von Bueren, André O.

[["dc.bibliographiccitation.firstpage","88"],["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.lastpage","89"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Mynarek, Martin"],["dc.contributor.author","von Hoff, Katja"],["dc.contributor.author","Mueller, Klaus"],["dc.contributor.author","Friedrich, Carsten"],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.contributor.author","Gerber, Nicolas U."],["dc.contributor.author","Benesch, Martin"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Ottensmeier, Holger"],["dc.contributor.author","Kwiecien, Robert"],["dc.contributor.author","Faldum, Andreas"],["dc.contributor.author","Kuehl, Joachim"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","Rutkowski, Stefan"],["dc.date.accessioned","2018-11-07T09:39:22Z"],["dc.date.available","2018-11-07T09:39:22Z"],["dc.date.issued","2014"],["dc.identifier.isi","000337924200337"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33262"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.eventlocation","Singapore, SINGAPORE"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","INTENSIFICATION OF INDUCTION CHEMOTHERAPY IMPROVES OUTCOMES IN PATIENTS WITH METASTATIC MEDULLOBLASTOMA BELOW 4 YEARS OF AGE: RESULTS OF A PROSPECTIVE, NON-RANDOMIZED PHASE II CLINICAL TRIAL"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Mynarek, Martin"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","Kaatsch, Peter"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Timmermann, Beate"],["dc.contributor.author","Fleischhack, Gudrun"],["dc.contributor.author","Benesch, Martin"],["dc.contributor.author","Friedrich, Carsten"],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.contributor.author","Gerber, Nicolas U."],["dc.contributor.author","Mueller, Klaus"],["dc.contributor.author","Tippelt, Stephan"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Rutkowski, Stefan"],["dc.contributor.author","von Hoff, Katja"],["dc.date.accessioned","2018-11-07T09:39:18Z"],["dc.date.available","2018-11-07T09:39:18Z"],["dc.date.issued","2014"],["dc.format.extent","22"],["dc.identifier.isi","000337924200082"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33251"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","16th International Symposium on Pediatric Neuro-Oncology (ISPNO)"],["dc.relation.eventlocation","Singapore, SINGAPORE"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","LONG-TERM FOLLOW-UP OF CHILDREN WITH EPENDYMOMA TREATED ACCORDING TO HIT-TRIALS 1987-1998"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","924"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.lastpage","932"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Gessi, Marco"],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.contributor.author","Treszl, Andras"],["dc.contributor.author","Muehlen, Anja zur"],["dc.contributor.author","Hartmann, Wolfgang"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Rutkowski, Stefan"],["dc.contributor.author","Pietsch, Torsten"],["dc.date.accessioned","2018-11-07T09:38:21Z"],["dc.date.available","2018-11-07T09:38:21Z"],["dc.date.issued","2014"],["dc.description.abstract","Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are a rare group of neoplasms occurring in the CNS that includes supratentorial CNS-PNETs, medulloepitheliomas, and ependymoblastomas. While ependymoblastomas frequently carry chromosome 19q13.41 amplification and show aggressive clinical behavior, the biological mechanisms and molecular alterations contributing to the pathogenesis of supratentorial CNS-PNETs remain poorly understood. Moreover, genetic alterations suitable for molecular risk stratification are undefined to date. In order to identify possible molecular markers, we performed multiplex ligation-dependent probe amplification (MLPA) and molecular inversion probe (MIP) analysis on DNA samples of 25 supratentorial CNS-PNETs (median age, 5.35 years; range, 2.41-17.28 years). Tumors with ependymoblastic rosettes (ependymoblastoma/ETANTR) and LIN28A positivity were excluded. MLPA and MIP analysis revealed large losses of genomic material of chromosomes 3, 4, 5, and 13, while frequent gains affected chromosomes 1, 17, 19, 20, and 22. High copy number gains (amplifications) were found in particular at chromosomes 2p24.3 (MYCN, n = 6 cases) and 4q12 (n = 2 cases). Patients with tumors harboring 2p gain or MYCN amplification showed unfavorable overall survival (P = .003 and P = .001, respectively).These markers were independent of the presence of metastases, which was indeed a clinical factor associated with poor overall survival (P = .01) in this series. In the era of the personalized neuro-oncology, the identification of these molecular prognostic markers associated with patient outcome may represent a significant step towards improved patient stratification and risk-adapted therapeutic strategies for patients suffering from supratentorial CNS-PNETs."],["dc.identifier.doi","10.1093/neuonc/not302"],["dc.identifier.isi","000338126100004"],["dc.identifier.pmid","24470553"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33048"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","MYCN amplification predicts poor outcome for patients with supratentorial primitive neuroectodermal tumors of the central nervous system"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Rutkowski, Stefan"],["dc.contributor.author","von Bueren, Andre"],["dc.contributor.author","Goschzik, Tobias"],["dc.contributor.author","Kortmann, Rolf"],["dc.contributor.author","von Hoff, Katja"],["dc.contributor.author","Friedrich, Carsten"],["dc.contributor.author","zur Muehlen, Anja"],["dc.contributor.author","Gerber, Nicolas U."],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Soerensen, Niels"],["dc.contributor.author","Deinlein, Frank"],["dc.contributor.author","Benesch, Martin"],["dc.contributor.author","Zwiener, Isabella"],["dc.contributor.author","Faldum, Andreas"],["dc.contributor.author","Kuehl, Joachim"],["dc.contributor.author","Pietsch, Torsten"],["dc.date.accessioned","2018-11-07T09:39:21Z"],["dc.date.available","2018-11-07T09:39:21Z"],["dc.date.issued","2014"],["dc.format.extent","86"],["dc.identifier.isi","000337924200329"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33259"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","16th International Symposium on Pediatric Neuro-Oncology (ISPNO)"],["dc.relation.eventlocation","Singapore, SINGAPORE"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","PROGNOSTIC IMPACT OF HISTOPATHOLOGY, WNT ACTIVATION AND MYCC/MYCN GENE AMPLIFICATION IN A HOMOGENOUSLY TREATED METASTATIC MEDULLOBLASTOMA HIT2000 COHORT"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Friedrich, Carsten"],["dc.contributor.author","Mueller, Klaus"],["dc.contributor.author","von Hoff, Katja"],["dc.contributor.author","Kwiecien, Robert"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Gerber, Nicolas U."],["dc.contributor.author","Hau, Peter"],["dc.contributor.author","Kuehl, Joachim"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.contributor.author","Rutkowski, Stefan"],["dc.date.accessioned","2018-11-07T09:17:47Z"],["dc.date.available","2018-11-07T09:17:47Z"],["dc.date.issued","2013"],["dc.format.extent","132"],["dc.identifier.isi","000327456200531"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28252"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","4th Quadrennial Meeting of the World-Federation-of-Neuro-Oncology (WFNO) held in conjunction with the 18th Annual Meeting of the Society-for-Neuro-Oncology (SNO)"],["dc.relation.eventlocation","San Francisco, CA"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","MULTIMODAL TREATMENT OF ADULTS WITH CNS PRIMITIVE NEUROECTODERMAL TUMORS/PINEOBLASTOMAS ACCORDING TO THE PEDIATRIC HIT 2000 PROTOCOL"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","693"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.lastpage","696"],["dc.bibliographiccitation.volume","189"],["dc.contributor.author","Mueller, K."],["dc.contributor.author","Schlamann, Annika"],["dc.contributor.author","Seidel, C."],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Christiansen, H."],["dc.contributor.author","Vordermark, Dirk"],["dc.contributor.author","Kortmann, R.-D."],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","von Bueren, A. O."],["dc.date.accessioned","2018-11-07T09:22:03Z"],["dc.date.available","2018-11-07T09:22:03Z"],["dc.date.issued","2013"],["dc.description.abstract","Primary metastatic diffuse intrinsic pontine glioma (DIPG) is relatively rare and associated with a dismal prognosis. Combining craniospinal irradiation (CSI) with concurrent temozolomide and nimotuzumab therapy may slightly improve tumor control and overall survival. However, little is known about the feasibility and toxicity of this treatment approach. Here, we describe the case of an 8-year-old girl with primary metastatic DIPG who received craniospinal radiotherapy, a local boost, and concurrent temozolomide and nimotuzumab treatment based on an individual therapy recommendation. Radiotherapy could be completed without any interruption. However, concurrent temozolomide had to be disrupted several times due to considerable acute myelotoxicity (grade III-IV).Maintenance immunochemotherapy could be started with a delay of 5 days and was performed according to treatment schedule. The disease could be stabilized for a few months. A routine MRI scan finally depicted disease progression 5.7 months after the start of irradiation. The patient died 1.9 months later."],["dc.identifier.doi","10.1007/s00066-013-0370-x"],["dc.identifier.isi","000322388100012"],["dc.identifier.pmid","23754473"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29251"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.relation.issn","0179-7158"],["dc.title","Craniospinal irradiation with concurrent temozolomide and nimotuzumab in a child with primary metastatic diffuse intrinsic pontine glioma A compassionate use treatment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Friedrich, Carsten"],["dc.contributor.author","Kuehn, Alexander"],["dc.contributor.author","Zimmermann, Martin"],["dc.contributor.author","Hoffmann, Marion"],["dc.contributor.author","Kuehnle, Ingrid"],["dc.contributor.author","Nowak, Johannes"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Schrappe, Martin"],["dc.contributor.author","Escherich, Gabriele"],["dc.contributor.author","Burkhardt, Birgit"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.contributor.author","Kramm, Christof M."],["dc.date.accessioned","2018-11-07T10:13:06Z"],["dc.date.available","2018-11-07T10:13:06Z"],["dc.date.issued","2016"],["dc.format.extent","55"],["dc.identifier.isi","000379749000210"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40369"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","17th International Symposium on Pediatric Neuro-Oncology (ISPNO)"],["dc.relation.eventlocation","Liverpool, ENGLAND"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","HIGH-GRADE GLIOMA ARISING IN SURVIVORS OF PEDIATRIC ACUTE LYMPHOBLASTIC MALIGNANCIES: A COOPERATIVE ANALYSIS OF THE GERMAN HIT-HGG/-GBM AND ALL-BFM/COALL STUDIES"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.contributor.author","Friedrich, Carsten"],["dc.contributor.author","von Hoff, Katja"],["dc.contributor.author","Kwiecien, Robert"],["dc.contributor.author","Mueller, Klaus"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Kuehl, Joachim"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","Rutkowski, Stefan"],["dc.date.accessioned","2018-11-07T09:17:48Z"],["dc.date.available","2018-11-07T09:17:48Z"],["dc.date.issued","2013"],["dc.format.extent","133"],["dc.identifier.isi","000327456200532"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28254"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","4th Quadrennial Meeting of the World-Federation-of-Neuro-Oncology (WFNO) held in conjunction with the 18th Annual Meeting of the Society-for-Neuro-Oncology (SNO)"],["dc.relation.eventlocation","San Francisco, CA"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","RESULTS OF ADULTS TREATED FOR METASTATIC MEDULLOBLASTOMA USING THE PEDIATRIC PROTOCOL HIT 2000. A PROSPECTIVE MULTICENTER OBSERVATIONAL STUDY"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1463"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Child's Nervous System"],["dc.bibliographiccitation.lastpage","1471"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Friedrich, Carsten"],["dc.contributor.author","Shalaby, Tarek"],["dc.contributor.author","Oehler, Christoph"],["dc.contributor.author","Pruschy, Martin"],["dc.contributor.author","Seifert, Burkhardt"],["dc.contributor.author","Picard, Daniel"],["dc.contributor.author","Remke, Marc"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","Rutkowski, Stefan"],["dc.contributor.author","Grotzer, Michael A."],["dc.contributor.author","von Bueren, André O."],["dc.date.accessioned","2020-12-10T14:10:20Z"],["dc.date.available","2020-12-10T14:10:20Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s00381-017-3506-y"],["dc.identifier.eissn","1433-0350"],["dc.identifier.issn","0256-7040"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70729"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Tropomyosin receptor kinase C (TrkC) expression in medulloblastoma: relation to the molecular subgroups and impact on treatment response"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","121"],["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.lastpage","122"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Friedrich, Carsten"],["dc.contributor.author","Shalaby, Tarek"],["dc.contributor.author","Oehler, Christoph"],["dc.contributor.author","Pruschy, Martin"],["dc.contributor.author","Seifert, Burkhardt"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","Rutkowski, Stefan"],["dc.contributor.author","Grotzer, Michael A."],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.date.accessioned","2018-11-07T10:13:11Z"],["dc.date.available","2018-11-07T10:13:11Z"],["dc.date.issued","2016"],["dc.identifier.isi","000379749000483"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40375"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","17th International Symposium on Pediatric Neuro-Oncology (ISPNO)"],["dc.relation.eventlocation","Liverpool, ENGLAND"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","EXPRESSION OF TROPOMYOSIN RECEPTOR KINASE C (TrkC) HAS NO MAJOR IMPACT ON THE RESPONSE TO THERAPY OF MEDULLOBLASTOMA IN VITRO AND IN A CLINICAL PATIENT COHORT"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]