Mohamed, Belal A.

[["dc.bibliographiccitation.firstpage","817"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","American Journal of Respiratory Cell and Molecular Biology"],["dc.bibliographiccitation.lastpage","824"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Mohamed, Belal A."],["dc.contributor.author","Barakat, Amal Z."],["dc.contributor.author","Held, Torsten"],["dc.contributor.author","Elkenani, Manar"],["dc.contributor.author","Muehlfeld, Christian"],["dc.contributor.author","Maenner, Joerg"],["dc.contributor.author","Adham, Ibrahim M."],["dc.date.accessioned","2018-11-07T09:41:50Z"],["dc.date.available","2018-11-07T09:41:50Z"],["dc.date.issued","2014"],["dc.description.abstract","Heat shock proteins HSPA4L and HSPA4 are closely related members of the HSP110 family and act as cochaperones. We generated Hspa4l(-1-) Hspa4(-1-) mice to investigate a functional complementarity between HSPA4L and HSPA4 during embryonic development. Hspa4l(-1-) Hspa4(-1-) 2 embryos exhibited marked pulmonary hypoplasia and neonatal death. Compared with lungs of wild- type, Hspa4l(-1-) , and Hspa4(-1-) embryos, Hspa4l(-1-) Hspa4(-1-) lungs were characterized by diminished saccular spaces and increased mesenchymal septa. Mesenchymal hypercellularity was determined to be due to an increased cell proliferation index and decreased cell death. A significant increase in expression levels of prosurvival protein B cell leukemia/ lymphoma 2 may be the cause for inhibition of apoptotic process in lungs of Hspa4(-1-) Hspa4l(-1-) embryos. Accumulation of glycogen and diminished expression of surfactant protein B, prosurfactant protein C, and aquaporin 5 in saccular epithelium suggested impaired maturation of type II and type I pneumocytes in the Hspa4l(-1-) Hspa4(-1-) lungs. Further experiments showed a significant accumulation of ubiquitinated proteins in the lungs of Hspa4l(-1-) Hspa4(-1-) embryos, indicating an impaired chaperone activity. Our study demonstrates that HSPA4L and HSPA4 collaborate in embryonic lung maturation, which is necessary for adaptation to air breathing at birth."],["dc.identifier.doi","10.1165/rcmb.2013-0132OC"],["dc.identifier.isi","000334403900016"],["dc.identifier.pmid","23980576"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33820"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Thoracic Soc"],["dc.relation.issn","1535-4989"],["dc.relation.issn","1044-1549"],["dc.title","Respiratory Distress and Early Neonatal Lethality in Hspa4l/Hspa4 Double-Mutant Mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","The FEBS Journal"],["dc.contributor.author","Elkenani, Manar"],["dc.contributor.author","Nyamsuren, Gunsmaa"],["dc.contributor.author","Toischer, Karl"],["dc.contributor.author","Adham, Ibrahim M."],["dc.contributor.author","Mohamed, Belal A."],["dc.date.accessioned","2021-04-14T08:23:52Z"],["dc.date.available","2021-04-14T08:23:52Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1111/febs.15643"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81077"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1742-4658"],["dc.relation.issn","1742-464X"],["dc.title","Perturbed differentiation of murine embryonic stem cells upon Pelota deletion due to dysregulated FOXO1/β‐catenin signaling"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]