Paul, Thomas

[["dc.bibliographiccitation.firstpage","1197"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Pacing and Clinical Electrophysiology"],["dc.bibliographiccitation.lastpage","1202"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Kriebel, Thomas"],["dc.contributor.author","Hermann, Hans-Peter"],["dc.contributor.author","Schneider, Heike"],["dc.contributor.author","Kroll, Maja"],["dc.contributor.author","Selle, Jakob"],["dc.contributor.author","Overwaul, Anna"],["dc.contributor.author","Sigler, Matthias"],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2021-11-22T14:31:49Z"],["dc.date.available","2021-11-22T14:31:49Z"],["dc.date.issued","2009"],["dc.description.abstract","BACKGROUND: Animal studies and clinical observations have demonstrated that radiofrequency current application at growing myocardium may result in coronary artery obstruction. Recently, cryoenergy has emerged as an effective alternative to radiofrequency ablation of arrhythmogenic substrates in pediatric patients. Up to now, there has been a lack of experimental data concerning the effects of cryoenergy application at growing myocardium. METHODS: During general anesthesia, selective coronary angiography of the right and left coronary artery was performed in 10 piglets (age: 6 weeks, body weight: 14-18 kg). Subsequently, cryoenergy was delivered at -75 degrees C for 4 minutes using a 7-F catheter with a 6-mm-tip electrode at the atrial aspect of the tricuspid valve annulus in a posterior and lateral position. Additional cryoenergy lesions were induced via a retrograde approach at the lateral and posterior atrial and ventricular aspect of the mitral valve annulus, respectively. Five animals were restudied after 48 hours by coronary angiography and intracoronary ultrasound and in the remaining five piglets after 3 and 6 months, respectively. RESULTS: Selective coronary angiography and intracoronary ultrasound studies did not demonstrate any evidence for coronary artery obstruction after 48 hours, 3 months, or 6 months after cryoenergy application. In addition, histological examinations of the cryolesions after 48 hours and after 6 months did not demonstrate any intimal proliferations of the coronary arteries, respectively. CONCLUSIONS: By means of the present study, we did not observe any affection of the coronary arteries after cryoenergy application at growing myocardium in young piglets."],["dc.description.abstract","Methods: During general anesthesia, selective coronary angiography of the right and left coronary artery was performed in 10 piglets (age: 6 weeks, body weight: 14-18 kg). Subsequently, cryoenergy was delivered at -75 degrees C for 4 minutes using a 7-F catheter with a 6-mm-tip electrode at the atrial aspect of the tricuspid valve annulus in a posterior and lateral position. Additional cryoenergy lesions were induced via a retrograde approach at the lateral and posterior atrial and ventricular aspect of the mitral valve annulus, respectively. Five animals were restudied after 48 hours by coronary angiography and intracoronary ultrasound and in the remaining five piglets after 3 and 6 months, respectively. Results: Selective coronary angiography and intracoronary ultrasound studies did not demonstrate any evidence for coronary artery obstruction after 48 hours, 3 months, or 6 months after cryoenergy application. In addition, histological examinations of the cryolesions after 48 hours and after 6 months did not demonstrate any intimal proliferations of the coronary arteries, respectively. Conclusions: By means of the present study, we did not observe any affection of the coronary arteries after cryoenergy application at growing myocardium in young piglets. (PACE 2009; 32:1197-1202)."],["dc.identifier.doi","10.1111/j.1540-8159.2009.02465.x"],["dc.identifier.isi","000269390500015"],["dc.identifier.pmid","19719499"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6288"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/93405"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.relation.issn","1540-8159"],["dc.rights.access","closedAccess"],["dc.subject.ddc","610"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Coronary Artery Disease"],["dc.subject.mesh","Coronary Stenosis"],["dc.subject.mesh","Coronary Vessels"],["dc.subject.mesh","Cryosurgery"],["dc.subject.mesh","Risk Assessment"],["dc.subject.mesh","Swine"],["dc.title","Cryoablation at growing myocardium: no evidence of coronary artery obstruction or intimal plaque formation early and late after energy application."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","935"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Nature Biotechnology"],["dc.bibliographiccitation.lastpage","942"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Demir, Emek"],["dc.contributor.author","Cary, Michael P."],["dc.contributor.author","Paley, Suzanne"],["dc.contributor.author","Fukuda, Ken"],["dc.contributor.author","Lemer, Christian"],["dc.contributor.author","Vastrik, Imre"],["dc.contributor.author","Wu, Guanming"],["dc.contributor.author","D'Eustachio, Peter"],["dc.contributor.author","Schaefer, Carl"],["dc.contributor.author","Luciano, Joanne"],["dc.contributor.author","Schacherer, Frank"],["dc.contributor.author","Martinez-Flores, Irma"],["dc.contributor.author","Hu, Zhenjun"],["dc.contributor.author","Jimenez-Jacinto, Veronica"],["dc.contributor.author","Joshi-Tope, Geeta"],["dc.contributor.author","Kandasamy, Kumaran"],["dc.contributor.author","Lopez-Fuentes, Alejandra C."],["dc.contributor.author","Mi, Huaiyu"],["dc.contributor.author","Pichler, Elgar"],["dc.contributor.author","Rodchenkov, Igor"],["dc.contributor.author","Splendiani, Andrea"],["dc.contributor.author","Tkachev, Sasha"],["dc.contributor.author","Zucker, Jeremy"],["dc.contributor.author","Gopinath, Gopal"],["dc.contributor.author","Rajasimha, Harsha"],["dc.contributor.author","Ramakrishnan, Ranjani"],["dc.contributor.author","Shah, Imran"],["dc.contributor.author","Syed, Mustafa"],["dc.contributor.author","Anwar, Nadia"],["dc.contributor.author","Babur, Özgün"],["dc.contributor.author","Blinov, Michael"],["dc.contributor.author","Brauner, Erik"],["dc.contributor.author","Corwin, Dan"],["dc.contributor.author","Donaldson, Sylva"],["dc.contributor.author","Gibbons, Frank"],["dc.contributor.author","Goldberg, Robert"],["dc.contributor.author","Hornbeck, Peter"],["dc.contributor.author","Luna, Augustin"],["dc.contributor.author","Murray-Rust, Peter"],["dc.contributor.author","Neumann, Eric"],["dc.contributor.author","Reubenacker, Oliver"],["dc.contributor.author","Samwald, Matthias"],["dc.contributor.author","van Iersel, Martijn"],["dc.contributor.author","Wimalaratne, Sarala"],["dc.contributor.author","Allen, Keith"],["dc.contributor.author","Braun, Burk"],["dc.contributor.author","Whirl-Carrillo, Michelle"],["dc.contributor.author","Cheung, Kei-Hoi"],["dc.contributor.author","Dahlquist, Kam"],["dc.contributor.author","Finney, Andrew"],["dc.contributor.author","Gillespie, Marc"],["dc.contributor.author","Glass, Elizabeth"],["dc.contributor.author","Gong, Li"],["dc.contributor.author","Haw, Robin"],["dc.contributor.author","Honig, Michael"],["dc.contributor.author","Hubaut, Olivier"],["dc.contributor.author","Kane, David"],["dc.contributor.author","Krupa, Shiva"],["dc.contributor.author","Kutmon, Martina"],["dc.contributor.author","Leonard, Julie"],["dc.contributor.author","Marks, Debbie"],["dc.contributor.author","Merberg, David"],["dc.contributor.author","Petri, Victoria"],["dc.contributor.author","Pico, Alex"],["dc.contributor.author","Ravenscroft, Dean"],["dc.contributor.author","Ren, Liya"],["dc.contributor.author","Shah, Nigam"],["dc.contributor.author","Sunshine, Margot"],["dc.contributor.author","Tang, Rebecca"],["dc.contributor.author","Whaley, Ryan"],["dc.contributor.author","Letovksy, Stan"],["dc.contributor.author","Buetow, Kenneth H."],["dc.contributor.author","Rzhetsky, Andrey"],["dc.contributor.author","Schachter, Vincent"],["dc.contributor.author","Sobral, Bruno S."],["dc.contributor.author","Dogrusoz, Ugur"],["dc.contributor.author","McWeeney, Shannon"],["dc.contributor.author","Aladjem, Mirit"],["dc.contributor.author","Birney, Ewan"],["dc.contributor.author","Collado-Vides, Julio"],["dc.contributor.author","Goto, Susumu"],["dc.contributor.author","Hucka, Michael"],["dc.contributor.author","Novère, Nicolas Le"],["dc.contributor.author","Maltsev, Natalia"],["dc.contributor.author","Pandey, Akhilesh"],["dc.contributor.author","Thomas, Paul"],["dc.contributor.author","Wingender, Edgar"],["dc.contributor.author","Karp, Peter D."],["dc.contributor.author","Sander, Chris"],["dc.contributor.author","Bader, Gary D."],["dc.date.accessioned","2019-07-09T11:52:52Z"],["dc.date.available","2019-07-09T11:52:52Z"],["dc.date.issued","2010"],["dc.description.abstract","Biological Pathway Exchange (BioPAX) is a standard language to represent biological pathways at the molecular and cellular level and to facilitate the exchange of pathway data. The rapid growth of the volume of pathway data has spurred the development of databases and computational tools to aid interpretation; however, use of these data is hampered by the current fragmentation of pathway information across many databases with incompatible formats. BioPAX, which was created through a community process, solves this problem by making pathway data substantially easier to collect, index, interpret and share. BioPAX can represent metabolic and signaling pathways, molecular and genetic interactions and gene regulation networks. Using BioPAX, millions of interactions, organized into thousands of pathways, from many organisms are available from a growing number of databases. This large amount of pathway data in a computable form will support visualization, analysis and biological discovery."],["dc.identifier.doi","10.1038/nbt.1666"],["dc.identifier.fs","574085"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6096"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60297"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","The BioPAX community standard for pathway data sharing"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2024"],["dc.bibliographiccitation.issue","19"],["dc.bibliographiccitation.journal","The New England Journal of Medicine"],["dc.bibliographiccitation.lastpage","2029"],["dc.bibliographiccitation.volume","358"],["dc.contributor.author","Wilde, Arthur A. M."],["dc.contributor.author","Bhuiyan, Zahurul A."],["dc.contributor.author","Crotti, Lia"],["dc.contributor.author","Facchini, Mario"],["dc.contributor.author","De Ferrari, Gaetano M."],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Ferrandi, Chiara"],["dc.contributor.author","Koolbergen, Dave R."],["dc.contributor.author","Odero, Attilio"],["dc.contributor.author","Schwartz, Peter J."],["dc.date.accessioned","2019-07-10T08:13:34Z"],["dc.date.available","2019-07-10T08:13:34Z"],["dc.date.issued","2008"],["dc.description.abstract","Catecholaminergic polymorphic ventricular tachycardia is a potentially lethal disease characterized by adrenergically mediated ventricular arrhythmias manifested especially in children and teenagers. Beta-blockers are the cornerstone of therapy, but some patients do not have a complete response to this therapy and receive an implantable cardioverter–defibrillator (ICD). Given the nature of catecholaminergic polymorphic ventricular tachycardia, ICD shocks may trigger new arrhythmias, leading to the administration of multiple shocks. We describe the long-term efficacy of surgical left cardiac sympathetic denervation in three young adults with catecholaminergic polymorphic ventricular tachycardia, all of whom had symptoms before the procedure and were symptom-free afterward."],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6218"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61276"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.rights","Goescholar"],["dc.rights.access","openAccess"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject","Cardiac Sympathetic Denervation"],["dc.subject.ddc","610"],["dc.title","Left Cardiac Sympathetic Denervation for Catecholaminergic Polymorphic Ventricular Tachycardia"],["dc.title.alternative","Catecholaminergic polymorphic ventricular tachycardia is a potentially lethal disease characterized by adrenergically mediated ventricular arrhythmias manifested especially in children and teenagers. Beta-blockers are the cornerstone of therapy, but some patients do not have a complete response to this therapy and receive an implantable cardioverter–defibrillator (ICD). Given the nature of catecholaminergic polymorphic ventricular tachycardia, ICD shocks may trigger new arrhythmias, leading to the administration of multiple shocks. We describe the long-term efficacy of surgical left cardiac sympathetic denervation in three young adults with catecholaminergic polymorphic ventricular tachycardia, all of whom had symptoms before the procedure and were symptom-free afterward."],["dc.title.subtitle","Catecholaminergic polymorphic ventricular tachycardia is a potentially lethal disease characterized by adrenergically mediated ventricular arrhythmias manifested especially in children and teenagers. Beta-blockers are the cornerstone of therapy, but some patients do not have a complete response to this therapy and receive an implantable cardioverter–defibrillator (ICD). Given the nature of catecholaminergic polymorphic ventricular tachycardia, ICD shocks may trigger new arrhythmias, leading to the administration of multiple shocks. We describe the long-term efficacy of surgical left cardiac sympathetic denervation in three young adults with catecholaminergic polymorphic ventricular tachycardia, all of whom had symptoms before the procedure and were symptom-free afterward."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]