Paul, Thomas

[["dc.bibliographiccitation.firstpage","2185"],["dc.bibliographiccitation.issue","25"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.lastpage","2193"],["dc.bibliographiccitation.volume","131"],["dc.contributor.author","De Ferrari, Gaetano M."],["dc.contributor.author","Dusi, Veronica"],["dc.contributor.author","Spazzolini, Carla"],["dc.contributor.author","Bos, J. Martijn"],["dc.contributor.author","Abrams, Dominic J."],["dc.contributor.author","Berul, Charles I."],["dc.contributor.author","Crotti, Lia"],["dc.contributor.author","Davis, Andrew M."],["dc.contributor.author","Eldar, Michael"],["dc.contributor.author","Kharlap, Maria"],["dc.contributor.author","Khoury, Asaad"],["dc.contributor.author","Krahn, Andrew D."],["dc.contributor.author","Leenhardt, Antoine"],["dc.contributor.author","Moir, Christopher R."],["dc.contributor.author","Odero, Attilio"],["dc.contributor.author","Olde Nordkamp, Louise"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Roses i Noguer, Ferran"],["dc.contributor.author","Shkolnikova, Maria"],["dc.contributor.author","Till, Jan"],["dc.contributor.author","Wilde, Arthur A. M."],["dc.contributor.author","Ackerman, Michael J."],["dc.contributor.author","Schwartz, Peter J."],["dc.date.accessioned","2018-11-07T09:55:42Z"],["dc.date.available","2018-11-07T09:55:42Z"],["dc.date.issued","2015"],["dc.description.abstract","Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a genetic disorder causing life-threatening arrhythmias whenever sympathetic activity increases. -Blockers are the mainstay of therapy; when they fail, implantable cardioverter-defibrillators (ICDs) are used but often cause multiple shocks. Preliminary results with flecainide appear encouraging. We proposed left cardiac sympathetic denervation (LCSD) as useful additional therapy, but evidence remains anecdotal. Methods and Results We report 63 patients with CPVT who underwent LCSD as secondary (n=54) or primary (n=9) prevention. The median post-LCSD follow-up was 37 months. The 9 asymptomatic patients remained free of major cardiac events. Of the 54 patients with prior major cardiac events either on (n=38) or off (n=16) optimal medical therapy, 13 (24%) had at least 1 recurrence: 0 patients had an aborted cardiac arrest, 2 patients had syncope only, 10 patients had 1 appropriate ICD discharges, and 1 patient died suddenly. The 1- and 2-year cumulative event-free survival rates were 87% and 81%. The percentage of patients with major cardiac events despite optimal medical therapy (n=38) was reduced from 100% to 32% (P<0.001) after LCSD, and among 29 patients with a presurgical ICD, the rate of shocks dropped by 93% from 3.6 to 0.6 shocks per person per year (P<0.001). Patients with an incomplete LCSD (n=7) were more likely to experience major cardiac events after LCSD (71% versus 17%; P<0.01) than those with a complete LCSD. Conclusions LCSD is an effective antifibrillatory intervention for patients with CPVT. Whenever syncope occurs despite optimal medical therapy, LCSD could be considered the next step rather than an ICD and could complement ICDs in patients with recurrent shocks."],["dc.identifier.doi","10.1161/CIRCULATIONAHA.115.015731"],["dc.identifier.isi","000360528400005"],["dc.identifier.pmid","26019152"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36810"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1524-4539"],["dc.relation.issn","0009-7322"],["dc.title","Clinical Management of Catecholaminergic Polymorphic Ventricular Tachycardia The Role of Left Cardiac Sympathetic Denervation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2024"],["dc.bibliographiccitation.issue","19"],["dc.bibliographiccitation.journal","The New England Journal of Medicine"],["dc.bibliographiccitation.lastpage","2029"],["dc.bibliographiccitation.volume","358"],["dc.contributor.author","Wilde, Arthur A. M."],["dc.contributor.author","Bhuiyan, Zahurul A."],["dc.contributor.author","Crotti, Lia"],["dc.contributor.author","Facchini, Mario"],["dc.contributor.author","De Ferrari, Gaetano M."],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Ferrandi, Chiara"],["dc.contributor.author","Koolbergen, Dave R."],["dc.contributor.author","Odero, Attilio"],["dc.contributor.author","Schwartz, Peter J."],["dc.date.accessioned","2019-07-10T08:13:34Z"],["dc.date.available","2019-07-10T08:13:34Z"],["dc.date.issued","2008"],["dc.description.abstract","Catecholaminergic polymorphic ventricular tachycardia is a potentially lethal disease characterized by adrenergically mediated ventricular arrhythmias manifested especially in children and teenagers. Beta-blockers are the cornerstone of therapy, but some patients do not have a complete response to this therapy and receive an implantable cardioverter–defibrillator (ICD). Given the nature of catecholaminergic polymorphic ventricular tachycardia, ICD shocks may trigger new arrhythmias, leading to the administration of multiple shocks. We describe the long-term efficacy of surgical left cardiac sympathetic denervation in three young adults with catecholaminergic polymorphic ventricular tachycardia, all of whom had symptoms before the procedure and were symptom-free afterward."],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6218"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61276"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.rights","Goescholar"],["dc.rights.access","openAccess"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject","Cardiac Sympathetic Denervation"],["dc.subject.ddc","610"],["dc.title","Left Cardiac Sympathetic Denervation for Catecholaminergic Polymorphic Ventricular Tachycardia"],["dc.title.alternative","Catecholaminergic polymorphic ventricular tachycardia is a potentially lethal disease characterized by adrenergically mediated ventricular arrhythmias manifested especially in children and teenagers. Beta-blockers are the cornerstone of therapy, but some patients do not have a complete response to this therapy and receive an implantable cardioverter–defibrillator (ICD). Given the nature of catecholaminergic polymorphic ventricular tachycardia, ICD shocks may trigger new arrhythmias, leading to the administration of multiple shocks. We describe the long-term efficacy of surgical left cardiac sympathetic denervation in three young adults with catecholaminergic polymorphic ventricular tachycardia, all of whom had symptoms before the procedure and were symptom-free afterward."],["dc.title.subtitle","Catecholaminergic polymorphic ventricular tachycardia is a potentially lethal disease characterized by adrenergically mediated ventricular arrhythmias manifested especially in children and teenagers. Beta-blockers are the cornerstone of therapy, but some patients do not have a complete response to this therapy and receive an implantable cardioverter–defibrillator (ICD). Given the nature of catecholaminergic polymorphic ventricular tachycardia, ICD shocks may trigger new arrhythmias, leading to the administration of multiple shocks. We describe the long-term efficacy of surgical left cardiac sympathetic denervation in three young adults with catecholaminergic polymorphic ventricular tachycardia, all of whom had symptoms before the procedure and were symptom-free afterward."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Dusi, Veronica"],["dc.contributor.author","De Ferrari, Gaetano M."],["dc.contributor.author","Bos, J. Martijn"],["dc.contributor.author","Moir, Christopher R."],["dc.contributor.author","Shkolnikova, Maria"],["dc.contributor.author","Abrams, Dominic J."],["dc.contributor.author","Crotti, Lia"],["dc.contributor.author","Wilde, Arthur A. M."],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Eldar, Michael"],["dc.contributor.author","Till, Jan"],["dc.contributor.author","Noguer, F. R. I."],["dc.contributor.author","Krahn, Andrew D."],["dc.contributor.author","Schwartz, Peter J."],["dc.contributor.author","Ackerman, Michael J."],["dc.date.accessioned","2018-11-07T10:10:24Z"],["dc.date.available","2018-11-07T10:10:24Z"],["dc.date.issued","2016"],["dc.format.extent","83"],["dc.identifier.isi","000383869500265"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39852"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.conference","Congress of the European-Society-of-Cardiology (ESC)"],["dc.relation.eventlocation","Rome, ITALY"],["dc.relation.issn","1522-9645"],["dc.relation.issn","0195-668X"],["dc.title","Supraventricular arrhythmias and implantable cardioverter defibrillator shocks in catecholaminergic polymorphic ventricular tachycardia"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Dusi, Veronica"],["dc.contributor.author","De Ferrari, Gaetano M."],["dc.contributor.author","Bos, J. Martijn"],["dc.contributor.author","Moir, Christopher R."],["dc.contributor.author","Wilde, Arthur A. M."],["dc.contributor.author","Shkolnikova, Maria"],["dc.contributor.author","Abrams, Dominic J."],["dc.contributor.author","Crotti, Lia"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Eldar, Michael"],["dc.contributor.author","Till, Jan"],["dc.contributor.author","Noguer, F. R. I."],["dc.contributor.author","Krahn, Andrew D."],["dc.contributor.author","Ackerman, Michael J."],["dc.contributor.author","Schwartz, Peter J."],["dc.date.accessioned","2018-11-07T10:10:25Z"],["dc.date.available","2018-11-07T10:10:25Z"],["dc.date.issued","2016"],["dc.format.extent","215"],["dc.identifier.isi","000383869501071"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39855"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.conference","Congress of the European-Society-of-Cardiology (ESC)"],["dc.relation.eventlocation","Rome, ITALY"],["dc.relation.issn","1522-9645"],["dc.relation.issn","0195-668X"],["dc.title","Electrical storms in catecholaminergic polymorphic ventricular tachycardia: findings from the international registry of left cardiac sympathetic denervation"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","E366"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.lastpage","E367"],["dc.bibliographiccitation.volume","133"],["dc.contributor.author","De Ferrari, Gaetano M."],["dc.contributor.author","Dusi, Veronica"],["dc.contributor.author","Spazzolini, Carla"],["dc.contributor.author","Bos, J. Martijn"],["dc.contributor.author","Abrams, Dominic J."],["dc.contributor.author","Berul, Charles I."],["dc.contributor.author","Crotti, Lia"],["dc.contributor.author","Eldar, Michael"],["dc.contributor.author","Kharlap, Maria"],["dc.contributor.author","Khoury, Asaad"],["dc.contributor.author","Krahn, Andrew D."],["dc.contributor.author","Leenhardt, Antoine"],["dc.contributor.author","Moir, Christopher R."],["dc.contributor.author","Odero, Attilio"],["dc.contributor.author","Nordkamp, Louise Olde"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Shkolnikova, Maria"],["dc.contributor.author","Till, Jan"],["dc.contributor.author","Wilde, Arthur A.M."],["dc.contributor.author","Ackerman, Michael J."],["dc.contributor.author","Schwartz, Peter J."],["dc.contributor.author","Roses i Noguer, Ferran"],["dc.date.accessioned","2020-12-10T18:38:01Z"],["dc.date.available","2020-12-10T18:38:01Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1161/CIRCULATIONAHA.115.019465"],["dc.identifier.eissn","1524-4539"],["dc.identifier.isi","000369259500008"],["dc.identifier.issn","0009-7322"],["dc.identifier.pmid","26811283"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77165"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1524-4539"],["dc.relation.issn","0009-7322"],["dc.title","Response to Letters Regarding Article, “Clinical Management of Catecholaminergic Polymorphic Ventricular Tachycardia: The Role of Left Cardiac Sympathetic Denervation”"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]