Zeeck, Axel

[["dc.bibliographiccitation.firstpage","7197"],["dc.bibliographiccitation.issue","42"],["dc.bibliographiccitation.journal","AFRICAN JOURNAL OF BIOTECHNOLOGY"],["dc.bibliographiccitation.lastpage","7202"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Gorajana, Adinarayana"],["dc.contributor.author","Poluri, Ellaiah"],["dc.contributor.author","Zeeck, Axel"],["dc.date.accessioned","2018-11-07T08:37:56Z"],["dc.date.available","2018-11-07T08:37:56Z"],["dc.date.issued","2010"],["dc.description.abstract","Marine sediment samples from Machilipatnam (Krishna District, A. P) coast off Bay of Bengal, India were investigated as a source of actinomycetes to screen for the production of novel bioactive compounds. More than 10,000 bioactive compounds have been described from marine actinomycetes, with many different properties, ranging from colour pigments to cytotoxic compounds. The search for cytotoxic compounds is continuing due to the demand for new anticancer drugs. In this work, compound I was isolated from the marine derived actinomycete strain AUBN(10)/2, obtained from marine sediment samples of Bay of Bengal, India. This was obtained by solvent extraction followed by chromatographic purification. The pure compound I was identified from spectroscopic data which was related to the actinomycin D, it showed a potent cytotoxic activity against cell lines HMO2 (gastric adenocarcinoma) and HePG2 (hepatic carcinoma) in vitro. It also exhibited antimicrobial activities against gram positive and negative bacteria."],["dc.identifier.isi","000283197400027"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18661"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Journals"],["dc.relation.issn","1684-5315"],["dc.title","Cytotoxic compounds from a marine actinomycete, Streptomyces albovinaceus var. baredar AUBN(10)/2"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","no"],["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","ChemInform"],["dc.bibliographiccitation.lastpage","no"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Puder, Carsten"],["dc.contributor.author","Loya, Shoshana"],["dc.contributor.author","Hizi, Ammon"],["dc.contributor.author","Zeeck, Axel"],["dc.date.accessioned","2021-12-08T12:28:38Z"],["dc.date.available","2021-12-08T12:28:38Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1002/chin.200021232"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95771"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.eissn","1522-2667"],["dc.relation.issn","0931-7597"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","ChemInform Abstract: Structural and Biosynthetic Investigations of the Rubromycins."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","no"],["dc.bibliographiccitation.issue","48"],["dc.bibliographiccitation.journal","ChemInform"],["dc.bibliographiccitation.lastpage","no"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Schiewe, Hans-Joerg"],["dc.contributor.author","Zeeck, Axel"],["dc.date.accessioned","2021-12-08T12:28:34Z"],["dc.date.available","2021-12-08T12:28:34Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1002/chin.199948240"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95742"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.eissn","1522-2667"],["dc.relation.issn","0931-7597"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","ChemInform Abstract: Secondary Metabolites by Chemical Screening. Part 38. Cineromycins, γ-Butyrolactones, and Ansamycins by Analysis of the Secondary Metabolite Pattern Created by a Single Strain of Streptomyces."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","no"],["dc.bibliographiccitation.issue","22"],["dc.bibliographiccitation.journal","ChemInform"],["dc.bibliographiccitation.lastpage","no"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Grond, Stephanie"],["dc.contributor.author","Langer, Hans-Joerg"],["dc.contributor.author","Henne, Petra"],["dc.contributor.author","Sattler, Isabel"],["dc.contributor.author","Thiericke, Ralf"],["dc.contributor.author","Grabley, Susanne"],["dc.contributor.author","Zaehner, Hans"],["dc.contributor.author","Zeeck, Axel"],["dc.date.accessioned","2021-12-08T12:28:38Z"],["dc.date.available","2021-12-08T12:28:38Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1002/chin.200022185"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95772"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.eissn","1522-2667"],["dc.relation.issn","0931-7597"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","ChemInform Abstract: Secondary Metabolites by Chemical Screening. Part 39. Acyl α-L-Rhamnopyranosides, a Novel Family of Secondary Metabolites from Streptomyces sp.: Isolation and Biosynthesis."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1525"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","European Journal of Organic Chemistry"],["dc.bibliographiccitation.lastpage","1534"],["dc.contributor.author","Zlatopolskiy, Boris D."],["dc.contributor.author","Radzom, Markus"],["dc.contributor.author","Zeeck, Axel"],["dc.contributor.author","de Meijere, Armin"],["dc.date.accessioned","2018-11-07T10:06:19Z"],["dc.date.available","2018-11-07T10:06:19Z"],["dc.date.issued","2006"],["dc.description.abstract","Several new analogues of hormaomycin (1), a peptide lactone with interesting biological activities, were prepared by total synthesis or by precursor-directed biosynthesis. The new analogues 2a-c, 3a-c, O-MOM-1 and epi-O-MOM-1 as well as the model acyl tripeptides 20a-c and 21a-e were tested for their antibiotic activities to give new insights into structure-activity relationships of this class of compounds. In this context, an unexpected activity of 2c against C. albicans was discovered. The precursors necessary for feeding experiments, the amino acids 14a, 14b and 17, were prepared in 31, 48 and 55% yield over 4 and 3 steps, respectively. In addition, these studies provided some new information about the biosynthetic route to furnish compound 1. They also support the notion that the combination of chemical and biological methods may provide a broad range of analogues of an interesting biologically active natural product, (c) Wiley-VCH Verlag GmbH & Co."],["dc.identifier.doi","10.1002/ejoc.200500856"],["dc.identifier.isi","000236262200021"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39069"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","1434-193X"],["dc.title","Synthesis and precursor-directed biosynthesis of new hormaomycin analogues"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","323"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1"],["dc.bibliographiccitation.lastpage","328"],["dc.contributor.author","Bode, H. B."],["dc.contributor.author","Zeeck, Axel"],["dc.date.accessioned","2018-11-07T11:10:34Z"],["dc.date.available","2018-11-07T11:10:34Z"],["dc.date.issued","2000"],["dc.description.abstract","Kendomycin [(-)-TAN 2162] 1 was re-isolated from Streptomyces violaceoruber (strain 3844-33C) in the course of our chemical screening programme. The structure with the relative configuration only was confirmed by the X-ray analysis of 1. The absolute configuration of 1 was determined by using the advanced Mosher's ester method applied to kendomycin acetonide 2. The biosynthesis of 1 was performed using stable isotope labelling experiments. From the results it is assumed that a highly oxygenated benzoic acid, derived from (3,5-dihydroxyphenyl)acetic acid, serves as the starter unit of the aliphatic polyketide chain. The cyclisation generating the 18-membered ansa-bridge by the formation of a C-C bond might follow a new type of aldol condensation. 1 and 2 exhibit antibacterial activity and strong cytotoxicity against different tumor cell lines."],["dc.identifier.doi","10.1039/a908387a"],["dc.identifier.isi","000085054900008"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53234"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Royal Soc Chemistry"],["dc.relation.issn","0300-922X"],["dc.title","Structure and biosynthesis of kendomycin, a carbocyclic ansa-compound from Streptomyces"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","985"],["dc.bibliographiccitation.journal","ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY"],["dc.bibliographiccitation.lastpage","992"],["dc.bibliographiccitation.volume","64"],["dc.contributor.author","Pal, Aritra"],["dc.contributor.author","Debreczeni, Judit E."],["dc.contributor.author","Sevvana, Madhumati"],["dc.contributor.author","Gruene, Tim"],["dc.contributor.author","Kahle, Beatrix"],["dc.contributor.author","Zeeck, Axel"],["dc.contributor.author","Sheldrick, George M."],["dc.date.accessioned","2018-11-07T11:11:00Z"],["dc.date.available","2018-11-07T11:11:00Z"],["dc.date.issued","2008"],["dc.description.abstract","Crystals of the cytotoxic thionin proteins viscotoxins A1 and B2 extracted from mistletoe diffracted to high resolution (1.25 and 1.05 angstrom, respectively) and are excellent candidates for testing crystallographic methods. Ab initio direct methods were only successful in solving the viscotoxin B2 structure, which with 861 unique non-H atoms is one of the largest unknown structures without an atom heavier than sulfur to be solved in this way, but sulfur-SAD phasing provided a convincing solution for viscotoxin A1. Both proteins form dimers in the crystal and viscotoxin B2 (net charge +4 per monomer), but not viscotoxin A1 (net charge +6), is coordinated by sulfate or phosphate anions. The viscotoxin A1 crystal has a higher solvent content than the viscotoxin B2 crystal (49% as opposed to 28%) with solvent channels along the crystallographic 43 axes."],["dc.identifier.doi","10.1107/S0907444908022646"],["dc.identifier.isi","000258411800011"],["dc.identifier.pmid","18703848"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53331"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0907-4449"],["dc.title","Structures of viscotoxins A1 and B2 from European mistletoe solved using native data alone"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","773"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Experimental Lung Research"],["dc.bibliographiccitation.lastpage","790"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Lantry, L. E."],["dc.contributor.author","Zhang, Z."],["dc.contributor.author","Crist, K. A."],["dc.contributor.author","Wang, Y."],["dc.contributor.author","Hara, M."],["dc.contributor.author","Zeeck, Axel"],["dc.contributor.author","Lubet, R. A."],["dc.contributor.author","You, M."],["dc.date.accessioned","2018-11-07T10:36:54Z"],["dc.date.available","2018-11-07T10:36:54Z"],["dc.date.issued","2000"],["dc.description.abstract","The studies presented were designed to test the efficacy of farnesyltransferase inhibitors (FTIs) as potential chemopreventive compounds in the mouse lung tumor model, and in tumor cell lines. The compounds included manumycin, gliotoxin, dihydroepiandrosterone (DHEA) perillyl alcohol (POH), and FTI-276. Each of these compounds had the potential, based on in vitro and limited in vivo evidence, to inhibit mouse lung tumorigenesis. In vitro studies were conducted with both K-ras-transformed NIH-3T3 cells and mouse lung tumor epithelial cell lines. We utilized 2 primary mouse lung tumor models that reliably produce lung tumors with an oncogenic K-ras mutation when induced by 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone (NNK). Manumycin, gliotoxin, DHEA, and POH were administered 3 times per week peritoneally (IP), starting 1 week prior to carcinogen treatment, and throughout the test period (4.5 months). FTI-276 was delivered daily for 4 months by a time-release pellet method. Both the manumycin and gliotoxin treatment groups demonstrated 100% incidence and an increase in tumor multiplicity over control, of 66% and 58% increase respectively (P < .05). Although DHEA showed no significant chemopreventive effect, POH treatment demonstrated a 22% reduction in tumor incidence (P < .05) and a 58% reduction in tumor multiplicity (P < .05). Finally, FTI-276 reduced both the tumor multiplicity by 41.7% (P < .005), and the total tumor volume/burden per mouse by 79.4% (P < .0001). The apoptotic index in FTI-276-treated tumors showed an increase of 77% over control tumors (P < .05). In vitro, all compounds demonstrated growth inhibition at a dose-response manner; however, manumycin, gliotoxin, and DHEA demonstrated an initial increase in growth rate at lower doses. In summary, we have shown that POH and FTI-276 are chemopreventive in a primary mouse lung tumor model. In contrast, DHEA was not significantly chemopreventive at the dosage utilized and treatment of an immunocompetent host with manumycin or gliotoxin demonstrated a significant increase in tumorigenicity over carcinogen control."],["dc.description.sponsorship","NCI NIH HHS [CA58554, CN55184]"],["dc.identifier.isi","000166205700016"],["dc.identifier.pmid","11195470"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45437"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Hemisphere Publ Corp"],["dc.publisher.place","Bristol"],["dc.relation.conference","3rd International Mouse Lung Tumorigenesis Symposium"],["dc.relation.eventlocation","MED COLL OHIO, TOLEDO, OHIO"],["dc.relation.issn","0190-2148"],["dc.title","Chemopreventive efficacy of promising farnesyltransferase inhibitors"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","212"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","INDIAN JOURNAL OF BIOTECHNOLOGY"],["dc.bibliographiccitation.lastpage","218"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Krishnaveni, J."],["dc.contributor.author","Radzom, Markus"],["dc.contributor.author","Zeeck, Axel"],["dc.contributor.author","Kishan, V."],["dc.date.accessioned","2018-11-07T08:57:11Z"],["dc.date.available","2018-11-07T08:57:11Z"],["dc.date.issued","2011"],["dc.description.abstract","An isolate, KC46 active against clinical resistant strains was isolated from Indian soil. Based on morphological features and biochemical characteristics it was identified as Streptomyces noursei. The active compounds isolated from KC46 using various fermentation methods (fermentation in shake flasks, in P-flasks, and also in a fermenter, using starch casein nitrate medium containing zinc sulphate) were characterized based on spectral data. The sulfur rich peptide, nosiheptide and related antibiotics were identified. Nosiheptide has been reported for the first time from a strain of S. noursei."],["dc.description.sponsorship","Goettingen University, Germany"],["dc.identifier.isi","000290549100008"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23333"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Natl Inst Science Communication-niscair"],["dc.relation.issn","0972-5849"],["dc.title","Taxonomy, fermentation, biological activities, isolation and characterization of metabolites obtained from a new strain of Streptomyces noursei (KC46)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3258"],["dc.bibliographiccitation.issue","18"],["dc.bibliographiccitation.journal","Angewandte Chemie International Edition"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Hofs, R."],["dc.contributor.author","Walker, M."],["dc.contributor.author","Zeeck, Axel"],["dc.date.accessioned","2018-11-07T10:59:40Z"],["dc.date.available","2018-11-07T10:59:40Z"],["dc.date.issued","2000"],["dc.identifier.doi","10.1002/1521-3773(20000915)39:18<3258::AID-ANIE3258>3.0.CO;2-Q"],["dc.identifier.isi","000089433600009"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50757"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","1433-7851"],["dc.title","Hexacyclinic acid, a polyketide from Streptomyces with a novel carbon skeleton"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]