Hewitt, Manuel

[["dc.bibliographiccitation.firstpage","557"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Restorative Neurology and Neuroscience"],["dc.bibliographiccitation.lastpage","569"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Ernst, Jennifer"],["dc.contributor.author","Grundey, Jessica"],["dc.contributor.author","Hewitt, Manuel"],["dc.contributor.author","von Lewinski, Friederike"],["dc.contributor.author","Kaus, Juergen"],["dc.contributor.author","Schmalz, Thomas"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Liebetanz, David"],["dc.date.accessioned","2018-11-07T09:29:40Z"],["dc.date.available","2018-11-07T09:29:40Z"],["dc.date.issued","2013"],["dc.description.abstract","Purpose: Functional electrical stimulation represents an alternative to conventional and passive ankle foot orthosis (AFO) for the treatment of stroke-related drop foot. We evaluated the implantable 4-channel stimulator ActiGait, which selectively and directly stimulates the peroneal nerve. In addition, it bypasses the need for surface electrodes and cables. Methods: Walking speed (10-meter gait test, [m/s]) and walking endurance (6-minute gait test [m/6min]) of 5 patients were tested prior to, as well as 6 and 12 weeks after, the implantation of the ActiGait implantable drop foot stimulator system. In addition, ankle joint angles were assessed during specific phases of the gait cycle, i.e. initiation angle (IA) at the first contact of the foot to the floor, initial plantar flexion (IPF), dorsiflexion (DF) and final plantar flexion (FPF) in [degrees] during stance phase. The ankle joint angles were measured at baseline and 12 weeks after ActiGait implantation. Results: At the first follow-up, patients' gait speed was found to have increased (0.55; 0.77 m/s) as had walking endurance (211; 260 m). Improvement in gait speed (0.55; 0.77 m/s) and endurance (214; 248 m) was still present after 12 weeks. In addition, gait analysis after 12 weeks revealed a nearly normal physiological initiation angle (113 degrees vs 122 degrees) and an increase in the initial plantar flexion (7 degrees vs. 0 degrees). The initiation angle (IA) represents a well-suited parameter for adequate pre-positioning of the foot at the beginning of the stance phase and is necessary to prevent stumbling and falling. Furthermore, IA is identical to the maximum achieved dorsiflexion during the swing phase of gait. Thus, analysis of the IA of subjects walking with the implantable drop foot stimulator systems ActiGait is particularly useful in showing that the implantable system restores the IA towards physiological ankle movements. Conclusion: The ActiGait system increased gait speed, walking endurance and the physiology of important ankle joint kinematics. This is most likely a result of ankle dorsiflexion by active peroneal stimulation during the swing phase of gait and optimized prepositioning (IA) of the foot at the beginning of stance phase. The ActiGait system represents a therapeutic option for the treatment of patients suffering drop foot due to a cerebrovascular insult."],["dc.identifier.doi","10.3233/RNN-120283"],["dc.identifier.isi","000324262100004"],["dc.identifier.pmid","23756541"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31099"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Ios Press"],["dc.relation.issn","0922-6028"],["dc.title","Towards physiological ankle movements with the ActiGait implantable drop foot stimulator in chronic stroke"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Psychology"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Korzeczek, Alexandra"],["dc.contributor.author","Cholin, Joana"],["dc.contributor.author","Jorschick, Annett"],["dc.contributor.author","Hewitt, Manuel"],["dc.contributor.author","Sommer, Martin"],["dc.date.accessioned","2021-04-14T08:23:49Z"],["dc.date.available","2021-04-14T08:23:49Z"],["dc.date.issued","2020"],["dc.description.abstract","Originary neurogenic, non-syndromatic stuttering has been linked to a dysfunctional sensorimotor system. Studies have demonstrated that adults who stutter (AWS) perform poorly at speech and finger motor tasks and learning (e.g., Smits-Bandstra et al., 2006b; Namasivayam and van Lieshout, 2008). The high relapse rate after stuttering treatment could be a further hint for deficient motor learning and, in particular, for the limited generalization of the learned technique in daily communication. In this study, we tested generalization of finger sequence skills in AWS using an effector-dependent transfer task after a 24-h retention period. Additionally, we wanted to corroborate previous motor learning results in AWS for practice and retention: 16 AWS and 16 age-, sex-, and education-matched controls performed the task during four test sessions. Our results indicate that generalization performance in AWS was not inferior to that of fluent controls. In addition, we found, contrary to previous results, that AWS showed a steeper learning progress after practice and consolidation compared with controls. We suggest that with sufficient practice and a 24-h consolidation phase, AWS are able to retain the learned performance of tapping a five-item finger sequence as well as fluent controls in terms of speed and accuracy."],["dc.identifier.doi","10.3389/fpsyg.2020.01543"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17496"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81058"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1664-1078"],["dc.rights","http://creativecommons.org/licenses/by/4.0/"],["dc.title","Finger Sequence Learning in Adults Who Stutter"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4276"],["dc.bibliographiccitation.issue","23"],["dc.bibliographiccitation.journal","Angewandte Chemie International Edition"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Zheng, W. J."],["dc.contributor.author","Mosch-Zanetti, Nadia C."],["dc.contributor.author","Roesky, H. W."],["dc.contributor.author","Noltemeyer, M."],["dc.contributor.author","Hewitt, M."],["dc.contributor.author","Schmidt, H. G."],["dc.contributor.author","Schneider, Thomas R."],["dc.date.accessioned","2018-11-07T10:59:50Z"],["dc.date.available","2018-11-07T10:59:50Z"],["dc.date.issued","2000"],["dc.identifier.doi","10.1002/1521-3773(20001201)39:23<4276::AID-ANIE4276>3.0.CO;2-8"],["dc.identifier.isi","000165747500018"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50791"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","1433-7851"],["dc.title","Alumoxane hydride and aluminum chalcogenide hydride compounds with pyrazolato ligands"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","056028"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Journal of Neural Engineering"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Schmalfuss, Leonie"],["dc.contributor.author","Hahne, Janne"],["dc.contributor.author","Farina, Dario"],["dc.contributor.author","Hewitt, Manuel"],["dc.contributor.author","Kogut, Andreas"],["dc.contributor.author","Doneit, Wolfgang"],["dc.contributor.author","Reischl, Markus"],["dc.contributor.author","Rupp, Rüdiger"],["dc.contributor.author","Liebetanz, David"],["dc.date.accessioned","2020-12-10T18:15:50Z"],["dc.date.available","2020-12-10T18:15:50Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1088/1741-2552/aad727"],["dc.identifier.eissn","1741-2552"],["dc.identifier.issn","1741-2560"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74971"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","A hybrid auricular control system: direct, simultaneous, and proportional myoelectric control of two degrees of freedom in prosthetic hands"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","340"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Neurophysiology"],["dc.bibliographiccitation.lastpage","348"],["dc.bibliographiccitation.volume","126"],["dc.contributor.author","Shorafa, Y."],["dc.contributor.author","Halawa, I."],["dc.contributor.author","Hewitt, M."],["dc.contributor.author","Nitsche, M. A."],["dc.contributor.author","Antal, A."],["dc.contributor.author","Paulus, W."],["dc.date.accessioned","2021-10-01T09:58:12Z"],["dc.date.available","2021-10-01T09:58:12Z"],["dc.date.issued","2021"],["dc.description.abstract","Stimulation intensity and activation of center versus surround muscles affect cortical excitability alterations generated by 140-Hz tACS. At rest, excitatory aftereffects were induced by tACS with 1 mA, but not 2 mA stimulation intensity. With agonistic muscle activation, excitability first decreases, and then increases with 2 mA. For antagonist activation, the MEP amplitude reduction observed in the sham condition is counteracted upon by 1 and 2 mA tACS. This reflects the relation of LTP-like aftereffects to Ca 2+ concentration alterations."],["dc.description.abstract","During transcranial electric stimulation, increasing intracellular Ca 2+ levels beyond those needed for inducing long term potentiation (LTP) may collapse aftereffects. State-dependent plastic aftereffects are reduced when applied during muscle activation as compared with rest. Cortical surround inhibition by antagonistic muscle activation inhibits the center-innervated agonist. The objective of this study is to determine the interaction of state dependency of transcranial alternating current stimulation (tACS) aftereffects at rest and under activation of agonist and antagonist muscles during stimulation with different intensities. In 13 healthy participants, we measured motor-evoked potential (MEP) amplitudes before and after applying tACS at 140 Hz over the motor cortex in nine single-blinded sessions using sham, 1 mA, and 2 mA stimulation intensities during rest and activation of agonist and antagonist muscles. During rest, only 1 mA tACS produced a significant MEP increase, whereas the 2 mA stimulation produced no significant MEP size shift. During agonist activation 1 mA did not induce MEP changes; after 2 mA, first a decrease and later an increase of MEPs were observed. Antagonist activation under sham tACS led to an inhibition, which was restored to baseline by 1 and 2 mA tACS. Increasing stimulation intensity beyond 1 mA does not increase excitability, compatible with too strong intracellular Ca 2+ increase. Antagonist innervation leads to MEP inhibition, supporting the concept of surround inhibition, which can be overcome by tACS at both intensities. During agonist innervation, a tACS dose-dependent relationship exists. Our results integrate concepts of “leaky membranes” under activation, surround inhibition, intracellular Ca 2+ increase, and their role in the aftereffects of tACS. NEW & NOTEWORTHY Stimulation intensity and activation of center versus surround muscles affect cortical excitability alterations generated by 140-Hz tACS. At rest, excitatory aftereffects were induced by tACS with 1 mA, but not 2 mA stimulation intensity. With agonistic muscle activation, excitability first decreases, and then increases with 2 mA. For antagonist activation, the MEP amplitude reduction observed in the sham condition is counteracted upon by 1 and 2 mA tACS. This reflects the relation of LTP-like aftereffects to Ca 2+ concentration alterations."],["dc.description.abstract","Stimulation intensity and activation of center versus surround muscles affect cortical excitability alterations generated by 140-Hz tACS. At rest, excitatory aftereffects were induced by tACS with 1 mA, but not 2 mA stimulation intensity. With agonistic muscle activation, excitability first decreases, and then increases with 2 mA. For antagonist activation, the MEP amplitude reduction observed in the sham condition is counteracted upon by 1 and 2 mA tACS. This reflects the relation of LTP-like aftereffects to Ca 2+ concentration alterations."],["dc.description.abstract","During transcranial electric stimulation, increasing intracellular Ca 2+ levels beyond those needed for inducing long term potentiation (LTP) may collapse aftereffects. State-dependent plastic aftereffects are reduced when applied during muscle activation as compared with rest. Cortical surround inhibition by antagonistic muscle activation inhibits the center-innervated agonist. The objective of this study is to determine the interaction of state dependency of transcranial alternating current stimulation (tACS) aftereffects at rest and under activation of agonist and antagonist muscles during stimulation with different intensities. In 13 healthy participants, we measured motor-evoked potential (MEP) amplitudes before and after applying tACS at 140 Hz over the motor cortex in nine single-blinded sessions using sham, 1 mA, and 2 mA stimulation intensities during rest and activation of agonist and antagonist muscles. During rest, only 1 mA tACS produced a significant MEP increase, whereas the 2 mA stimulation produced no significant MEP size shift. During agonist activation 1 mA did not induce MEP changes; after 2 mA, first a decrease and later an increase of MEPs were observed. Antagonist activation under sham tACS led to an inhibition, which was restored to baseline by 1 and 2 mA tACS. Increasing stimulation intensity beyond 1 mA does not increase excitability, compatible with too strong intracellular Ca 2+ increase. Antagonist innervation leads to MEP inhibition, supporting the concept of surround inhibition, which can be overcome by tACS at both intensities. During agonist innervation, a tACS dose-dependent relationship exists. Our results integrate concepts of “leaky membranes” under activation, surround inhibition, intracellular Ca 2+ increase, and their role in the aftereffects of tACS. NEW & NOTEWORTHY Stimulation intensity and activation of center versus surround muscles affect cortical excitability alterations generated by 140-Hz tACS. At rest, excitatory aftereffects were induced by tACS with 1 mA, but not 2 mA stimulation intensity. With agonistic muscle activation, excitability first decreases, and then increases with 2 mA. For antagonist activation, the MEP amplitude reduction observed in the sham condition is counteracted upon by 1 and 2 mA tACS. This reflects the relation of LTP-like aftereffects to Ca 2+ concentration alterations."],["dc.identifier.doi","10.1152/jn.00065.2021"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/90008"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-469"],["dc.relation.eissn","1522-1598"],["dc.relation.issn","0022-3077"],["dc.title","Isometric agonist and antagonist muscle activation interacts differently with 140-Hz transcranial alternating current stimulation aftereffects at different intensities"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","509"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","517"],["dc.bibliographiccitation.volume","124"],["dc.contributor.author","Meincke, Jonna"],["dc.contributor.author","Hewitt, Manuel"],["dc.contributor.author","Batsikadze, Giorgi"],["dc.contributor.author","Liebetanz, David"],["dc.date.accessioned","2018-11-07T10:21:46Z"],["dc.date.available","2018-11-07T10:21:46Z"],["dc.date.issued","2016"],["dc.description.abstract","Background: Although neuronavigation is increasingly used for optimizing coil positioning, the inter-session reliability of hotspot location remains unsatisfactory, probably due to the variability of motor evoked potentials (MEPs) and residual investigator bias. Purpose: To increase the reliability and accuracy of hotspot location we introduce a novel automated hotspot-hunting procedure (AHH). Methods: AHH is based on resting motor thresholds (RMTs) instead of MEP amplitudes. By combining robotic coil positioning with a closed loop target search algorithm AHH runs independently from the investigator. AHH first identifies all targets with an RMT below a defined intensity of stimulator output (MEP-positive) and then locates the motor hotspot of a target muscle by measuring RMTs at all identified MEP-positive targets. Results were compared to robotic MEP amplitude TMS mapping (MAM) using a 7 x 7 predefined target grid and suprathreshold intensities and manual hotspot search (MHS). Sequence of stimulation was randomized from pulse to pulse in AHH and MAM. Each procedure was tested in 8 subjects. Results: Inter-session CoG shift was significantly reduced with AHH (1.4 mm (SEM: 0.4)) as compared to MAM (7.0 mm (SEM: 1.8)) (p=0.018) and MHS (9.6 mm (SEM: 2.2)) (p=0.007). No statistical difference was observed between MAM and MHS. RMTs were reliable between sessions. Conclusion: Our method represents the first fully automated, i.e. investigator-independent, TMS hotspot-hunting procedure. Measuring RMTs instead of MEP amplitudes leads to significantly increased accuracy and reliability of CoG locations. Moreover, by assessing thresholds AHH is the first procedure to fulfill the original hotspot definition. (C) 2015 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.neuroimage.2015.09.013"],["dc.identifier.isi","000366646700047"],["dc.identifier.pmid","26385012"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42150"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","1095-9572"],["dc.relation.issn","1053-8119"],["dc.title","Automated TMS hotspot-hunting using a closed loop threshold-based algorithm"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1181"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","European Journal of Inorganic Chemistry"],["dc.bibliographiccitation.lastpage","1185"],["dc.contributor.author","Mosch-Zanetti, Nadia C."],["dc.contributor.author","Hewitt, M."],["dc.contributor.author","Schneider, Thomas R."],["dc.contributor.author","Magull, Joerg"],["dc.date.accessioned","2018-11-07T10:30:10Z"],["dc.date.available","2018-11-07T10:30:10Z"],["dc.date.issued","2002"],["dc.description.abstract","The unusual eta(2)-coordination of a 1,2,4-triazolato ligand to a transition metal is described. The synthesized compounds [Ti(eta(2)-tz)(4)] (1), [(C5Me4CH2Ph)Ti(eta(2)-tz)Cl-2] (2), [Cp Ti(eta2-tz)-Cl-2] (3) and [Cp Ti(eta(2)-tz)(3)] (4) (tzH = 3,5-diisopropyl-1,2,4-triazole) were characterized by H-1 and C-13 NMR spectroscopy and, in the case of 1 and 2, by X-ray crystallography. Both structures confirm the eta(2)-coordination of the ligand. In compound 1 all four ligands coordinate in an T, 2 fashion leading to a metal center surrounded by eight nitrogen atoms. The core of the fragment formed by the central atom and the triazolato planes exhibits a distorted D-2d symmetry. A variable temperature NMR spectroscopy experiment performed on 1 confirms the occurrence of two different isopropyl groups at low temperature. The structure of compound 2 shows the geometry of the molecule in a distorted C, symmetry, with the mirror plane perpendicular to the cyclopentadienyl and triazolato rings. The tz ligand is oriented in a transoid position relative to the benzyl substituent of the C5Me4CH2Ph group."],["dc.identifier.isi","000175267800027"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43806"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","1434-1948"],["dc.title","Titanium complexes containing bulky eta(2)-1,2,4-triazolato"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","618"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Brain Stimulation"],["dc.bibliographiccitation.lastpage","619"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Shirota, Yuichiro"],["dc.contributor.author","Hewitt, Manuel"],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T09:38:03Z"],["dc.date.available","2018-11-07T09:38:03Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.1016/j.brs.2014.01.061"],["dc.identifier.isi","000339984300018"],["dc.identifier.pmid","24685516"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32979"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1876-4754"],["dc.relation.issn","1935-861X"],["dc.title","Neuroscientists Do Not Use Non-invasive Brain Stimulation on Themselves for Neural Enhancement"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3513"],["dc.bibliographiccitation.issue","13"],["dc.bibliographiccitation.journal","Inorganic Chemistry"],["dc.bibliographiccitation.lastpage","3520"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Mosch-Zanetti, Nadia C."],["dc.contributor.author","Kopke, S."],["dc.contributor.author","Herbst-Irmer, R."],["dc.contributor.author","Hewitt, M."],["dc.date.accessioned","2018-11-07T10:21:28Z"],["dc.date.available","2018-11-07T10:21:28Z"],["dc.date.issued","2002"],["dc.description.abstract","Reaction of bis(2-aminoethyl)(3-aminopropyl)amine with C6F6 and K2CO3 in DMSO yields unsymmetrical {(C6F5)HNCH2CH2}(2)NCH2CH2CH2NH(C6F5) ([N3N]H-3), The tetraamine acts as a tridentate ligand in complexes of the type H[N3N]Re(O)X (X = Cl 1, Br 2) prepared by reacting Re(O)X-3(PPh3)(2) with [N3N]H-3 and an excess of NEt3 in THF, Addition of 1 equiv of TaCH(CMe2Ph)Br-3(THF)(2) to 1 gives the dimeric compound H[N3N]ClReOReBrCl-N [N3N]H (3) in quantitative yield that contains a Re(V)=O-Re(IV) core with uncoordinated aminopropyl groups in each ligand. Addition of 2 equiv of TaCH(CMe2Ph)Cl-3(THF)(2) to 1 leads to the chloro complex [N3N]ReCl (4) with all three amido groups coordinated to the metal, whereas by addition of 2 equiv of TaCH(CMe2Ph)Br-3(THF)(2) to 2 the dibromo species H[N3N]ReBr2 (5) with one uncoordinated amino group is isolated. Reduction of 4 under an atmosphere of dinitrogen with sodium amalgam gives the dinitrogen complex [N3N]Re(N-2) (6). Single-crystal X-ray structure determinations have been carried out on complexes 1, 3, 5, and 6."],["dc.identifier.doi","10.1021/ic025572u"],["dc.identifier.isi","000176507200027"],["dc.identifier.pmid","12079472"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42099"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Chemical Soc"],["dc.relation.issn","0020-1669"],["dc.title","Unsymmetrical tren-based ligands: Synthesis and reactivity of rhenium complexes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","683"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Frontiers in human neuroscience"],["dc.bibliographiccitation.lastpage","8"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Kunz, Patrik"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Hewitt, Manuel"],["dc.contributor.author","Neef, Andreas"],["dc.contributor.author","Opitz, Alexander"],["dc.contributor.author","Paulus, Walter"],["dc.date.accessioned","2018-10-10T10:33:35Z"],["dc.date.available","2018-10-10T10:33:35Z"],["dc.date.issued","2017-01-10"],["dc.description.abstract","Background: Suprathreshold transcranial single pulse electrical stimulation (tES) is painful and not applicable in a repetitive mode to induce plastic after-effects. Objective: In order to circumvent this pain problem, we applied here a 5 kHz transcranial alternating current stimulation (tACS) theta burst protocol with a field intensity of up to 10 mA to the primary motor cortex (M1). Furthermore, we were interested in finding out whether electrical theta burst stimulation (eTBS) is able to induce lasting after-effects on cortical plasticity. Methods: Three different eTBS protocols were applied at 5 mA in a sham controlled, double blinded cross-over design on the M1 region of seventeen healthy subjects during the first part of the study. The second study part consists of three different eTBS protocols ranging from 5 mA to 10 mA and 1 ms to 5 ms sinusoidal bursts, applied to the M1 region of 14 healthy subjects. Results: We were able to apply all eTBS protocols in a safe manner, with only six subjects reporting mild side effects related to the stimulation. However, no eTBS protocol induced lasting effects on muscle- evoked potential (MEP) amplitudes when compared to sham stimulation. Significant inhibition of MEP amplitude was only seen in the lower intensity protocols as compared to baseline. Conclusion: eTBS is a safe method to apply high frequency tACS with up to 10 mA intensity. Future studies need to explore the parameter space to a larger extent in order to assure efficacy."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2016"],["dc.identifier.doi","10.3389/fnhum.2016.00683"],["dc.identifier.pmid","28119589"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14139"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15942"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1662-5161"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","5 kHz Transcranial Alternating Current Stimulation: Lack of Cortical Excitability Changes When Grouped in a Theta Burst Pattern"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]