Paul, Thomas

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","European Journal of Pediatrics"],["dc.bibliographiccitation.volume","168"],["dc.contributor.author","Kriebel, TA"],["dc.contributor.author","Schneider, H."],["dc.contributor.author","Kroll, Maja"],["dc.contributor.author","Selle, Jakob"],["dc.contributor.author","Quentin, Thomas"],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2018-11-07T08:31:59Z"],["dc.date.available","2018-11-07T08:31:59Z"],["dc.date.issued","2009"],["dc.format.extent","379"],["dc.identifier.isi","000262826600039"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17242"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.issn","0340-6199"],["dc.title","Histological characterisation of cryolesions and results of intracoronary ultrasound and coronary angiography after energy application at growing myocardium"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Clinical Research in Cardiology"],["dc.bibliographiccitation.volume","98"],["dc.contributor.author","Sigler, Matthias"],["dc.contributor.author","Foth, Rudi"],["dc.contributor.author","Quentin, Thomas"],["dc.contributor.author","Ruschewski, Wolfgang"],["dc.contributor.author","Kriebel, TA"],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2018-11-07T11:24:38Z"],["dc.date.available","2018-11-07T11:24:38Z"],["dc.date.issued","2009"],["dc.format.extent","612"],["dc.identifier.isi","000269926600098"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56449"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1861-0684"],["dc.title","Histopathology and morphometry of 12 explanted modified Blalock-Taussig shunts"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","263"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Basic Research in Cardiology"],["dc.bibliographiccitation.lastpage","269"],["dc.bibliographiccitation.volume","100"],["dc.contributor.author","Steinmetz, M."],["dc.contributor.author","Quentin, Thomas"],["dc.contributor.author","Poppe, Andrea"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Jux, Christian"],["dc.date.accessioned","2018-11-07T11:01:53Z"],["dc.date.available","2018-11-07T11:01:53Z"],["dc.date.issued","2005"],["dc.description.abstract","During neonatal cardiac development, the heart changes its substrate preference from glucose to fatty acids. The aim of this study was to investigate the changes in mRNA expression levels of genes involved in the control of cardiac fatty acid metabolism in the transition from neonatal to adult life. Methods mRNA expression levels for peroxisome proliferator activated receptor (PPAR) alpha, gamma and delta, PPAR gamma co-factor 1 alpha and beta (PGC-1 alpha and beta), 9-cis retinoc-acid-activated receptor alpha, beta and gamma (RXR alpha, beta, gamma), 5'-AMP activated protein kinase (AMPK) alpha 1 and alpha 2, adiponectin receptor 1 and 2 (AR 1 and AR 2) were measured in heart tissue of neonatal 0-day, 7-day and 21-day old rats. Results mRNA expression of all three members of the PPAR family were upregulated significantly from day 0 to day 21 (alpha + 117%, gamma + 133%, delta + 203%). In addition, m-RNA expression of all RXR isoforms increased from day 0 to day 7 (alpha + 125%, beta + 69%; gamma + 41%). AR 2 exhibited a small but significant increase in mRNA expression (+ 46%). Conclusions We were able to demonstrate for the first time that in addition to PPAR alpha, also PPAR gamma and delta, as well as all RXR isoforms and AR 2 are upregulated in the heart during neonatal development."],["dc.identifier.doi","10.1007/s00395-005-0520-0"],["dc.identifier.isi","000228638100010"],["dc.identifier.pmid","15754086"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51249"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.relation.issn","0300-8428"],["dc.title","Changes in expression levels of genes involved in fatty acid metabolism: upregulation of all three members of the PPAR family (alpha, gamma, delta) and the newly described adiponectin receptor 2, but not adiponectin receptor 1 during neonatal cardiac development of the rat"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Clinical Research in Cardiology"],["dc.bibliographiccitation.volume","100"],["dc.contributor.author","Gravenhorst, Verena D."],["dc.contributor.author","Ebenebe, Chinedu U."],["dc.contributor.author","Quentin, Thomas"],["dc.contributor.author","Jung, K."],["dc.contributor.author","Schneider, Heike E."],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2018-11-07T08:52:34Z"],["dc.date.available","2018-11-07T08:52:34Z"],["dc.date.issued","2011"],["dc.format.extent","828"],["dc.identifier.isi","000294690900044"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22199"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1861-0684"],["dc.title","Intraventricular dyssynchrony detected by 3-dimensional echocardiography in young patients with Duchenne muscular dystrophy and normal left ventricular ejection fraction"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","European Journal of Pediatrics"],["dc.bibliographiccitation.volume","167"],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Quentin, Thomas"],["dc.contributor.author","Krause, Ulrich J."],["dc.contributor.author","Poppe, Andrea"],["dc.contributor.author","Jux, Christian"],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2018-11-07T11:17:33Z"],["dc.date.available","2018-11-07T11:17:33Z"],["dc.date.issued","2008"],["dc.format.extent","367"],["dc.identifier.isi","000252991400040"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54834"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.issn","0340-6199"],["dc.title","Regulation of PPAR alpha activity and expression by metformin in neonatal cardiomyocytes: involvement of the AMP-activated protein kinase"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","90"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Circulation Cardiovascular Interventions"],["dc.bibliographiccitation.lastpage","96"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Foth, Rudi"],["dc.contributor.author","Quentin, Thomas"],["dc.contributor.author","Michel-Behnke, Ina"],["dc.contributor.author","Vogt, Manfred"],["dc.contributor.author","Kriebel, Thomas"],["dc.contributor.author","Kreischer, Anne"],["dc.contributor.author","Ruschewski, Wolfgang"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Sigler, Matthias"],["dc.date.accessioned","2018-11-07T08:30:58Z"],["dc.date.available","2018-11-07T08:30:58Z"],["dc.date.issued","2009"],["dc.description.abstract","Background-We sought to evaluate tissue reactions within and at the surface of devices for interventional therapy of septal defects and to identify antigen characteristics of neotissues. Methods and Results-Atrial or ventricular septal defect-occlusion devices (Amplatzer, n=7; Cardioseal/Starflex, n=3) were processed using a uniform protocol after surgical removal from humans (implantation time, 5 days to 4 years). Devices were fixed in formalin and embedded in methylmethacrylate. Serial sections were obtained by sectioning with a diamond cutter and grinding, thus saving the metal/tissue interface for histologic evaluation. Immunohistochemical staining was performed using conventional protocols. Superficial endothelial cells stained positive for von Willebrand factor. Within the newly formed tissues, fibroblast-like cells were identified with a time-dependent expression of smooth muscle cell maturation markers (smooth muscle actin, smooth muscle myosin, h-caldesmon, and desmin) beside extracellular matrix components. Neovascularization of the newly formed tissues was demonstrated with the typical immunohistochemical pattern of capillaries and small vessels. Inflammatory cells could be identified as macrophages (CD68+) and both T-type and B-type lymphocytes (CD3+, CD79+). Conclusions-This is the first presentation of results from serial immunohistochemical staining of a collection of explanted human septal-occlusion devices. A time-dependent maturation pattern of the fibroblast-like cells in the neotissues around the implants could be described. Neoendothelialization was seen in all specimens with implantation times of 10 weeks or more. The time course of neoendothelialization, as seen in our study, further supports the clinical practice of anticoagulant or antiplatelet therapy for 6 months after implantation. This time interval should be sufficient to prevent thromboembolic events due to thrombus formation at the foreign surface of cardiovascular implants. (Circ Cardiovasc Intervent. 2009; 2: 90-96.)"],["dc.identifier.doi","10.1161/CIRCINTERVENTIONS.108.810507"],["dc.identifier.isi","000276051600003"],["dc.identifier.pmid","20031701"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17012"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1941-7640"],["dc.title","Immunohistochemical Characterization of Neotissues and Tissue Reactions to Septal Defect-Occlusion Devices"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","590"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Clinical Research in Cardiology"],["dc.bibliographiccitation.lastpage","591"],["dc.bibliographiccitation.volume","98"],["dc.contributor.author","Kriebel, TA"],["dc.contributor.author","Schneider, H."],["dc.contributor.author","Selle, Jakob"],["dc.contributor.author","Overwaul, Anna"],["dc.contributor.author","Stahl, M."],["dc.contributor.author","Quentin, Thomas"],["dc.contributor.author","Sigler, Matthias"],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2018-11-07T11:24:38Z"],["dc.date.available","2018-11-07T11:24:38Z"],["dc.date.issued","2009"],["dc.identifier.isi","000269926600037"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56447"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1861-0684"],["dc.title","Histopathologic characterization of cryo-lesions"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Clinical Research in Cardiology"],["dc.bibliographiccitation.volume","100"],["dc.contributor.author","Sigler, Matthias"],["dc.contributor.author","Leyh, J."],["dc.contributor.author","Quentin, Thomas"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Moeller, Oliver"],["dc.date.accessioned","2018-11-07T08:52:34Z"],["dc.date.available","2018-11-07T08:52:34Z"],["dc.date.issued","2011"],["dc.format.extent","852"],["dc.identifier.isi","000294690900112"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22201"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1861-0684"],["dc.title","Animal Experiments Stent Implantation in Tracheobronchial System: Histological comparison between coated and uncoated Stents"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","10"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Molecular and cellular pediatrics"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Sigler, Matthias"],["dc.contributor.author","Klötzer, Julia"],["dc.contributor.author","Quentin, Thomas"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Möller, Oliver"],["dc.date.accessioned","2019-07-09T11:41:55Z"],["dc.date.available","2019-07-09T11:41:55Z"],["dc.date.issued","2015-12-01"],["dc.description.abstract","BACKGROUND: Stent implantation into the tracheo-bronchial system may be life-saving in selected pediatric patients with otherwise intractable stenosis of the upper airways. Following implantation, significant tissue proliferation may occur, requiring re-interventions. We sought to evaluate the effect of immunosuppressive coating of the stents on the extent of tissue proliferation in an animal model. METHODS: Bare metal and sirolimus-coated stents (Bx Sonic and Cypher Select, Johnson & Johnson, Cordis) were implanted into non-stenotic lower airways of New Zealand white rabbits (weight 3.1 to 4.8 kg). Three stents with sirolimus coating and six bare metal stents could be analyzed by means of histology and immunohistochemistry 12 months after implantation. RESULTS: On a macroscopic evaluation, all stents were partially covered with a considerable amount of whitish tissue. Histologically, these proliferations contained fiber-rich connective tissue and some fibromuscular cells without significant differences between both stent types. The superficial tissue layer was formed by typical respiratory epithelium and polygonal cells. Abundant lymphocyte infiltrations and moderate granulocyte infiltrations were found in both groups correspondingly, whereas foreign-body reaction was more pronounced around sirolimus-eluting stents. CONCLUSIONS: After stent implantation in the tracheo-bronchial system of rabbits, we found tissue reactions comparable to those seen after stent implantation into the vascular system. There was no difference between coated and uncoated stents with regard to quality and quantity of tissue proliferation. We found, however, a significantly different inflammatory reaction with a more pronounced foreign-body reaction in sirolimus-coated stents. In our small series, drug-eluting stents did not exhibit any benefit over bare metal stents in an experimental setting."],["dc.identifier.doi","10.1186/s40348-015-0021-7"],["dc.identifier.pmid","26542300"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12586"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58548"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2194-7791"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Stent implantation into the tracheo-bronchial system in rabbits: histopathologic sequelae in bare metal vs. drug-eluting stents."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Jux, Christian"],["dc.contributor.author","Quentin, Thomas"],["dc.contributor.author","Sigler, Matthias"],["dc.contributor.author","Poppe, Andrea"],["dc.contributor.author","Baer, K."],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2018-11-07T10:58:55Z"],["dc.date.available","2018-11-07T10:58:55Z"],["dc.date.issued","2007"],["dc.format.extent","453"],["dc.identifier.isi","000208702202365"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50577"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.issn","0195-668X"],["dc.title","Healing response to various septal occluder devices at the cellular and molecular level"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]