Paul, Thomas

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Foth, Rudi"],["dc.contributor.author","Shomroni, Orr"],["dc.contributor.author","Sigler, Matthias"],["dc.contributor.author","Hörer, Jürgen"],["dc.contributor.author","Cleuziou, Julie"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Eildermann, Katja"],["dc.date.accessioned","2021-04-14T08:30:16Z"],["dc.date.available","2021-04-14T08:30:16Z"],["dc.date.issued","2021"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.1038/s41598-021-81340-2"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83174"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2045-2322"],["dc.rights","CC BY 4.0"],["dc.title","Screening for potential targets to reduce stenosis in bioprosthetic heart valves"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Clinical Research in Cardiology"],["dc.bibliographiccitation.volume","98"],["dc.contributor.author","Sigler, Matthias"],["dc.contributor.author","Foth, Rudi"],["dc.contributor.author","Quentin, Thomas"],["dc.contributor.author","Ruschewski, Wolfgang"],["dc.contributor.author","Kriebel, TA"],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2018-11-07T11:24:38Z"],["dc.date.available","2018-11-07T11:24:38Z"],["dc.date.issued","2009"],["dc.format.extent","612"],["dc.identifier.isi","000269926600098"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56449"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1861-0684"],["dc.title","Histopathology and morphometry of 12 explanted modified Blalock-Taussig shunts"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Clinical Research in Cardiology"],["dc.bibliographiccitation.volume","97"],["dc.contributor.author","Kriebel, TA"],["dc.contributor.author","Schneider, H."],["dc.contributor.author","Dann, Gisela"],["dc.contributor.author","Sigler, Matthias"],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2018-11-07T11:11:11Z"],["dc.date.available","2018-11-07T11:11:11Z"],["dc.date.issued","2008"],["dc.format.extent","682"],["dc.identifier.isi","000258897900058"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53373"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1861-0684"],["dc.title","Catheter ablation of idiopathic ventricular tachycardia with the non-contact-mapping system in infancy"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1197"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Pacing and Clinical Electrophysiology"],["dc.bibliographiccitation.lastpage","1202"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Kriebel, Thomas"],["dc.contributor.author","Hermann, Hans-Peter"],["dc.contributor.author","Schneider, Heike"],["dc.contributor.author","Kroll, Maja"],["dc.contributor.author","Selle, Jakob"],["dc.contributor.author","Overwaul, Anna"],["dc.contributor.author","Sigler, Matthias"],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2021-11-22T14:31:49Z"],["dc.date.available","2021-11-22T14:31:49Z"],["dc.date.issued","2009"],["dc.description.abstract","BACKGROUND: Animal studies and clinical observations have demonstrated that radiofrequency current application at growing myocardium may result in coronary artery obstruction. Recently, cryoenergy has emerged as an effective alternative to radiofrequency ablation of arrhythmogenic substrates in pediatric patients. Up to now, there has been a lack of experimental data concerning the effects of cryoenergy application at growing myocardium. METHODS: During general anesthesia, selective coronary angiography of the right and left coronary artery was performed in 10 piglets (age: 6 weeks, body weight: 14-18 kg). Subsequently, cryoenergy was delivered at -75 degrees C for 4 minutes using a 7-F catheter with a 6-mm-tip electrode at the atrial aspect of the tricuspid valve annulus in a posterior and lateral position. Additional cryoenergy lesions were induced via a retrograde approach at the lateral and posterior atrial and ventricular aspect of the mitral valve annulus, respectively. Five animals were restudied after 48 hours by coronary angiography and intracoronary ultrasound and in the remaining five piglets after 3 and 6 months, respectively. RESULTS: Selective coronary angiography and intracoronary ultrasound studies did not demonstrate any evidence for coronary artery obstruction after 48 hours, 3 months, or 6 months after cryoenergy application. In addition, histological examinations of the cryolesions after 48 hours and after 6 months did not demonstrate any intimal proliferations of the coronary arteries, respectively. CONCLUSIONS: By means of the present study, we did not observe any affection of the coronary arteries after cryoenergy application at growing myocardium in young piglets."],["dc.description.abstract","Methods: During general anesthesia, selective coronary angiography of the right and left coronary artery was performed in 10 piglets (age: 6 weeks, body weight: 14-18 kg). Subsequently, cryoenergy was delivered at -75 degrees C for 4 minutes using a 7-F catheter with a 6-mm-tip electrode at the atrial aspect of the tricuspid valve annulus in a posterior and lateral position. Additional cryoenergy lesions were induced via a retrograde approach at the lateral and posterior atrial and ventricular aspect of the mitral valve annulus, respectively. Five animals were restudied after 48 hours by coronary angiography and intracoronary ultrasound and in the remaining five piglets after 3 and 6 months, respectively. Results: Selective coronary angiography and intracoronary ultrasound studies did not demonstrate any evidence for coronary artery obstruction after 48 hours, 3 months, or 6 months after cryoenergy application. In addition, histological examinations of the cryolesions after 48 hours and after 6 months did not demonstrate any intimal proliferations of the coronary arteries, respectively. Conclusions: By means of the present study, we did not observe any affection of the coronary arteries after cryoenergy application at growing myocardium in young piglets. (PACE 2009; 32:1197-1202)."],["dc.identifier.doi","10.1111/j.1540-8159.2009.02465.x"],["dc.identifier.isi","000269390500015"],["dc.identifier.pmid","19719499"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6288"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/93405"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.relation.issn","1540-8159"],["dc.rights.access","closedAccess"],["dc.subject.ddc","610"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Coronary Artery Disease"],["dc.subject.mesh","Coronary Stenosis"],["dc.subject.mesh","Coronary Vessels"],["dc.subject.mesh","Cryosurgery"],["dc.subject.mesh","Risk Assessment"],["dc.subject.mesh","Swine"],["dc.title","Cryoablation at growing myocardium: no evidence of coronary artery obstruction or intimal plaque formation early and late after energy application."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","677"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Pediatric Cardiology"],["dc.bibliographiccitation.lastpage","679"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Lucas, J. F."],["dc.contributor.author","Bradley, S. M."],["dc.contributor.author","Eicher, D."],["dc.contributor.author","Sigler, Matthias"],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2018-11-07T10:56:32Z"],["dc.date.available","2018-11-07T10:56:32Z"],["dc.date.issued","2005"],["dc.description.abstract","We report on a premature infant with a body weight < 900 g who developed complete heart block as a complication of Enterobacter bacteremia. The infant could be successfully paced using a transcutaneous pacemaker for a limited time. Histopathological examination of the heart did not reveal any abnormalities of the specialized conduction system."],["dc.identifier.doi","10.1007/s00246-005-0854-2"],["dc.identifier.isi","000233663800032"],["dc.identifier.pmid","16132286"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50034"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0172-0643"],["dc.title","Fatal complete atrioventricular block as a complication of bacterial sepsis in a premature newborn"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","668"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Clinical Research in Cardiology"],["dc.bibliographiccitation.lastpage","670"],["dc.bibliographiccitation.volume","95"],["dc.contributor.author","Kriebel, TA"],["dc.contributor.author","Schneider, H."],["dc.contributor.author","Sigler, Matthias"],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2018-11-07T08:52:28Z"],["dc.date.available","2018-11-07T08:52:28Z"],["dc.date.issued","2006"],["dc.identifier.doi","10.1007/s00392-006-0438-z"],["dc.identifier.isi","000242421200005"],["dc.identifier.pmid","16998743"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22169"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.relation.issn","1861-0684"],["dc.title","Slow pathway ablation in a 5-year-old boy with atrioventricular septal defect: Value of cryoenergy application"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","90"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Circulation Cardiovascular Interventions"],["dc.bibliographiccitation.lastpage","96"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Foth, Rudi"],["dc.contributor.author","Quentin, Thomas"],["dc.contributor.author","Michel-Behnke, Ina"],["dc.contributor.author","Vogt, Manfred"],["dc.contributor.author","Kriebel, Thomas"],["dc.contributor.author","Kreischer, Anne"],["dc.contributor.author","Ruschewski, Wolfgang"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Sigler, Matthias"],["dc.date.accessioned","2018-11-07T08:30:58Z"],["dc.date.available","2018-11-07T08:30:58Z"],["dc.date.issued","2009"],["dc.description.abstract","Background-We sought to evaluate tissue reactions within and at the surface of devices for interventional therapy of septal defects and to identify antigen characteristics of neotissues. Methods and Results-Atrial or ventricular septal defect-occlusion devices (Amplatzer, n=7; Cardioseal/Starflex, n=3) were processed using a uniform protocol after surgical removal from humans (implantation time, 5 days to 4 years). Devices were fixed in formalin and embedded in methylmethacrylate. Serial sections were obtained by sectioning with a diamond cutter and grinding, thus saving the metal/tissue interface for histologic evaluation. Immunohistochemical staining was performed using conventional protocols. Superficial endothelial cells stained positive for von Willebrand factor. Within the newly formed tissues, fibroblast-like cells were identified with a time-dependent expression of smooth muscle cell maturation markers (smooth muscle actin, smooth muscle myosin, h-caldesmon, and desmin) beside extracellular matrix components. Neovascularization of the newly formed tissues was demonstrated with the typical immunohistochemical pattern of capillaries and small vessels. Inflammatory cells could be identified as macrophages (CD68+) and both T-type and B-type lymphocytes (CD3+, CD79+). Conclusions-This is the first presentation of results from serial immunohistochemical staining of a collection of explanted human septal-occlusion devices. A time-dependent maturation pattern of the fibroblast-like cells in the neotissues around the implants could be described. Neoendothelialization was seen in all specimens with implantation times of 10 weeks or more. The time course of neoendothelialization, as seen in our study, further supports the clinical practice of anticoagulant or antiplatelet therapy for 6 months after implantation. This time interval should be sufficient to prevent thromboembolic events due to thrombus formation at the foreign surface of cardiovascular implants. (Circ Cardiovasc Intervent. 2009; 2: 90-96.)"],["dc.identifier.doi","10.1161/CIRCINTERVENTIONS.108.810507"],["dc.identifier.isi","000276051600003"],["dc.identifier.pmid","20031701"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17012"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1941-7640"],["dc.title","Immunohistochemical Characterization of Neotissues and Tissue Reactions to Septal Defect-Occlusion Devices"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","590"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Clinical Research in Cardiology"],["dc.bibliographiccitation.lastpage","591"],["dc.bibliographiccitation.volume","98"],["dc.contributor.author","Kriebel, TA"],["dc.contributor.author","Schneider, H."],["dc.contributor.author","Selle, Jakob"],["dc.contributor.author","Overwaul, Anna"],["dc.contributor.author","Stahl, M."],["dc.contributor.author","Quentin, Thomas"],["dc.contributor.author","Sigler, Matthias"],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2018-11-07T11:24:38Z"],["dc.date.available","2018-11-07T11:24:38Z"],["dc.date.issued","2009"],["dc.identifier.isi","000269926600037"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56447"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1861-0684"],["dc.title","Histopathologic characterization of cryo-lesions"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Clinical Research in Cardiology"],["dc.bibliographiccitation.volume","100"],["dc.contributor.author","Sigler, Matthias"],["dc.contributor.author","Leyh, J."],["dc.contributor.author","Quentin, Thomas"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Moeller, Oliver"],["dc.date.accessioned","2018-11-07T08:52:34Z"],["dc.date.available","2018-11-07T08:52:34Z"],["dc.date.issued","2011"],["dc.format.extent","852"],["dc.identifier.isi","000294690900112"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22201"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1861-0684"],["dc.title","Animal Experiments Stent Implantation in Tracheobronchial System: Histological comparison between coated and uncoated Stents"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","10"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Molecular and cellular pediatrics"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Sigler, Matthias"],["dc.contributor.author","Klötzer, Julia"],["dc.contributor.author","Quentin, Thomas"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Möller, Oliver"],["dc.date.accessioned","2019-07-09T11:41:55Z"],["dc.date.available","2019-07-09T11:41:55Z"],["dc.date.issued","2015-12-01"],["dc.description.abstract","BACKGROUND: Stent implantation into the tracheo-bronchial system may be life-saving in selected pediatric patients with otherwise intractable stenosis of the upper airways. Following implantation, significant tissue proliferation may occur, requiring re-interventions. We sought to evaluate the effect of immunosuppressive coating of the stents on the extent of tissue proliferation in an animal model. METHODS: Bare metal and sirolimus-coated stents (Bx Sonic and Cypher Select, Johnson & Johnson, Cordis) were implanted into non-stenotic lower airways of New Zealand white rabbits (weight 3.1 to 4.8 kg). Three stents with sirolimus coating and six bare metal stents could be analyzed by means of histology and immunohistochemistry 12 months after implantation. RESULTS: On a macroscopic evaluation, all stents were partially covered with a considerable amount of whitish tissue. Histologically, these proliferations contained fiber-rich connective tissue and some fibromuscular cells without significant differences between both stent types. The superficial tissue layer was formed by typical respiratory epithelium and polygonal cells. Abundant lymphocyte infiltrations and moderate granulocyte infiltrations were found in both groups correspondingly, whereas foreign-body reaction was more pronounced around sirolimus-eluting stents. CONCLUSIONS: After stent implantation in the tracheo-bronchial system of rabbits, we found tissue reactions comparable to those seen after stent implantation into the vascular system. There was no difference between coated and uncoated stents with regard to quality and quantity of tissue proliferation. We found, however, a significantly different inflammatory reaction with a more pronounced foreign-body reaction in sirolimus-coated stents. In our small series, drug-eluting stents did not exhibit any benefit over bare metal stents in an experimental setting."],["dc.identifier.doi","10.1186/s40348-015-0021-7"],["dc.identifier.pmid","26542300"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12586"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58548"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2194-7791"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Stent implantation into the tracheo-bronchial system in rabbits: histopathologic sequelae in bare metal vs. drug-eluting stents."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]