Hahn, Günter

[["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Journal of Applied Physiology"],["dc.bibliographiccitation.volume","112"],["dc.contributor.author","Hellige, Niels Christian"],["dc.contributor.author","Hahn, Guenter"],["dc.contributor.author","Hellige, Gerhard"],["dc.date.accessioned","2018-11-07T09:09:37Z"],["dc.date.available","2018-11-07T09:09:37Z"],["dc.date.issued","2012"],["dc.format.extent","2127"],["dc.identifier.doi","10.1152/japplphysiol.00286.2012"],["dc.identifier.isi","000305422100026"],["dc.identifier.pmid","22707673"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26300"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Physiological Soc"],["dc.relation.issn","8750-7587"],["dc.title","Comment on Borges et al. \"Regional lung perfusion estimated by electrical impedance tomography in a piglet model of lung collapse\""],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","680"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Respirology"],["dc.bibliographiccitation.lastpage","688"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Herber-Jonat, Susanne"],["dc.contributor.author","Hajek, Kerstin"],["dc.contributor.author","Mittal, Rashmi"],["dc.contributor.author","Just, Anita"],["dc.contributor.author","Hahn, Guenter"],["dc.contributor.author","Schulze, Andreas"],["dc.contributor.author","Flemmer, Andreas W."],["dc.date.accessioned","2018-11-07T08:28:35Z"],["dc.date.available","2018-11-07T08:28:35Z"],["dc.date.issued","2009"],["dc.description.abstract","Background and objective: In order to assess and optimize the effect of new therapies for acute lung injury (ALI) in rodent models, a monitoring technique that continuously assesses the functional state of the lung is mandatory. Electrical impedance tomography (EIT) has been suggested as a technique for quantifying lung inflammation in ALI. However, EIT has not been evaluated in a rodent model of ALI. Methods: EIT measurements were compared in ventilated Sprague-Dawley rats (n = 14), randomly subjected to intratracheal administration of endotoxin (LPS) or saline (control). Lung mechanics, lung weight wet/dry ratio and inflammatory markers in bronchoalveolar lavage fluid were also evaluated. Results: LPS caused a significant decrease in lung compliance and TLC as compared with control (-42.0%, P = 0.04, and -27.9%, P = 0.02, respectively). These changes were paralleled by differences in mean impedance changes as detected by EIT (Spearman's rank correlation coefficient: rho = 0.66 and 0.73, respectively, P < 0.01). LPS increased the lung weight wet/dry ratio (6.35 +/- 0.42 vs 5.15 +/- 0.07, P = 0.003), and the bronchoalveolar lavage total WCC (8.96 +/- 1.87 vs 1.16 +/- 0.10 x 10(9)/L, P = 0.002) as compared with control. The lung weight wet/dry ratio was inversely related to the mean impedance change (rho = -0.76, P < 0.01). Conclusions: This study has demonstrated for the first time that eight-electrode EIT readily tracks the inflammatory response of lung tissue in a rodent model of ALI. EIT may thus provide a promising, non-invasive technique for monitoring the time-course of ALI in rodent models, and for testing novel pharmacological strategies to counter it."],["dc.identifier.doi","10.1111/j.1440-1843.2009.01537.x"],["dc.identifier.isi","000268061300009"],["dc.identifier.pmid","19476603"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16455"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.relation.issn","1323-7799"],["dc.title","Electrical impedance tomography is able to track changes in respiratory function in endotoxin-challenged rodents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","260"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Current Opinion in Critical Care"],["dc.bibliographiccitation.lastpage","267"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Hahn, Guenter"],["dc.contributor.author","Quintel, Michael"],["dc.date.accessioned","2018-11-07T08:55:54Z"],["dc.date.available","2018-11-07T08:55:54Z"],["dc.date.issued","2011"],["dc.description.abstract","Purpose of review Electrical impedance tomography (EIT) is an attractive method of monitoring patients during mechanical ventilation because it can provide a noninvasive continuous image of pulmonary impedance, which indicates the distribution of ventilation. This article will discuss ongoing research on EIT, with a focus on methodological aspects and limitations and novel approaches in terms of pathophysiology, diagnosis and therapeutic advancements. Recent findings EIT enables the detection of regional distribution of alveolar ventilation and, thus, the quantification of local inhomogeneities in lung mechanics. By detecting recruitment and derecruitment, a positive end-expiratory pressure level at which tidal ventilation is relatively homogeneous in all lung regions can be defined. Additionally, different approaches to characterize the temporal local behaviour of lung tissue during ventilation have been proposed, which adds important information. Summary There is growing evidence that supports EIT usage as a bedside measure to individually optimize ventilator settings in critically ill patients in order to prevent ventilator-induced lung injury. A standardization of current approaches to analyse and interpret EIT data is required in order to facilitate the clinical implementation."],["dc.identifier.doi","10.1097/MCC.0b013e3283463c9c"],["dc.identifier.isi","000290040400010"],["dc.identifier.pmid","21478747"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23016"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1531-7072"],["dc.relation.issn","1070-5295"],["dc.title","Lung impedance measurements to monitor alveolar ventilation"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","japplphysiol.00426.2022"],["dc.bibliographiccitation.journal","Journal of Applied Physiology"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Zinnato, Carmelo"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Palumbo, Michela"],["dc.contributor.author","Gattarello, Simone"],["dc.contributor.author","Sonzogni, Aurelio"],["dc.contributor.author","Gersmann, Ann-Kathrin"],["dc.contributor.author","Richter, Annika"],["dc.contributor.author","Herrmann, Peter"],["dc.contributor.author","Hahn, Günter"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2022-10-04T10:21:51Z"],["dc.date.available","2022-10-04T10:21:51Z"],["dc.date.issued","2022"],["dc.description.abstract","The amount of energy delivered to the respiratory system is recognized as a cause of Ventilator Induced Lung Injury (VILI). How energy dissipation within the lung causes damage is still a matter of debate. Expiratory flow control has been proposed as a strategy to reduce the energy dissipated into the respiratory system during expiration and, possibly, VILI. We studied 22 healthy pigs (29±2 kg), which were randomized into a control (n=11) and a valve group (n=11), where the expiratory flow was controlled through a variable resistor. Both groups were ventilated with the same tidal volume, PEEP and inspiratory flow. Electric impedance tomography was continuously acquired. At completion, lung weight, wet to dry ratios and histology were evaluated. The total mechanical power was similar in the control and valve groups (8.54±0.83 J min\n -1\n and 8.42±0.54 J min\n -\n 1\n respectively, p=0.552). The total energy dissipated within the whole system (circuit + respiratory system) was remarkably different (4.34±0.66 vs 2.62±0.31 J/min, p<0.001). However, most of this energy was dissipated across the endotracheal tube (2.87±0.3 vs 1.88±0.2 J/min, p<0.001). The amount dissipated into the respiratory system averaged 1.45±0.5 in controls vs 0.73±0.16 J min\n -1\n in the valve group, p<0.001. Although respiratory mechanics, gas exchange, hemodynamics, wet to dry ratios and histology were similar in the two groups, the decrease of end-expiratory lung impedance was significantly greater in the control group (p=0.02). We conclude that with our experimental conditions, the reduction of energy dissipated in the respiratory system did not lead to appreciable differences in VILI."],["dc.identifier.doi","10.1152/japplphysiol.00426.2022"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114520"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-600"],["dc.relation.eissn","1522-1601"],["dc.relation.issn","8750-7587"],["dc.title","Energy dissipation during expiration and Ventilator Induced Lung Injury: an experimental animal study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","158"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Clinical Physiology and Functional Imaging"],["dc.bibliographiccitation.lastpage","162"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Cambiaghi, B."],["dc.contributor.author","Moerer, O."],["dc.contributor.author","Kunze-Szikszay, N."],["dc.contributor.author","Mauri, T."],["dc.contributor.author","Just, A."],["dc.contributor.author","Dittmar, J."],["dc.contributor.author","Hahn, G."],["dc.date.accessioned","2020-12-10T18:27:14Z"],["dc.date.available","2020-12-10T18:27:14Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1111/cpf.12385"],["dc.identifier.issn","1475-0961"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76282"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","A spiky pattern in the course of electrical thoracic impedance as a very early sign of a developing pneumothorax"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Critical Care Medicine"],["dc.contributor.author","Steinberg, Irene"],["dc.contributor.author","Pasticci, Iacopo"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Costamagna, Andrea"],["dc.contributor.author","Hahn, Günter"],["dc.contributor.author","Gattarello, Simone"],["dc.contributor.author","Palermo, Paola"],["dc.contributor.author","Lazzari, Stefano"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Herrmann, Peter"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2022-04-01T10:02:54Z"],["dc.date.available","2022-04-01T10:02:54Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1097/CCM.0000000000005479"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/106031"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.issn","0090-3493"],["dc.title","Lung Ultrasound and Electrical Impedance Tomography During Ventilator-Induced Lung Injury"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1126"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Anesthesiology"],["dc.bibliographiccitation.lastpage","1137"],["dc.bibliographiccitation.volume","132"],["dc.contributor.author","Vassalli, Francesco"],["dc.contributor.author","Pasticci, Iacopo"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Duscio, Eleonora"],["dc.contributor.author","Aßmann, David Jerome"],["dc.contributor.author","Grünhagen, Hannah"],["dc.contributor.author","Vasques, Francesco"],["dc.contributor.author","Bonifazi, Matteo"],["dc.contributor.author","Busana, Mattia"],["dc.contributor.author","Macrì, Matteo Maria"],["dc.contributor.author","Giosa, Lorenzo"],["dc.contributor.author","Reupke, Verena"],["dc.contributor.author","Herrmann, Peter"],["dc.contributor.author","Hahn, Günter"],["dc.contributor.author","Leopardi, Orazio"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Marini, John J."],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2020-12-10T18:19:48Z"],["dc.date.available","2020-12-10T18:19:48Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1097/ALN.0000000000003189"],["dc.identifier.issn","0003-3022"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75386"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Does Iso-mechanical Power Lead to Iso-lung Damage?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S35"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Physiological Measurement"],["dc.bibliographiccitation.lastpage","S55"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Adler, Andy"],["dc.contributor.author","Arnold, John H."],["dc.contributor.author","Bayford, Richard"],["dc.contributor.author","Borsic, Andrea"],["dc.contributor.author","Brown, Brian"],["dc.contributor.author","Dixon, Paul"],["dc.contributor.author","Faes, Theo J. C."],["dc.contributor.author","Frerichs, Inez"],["dc.contributor.author","Gagnon, Herve"],["dc.contributor.author","Gaerber, Yvo"],["dc.contributor.author","Grychtol, Bartlomiej"],["dc.contributor.author","Hahn, Guenter"],["dc.contributor.author","Lionheart, William R. B."],["dc.contributor.author","Malik, Anjum"],["dc.contributor.author","Patterson, Robert P."],["dc.contributor.author","Stocks, Janet"],["dc.contributor.author","Tizzard, Andrew"],["dc.contributor.author","Weiler, Norbert"],["dc.contributor.author","Wolf, Gerhard K."],["dc.date.accessioned","2018-11-07T08:29:34Z"],["dc.date.available","2018-11-07T08:29:34Z"],["dc.date.issued","2009"],["dc.description.abstract","Electrical impedance tomography (EIT) is an attractive method for clinically monitoring patients during mechanical ventilation, because it can provide a non-invasive continuous image of pulmonary impedance which indicates the distribution of ventilation. However, most clinical and physiological research in lung EIT is done using older and proprietary algorithms; this is an obstacle to interpretation of EIT images because the reconstructed images are not well characterized. To address this issue, we develop a consensus linear reconstruction algorithm for lung EIT, called GREIT (Graz consensus Reconstruction algorithm for EIT). This paper describes the unified approach to linear image reconstruction developed for GREIT. The framework for the linear reconstruction algorithm consists of (1) detailed finite element models of a representative adult and neonatal thorax, (2) consensus on the performance figures of merit for EIT image reconstruction and (3) a systematic approach to optimize a linear reconstruction matrix to desired performance measures. Consensus figures of merit, in order of importance, are (a) uniform amplitude response, (b) small and uniform position error, (c) small ringing artefacts, (d) uniform resolution, (e) limited shape deformation and (f) high resolution. Such figures of merit must be attained while maintaining small noise amplification and small sensitivity to electrode and boundary movement. This approach represents the consensus of a large and representative group of experts in EIT algorithm design and clinical applications for pulmonary monitoring. All software and data to implement and test the algorithm have been made available under an open source license which allows free research and commercial use."],["dc.identifier.doi","10.1088/0967-3334/30/6/S03"],["dc.identifier.isi","000266577800004"],["dc.identifier.pmid","19491438"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16684"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Iop Publishing Ltd"],["dc.publisher.place","Bristol"],["dc.relation.conference","9th International Conference on Electrical Impedance Tomography"],["dc.relation.eventlocation","Dartmouth Coll, Dartmouth, NH"],["dc.relation.issn","1361-6579"],["dc.relation.issn","0967-3334"],["dc.title","GREIT: a unified approach to 2D linear EIT reconstruction of lung images"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","119"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Anesthesiology"],["dc.bibliographiccitation.lastpage","130"],["dc.bibliographiccitation.volume","130"],["dc.contributor.author","Collino, Francesca"],["dc.contributor.author","Rapetti, Francesca"],["dc.contributor.author","Vasques, Francesco"],["dc.contributor.author","Maiolo, Giorgia"],["dc.contributor.author","Tonetti, Tommaso"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Niewenhuys, Julia"],["dc.contributor.author","Behnemann, Tim"],["dc.contributor.author","Camporota, Luigi"],["dc.contributor.author","Hahn, Günter"],["dc.contributor.author","Reupke, Verena"],["dc.contributor.author","Holke, Karin"],["dc.contributor.author","Herrmann, Peter"],["dc.contributor.author","Duscio, Eleonora"],["dc.contributor.author","Cipulli, Francesco"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Marini, John J."],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2020-12-10T18:19:47Z"],["dc.date.available","2020-12-10T18:19:47Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1097/ALN.0000000000002458"],["dc.identifier.issn","0003-3022"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75382"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Positive End-expiratory Pressure and Mechanical Power"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","990"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Pediatric Cardiology"],["dc.bibliographiccitation.lastpage","997"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Krause, Ulrich J."],["dc.contributor.author","Becker, Kristin"],["dc.contributor.author","Hahn, Guenter"],["dc.contributor.author","Dittmar, Joerg"],["dc.contributor.author","Ruschewski, Wolfgang"],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2018-11-07T09:37:24Z"],["dc.date.available","2018-11-07T09:37:24Z"],["dc.date.issued","2014"],["dc.description.abstract","Electrical impedance tomography (EIT) is a noninvasive method to monitor regional lung ventilation in infants and children without using radiation. The objective of this prospective study was to determine the value of EIT as an additional monitoring tool to assess regional lung ventilation after pediatric cardiac surgery for congenital heart disease in infants and children. EIT monitoring was performed in a prospective study comprising 30 pediatric patients who were mechanically ventilated after cardiac surgery. Data were analyzed off-line with respect to regional lung ventilation in different clinical situations. EIT data were correlated with respirator settings and arterial carbon dioxide (CO2) partial pressure in the blood. In 29 of 30 patients, regional ventilation of the lung could sufficiently and reliably be monitored by means of EIT. The effects of the transition from mechanical ventilation to spontaneous breathing after extubation on regional lung ventilation were studied. After extubation, a significant decrease of relative impedance changes was evident. In addition, a negative correlation of arterial CO2 partial pressure and relative impedance changes could be shown. EIT was sufficient to discriminate differences of regional lung ventilation in children and adolescents after cardiac surgery. EIT reliably provided additional information on regional lung ventilation in children after cardiac surgery. Neither chest tubes nor pacemaker wires nor the intensive care unit environment interfered with the application of EIT. EIT therefore may be used as an additional real-time monitoring tool in pediatric cardiac intensive care because it is noninvasive."],["dc.identifier.doi","10.1007/s00246-014-0886-6"],["dc.identifier.isi","000339112400015"],["dc.identifier.pmid","24569885"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32831"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-1971"],["dc.relation.issn","0172-0643"],["dc.title","Monitoring of Regional Lung Ventilation Using Electrical Impedance Tomography After Cardiac Surgery in Infants and Children"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]