","2003"],["dc.description.abstract","Background: Chemotherapy-induced mucositis can be related to a decrease in oral neutrophils. We tested the relationship between radiation-induced mucositis and oral neutrophil counts. Patients and Methods: Oral neutrophil counts were obtained for ten patients with head and neck cancer who received radiotherapy of the pharynx and oral cavity. Four patients received additional chemotherapy (5-FU, Mitomycin). Counts were obtained before and during treatment; four healthy volunteers were included in the study as well. For evaluation, a quantitative mouth rinse assay, including neutrophil-staining with acridin-orange, was applied. Results: We observed large inter-individual variations with respect to neutrophil counts for patients and control persons (Table 1). During treatment (irradiation or chemoirradiation), large intra-individual variations were seen additionally (Figure 1). We found a correlation between neutrophil counts and clinical reaction grade. Neutrophil counts increased with increasing mucositis (Figure 2). This increase was more pronounced for patients treated with chemoirradiation compared to radiation alone. Treatment breaks at weekends had no clear influence on neutrophil counts. Conclusions: We observed a weak correlation between neutrophil counts and clinical reaction grade. However, the variations in neutrophil counts are too large to utilize this parameter as a surrogate for clinical mucositis grading. The assumption that a decrease in oral neutrophils is associated with radiation-induced mucositis was clearly negated."],["dc.identifier.doi","10.1007/s00066-003-1121-1"],["dc.identifier.isi","000185950700002"],["dc.identifier.pmid","14566474"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45227"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.relation.issn","0179-7158"],["dc.title","Radiation-induced mucositis and neutrophil granulocytes in oral mucosa"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","148"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Radiation Research"],["dc.bibliographiccitation.lastpage","156"],["dc.bibliographiccitation.volume","164"],["dc.contributor.author","Virsik-Köpp, Patricia"],["dc.contributor.author","Hofman-Hüther, Hana"],["dc.contributor.author","Rave-Fränk, Margret"],["dc.contributor.author","Schmidberger, Heinz"],["dc.date.accessioned","2021-06-01T10:48:29Z"],["dc.date.available","2021-06-01T10:48:29Z"],["dc.date.issued","2005"],["dc.description.abstract","We analyzed the formation of radiation-induced chromosome aberrations in the cells of the radioresistant colon carcinoma cell line WiDr after treatment with wortmannin, an inhibitor of PI-3 kinases, including DNA-PK. Cells irradiated in G(0)/G(1) phase with 200 kV X rays were treated with wortmannin before or after irradiation. Chromosome-type and chromatid-type aberrations were scored in metaphase cells by either Giemsa staining or FISH. Moreover, DNA-PK activity was measured in the absence and presence of wortmannin. In irradiated G(0)/G(1)-phase WiDr cells, only chromosome-type aberrations, including simple and complex exchanges and excess acentrics, were observed. After addition of 1 to 20 mu M wortmannin, the formation of chromosome-type exchange aberrations was completely suppressed. The irradiated cells displayed exclusively chromatid-type aberrations including simple and complex chromatid exchanges and chromatid/isochromatid breaks. Whether the chromatid-type aberrations arise during G(0)/G(1) as a result of homologous recombination processes coping with damaged DNA or whether DNA damage induced during G(0)/G(1) phase persists until S and G(2) phase and is then processed by homologous recombination pathways must be investigated further. (c) 2005 by Radiation Research Society."],["dc.identifier.doi","10.1667/RR3396.1"],["dc.identifier.isi","000230798500005"],["dc.identifier.pmid","16138421"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85954"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Radiation Research Soc"],["dc.relation.eissn","1938-5404"],["dc.relation.issn","0033-7587"],["dc.title","The effect of Wortmannin on radiation-induced chromosome aberration formation in the radioresistant tumor cell line WiDr"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.volume","180"],["dc.contributor.author","Rave-Fraenk, Margret"],["dc.contributor.author","Lucke, E."],["dc.contributor.author","Pradier, Olivier"],["dc.contributor.author","Schmidberger, Heinz"],["dc.date.accessioned","2018-11-07T10:48:47Z"],["dc.date.available","2018-11-07T10:48:47Z"],["dc.date.issued","2004"],["dc.format.extent","63"],["dc.identifier.isi","000221877000247"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48278"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.conference","10th Annual Congress of the Deutschen-Gesellschaft-fur-Radioonkologie"],["dc.relation.eventlocation","Erfurt, GERMANY"],["dc.relation.issn","0179-7158"],["dc.title","Quantitative assessment of radiation-induced apoptosis of solid tumor cells - Comparison of methods"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.volume","178"],["dc.contributor.author","Schmidberger, Heinz"],["dc.contributor.author","Hofman-Huther, H."],["dc.contributor.author","Scholz, M."],["dc.contributor.author","Rave-Fraenk, Margret"],["dc.contributor.author","Virsik-Koepp, Patricia"],["dc.date.accessioned","2018-11-07T10:29:42Z"],["dc.date.available","2018-11-07T10:29:42Z"],["dc.date.issued","2002"],["dc.format.extent","6"],["dc.identifier.isi","000176659600025"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43694"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.conference","8th Meeting of the Deutschen-Gesellschaft-fur-Radioonkologie"],["dc.relation.eventlocation","BERLIN, GERMANY"],["dc.relation.issn","0179-7158"],["dc.title","Effects of heavy carbon ions on radioresistant and radiosensitive tumor cells"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.volume","178"],["dc.contributor.author","Hille, Andrea"],["dc.contributor.author","Rave-Fraenk, Margret"],["dc.contributor.author","Damm, C."],["dc.contributor.author","Pradier, Olivier"],["dc.contributor.author","Schmidberger, Heinz"],["dc.contributor.author","Dorr, W."],["dc.date.accessioned","2018-11-07T10:29:42Z"],["dc.date.available","2018-11-07T10:29:42Z"],["dc.date.issued","2002"],["dc.identifier.isi","000176659600023"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43693"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.conference","8th Meeting of the Deutschen-Gesellschaft-fur-Radioonkologie"],["dc.relation.eventlocation","BERLIN, GERMANY"],["dc.relation.eventstart","2002"],["dc.title","Determining expression of KGF and KGF receptor in tumor calls of the head and neck"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.volume","178"],["dc.contributor.author","Rave-Fraenk, Margret"],["dc.contributor.author","Virsik-Koepp, Patricia"],["dc.contributor.author","Martin, T."],["dc.contributor.author","Hofman-Huther, H."],["dc.contributor.author","Hess, C. F."],["dc.contributor.author","Schmidberger, Heinz"],["dc.date.accessioned","2018-11-07T10:29:43Z"],["dc.date.available","2018-11-07T10:29:43Z"],["dc.date.issued","2002"],["dc.format.extent","17"],["dc.identifier.isi","000176659600067"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43696"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.conference","8th Meeting of the Deutschen-Gesellschaft-fur-Radioonkologie"],["dc.relation.eventlocation","BERLIN, GERMANY"],["dc.relation.issn","0179-7158"],["dc.title","Role of DNA-dependent protein kinase for radiosensitivity and DNA double-strand break repair in tumor cells"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","27"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Radiation and Environmental Biophysics"],["dc.bibliographiccitation.lastpage","37"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Hille, Andrea"],["dc.contributor.author","Hofman-Hüther, Hana"],["dc.contributor.author","Kühnle, Elna"],["dc.contributor.author","Wilken, Barbara"],["dc.contributor.author","Rave-Fränk, Margret"],["dc.contributor.author","Schmidberger, Heinz"],["dc.contributor.author","Virsik, Patricia"],["dc.date.accessioned","2018-11-07T08:45:46Z"],["dc.date.available","2018-11-07T08:45:46Z"],["dc.date.issued","2010"],["dc.description.abstract","The aim of the study was to compare the spontaneous and ex vivo radiation-induced chromosomal damage in lymphocytes of untreated prostate cancer patients and age-matched healthy donors, and to evaluate the chromosomal damage, induced by radiotherapy, and its persistence. Blood samples from 102 prostate cancer patients were obtained before radiotherapy to investigate the excess acentric fragments and dicentric chromosomes. In addition, in a subgroup of ten patients, simple exchanges in chromosomes 2 and 4 were evaluated by fluorescent in situ hybridization (FISH), before the onset of therapy, in the middle and at the end of therapy, and 1 year later. Data were compared to blood samples from ten age-matched healthy donors. We found that spontaneous yields of acentric chromosome fragments and simple exchanges were significantly increased in lymphocytes of patients before onset of therapy, indicating chromosomal instability in these patients. Ex vivo radiation-induced aberrations were not significantly increased, indicating proficient repair of radiation-induced DNA double-strand breaks in lymphocytes of these patients. As expected, the yields of dicentric and acentric chromosomes, and the partial yields of simple exchanges, were increased after the onset of therapy. Surprisingly, yields after 1 year were comparable to those directly after radiotherapy, indicating persistence of chromosomal instability over this time. Our results indicate that prostate cancer patients are characterized by increased spontaneous chromosomal instability. This instability seems to result from defects other than a deficient repair of radiation-induced DNA double-strand breaks. Radiotherapy-induced chromosomal damage persists 1 year after treatment."],["dc.description.sponsorship","Bundesministerium fur Bildung und Forschung [02S8203]"],["dc.identifier.doi","10.1007/s00411-009-0244-x"],["dc.identifier.isi","000274549400004"],["dc.identifier.pmid","19760427"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/4149"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20528"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","Najko"],["dc.relation.issn","0301-634X"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Spontaneous and radiation-induced chromosomal instability and persistence of chromosome aberrations after radiotherapy in lymphocytes from prostate cancer patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.volume","178"],["dc.contributor.author","Rave-Fraenk, Margret"],["dc.contributor.author","Virsik-Koepp, Patricia"],["dc.contributor.author","Dork, T."],["dc.contributor.author","Baltes, R."],["dc.contributor.author","Nitsche, M."],["dc.contributor.author","Schmidberger, Heinz"],["dc.date.accessioned","2018-11-07T10:29:45Z"],["dc.date.available","2018-11-07T10:29:45Z"],["dc.date.issued","2002"],["dc.format.extent","85"],["dc.identifier.isi","000176659600337"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43706"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.conference","8th Meeting of the Deutschen-Gesellschaft-fur-Radioonkologie"],["dc.relation.eventlocation","BERLIN, GERMANY"],["dc.relation.issn","0179-7158"],["dc.title","Comparison of radiosensitivity of lymphocytes and fibroblasts from three donors with fibroblasts identified as radiosensitive"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","41"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","International Journal of Radiation Biology"],["dc.bibliographiccitation.lastpage","47"],["dc.bibliographiccitation.volume","83"],["dc.contributor.author","Rave-Fraenk, Margret"],["dc.contributor.author","Schmidberger, Heinz"],["dc.contributor.author","Christiansen, Hans"],["dc.contributor.author","Boll, Christine"],["dc.contributor.author","Lehmann, Joerg"],["dc.contributor.author","Weiss, Elisabeth"],["dc.date.accessioned","2018-11-07T11:06:44Z"],["dc.date.available","2018-11-07T11:06:44Z"],["dc.date.issued","2007"],["dc.description.abstract","Background and purpose: To test the combined effects of oxaliplatin and radiation versus cisplatin and radiation using human cervical and lung cancer cell lines. Material and Methods: CaSki cervical cancer cells, and A549 lung cancer cells were cultured under standard conditions. Cells were treated with escalating doses of gamma-irradiation (0 - 6 Gy), and with oxali- and cisplatin for 2 h or 24 h, or a combination of both. Cell survival was measured by a colony-forming assay. Survival curves were fitted to the data using the linear quadratic model. Sensitizer enhancement ratios (SER) were calculated at the 37% survival level, and isobologram analysis was applied to test for the drug-radiation interactions. Results: Oxaliplatin as well as cisplatin alone were cytotoxic in both cell lines. In CaSki cells, oxaliplatin and cisplatin significantly increased radiation toxicity. In A549 cells no increase of radiation toxicity was observed after treatment with cisplatin, however, isobologram analysis revealed supra-additive interaction between oxaliplatin and radiation in A549 cells. Conclusion: Oxaliplatin had the same effectiveness on tumor cells as cisplatin and induced enhanced radiation toxicity in lung cancer cells, where cisplatin was not able to achieve radiosensitization."],["dc.identifier.doi","10.1080/09553000601121108"],["dc.identifier.isi","000244144600004"],["dc.identifier.pmid","17357438"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52386"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Taylor & Francis Ltd"],["dc.relation.issn","0955-3002"],["dc.title","Comparison of the combined action of oxaliplatin or cisplatin and radiation in cervical and lung cancer cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]