von Bueren, André O.

[["dc.bibliographiccitation.firstpage","88"],["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.lastpage","89"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Mynarek, Martin"],["dc.contributor.author","von Hoff, Katja"],["dc.contributor.author","Mueller, Klaus"],["dc.contributor.author","Friedrich, Carsten"],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.contributor.author","Gerber, Nicolas U."],["dc.contributor.author","Benesch, Martin"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Ottensmeier, Holger"],["dc.contributor.author","Kwiecien, Robert"],["dc.contributor.author","Faldum, Andreas"],["dc.contributor.author","Kuehl, Joachim"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","Rutkowski, Stefan"],["dc.date.accessioned","2018-11-07T09:39:22Z"],["dc.date.available","2018-11-07T09:39:22Z"],["dc.date.issued","2014"],["dc.identifier.isi","000337924200337"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33262"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.eventlocation","Singapore, SINGAPORE"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","INTENSIFICATION OF INDUCTION CHEMOTHERAPY IMPROVES OUTCOMES IN PATIENTS WITH METASTATIC MEDULLOBLASTOMA BELOW 4 YEARS OF AGE: RESULTS OF A PROSPECTIVE, NON-RANDOMIZED PHASE II CLINICAL TRIAL"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Mynarek, Martin"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","Kaatsch, Peter"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Timmermann, Beate"],["dc.contributor.author","Fleischhack, Gudrun"],["dc.contributor.author","Benesch, Martin"],["dc.contributor.author","Friedrich, Carsten"],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.contributor.author","Gerber, Nicolas U."],["dc.contributor.author","Mueller, Klaus"],["dc.contributor.author","Tippelt, Stephan"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Rutkowski, Stefan"],["dc.contributor.author","von Hoff, Katja"],["dc.date.accessioned","2018-11-07T09:39:18Z"],["dc.date.available","2018-11-07T09:39:18Z"],["dc.date.issued","2014"],["dc.format.extent","22"],["dc.identifier.isi","000337924200082"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33251"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","16th International Symposium on Pediatric Neuro-Oncology (ISPNO)"],["dc.relation.eventlocation","Singapore, SINGAPORE"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","LONG-TERM FOLLOW-UP OF CHILDREN WITH EPENDYMOMA TREATED ACCORDING TO HIT-TRIALS 1987-1998"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","325"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Neuro-Oncology"],["dc.bibliographiccitation.lastpage","332"],["dc.bibliographiccitation.volume","124"],["dc.contributor.author","Mueller, Klaus"],["dc.contributor.author","Henke, Guido"],["dc.contributor.author","Pietschmann, Sophie"],["dc.contributor.author","van Gool, Stefaan"],["dc.contributor.author","De Vleeschouwer, Steven"],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.contributor.author","Compter, Inge"],["dc.contributor.author","Friedrich, Carsten"],["dc.contributor.author","Matuschek, Christiane"],["dc.contributor.author","Klautke, Gunther"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","Hundsberger, Thomas"],["dc.contributor.author","Baumert, Brigitta G."],["dc.date.accessioned","2018-11-07T09:52:19Z"],["dc.date.available","2018-11-07T09:52:19Z"],["dc.date.issued","2015"],["dc.description.abstract","We aimed to compare two different salvage treatment strategies for relapsed high-grade glioma (HGG) patients by means of a new prognostic model. A simplified version of the so-called HGG-Immuno RPA model estimates the prognosis of relapsed HGG patients and distinguishes three different prognostic classes (I = good, II = intermediate, III = poor). The model has been constructed with a cohort of 117 patients whose salvage treatment consisted of re-operation followed by dendritic cell vaccination (ReOP + DCV). However, using only the predictors histology, age and performance status, the simplified HGG-Immuno RPA model is basically independent from treatment. In the present study we applied the simplified model to the cohort used to construct the original HGG-Immuno RPA model and another cohort of 165 patients who underwent re-irradiation (ReRT) at relapse. Then, we compared the outcomes achieved by the two different salvage treatments in each prognostic class. The model predicted good, intermediate and poor prognosis for 11, 31 and 75 patients of the ReOP + DCV cohort and for 20, 39 and 106 patients of the ReRT cohort, respectively. Neither of the two strategies was superior to the other. In the groups with good, intermediate and poor prognosis 12-months survival rates were 73, 59 and 25 % after ReOP + DCV and 72, 36 and 23 % after ReRT, respectively. Being easy to handle and independent from treatment, the aforementioned model is useful for therapeutic decisions. ReRT and ReOP + DVC seem to be equally effective. The choice of salvage treatment should be based on the expected side effects."],["dc.identifier.doi","10.1007/s11060-015-1844-8"],["dc.identifier.isi","000361883000021"],["dc.identifier.pmid","26070556"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36102"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1573-7373"],["dc.relation.issn","0167-594X"],["dc.title","Re-irradiation or re-operation followed by dendritic cell vaccination? Comparison of two different salvage strategies for relapsed high-grade gliomas by means of a new prognostic model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Friedrich, Carsten"],["dc.contributor.author","Mueller, Klaus"],["dc.contributor.author","von Hoff, Katja"],["dc.contributor.author","Kwiecien, Robert"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Gerber, Nicolas U."],["dc.contributor.author","Hau, Peter"],["dc.contributor.author","Kuehl, Joachim"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.contributor.author","Rutkowski, Stefan"],["dc.date.accessioned","2018-11-07T09:17:47Z"],["dc.date.available","2018-11-07T09:17:47Z"],["dc.date.issued","2013"],["dc.format.extent","132"],["dc.identifier.isi","000327456200531"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28252"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","4th Quadrennial Meeting of the World-Federation-of-Neuro-Oncology (WFNO) held in conjunction with the 18th Annual Meeting of the Society-for-Neuro-Oncology (SNO)"],["dc.relation.eventlocation","San Francisco, CA"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","MULTIMODAL TREATMENT OF ADULTS WITH CNS PRIMITIVE NEUROECTODERMAL TUMORS/PINEOBLASTOMAS ACCORDING TO THE PEDIATRIC HIT 2000 PROTOCOL"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","177"],["dc.bibliographiccitation.journal","Radiation Oncology"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Mueller, Klaus"],["dc.contributor.author","Scheithauer, Heike"],["dc.contributor.author","Pietschmann, Sophie"],["dc.contributor.author","Hoffmann, Marion"],["dc.contributor.author","Roessler, Jochen"],["dc.contributor.author","Graf, Norbert"],["dc.contributor.author","Baumert, Brigitta G."],["dc.contributor.author","Christiansen, Hans"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.date.accessioned","2018-11-07T09:36:38Z"],["dc.date.available","2018-11-07T09:36:38Z"],["dc.date.issued","2014"],["dc.description.abstract","Background and purpose: The aim of the present analysis was to assess the feasibility, toxicity, and the tumor control of reirradiation as a salvage treatment for progressive pediatric non-pontine high-grade gliomas (HGG). Patients and methods: The database of the Reference Center for Radiation Oncology of the German HIT (HIT = German acronym for brain tumor) treatment network for childhood brain tumors was screened for children who were reirradiated for progressive non-pontine HGG. Results: We identified eight patients (WHO grade III: n = 5; WHO grade IV: n = 3) who underwent reirradiation between April 2006 and July 2012. Median age was 13.5 years at primary diagnosis and 14.8 years at first progression. All patients initially underwent surgery (incomplete resection, n = 7; biopsy, n = 1) followed by radiochemotherapy. Relapses occurred inside (n = 2), at the margin (n = 4), and outside of the preirradiated area (n = 2). In all patients, reirradiation was tolerated well without significant acute toxicity. Temporary clinical improvement and tumor regression on magnetic resonance imaging (MRI) following reirradiation was reported (n = 3). However, all patients finally died by disease progression. Median survival time was 26.2 months from initial diagnosis and 11.4 months after first progression. Median time interval between initial radiotherapy and first reirradiation was 9.0 months. In six patients, all macroscopic tumor deposits were reirradiated. In these patients, median progression-free (overall) survival from the start of reirradiation was 2.4 (4.6) months. Conclusion: Our analysis, although based on a limited patient number, suggests that reirradiation of progressive non-pontine HGG is feasible in children. Benefit in terms of quality of life and/or survival needs to be assessed in a prospective and ideally in a randomized manner."],["dc.identifier.doi","10.1186/1748-717X-9-177"],["dc.identifier.isi","000341198300001"],["dc.identifier.pmid","25112658"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32662"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1748-717X"],["dc.title","Reirradiation as part of a salvage treatment approach for progressive non-pontine pediatric high-grade gliomas: preliminary experiences from the German HIT-HGG study group"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","53"],["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.lastpage","54"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Pietschmann, Sophie"],["dc.contributor.author","Kerber, Michael Josef"],["dc.contributor.author","Zwiener, Isabella"],["dc.contributor.author","Henke, Guido"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","Mueller, Klaus"],["dc.contributor.author","von Bueren, Andre"],["dc.date.accessioned","2018-11-07T09:39:20Z"],["dc.date.available","2018-11-07T09:39:20Z"],["dc.date.issued","2014"],["dc.identifier.isi","000337924200202"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33256"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","16th International Symposium on Pediatric Neuro-Oncology (ISPNO)"],["dc.relation.eventlocation","Singapore, SINGAPORE"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","AN INDIVIDUAL PATIENT DATA META-ANALYSIS ON CHARACTERISTICS, TREATMENT AND OUTCOME OF PATIENTS WITH METASTATIC HIGH-GRADE GLIOMAS"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Friedrich, Carsten"],["dc.contributor.author","Kuehn, Alexander"],["dc.contributor.author","Zimmermann, Martin"],["dc.contributor.author","Hoffmann, Marion"],["dc.contributor.author","Kuehnle, Ingrid"],["dc.contributor.author","Nowak, Johannes"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Schrappe, Martin"],["dc.contributor.author","Escherich, Gabriele"],["dc.contributor.author","Burkhardt, Birgit"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.contributor.author","Kramm, Christof M."],["dc.date.accessioned","2018-11-07T10:13:06Z"],["dc.date.available","2018-11-07T10:13:06Z"],["dc.date.issued","2016"],["dc.format.extent","55"],["dc.identifier.isi","000379749000210"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40369"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","17th International Symposium on Pediatric Neuro-Oncology (ISPNO)"],["dc.relation.eventlocation","Liverpool, ENGLAND"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","HIGH-GRADE GLIOMA ARISING IN SURVIVORS OF PEDIATRIC ACUTE LYMPHOBLASTIC MALIGNANCIES: A COOPERATIVE ANALYSIS OF THE GERMAN HIT-HGG/-GBM AND ALL-BFM/COALL STUDIES"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","161"],["dc.bibliographiccitation.journal","Radiation Oncology"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Scholtyssek, Felix"],["dc.contributor.author","Zwiener, Isabella"],["dc.contributor.author","Schlamann, Annika"],["dc.contributor.author","Seidel, Clemens"],["dc.contributor.author","Meixensberger, Juergen"],["dc.contributor.author","Bauer, Manfred"],["dc.contributor.author","Hoffmann, Karl-Titus"],["dc.contributor.author","Combs, Stephanie E."],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","Mueller, Klaus"],["dc.date.accessioned","2018-11-07T09:22:30Z"],["dc.date.available","2018-11-07T09:22:30Z"],["dc.date.issued","2013"],["dc.description.abstract","Purposes: First, to evaluate outcome, the benefit of concurrent chemotherapy and prognostic factors in a cohort of sixty-four high-grade glioma patients who underwent a second course of radiation therapy at progression. Second, to validate a new prognostic score for overall survival after reirradiation of progressive gliomas with an independent patient cohort. Patients and methods: All patients underwent fractionated reirradiation with a median physical dose of 36 Gy. Median planned target volume was 110.4 ml. Thirty-six patients received concurrent chemotherapy consisting in 24/36 cases (67%) of carboplatin and etoposide and in 12/36 cases (33%) of temozolomide. We used the Kaplan Meier method, log rank test and proportional hazards regression analysis for statistical assessment. Results: Median overall survival from the start of reirradiation was 7.7 +/- 0.7 months. Overall survival rates at 6 and 12 months were 60 +/- 6% and 24 +/- 6%, respectively. Despite relatively large target volumes we did not observe any major acute toxicity. Concurrent chemotherapy did not appear to improve outcome. In contrast, female gender, young age, WHO grade III histology, favorable Karnofsky performance score and complete resection of the tumor prior to reirradiation were identified as positive prognostic factors for overall survival. We finally validated a recent suggestion for a prognostic score with our independent but small patient cohort. Our preliminary findings suggest that its ability to discriminate between different prognostic groups is limited. Conclusions: Outcome of our patients was comparable to previous studies. Even in case of large target volumes reirradiation seems to be feasible without observing major toxicity. The benefit of concurrent chemotherapy is still elusive. A reassessment of the prognostic score, tested in this study, using a larger patient cohort is needed."],["dc.identifier.doi","10.1186/1748-717X-8-161"],["dc.identifier.isi","000321565200001"],["dc.identifier.pmid","23822643"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9136"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29353"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1748-717X"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Reirradiation in progressive high-grade gliomas: outcome, role of concurrent chemotherapy, prognostic factors and validation of a new prognostic score with an independent patient cohort"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.contributor.author","Friedrich, Carsten"],["dc.contributor.author","von Hoff, Katja"],["dc.contributor.author","Kwiecien, Robert"],["dc.contributor.author","Mueller, Klaus"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Kuehl, Joachim"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","Rutkowski, Stefan"],["dc.date.accessioned","2018-11-07T09:17:48Z"],["dc.date.available","2018-11-07T09:17:48Z"],["dc.date.issued","2013"],["dc.format.extent","133"],["dc.identifier.isi","000327456200532"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28254"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","4th Quadrennial Meeting of the World-Federation-of-Neuro-Oncology (WFNO) held in conjunction with the 18th Annual Meeting of the Society-for-Neuro-Oncology (SNO)"],["dc.relation.eventlocation","San Francisco, CA"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","RESULTS OF ADULTS TREATED FOR METASTATIC MEDULLOBLASTOMA USING THE PEDIATRIC PROTOCOL HIT 2000. A PROSPECTIVE MULTICENTER OBSERVATIONAL STUDY"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1463"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Child's Nervous System"],["dc.bibliographiccitation.lastpage","1471"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Friedrich, Carsten"],["dc.contributor.author","Shalaby, Tarek"],["dc.contributor.author","Oehler, Christoph"],["dc.contributor.author","Pruschy, Martin"],["dc.contributor.author","Seifert, Burkhardt"],["dc.contributor.author","Picard, Daniel"],["dc.contributor.author","Remke, Marc"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","Rutkowski, Stefan"],["dc.contributor.author","Grotzer, Michael A."],["dc.contributor.author","von Bueren, André O."],["dc.date.accessioned","2020-12-10T14:10:20Z"],["dc.date.available","2020-12-10T14:10:20Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s00381-017-3506-y"],["dc.identifier.eissn","1433-0350"],["dc.identifier.issn","0256-7040"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70729"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Tropomyosin receptor kinase C (TrkC) expression in medulloblastoma: relation to the molecular subgroups and impact on treatment response"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]