Mißbach-Güntner, Jeannine

[["dc.bibliographiccitation.firstpage","1460"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Journal of Synchrotron Radiation"],["dc.bibliographiccitation.lastpage","1466"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Pacilè, Serena"],["dc.contributor.author","Baran, Patrycja"],["dc.contributor.author","Dullin, Christian"],["dc.contributor.author","Dimmock, Matthew"],["dc.contributor.author","Lockie, Darren"],["dc.contributor.author","Missbach-Guntner, Jeannine"],["dc.contributor.author","Quiney, Harry"],["dc.contributor.author","McCormack, Mikkaela"],["dc.contributor.author","Mayo, Sheridan"],["dc.contributor.author","Thompson, Darren"],["dc.contributor.author","Nesterets, Yakov"],["dc.contributor.author","Hall, Chris"],["dc.contributor.author","Pavlov, Konstantin"],["dc.contributor.author","Prodanovic, Zdenka"],["dc.contributor.author","Tonutti, Maura"],["dc.contributor.author","Accardo, Agostino"],["dc.contributor.author","Fox, Jane"],["dc.contributor.author","Tavakoli Taba, Seyedamir"],["dc.contributor.author","Lewis, Sarah"],["dc.contributor.author","Brennan, Patrick"],["dc.contributor.author","Hausermann, Daniel"],["dc.contributor.author","Tromba, Giuliana"],["dc.contributor.author","Gureyev, Tim"],["dc.date.accessioned","2020-12-10T18:25:58Z"],["dc.date.available","2020-12-10T18:25:58Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1107/S1600577518010172"],["dc.identifier.eissn","1600-5775"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75898"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Advantages of breast cancer visualization and characterization using synchrotron radiation phase-contrast tomography"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","286"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Journal of Radiology"],["dc.bibliographiccitation.lastpage","293"],["dc.bibliographiccitation.volume","70"],["dc.contributor.author","Alves, Frauke"],["dc.contributor.author","Dullin, Christian"],["dc.contributor.author","Napp, Joanna"],["dc.contributor.author","Missbach-Guentner, Jeannine"],["dc.contributor.author","Jannasch, Katharina"],["dc.contributor.author","Mathejczyk, Julia"],["dc.contributor.author","Pardo, Luis A."],["dc.contributor.author","Stühmer, Walter"],["dc.contributor.author","Tietze, Lutz Friedjan"],["dc.date.accessioned","2018-11-07T08:30:16Z"],["dc.date.available","2018-11-07T08:30:16Z"],["dc.date.issued","2009"],["dc.description.abstract","Conventional chemotherapy of cancer has its limitations, especially in advanced and disseminated disease and suffers from lack of specificity. This results in a poor therapeutic index and considerable toxicity to normal organs. Therefore, many efforts are made to develop novel therapeutic tools against cancer with the aim of selectively targeting the drug to the turnout site. Drug delivery strategies fundamentally rely on the identification of good-quality biomarkers, allowing unequivocal discrimination between cancer and healthy tissue. At present, antibodies or antibody fragments have clearly proven their value as carrier molecules specific for a tumour-associated molecular marker. This present review draws attention to the use of near-infrared fluorescence (NIRF) imaging to investigate binding specificity and kinetics of carrier molecules such as monoclonal antibodies. In addition, flat-panel volume computed tomography (fpVCT) will be presented to monitor anatomical structures in turnout mouse models over time in a non-invasive manner. Each imaging device sheds light on a different aspect; functional imaging is applied to optimise the dose schedule and the concept of selective tumour therapies, whereas anatomical imaging assesses preclinically the efficacy of novel turnout therapies. Both imaging techniques in combination allow the visualisation of functional information obtained by NIRF imaging within an adequate anatomic framework. (C) 2009 Elsevier Ireland Ltd. All rights reserved."],["dc.description.sponsorship","DFG [SFB 416, AL336/5-1]"],["dc.identifier.doi","10.1016/j.ejrad.2009.01.048"],["dc.identifier.isi","000266868900012"],["dc.identifier.pmid","19285818"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16849"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0720-048X"],["dc.title","Concept of a selective tumour therapy and its evaluation by near-infrared fluorescence imaging and flat-panel volume computed tomography in mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Molecular Imaging"],["dc.bibliographiccitation.lastpage","14"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Dullin, Christian"],["dc.contributor.author","Zientkowska, Marta"],["dc.contributor.author","Napp, Joanna"],["dc.contributor.author","Missbach-Guentner, Jeannine"],["dc.contributor.author","Krell, Hans-Willi"],["dc.contributor.author","Mueller, Friedernann"],["dc.contributor.author","Grabbe, Eckhardt"],["dc.contributor.author","Tietze, Lutz Friedjan"],["dc.contributor.author","Alves, Frauke"],["dc.date.accessioned","2018-11-07T08:35:08Z"],["dc.date.available","2018-11-07T08:35:08Z"],["dc.date.issued","2009"],["dc.description.abstract","Connecting fluorescence signals with anatomic structures enhances our ability to monitor biologic processes in mice. Here, we present a semiautomated approach to correlate two-dimensional (2D) noninvasive near-infrared fluorescence (NIRF) imaging with three-dimensional (3D), high-resolution, flat-panel volume computed tomography (fpVCT). We developed an algorithm to colocalize fluorescence signals of NIRF-labeled antibodies directed against matriptase and urokinase plasminogen activator receptor (uPAR) to orthotopic carcinomas in mice visualized by fpVCT. For this purpose, mice were anesthetized and fixed on a multimodality animal bed containing fiducial markers filled with iodine-containing contrast agent and fluorescent dye. After intravenous administration of contrast agent and Cy5.5-labeled antibodies, NIRF and fpVCT images were obtained, without repositioning the mice. Binding of Cy5.5-labeled matriptase-specific antibody to pancreatic tumors and Cy5.5-labeled uPAR-specific antibody to mammary carcinomas was assessed by time-domain NIRF imaging measuring the location of fluorescence intensity and its lifetime. In summary, we developed a novel 2D-3D registration technique for image fusion with NIRF imaging and fpVCT to provide complementary information in tumor models on the in vivo association of functional information with anatomic structures. The combination of fpVCT with NIRF imaging will now allow targeted and effective monitoring of preclinical tumor therapies."],["dc.identifier.doi","10.2310/7290.2009.00001"],["dc.identifier.isi","000263883600001"],["dc.identifier.pmid","19344571"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17988"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","B C Decker Inc"],["dc.relation.issn","1535-3508"],["dc.title","Semiautomatic Landmark-Based Two-Dimensional-Three-Dimensional Image Fusion in Living Mice: Correlation of Near-Infrared Fluorescence Imaging of Cy5.5-Labeled Antibodies with Flat-Panel Volume Computed Tomography"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","18"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Clinical Imaging"],["dc.bibliographiccitation.lastpage","22"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Obenauer, Silvia"],["dc.contributor.author","Dullin, Christian"],["dc.contributor.author","Alves, Frauke"],["dc.contributor.author","Missbach-Guentner, Jeannine"],["dc.contributor.author","Grabbe, Eckhardt"],["dc.contributor.author","Heuser, Markus"],["dc.date.accessioned","2018-11-07T11:06:17Z"],["dc.date.available","2018-11-07T11:06:17Z"],["dc.date.issued","2007"],["dc.description.abstract","Objectives: The aim of this study was to compare the image performance of silicon-based flat-panel-detector-based volumetric computed tomography (fpVCT) to multislice spiral computed tomography (MSCT) for the visualization and detail delectability of skeletal structures in rodents of different development stages. Materials and Methods: Rodents of different development stages were imaged with fpVCT (GE prototype with circular gantry with two 1024 x 1024, 200-mu m pixel size, amorphous silicon/Cesium lodid (Csl) flat-panel detector) and eightslice MSCT (LightSpeed Ultra). Imaging parameters (80 kVp, 100 mA) and the position of the rodents were identical in both techniques. Image quality, detail delectability, and contour of skeletal structures were judged by two observers in consensus using a 4-point scale (1=unsatisfactory... 4=good). Findings were displayed and evaluated in axial slices, multiplanar reconstructions (MPR), maximum intensity projections (MIP) and volume rendering technique (VRT) in both modalities. Mean and standard of error of mean were calculated. Results: In axial slices, visualization and detail delectability of very subtle skeletal structures, e.g., the basis of the skull was better in fpVCT than in MSCT (4 vs. 2 points). The MPRs of fpVCT showed less artifacts and more details than those of the MSCT. The MIPs and VRTs of the fpVCT demonstrated best image quality in all rodents of different development stages, whereas MSCT showed significant artifacts. Conclusion: fpVCT outperformed MSCT in imaging of small rodents. Due to the truly isotropic volume data set with high spatial resolution, fpVCT is a powerful tool in evaluating detailed skeletal structures. (c) 2007 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.clinimag.2006.09.029"],["dc.identifier.isi","000243468100004"],["dc.identifier.pmid","17189841"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52269"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","0899-7071"],["dc.title","Flat-panel-detector-based volumetric CT: performance evaluation of imaging for skeletal structures of small animals in comparison to multislice CT"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","535"],["dc.bibliographiccitation.issue","4-5"],["dc.bibliographiccitation.journal","The International Journal of Developmental Biology"],["dc.bibliographiccitation.lastpage","546"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Missbach-Guentner, Jeannine"],["dc.contributor.author","Hunia, Julia"],["dc.contributor.author","Alves, Frauke"],["dc.date.accessioned","2018-11-07T09:01:27Z"],["dc.date.available","2018-11-07T09:01:27Z"],["dc.date.issued","2011"],["dc.description.abstract","Significant advances have been made in understanding the role of tumor angiogenesis and its influence on tumor progression in cancer. Based on this knowledge, a series of inhibitors of angiogenesis have been developed and evaluated in preclinical and clinical trials. Since detailed information of tumor progression in response to therapy is important to assess the efficacy of antitumor treatment in vivo, noninvasive imaging techniques emerge more and more as important tools to monitor alterations in tumor growth and vessel recruitment, as well as metastatic spread over time. So far, remarkable efforts have been made to improve the technical capability of these imaging modalities based on better resolution, as well as to implement multimodal approaches combining molecular with anatomical information. Advanced imaging techniques not only allow the detection and monitoring of tumor development, but also facilitate a broad understanding of the cellular and molecular events that propagate tumor angiogenesis, as well as those occurring in response to therapy.This review provides an overview of different imaging techniques in preclinical settings of oncological research and discusses their potential impact on clinical translation. Imaging modalities will be presented that have been implemented to address key biological issues by exploring tumor angiogenic processes and evaluating antiangiogenic therapy."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [AL336/5-1, SPP1190]"],["dc.identifier.doi","10.1387/ijdb.103229jm"],["dc.identifier.isi","000295748300023"],["dc.identifier.pmid","21858774"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24427"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","U B C Press"],["dc.relation.issn","0214-6282"],["dc.title","Tumor blood vessel visualization"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]