Hasenfuß, Gerd P.

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","European Heart Journal - Case Reports"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Schroeter, Marco R"],["dc.contributor.author","Klingel, Karin"],["dc.contributor.author","Korsten, Peter"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.editor","De Potter, Tom"],["dc.contributor.editor","Vidal-Perez, Rafael"],["dc.contributor.editor","Nistor, Dan Octavian"],["dc.contributor.editor","Agarwal, Megha"],["dc.contributor.editor","Sunjaya, Antony Paulo"],["dc.date.accessioned","2022-04-01T10:01:50Z"],["dc.date.available","2022-04-01T10:01:50Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract Background Lyme disease is a tick-borne multisystem infection. The most common cardiac manifestation is an acute presentation of Lyme carditis, which often manifests as conduction disorder and rarely as myocarditis. Case summary We report the case of a 37-year-old male with a history of microscopic polyangiitis receiving immunosuppressive therapy. He was admitted for severe dyspnoea secondary to acute heart failure. Echocardiography and cardiac magnetic resonance imaging indicated a severely reduced left ventricular ejection fraction (LVEF) with global hypokinesia. Coronary heart disease was excluded, and endomyocardial biopsies (EMB) were performed. The left ventricular EMB revealed a rare case of fulminant Lyme carditis with evidence of typical lymphocytic myocarditis. Borrelia afzelii-DNA was detected without any relevant atrioventricular blockage or systemic signs of Lyme disease. The patient had no clinically apparent tick-borne infection or self-reported history of a tick bite. Immunological testing revealed a positive ELISA and Immunoblot for anti-Borrelia immunoglobulin G antibodies. After specific intravenous antibiotic therapy and optimized medical therapy for heart failure, the LVEF recovered, and the patient could be discharged in an improved condition. Repeat EMB a few months later revealed a dramatic regression of the cardiac inflammation and absence of Borrelia DNA in the myocardium. Discussion A severely reduced LVEF can be the primary manifestation of Lyme disease even without typical systemic findings and can have a favourable prognosis with antibiotic treatment. A thorough workup for Lyme carditis is required in patients with unexplained heart failure, particularly with EMB, especially in immunosuppressed patients."],["dc.identifier.doi","10.1093/ehjcr/ytac062"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105759"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","2514-2119"],["dc.title","Fulminant Lyme myocarditis without any other signs of Lyme disease in a 37-year-old male patient with microscopic polyangiitis—a case report"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","816"],["dc.bibliographiccitation.issue","16"],["dc.bibliographiccitation.journal","DMW - Deutsche Medizinische Wochenschrift"],["dc.bibliographiccitation.lastpage","819"],["dc.bibliographiccitation.volume","136"],["dc.contributor.author","Moeller, K."],["dc.contributor.author","Klingel, Karin"],["dc.contributor.author","Kaiser, U."],["dc.contributor.author","Thum, M."],["dc.contributor.author","Boenig, A."],["dc.contributor.author","Kandolf, Reinhard"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Scholz, K. H."],["dc.date.accessioned","2017-09-07T11:44:19Z"],["dc.date.available","2017-09-07T11:44:19Z"],["dc.date.issued","2011"],["dc.description.abstract","History and admission findings: A 52 year-old women presented with long-standing dyspnoea at exercise as a symptom of heart failure. A coronary heart disease had been excluded by coronary angiography a year before. The symptoms had persisted despite application of guideline-based anticongestive medication. Investigations: Electrocardiography showed sinus rhythm with decreased anterior wall amplitudes without acute ischemic signs. The white blood count revealed elevated leucocytes with high numbers of eosinophilic granulocytes. Echocardiography demonstrated severe left ventricular dysfunction with an ejection fraction of 30% and a left ventricular end-diastolic diameter of 75 mm. Magnetic resonance imaging showed a pathologic late enhancement in the left ventricular wall. Six myocardial biopsies were obtained and revealed virus-negative eosinophilic inflammatory cardiomyopathy with focal fibrotic scarring. Diagnosis, treatment and course: The patient was treated according to a previously published study on virus-negative inflammatory heart disease with prednisone 1 mg/kg daily for 4 weeks followed by 0.33 mg/kg daily for 5 month and azathioprine 2 mg/kg daily for 6 month. The echocardiography of the left ventricular function showed an increase from 30 to 45% and the clinical symptoms of the heart failure resolved to NYHA II. Conclusion: In patients with virus-negative eosinophilic inflammatory cardiomyopathy standardized therapy with prednisone and azathioprine can improve LV function and clinical symptoms."],["dc.identifier.doi","10.1055/s-0031-1275810"],["dc.identifier.gro","3142752"],["dc.identifier.isi","000289460900003"],["dc.identifier.pmid","21487971"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/190"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0012-0472"],["dc.title","Immunsuppressive therapy in virus-negative eosinophilic inflammatory cardiomyopathy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]