Hahn, Günter

[["dc.bibliographiccitation.artnumber","japplphysiol.00426.2022"],["dc.bibliographiccitation.journal","Journal of Applied Physiology"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Zinnato, Carmelo"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Palumbo, Michela"],["dc.contributor.author","Gattarello, Simone"],["dc.contributor.author","Sonzogni, Aurelio"],["dc.contributor.author","Gersmann, Ann-Kathrin"],["dc.contributor.author","Richter, Annika"],["dc.contributor.author","Herrmann, Peter"],["dc.contributor.author","Hahn, Günter"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2022-10-04T10:21:51Z"],["dc.date.available","2022-10-04T10:21:51Z"],["dc.date.issued","2022"],["dc.description.abstract","The amount of energy delivered to the respiratory system is recognized as a cause of Ventilator Induced Lung Injury (VILI). How energy dissipation within the lung causes damage is still a matter of debate. Expiratory flow control has been proposed as a strategy to reduce the energy dissipated into the respiratory system during expiration and, possibly, VILI. We studied 22 healthy pigs (29±2 kg), which were randomized into a control (n=11) and a valve group (n=11), where the expiratory flow was controlled through a variable resistor. Both groups were ventilated with the same tidal volume, PEEP and inspiratory flow. Electric impedance tomography was continuously acquired. At completion, lung weight, wet to dry ratios and histology were evaluated. The total mechanical power was similar in the control and valve groups (8.54±0.83 J min\n -1\n and 8.42±0.54 J min\n -\n 1\n respectively, p=0.552). The total energy dissipated within the whole system (circuit + respiratory system) was remarkably different (4.34±0.66 vs 2.62±0.31 J/min, p<0.001). However, most of this energy was dissipated across the endotracheal tube (2.87±0.3 vs 1.88±0.2 J/min, p<0.001). The amount dissipated into the respiratory system averaged 1.45±0.5 in controls vs 0.73±0.16 J min\n -1\n in the valve group, p<0.001. Although respiratory mechanics, gas exchange, hemodynamics, wet to dry ratios and histology were similar in the two groups, the decrease of end-expiratory lung impedance was significantly greater in the control group (p=0.02). We conclude that with our experimental conditions, the reduction of energy dissipated in the respiratory system did not lead to appreciable differences in VILI."],["dc.identifier.doi","10.1152/japplphysiol.00426.2022"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114520"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-600"],["dc.relation.eissn","1522-1601"],["dc.relation.issn","8750-7587"],["dc.title","Energy dissipation during expiration and Ventilator Induced Lung Injury: an experimental animal study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","46"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Intensive Care Medicine Experimental"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Cambiaghi, Barbara"],["dc.contributor.author","Vasques, Francesco"],["dc.contributor.author","Mörer, Onnen"],["dc.contributor.author","Ritter, Christian"],["dc.contributor.author","Mauri, Tommaso"],["dc.contributor.author","Kunze-Szikszay, Nils"],["dc.contributor.author","Holke, Karin"],["dc.contributor.author","Collino, Francesca"],["dc.contributor.author","Maiolo, Giorgia"],["dc.contributor.author","Rapetti, Francesca"],["dc.contributor.author","Schulze-Kalthoff, Elias"],["dc.contributor.author","Tonetti, Tommaso"],["dc.contributor.author","Hahn, Günter"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2020-12-10T18:41:24Z"],["dc.date.available","2020-12-10T18:41:24Z"],["dc.date.issued","2017"],["dc.description.abstract","Abstract Background Severe hypoperfusion can cause lung damage. We studied the effects of regional perfusion block in normal lungs and in the lungs that had been conditioned by lavage with 500 ml saline and high V T (20 ml kg−1) ventilation. Methods Nineteen pigs (61.2 ± 2.5 kg) were randomized to five groups: controls (n = 3), the right lower lobe block alone (n = 3), lavage and high V T (n = 4), lung lavage, and high V T plus perfusion block of the right (n = 5) or left (n = 4) lower lobe. Gas exchange, respiratory mechanics, and hemodynamics were measured hourly. After an 8-h observation period, CT scans were obtained at 0 and 15 cmH2O airway pressure. Results Perfusion block did not damage healthy lungs. In conditioned lungs, the left perfusion block caused more edema in the contralateral lung (777 ± 62 g right lung vs 484 ± 204 g left; p < 0.05) than the right perfusion block did (581 ± 103 g right lung vs 484 ± 204 g left; p n.s.). The gas/tissue ratio, however, was similar (0.5 ± 0.3 and 0.8 ± 0.5; p n.s.). The lobes with perfusion block were not affected (gas/tissue ratio right 1.6 ± 0.9; left 1.7 ± 0.5, respectively). Pulmonary artery pressure, PaO2/FiO2, dead space, and lung mechanics were more markedly affected in animals with left perfusion block, while the gas/tissue ratios were similar in the non-occluded lobes. Conclusions The right and left perfusion blocks caused the same “intensity” of edema in conditioned lungs. The total amount of edema in the two lungs differed because of differences in lung size. If capillary permeability is altered, increased blood flow may induce or increase edema."],["dc.identifier.doi","10.1186/s40635-017-0161-2"],["dc.identifier.eissn","2197-425X"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15183"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77572"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","Springer"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Effects of regional perfusion block in healthy and injured lungs"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Critical Care Medicine"],["dc.contributor.author","Steinberg, Irene"],["dc.contributor.author","Pasticci, Iacopo"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Costamagna, Andrea"],["dc.contributor.author","Hahn, Günter"],["dc.contributor.author","Gattarello, Simone"],["dc.contributor.author","Palermo, Paola"],["dc.contributor.author","Lazzari, Stefano"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Herrmann, Peter"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2022-04-01T10:02:54Z"],["dc.date.available","2022-04-01T10:02:54Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1097/CCM.0000000000005479"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/106031"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.issn","0090-3493"],["dc.title","Lung Ultrasound and Electrical Impedance Tomography During Ventilator-Induced Lung Injury"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1126"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Anesthesiology"],["dc.bibliographiccitation.lastpage","1137"],["dc.bibliographiccitation.volume","132"],["dc.contributor.author","Vassalli, Francesco"],["dc.contributor.author","Pasticci, Iacopo"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Duscio, Eleonora"],["dc.contributor.author","Aßmann, David Jerome"],["dc.contributor.author","Grünhagen, Hannah"],["dc.contributor.author","Vasques, Francesco"],["dc.contributor.author","Bonifazi, Matteo"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Macrì, Matteo Maria"],["dc.contributor.author","Giosa, Lorenzo"],["dc.contributor.author","Reupke, Verena"],["dc.contributor.author","Herrmann, Peter"],["dc.contributor.author","Hahn, Günter"],["dc.contributor.author","Leopardi, Orazio"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Marini, John J."],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2020-12-10T18:19:48Z"],["dc.date.available","2020-12-10T18:19:48Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1097/ALN.0000000000003189"],["dc.identifier.issn","0003-3022"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75386"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Does Iso-mechanical Power Lead to Iso-lung Damage?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","119"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Anesthesiology"],["dc.bibliographiccitation.lastpage","130"],["dc.bibliographiccitation.volume","130"],["dc.contributor.author","Collino, Francesca"],["dc.contributor.author","Rapetti, Francesca"],["dc.contributor.author","Vasques, Francesco"],["dc.contributor.author","Maiolo, Giorgia"],["dc.contributor.author","Tonetti, Tommaso"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Niewenhuys, Julia"],["dc.contributor.author","Behnemann, Tim"],["dc.contributor.author","Camporota, Luigi"],["dc.contributor.author","Hahn, Günter"],["dc.contributor.author","Reupke, Verena"],["dc.contributor.author","Holke, Karin"],["dc.contributor.author","Herrmann, Peter"],["dc.contributor.author","Duscio, Eleonora"],["dc.contributor.author","Cipulli, Francesco"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Marini, John J."],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2020-12-10T18:19:47Z"],["dc.date.available","2020-12-10T18:19:47Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1097/ALN.0000000000002458"],["dc.identifier.issn","0003-3022"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75382"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Positive End-expiratory Pressure and Mechanical Power"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]