Rüther, Eckart

[["dc.bibliographiccitation.firstpage","547"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Alzheimer s Disease"],["dc.bibliographiccitation.lastpage","560"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Koppara, Alexander"],["dc.contributor.author","Wolfsgruber, Steffen"],["dc.contributor.author","Kleineidam, Luca"],["dc.contributor.author","Schmidtke, Klaus"],["dc.contributor.author","Froelich, Lutz"],["dc.contributor.author","Kurz, Alexander"],["dc.contributor.author","Schulz, Stefanie"],["dc.contributor.author","Hampel, Harald"],["dc.contributor.author","Heuser, Isabella"],["dc.contributor.author","Peters, Oliver"],["dc.contributor.author","Reischies, Friedel M."],["dc.contributor.author","Jahn, Holger"],["dc.contributor.author","Luckhaus, Christian"],["dc.contributor.author","Huell, Michael"],["dc.contributor.author","Gertz, Hermann-Josef"],["dc.contributor.author","Schroeder, Johannes"],["dc.contributor.author","Pantel, Johannes"],["dc.contributor.author","Rienhoff, Otto"],["dc.contributor.author","Ruether, Eckart"],["dc.contributor.author","Henn, Fritz A."],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Maier, Wolfgang"],["dc.contributor.author","Jessen, Frank"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Wagner, Michael"],["dc.date.accessioned","2018-11-07T10:21:47Z"],["dc.date.available","2018-11-07T10:21:47Z"],["dc.date.issued","2016"],["dc.description.abstract","Background: The recently proposed latent variable delta is a new tool for dementia case finding. It is built in a structural equation modeling framework of cognitive and functional data and constitutes a novel endophenotype for Alzheimer's disease (AD) research and clinical trials. Objective: To investigate the association of delta with AD biomarkers and to compare the prediction of d with established scales for conversion to dementia in patients with mild cognitive impairment (MCI). Methods: Using data from a multicenter memory clinic study, we examined the external associations of the latent variable delta and compared delta with well-established cognitive and functional scales and cognitive-functional composite scores. For that purpose, logistic regressions with cerebrospinal fluid (CSF) biomarkers and conversion to dementia as dependent variables were performed with the investigated scores. The models were tested for significant differences. Results: In patients with MCI, delta based on a broad range of cognitive scales (including the ADAS-cog, the MMSE, and the CERAD neuropsychological battery) predicted an abnormal CSF A beta(42)/tau ratio indicative of AD (n = 340, AUC = 0.78, p < 0.001), and predicted incident dementia within 1-3 years of follow-up (n = 525, AUC= 0.84, p < 0.001). These associations were generally stronger than for any other scale or cognitive-functional composite examined. Homologs of d based on reduced test batteries yielded somewhat lower effects. Conclusion: These findings support the interpretation of d as a construct capturing the disease-related \"essence\" of cognitive and functional impairments in patients with MCI and dementia, and suggest that d might become an analytical tool for dementia research."],["dc.identifier.doi","10.3233/JAD-150257"],["dc.identifier.isi","000365710600024"],["dc.identifier.pmid","26484902"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42156"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Ios Press"],["dc.relation.issn","1875-8908"],["dc.relation.issn","1387-2877"],["dc.title","The Latent Dementia Phenotype delta is Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Predicts Conversion to Dementia in Subjects with Mild Cognitive Impairment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","297"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Psychiatry Research"],["dc.bibliographiccitation.lastpage","305"],["dc.bibliographiccitation.volume","158"],["dc.contributor.author","Jaeger, Markus"],["dc.contributor.author","Riedel, Michael"],["dc.contributor.author","Schmauss, Max"],["dc.contributor.author","Pfeiffer, Herbert"],["dc.contributor.author","Laux, Gerd"],["dc.contributor.author","Naber, Dieter"],["dc.contributor.author","Gaebel, Wolfgang"],["dc.contributor.author","Huff, Wolfgang"],["dc.contributor.author","Schmidt, Lutz G."],["dc.contributor.author","Heuser, Isabella"],["dc.contributor.author","Buchkremer, Gerhard"],["dc.contributor.author","Kuehn, Kai-Uwe"],["dc.contributor.author","Ruether, Eckart"],["dc.contributor.author","Hoff, Paul"],["dc.contributor.author","Gastpar, Markus"],["dc.contributor.author","Bottlender, Ronald"],["dc.contributor.author","Strauss, Anton"],["dc.contributor.author","Moeller, Hans-Juergen"],["dc.date.accessioned","2018-11-07T11:16:06Z"],["dc.date.available","2018-11-07T11:16:06Z"],["dc.date.issued","2008"],["dc.description.abstract","The aim of the present study was to examine the relevance of depressive symptoms during an acute schizophrenic episode for the prediction of treatment response. Two hundred inpatients who fulfilled DSM-IV criteria for schizophrenia or schizophreniform disorders were assessed at hospital admission and after 6 weeks of inpatient treatment using the Positive and Negative Syndrome Scale (PANSS) and the Hamilton Rating Scale for Depression (HAM-D). Depressive symptoms showed positive correlations with both positive and negative symptoms at admission and after 6 weeks, and decreased during 6 weeks of treatment. Pronounced depressive symptoms (HAM-D scored >= 16) were found in 28% of the sample at admission and in 9% after 6 weeks of treatment. Depressive symptoms at admission predicted a greater improvement of positive and negative symptoms over 6 weeks of treatment, but also more, rather than fewer remaining symptoms after 6 weeks. Both results, however, lost statistical significance when analyses were controlled for the influence of positive and negative symptoms at admission. Therefore, the hypothesis that depressive symptoms are predictive of a favorable treatment response was not supported by the present study. (C) 2007 Elsevier Ireland Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.psychres.2007.01.002"],["dc.identifier.isi","000255379000004"],["dc.identifier.pmid","18280582"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54516"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Ireland Ltd"],["dc.relation.issn","0165-1781"],["dc.title","Depression during an acute episode of schizophrenia or schizophreniform disorder and its impact on treatment response"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1639"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Journal of Psychiatric Research"],["dc.bibliographiccitation.lastpage","1647"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Schennach-Wolff, Rebecca"],["dc.contributor.author","Meyer, Sebastian T."],["dc.contributor.author","Seemueller, Florian"],["dc.contributor.author","Jaeger, Markus"],["dc.contributor.author","Schmauss, Max"],["dc.contributor.author","Laux, Gerd"],["dc.contributor.author","Pfeiffer, Herbert"],["dc.contributor.author","Naber, Dieter"],["dc.contributor.author","Schmidt, Lutz G."],["dc.contributor.author","Gaebel, Wolfgang"],["dc.contributor.author","Klosterkoetter, Joachim"],["dc.contributor.author","Heuser, Isabella"],["dc.contributor.author","Maier, Wolfgang"],["dc.contributor.author","Lemke, Matthias R."],["dc.contributor.author","Ruether, Eckart"],["dc.contributor.author","Klingberg, Stefan"],["dc.contributor.author","Gastpar, Markus"],["dc.contributor.author","Moeller, Hans-Juergen"],["dc.contributor.author","Riedel, Michael"],["dc.date.accessioned","2018-11-07T08:49:12Z"],["dc.date.available","2018-11-07T08:49:12Z"],["dc.date.issued","2011"],["dc.description.abstract","Background: To examine the influencing factors and predictors of early improvement in schizophrenia patients. Methods: 370 patients suffering from a schizophrenia spectrum disorder were examined within a naturalistic multicenter study. Early improvement was defined as a >= 30% PANSS total score reduction within the first two treatment weeks, response as a >= 50% improvement of the PANSS total score from admission to discharge and remission according to the consensus, remission criteria. Baseline and course-related variables such as positive, negative and depressive symptoms, side effects, functioning and subjective well-being were examined regarding their explanatory value for early improvement. Results: 46% of the patients were identified to be early improvers. Of these, 77% became treatment responder at discharge and 74% achieved the consensus remission criteria. Amongst others, early improvers were significantly more often first-episode patients (p = 0.009), with a significantly shorter duration of current episode (p = 0.024) and a shorter duration of the illness (p = 0.0094). A higher PANSS positive subscore (p = 0.0089), a higher score in the Strauss-Carpenter-Prognostic Scale (SCPS) (p < 0.0001), less extrapyramidal side effects (p = 0.0004) at admission and the development of less extrapyramidal side effects within the first two treatment weeks (p = 0.0013) as well as a duration of current episode of <= 6 months (p = 0.0373) were identified to be significant predictors of early improvement. Conclusion: Early improvement is associated with less illness chronicity and seems to be independent of the type of antipsychotic and the antipsychotic dosage applied. The SCPS was found to be a valuable tool to detect early improvers already at the initiation of antipsychotic treatment. (C) 2011 Elsevier Ltd. All rights reserved."],["dc.description.sponsorship","German Federal Ministry for Education and Research BMBF [01 GI 0233]"],["dc.identifier.doi","10.1016/j.jpsychires.2011.07.014"],["dc.identifier.isi","000297893900015"],["dc.identifier.pmid","21862035"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21404"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","0022-3956"],["dc.title","Influencing factors and predictors of early improvement in the acute treatment of schizophrenia and schizophrenia spectrum disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","426"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The World Journal of Biological Psychiatry"],["dc.bibliographiccitation.lastpage","434"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Jaeger, Markus"],["dc.contributor.author","Riedel, Michael"],["dc.contributor.author","Schmauss, Max"],["dc.contributor.author","Laux, Gerd"],["dc.contributor.author","Pfeiffer, Herbert"],["dc.contributor.author","Naber, Dieter"],["dc.contributor.author","Schmidt, Lutz G."],["dc.contributor.author","Gaebel, Wolfgang"],["dc.contributor.author","Klosterkoetter, Joachim"],["dc.contributor.author","Heuser, Isabella"],["dc.contributor.author","Kuehn, Kai-Uwe"],["dc.contributor.author","Lemke, Matthias R."],["dc.contributor.author","Ruether, Eckart"],["dc.contributor.author","Buchkremer, Gerd"],["dc.contributor.author","Gastpar, Markus"],["dc.contributor.author","Bottlender, Ronald"],["dc.contributor.author","Strauss, Anton"],["dc.contributor.author","Moeller, Hans-Juergen"],["dc.date.accessioned","2018-11-07T08:35:37Z"],["dc.date.available","2018-11-07T08:35:37Z"],["dc.date.issued","2009"],["dc.description.abstract","Objective: Standardized consensus criteria for remission in schizophrenia were recently proposed. The present study applied the symptom-severity component of these criteria to a sample of inpatients in order to determine the rates of remission during inpatient treatment and to explore predictors of remission. Method: A total of 288 inpatients from a multi-centre follow-up programme who fulfilled ICD-10 criteria for schizophrenia were included in the present analyses. PANSS ratings at admission and at discharge from hospitalization were used to examine remission status. Clinical and sociodemographic variables at admission were tested for their ability to predict remission at discharge. Results: In total, 55% of the sample achieved symptom remission during inpatient treatment; 84% percent showed remission with respect to 'reality distortion', 85% with respect to 'disorganization' and only 65% with respect to 'negative symptoms'. Logistic regression analysis revealed that the global functioning (GAF) in the year before admission, the total score of the Strauss-Carpenter Prognostic Scale and the PANSS negative subscore at admission were predictive for symptom remission. The regression model showed a predictive value of about 70% and explained 36% of the observed variance. Conclusion: The results highlight the impact of negative symptoms for the course and treatment response of schizophrenic illness."],["dc.identifier.doi","10.1080/15622970701541054"],["dc.identifier.isi","000273003200011"],["dc.identifier.pmid","17853260"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18112"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1562-2975"],["dc.title","Prediction of symptom remission in schizophrenia during inpatient treatment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","438"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz"],["dc.bibliographiccitation.lastpage","443"],["dc.bibliographiccitation.volume","59"],["dc.contributor.author","Peters, Oliver"],["dc.contributor.author","Heuser, Isabella"],["dc.contributor.author","Frölich, Lutz"],["dc.contributor.author","Rüther, Eckart"],["dc.contributor.author","Rienhoff, Otto"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Maier, Wolfgang"],["dc.date.accessioned","2017-09-07T11:45:23Z"],["dc.date.available","2017-09-07T11:45:23Z"],["dc.date.issued","2016"],["dc.description.abstract","Hintergrund: Das Kompetenznetz Demenzen (KND) ist ein akademischer Verbund mehrheitlich psychiatrischer Gedächtnissprechstunden und verfolgt drei Ziele: (1) Die Weiterentwicklung der Demenzdiagnostik einschließlich Neuropsychologie, Biomarker, Bildgebung und Genetik. (2) Die Durchführung von Therapiestudien bei kognitiven Störungen und Demenzen. (3) Die Verbesserung der Versorgung von Demenzerkrankten in Deutschland. Ziel der Arbeit: In diesem Beitrag werden die bisherigen Ergebnisse einzelner Teilprojekte des KND zusammengefasst sowie Ausblicke über die laufende Forschung gegeben. Methoden: Es wurden zwei multizentrische Kohorten aufgebaut. In einer ersten Kohorte wurden Menschen mit einer leichten kognitiven Störung und Menschen mit einer beginnenden Demenz klinisch, neuropsychologisch sowie hinsichtlich verschiedener Biomarker untersucht. Ein Teil dieser Kohorte wurde im Rahmen einer Beobachtungsstudie über Jahre nachverfolgt, ein weiterer Teil im Rahmen von zwei Behandlungsstudien untersucht. In der zweiten Kohorte wurden Menschen ohne Demenz klinisch, neuropsychologisch und genetisch untersucht, und es wurden psychosoziale Faktoren erhoben. In den verschiedenen Teilprojekten des KND werden Daten über Follow-up-Zeiträume bis zu zehn Jahren ausgewertet. Ergebnisse und Diskussion: Das Kompetenznetz Demenzen hat zahlreiche Publikationen zur Diagnostik und Therapie von kognitiven Störungen und Demenzen sowie zur Versorgung von Demenzerkrankten in Deutschland ermöglicht. Der Verbund hat Strukturen sowie eine Daten- und Biomaterialbank geschaffen, die auch weiterhin die Grundlage für nationale und internationale Kooperationen sind. Darüber hinaus hat das KND zur Entstigmatisierung von Demenzerkrankungen beigetragen."],["dc.description.abstract","BACKGROUND: The Dementia Competence Network (DCN) is represented by academic memory clinics and has three major aims: (1) To facilitate the development of diagnostic tools including neuropsychology, biomarkers, imaging and genetics. (2) To implement clinical trials in mild cognitive impairment and dementia and (3) to improve standard care for dementia in Germany. AIMS: This article summarizes the achievements of the DCN so far and highlights future perspectives. METHODS: The DCN has built up two multicentre cohorts. Within the first cohort, patients with mild cognitive impairment or mild dementia were examined longitudinally using multiple neuropsychological assessments and numerous different biomarkers. In a subgroup of the first cohort, patients were treated with antidementive drugs in two placebo-controlled clinical trials. The second cohort included cognitively healthy older people and examined repetitively clinical, neuropsychological and psychosocial parameters for ten years. RESULTS AND DISCUSSION: The DCN has generated a large data and biomaterial bank. Numerous publications have helped to develop further diagnostic procedures and treatment of cognitive disorders and dementia. The DCN has contributed to end stigmatisation of dementia."],["dc.identifier.doi","10.1007/s00103-016-2314-y"],["dc.identifier.gro","3151746"],["dc.identifier.pmid","26979717"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13302"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8569"],["dc.language.iso","de"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","chake"],["dc.relation.issn","1436-9990"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Das Kompetenznetz Demenzen"],["dc.title.subtitle","Erfolge und Ausblicke"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","136"],["dc.bibliographiccitation.issue","04"],["dc.bibliographiccitation.journal","Pharmacopsychiatry"],["dc.bibliographiccitation.lastpage","144"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Schennach, Rebecca"],["dc.contributor.author","Obermeier, Michael"],["dc.contributor.author","Seemüller, Florian"],["dc.contributor.author","Jäger, Markus"],["dc.contributor.author","Schmauss, Max"],["dc.contributor.author","Laux, Gerd"],["dc.contributor.author","Pfeiffer, Herbert"],["dc.contributor.author","Naber, Dieter"],["dc.contributor.author","Schmidt, Lutz"],["dc.contributor.author","Gaebel, Wolfgang"],["dc.contributor.author","Klosterkötter, Joachim"],["dc.contributor.author","Heuser, Isabella"],["dc.contributor.author","Maier, Wolfgang"],["dc.contributor.author","Lemke, Matthias"],["dc.contributor.author","Rüther, Eckart"],["dc.contributor.author","Klingberg, Stefan"],["dc.contributor.author","Gastpar, Markus"],["dc.contributor.author","Spellmann, Ilja"],["dc.contributor.author","Musil, Richard"],["dc.contributor.author","Möller, Hans-Jürgen"],["dc.contributor.author","Riedel, Michael"],["dc.date.accessioned","2020-12-10T18:12:23Z"],["dc.date.available","2020-12-10T18:12:23Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1055/s-0043-106436"],["dc.identifier.eissn","1439-0795"],["dc.identifier.issn","0176-3679"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74355"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Add-on Antidepressants in the Naturalistic Treatment of Schizophrenia Spectrum Disorder – When, Who, and How?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","276"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Psychopathology"],["dc.bibliographiccitation.lastpage","285"],["dc.bibliographiccitation.volume","45"],["dc.contributor.affiliation","Schennach, Rebecca; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Psychiatric Clinic, District Hospital, Augsburg, Psychiatric Clinic, Inn-Salzach Hospital, Wasserburg/Inn, Psychiatric Clinic, Isar-Amper Hospital, Munich-Haar, Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Department of Psychiatry and Psychotherapy, Charite Berlin, Campus Benjamin Franklin, Berlin, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Department of Psychiatry, Alsterdorf Hospital, Hamburg, Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Department of Psychiatry and Psychotherapy, University of Essen, Essen, and Psychiatric Clinic, Vinzenz von Paul Hospital, Rottweil, Germany"],["dc.contributor.affiliation","Obermeier, Michael; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Psychiatric Clinic, District Hospital, Augsburg, Psychiatric Clinic, Inn-Salzach Hospital, Wasserburg/Inn, Psychiatric Clinic, Isar-Amper Hospital, Munich-Haar, Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Department of Psychiatry and Psychotherapy, Charite Berlin, Campus Benjamin Franklin, Berlin, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Department of Psychiatry, Alsterdorf Hospital, Hamburg, Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Department of Psychiatry and Psychotherapy, University of Essen, Essen, and Psychiatric Clinic, Vinzenz von Paul Hospital, Rottweil, Germany"],["dc.contributor.affiliation","Seemüller, Florian; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Psychiatric Clinic, District Hospital, Augsburg, Psychiatric Clinic, Inn-Salzach Hospital, Wasserburg/Inn, Psychiatric Clinic, Isar-Amper Hospital, Munich-Haar, Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Department of Psychiatry and Psychotherapy, Charite Berlin, Campus Benjamin Franklin, Berlin, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Department of Psychiatry, Alsterdorf Hospital, Hamburg, Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Department of Psychiatry and Psychotherapy, University of Essen, Essen, and Psychiatric Clinic, Vinzenz von Paul Hospital, Rottweil, Germany"],["dc.contributor.affiliation","Jäger, Markus; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Psychiatric Clinic, District Hospital, Augsburg, Psychiatric Clinic, Inn-Salzach Hospital, Wasserburg/Inn, Psychiatric Clinic, Isar-Amper Hospital, Munich-Haar, Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Department of Psychiatry and Psychotherapy, Charite Berlin, Campus Benjamin Franklin, Berlin, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Department of Psychiatry, Alsterdorf Hospital, Hamburg, Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Department of Psychiatry and Psychotherapy, University of Essen, Essen, and Psychiatric Clinic, Vinzenz von Paul Hospital, Rottweil, Germany"],["dc.contributor.affiliation","Schmauss, Max; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Psychiatric Clinic, District Hospital, Augsburg, Psychiatric Clinic, Inn-Salzach Hospital, Wasserburg/Inn, Psychiatric Clinic, Isar-Amper Hospital, Munich-Haar, Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Department of Psychiatry and Psychotherapy, Charite Berlin, Campus Benjamin Franklin, Berlin, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Department of Psychiatry, Alsterdorf Hospital, Hamburg, Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Department of Psychiatry and Psychotherapy, University of Essen, Essen, and Psychiatric Clinic, Vinzenz von Paul Hospital, Rottweil, Germany"],["dc.contributor.affiliation","Laux, Gerd; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Psychiatric Clinic, District Hospital, Augsburg, Psychiatric Clinic, Inn-Salzach Hospital, Wasserburg/Inn, Psychiatric Clinic, Isar-Amper Hospital, Munich-Haar, Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Department of Psychiatry and Psychotherapy, Charite Berlin, Campus Benjamin Franklin, Berlin, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Department of Psychiatry, Alsterdorf Hospital, Hamburg, Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Department of Psychiatry and Psychotherapy, University of Essen, Essen, and Psychiatric Clinic, Vinzenz von Paul Hospital, Rottweil, Germany"],["dc.contributor.affiliation","Pfeiffer, Herbert; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Psychiatric Clinic, District Hospital, Augsburg, Psychiatric Clinic, Inn-Salzach Hospital, Wasserburg/Inn, Psychiatric Clinic, Isar-Amper Hospital, Munich-Haar, Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Department of Psychiatry and Psychotherapy, Charite Berlin, Campus Benjamin Franklin, Berlin, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Department of Psychiatry, Alsterdorf Hospital, Hamburg, Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Department of Psychiatry and Psychotherapy, University of Essen, Essen, and Psychiatric Clinic, Vinzenz von Paul Hospital, Rottweil, Germany"],["dc.contributor.affiliation","Naber, Dieter; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Psychiatric Clinic, District Hospital, Augsburg, Psychiatric Clinic, Inn-Salzach Hospital, Wasserburg/Inn, Psychiatric Clinic, Isar-Amper Hospital, Munich-Haar, Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Department of Psychiatry and Psychotherapy, Charite Berlin, Campus Benjamin Franklin, Berlin, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Department of Psychiatry, Alsterdorf Hospital, Hamburg, Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Department of Psychiatry and Psychotherapy, University of Essen, Essen, and Psychiatric Clinic, Vinzenz von Paul Hospital, Rottweil, Germany"],["dc.contributor.affiliation","Schmidt, Lutz G.; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Psychiatric Clinic, District Hospital, Augsburg, Psychiatric Clinic, Inn-Salzach Hospital, Wasserburg/Inn, Psychiatric Clinic, Isar-Amper Hospital, Munich-Haar, Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Department of Psychiatry and Psychotherapy, Charite Berlin, Campus Benjamin Franklin, Berlin, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Department of Psychiatry, Alsterdorf Hospital, Hamburg, Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Department of Psychiatry and Psychotherapy, University of Essen, Essen, and Psychiatric Clinic, Vinzenz von Paul Hospital, Rottweil, Germany"],["dc.contributor.affiliation","Gaebel, Wolfgang; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Psychiatric Clinic, District Hospital, Augsburg, Psychiatric Clinic, Inn-Salzach Hospital, Wasserburg/Inn, Psychiatric Clinic, Isar-Amper Hospital, Munich-Haar, Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Department of Psychiatry and Psychotherapy, Charite Berlin, Campus Benjamin Franklin, Berlin, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Department of Psychiatry, Alsterdorf Hospital, Hamburg, Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Department of Psychiatry and Psychotherapy, University of Essen, Essen, and Psychiatric Clinic, Vinzenz von Paul Hospital, Rottweil, Germany"],["dc.contributor.affiliation","Klosterkötter, Joachim; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Psychiatric Clinic, District Hospital, Augsburg, Psychiatric Clinic, Inn-Salzach Hospital, Wasserburg/Inn, Psychiatric Clinic, Isar-Amper Hospital, Munich-Haar, Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Department of Psychiatry and Psychotherapy, Charite Berlin, Campus Benjamin Franklin, Berlin, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Department of Psychiatry, Alsterdorf Hospital, Hamburg, Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Department of Psychiatry and Psychotherapy, University of Essen, Essen, and Psychiatric Clinic, Vinzenz von Paul Hospital, Rottweil, Germany"],["dc.contributor.affiliation","Heuser, Isabella; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Psychiatric Clinic, District Hospital, Augsburg, Psychiatric Clinic, Inn-Salzach Hospital, Wasserburg/Inn, Psychiatric Clinic, Isar-Amper Hospital, Munich-Haar, Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Department of Psychiatry and Psychotherapy, Charite Berlin, Campus Benjamin Franklin, Berlin, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Department of Psychiatry, Alsterdorf Hospital, Hamburg, Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Department of Psychiatry and Psychotherapy, University of Essen, Essen, and Psychiatric Clinic, Vinzenz von Paul Hospital, Rottweil, Germany"],["dc.contributor.affiliation","Maier, Wolfgang; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Psychiatric Clinic, District Hospital, Augsburg, Psychiatric Clinic, Inn-Salzach Hospital, Wasserburg/Inn, Psychiatric Clinic, Isar-Amper Hospital, Munich-Haar, Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Department of Psychiatry and Psychotherapy, Charite Berlin, Campus Benjamin Franklin, Berlin, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Department of Psychiatry, Alsterdorf Hospital, Hamburg, Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Department of Psychiatry and Psychotherapy, University of Essen, Essen, and Psychiatric Clinic, Vinzenz von Paul Hospital, Rottweil, Germany"],["dc.contributor.affiliation","Lemke, Matthias R.; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Psychiatric Clinic, District Hospital, Augsburg, Psychiatric Clinic, Inn-Salzach Hospital, Wasserburg/Inn, Psychiatric Clinic, Isar-Amper Hospital, Munich-Haar, Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Department of Psychiatry and Psychotherapy, Charite Berlin, Campus Benjamin Franklin, Berlin, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Department of Psychiatry, Alsterdorf Hospital, Hamburg, Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Department of Psychiatry and Psychotherapy, University of Essen, Essen, and Psychiatric Clinic, Vinzenz von Paul Hospital, Rottweil, Germany"],["dc.contributor.affiliation","Rüther, Eckart; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Psychiatric Clinic, District Hospital, Augsburg, Psychiatric Clinic, Inn-Salzach Hospital, Wasserburg/Inn, Psychiatric Clinic, Isar-Amper Hospital, Munich-Haar, Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Department of Psychiatry and Psychotherapy, Charite Berlin, Campus Benjamin Franklin, Berlin, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Department of Psychiatry, Alsterdorf Hospital, Hamburg, Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Department of Psychiatry and Psychotherapy, University of Essen, Essen, and Psychiatric Clinic, Vinzenz von Paul Hospital, Rottweil, Germany"],["dc.contributor.affiliation","Klingberg, Stefan; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Psychiatric Clinic, District Hospital, Augsburg, Psychiatric Clinic, Inn-Salzach Hospital, Wasserburg/Inn, Psychiatric Clinic, Isar-Amper Hospital, Munich-Haar, Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Department of Psychiatry and Psychotherapy, Charite Berlin, Campus Benjamin Franklin, Berlin, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Department of Psychiatry, Alsterdorf Hospital, Hamburg, Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Department of Psychiatry and Psychotherapy, University of Essen, Essen, and Psychiatric Clinic, Vinzenz von Paul Hospital, Rottweil, Germany"],["dc.contributor.affiliation","Gastpar, Markus; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Psychiatric Clinic, District Hospital, Augsburg, Psychiatric Clinic, Inn-Salzach Hospital, Wasserburg/Inn, Psychiatric Clinic, Isar-Amper Hospital, Munich-Haar, Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Department of Psychiatry and Psychotherapy, Charite Berlin, Campus Benjamin Franklin, Berlin, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Department of Psychiatry, Alsterdorf Hospital, Hamburg, Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Department of Psychiatry and Psychotherapy, University of Essen, Essen, and Psychiatric Clinic, Vinzenz von Paul Hospital, Rottweil, Germany"],["dc.contributor.affiliation","Riedel, Michael; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Psychiatric Clinic, District Hospital, Augsburg, Psychiatric Clinic, Inn-Salzach Hospital, Wasserburg/Inn, Psychiatric Clinic, Isar-Amper Hospital, Munich-Haar, Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Department of Psychiatry and Psychotherapy, Charite Berlin, Campus Benjamin Franklin, Berlin, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Department of Psychiatry, Alsterdorf Hospital, Hamburg, Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Department of Psychiatry and Psychotherapy, University of Essen, Essen, and Psychiatric Clinic, Vinzenz von Paul Hospital, Rottweil, Germany"],["dc.contributor.affiliation","Möller, Hans-Jürgen; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Psychiatric Clinic, District Hospital, Augsburg, Psychiatric Clinic, Inn-Salzach Hospital, Wasserburg/Inn, Psychiatric Clinic, Isar-Amper Hospital, Munich-Haar, Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Department of Psychiatry and Psychotherapy, Charite Berlin, Campus Benjamin Franklin, Berlin, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Department of Psychiatry, Alsterdorf Hospital, Hamburg, Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Department of Psychiatry and Psychotherapy, University of Essen, Essen, and Psychiatric Clinic, Vinzenz von Paul Hospital, Rottweil, Germany"],["dc.contributor.author","Schennach, Rebecca"],["dc.contributor.author","Obermeier, Michael"],["dc.contributor.author","Schmauss, Max"],["dc.contributor.author","Pfeiffer, Herbert"],["dc.contributor.author","Naber, Dieter"],["dc.contributor.author","Schmidt, Lutz G."],["dc.contributor.author","Gaebel, Wolfgang"],["dc.contributor.author","Heuser, Isabella"],["dc.contributor.author","Maier, Wolfgang"],["dc.contributor.author","Lemke, Matthias R."],["dc.contributor.author","Klingberg, Stefan"],["dc.contributor.author","Gastpar, Markus"],["dc.contributor.author","Riedel, Michael"],["dc.contributor.author","Seemüller, Florian"],["dc.contributor.author","Jäger, Markus"],["dc.contributor.author","Laux, Gerd"],["dc.contributor.author","Klosterkötter, Joachim"],["dc.contributor.author","Rüther, Eckart"],["dc.contributor.author","Möller, Hans-Jürgen"],["dc.date.accessioned","2018-11-07T09:15:00Z"],["dc.date.available","2018-11-07T09:15:00Z"],["dc.date.issued","2012"],["dc.date.updated","2022-02-09T13:23:12Z"],["dc.description.abstract","Background: The aim of this study was to compare two measures of depression in patients with schizophrenia and schizophrenia spectrum disorder, including patients with delusional and schizoaffective disorder, to conclude implications for their application. Sampling and Methods: A total of 278 patients were assessed using the Calgary Depression Scale for Schizophrenia (CDSS) and the Hamilton Depression Rating Scale (HAMD-17). The Positive and Negative Syndrome Scale (PANSS) was also applied. At admission and discharge, a principal component analysis was performed with each depression scale. The two depression rating scales were furthermore compared using correlation and regression analyses. Results: Three factors were revealed for the CDSS and HAMD-17 factor component analysis. A very similar item loading was found for the CDSS at admission and discharge, whereas results of the loadings of the HAMD-17 items were less stable. The first two factors of the CDSS revealed correlations with positive, negative and general psychopathology. In contrast, multiple significant correlations were found for the HAMD-17 factors and the PANSS sub-scores. Multiple regression analyses demonstrated that the HAMD-17 accounted more for the positive and negative symptom domains than the CDSS. Conclusions:The present results suggest that compared to the HAMD-17, the CDSS is a more specific instrument to measure depressive symptoms in schizophrenia and schizophrenia spectrum disorder, especially in acutely ill patients. Copyright (c) 2012 S. Karger AG, Basel"],["dc.description.sponsorship","German Federal Ministry for Education and Research [01 GI 0233]"],["dc.identifier","22796716"],["dc.identifier.doi","10.1159/000336729"],["dc.identifier.eissn","1423-033X"],["dc.identifier.isi","000307992300002"],["dc.identifier.issn","0254-4962"],["dc.identifier.pmid","22796716"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9082"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27565"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","S. Karger AG"],["dc.relation.eissn","1423-033X"],["dc.relation.issn","0254-4962"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Evaluating Depressive Symptoms in Schizophrenia: A Psychometric Comparison of the Calgary Depression Scale for Schizophrenia and the Hamilton Depression Rating Scale"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","47"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","European Archives of Psychiatry and Clinical Neuroscience"],["dc.bibliographiccitation.lastpage","53"],["dc.bibliographiccitation.volume","257"],["dc.contributor.author","Jaeger, Markus"],["dc.contributor.author","Riedel, Michael"],["dc.contributor.author","Messer, Thomas"],["dc.contributor.author","Laux, Gerd"],["dc.contributor.author","Pfeiffer, Herbert"],["dc.contributor.author","Naber, Dieter"],["dc.contributor.author","Schmidt, Lutz G."],["dc.contributor.author","Gaebel, Wolfgang"],["dc.contributor.author","Huff, Wolfgang"],["dc.contributor.author","Heuser, Isabella"],["dc.contributor.author","Kuehn, Kai-Uwe"],["dc.contributor.author","Lemke, Matthias R."],["dc.contributor.author","Ruether, Eckart"],["dc.contributor.author","Buchkremer, Gerhard"],["dc.contributor.author","Gastpar, Markus"],["dc.contributor.author","Bottlender, Ronald"],["dc.contributor.author","Strauss, Anton"],["dc.contributor.author","Moeller, Hans-Juergen"],["dc.date.accessioned","2018-11-07T11:05:12Z"],["dc.date.available","2018-11-07T11:05:12Z"],["dc.date.issued","2007"],["dc.description.abstract","Objective The aim was to investigate the hypothesis that patients with first episode schizophrenic disorders have a more favorable treatment response than those with multiple episodes. Method A total of 400 inpatients from an ongoing multi-centre, follow-up program who fulfilled ICD-10 criteria for schizophrenic disorders (F2) were assessed at admission to and discharge from hospital using the Positive and Negative Syndrome Scale (PANSS). Results At admission, first episode patients (n = 121) showed higher levels of positive symptoms (PANSS positive subscore) and lower ones of negative symptoms (PANSS negative subscore) than multiple episode patients (n = 279), whereas the global disease severity (PANSS total score) was comparable. Analyses of covariance revealed that treatment response (adjusted symptom levels at discharge) was more favorable in first-episode patients, with respect to both positive and negative symptoms. Conclusion The results are compatible with the hypothesis that treatment response becomes less favorable during the course of schizophrenic illness. This finding might be associated with progressive neurobiological alterations."],["dc.identifier.doi","10.1007/s00406-006-0683-1"],["dc.identifier.isi","000244294500008"],["dc.identifier.pmid","17033915"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11174"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52014"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.relation.issn","0940-1334"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Psychopathological characteristics and treatment response of first episode compared with multiple episode schizophrenic disorders"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S269"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Alzheimer s & Dementia"],["dc.bibliographiccitation.lastpage","S276"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Morgen, Katrin"],["dc.contributor.author","Ramirez, Alfredo"],["dc.contributor.author","Froelich, Lutz"],["dc.contributor.author","Tost, Heike"],["dc.contributor.author","Plichta, Michael M."],["dc.contributor.author","Koelsch, Heike"],["dc.contributor.author","Rakebrandt, Fabian"],["dc.contributor.author","Rienhoff, Otto"],["dc.contributor.author","Jessen, Frank"],["dc.contributor.author","Peters, Oliver"],["dc.contributor.author","Jahn, Holger"],["dc.contributor.author","Luckhaus, Christian"],["dc.contributor.author","Huell, Michael"],["dc.contributor.author","Gertz, Hermann-Josef"],["dc.contributor.author","Schroeder, Johannes"],["dc.contributor.author","Hampel, Harald"],["dc.contributor.author","Teipel, Stefan J."],["dc.contributor.author","Pantel, Johannes"],["dc.contributor.author","Heuser, Isabella"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Ruether, Eckart"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Maier, Wolfgang"],["dc.contributor.author","Meyer-Lindenberg, Andreas"],["dc.date.accessioned","2018-11-07T09:34:54Z"],["dc.date.available","2018-11-07T09:34:54Z"],["dc.date.issued","2014"],["dc.description.abstract","Background: Evidence has emerged indicating that the epsilon 4 allele of APOE and PICALM interact in conferring risk of Alzheimer's disease (AD). The biologic basis of this interaction is unclear, but it is likely to have phenotypic relevance and contribute to the structural and clinical heterogeneity of AD. Methods: The aim of this study was to investigate interaction effects of the APOE epsilon 4 allele and the alleles at the single-nucleotide polymorphism rs3851179 located in the PICALM locus. We analyzed brain volumes and cognitive phenotypes of 165 patients with early AD dementia. Results: There was a synergistic adverse effect of homozygosity for the PICALM risk allele G in rs3851179 and APOE epsilon 4 on volume in prefrontal and performance on the Trail Making Test A, which is sensitive to processing speed and working memory function. Conclusions: The data suggest a neural mechanism for APOE-PICALM interactions in patients with manifest AD and indicate that the PICALM genotype modulates both brain atrophy and cognitive performance in APOE epsilon 4 carriers. (C) 2014 The Alzheimer's Association. All rights reserved."],["dc.identifier.doi","10.1016/j.jalz.2013.11.001"],["dc.identifier.isi","000366828100002"],["dc.identifier.pmid","24613704"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32279"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1552-5279"],["dc.relation.issn","1552-5260"],["dc.title","Genetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in Alzheimer's disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","107"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Archives of Psychiatry and Clinical Neuroscience"],["dc.bibliographiccitation.lastpage","116"],["dc.bibliographiccitation.volume","265"],["dc.contributor.author","Schennach, Rebecca"],["dc.contributor.author","Riedel, Michael"],["dc.contributor.author","Obermeier, Michael"],["dc.contributor.author","Spellmann, Ilja"],["dc.contributor.author","Musil, Richard"],["dc.contributor.author","Jaeger, Markus"],["dc.contributor.author","Schmauss, Max"],["dc.contributor.author","Laux, Gerd"],["dc.contributor.author","Pfeiffer, Herbert"],["dc.contributor.author","Naber, Dieter"],["dc.contributor.author","Schmidt, Lutz G."],["dc.contributor.author","Gaebel, Wolfgang"],["dc.contributor.author","Klosterkoetter, Joachim"],["dc.contributor.author","Heuser, Isabella"],["dc.contributor.author","Maier, Wolfgang"],["dc.contributor.author","Lemke, Matthias R."],["dc.contributor.author","Ruether, Eckart"],["dc.contributor.author","Klingberg, Stefan"],["dc.contributor.author","Gastpar, Markus"],["dc.contributor.author","Moeller, Hans-Juergen"],["dc.date.accessioned","2018-11-07T10:00:30Z"],["dc.date.available","2018-11-07T10:00:30Z"],["dc.date.issued","2015"],["dc.description.abstract","The aim of this study was to evaluate residual symptoms in patients achieving remission according to the consensus criteria and to analyze their potential influence on the patient's outcome one year after discharge. In total, 399 patients suffering from a schizophrenia spectrum disorder were evaluated within a naturalistic study. Remission status was examined using the consensus criteria. Residual symptoms were defined as any symptom present at the time-point of remission following analogous analyses performed in depressed patients. Therefore, a PANSS item with a symptom severity of > 1 (= at least borderline mentally ill) was defined to be a residual symptom. Remitters with and without residual symptoms were compared regarding psychopathology, functioning and side effects. In total, 236 patients (59 %) were remitters at discharge with 94 % of them suffering from at least one residual symptom. The most common residual symptoms were blunted affect (49 %), conceptual disorganization (42 %) and social withdrawal (40 %). A significant association was found between the presence of residual symptoms and the severity of side effects (p < 0.0001) and functioning (p = 0.0003) at discharge as well as between residual symptoms and the risk of relapse and chance of remission one year after discharge. Residual symptoms were highly prevalent in remitted schizophrenia inpatients following the suggested definition. Most residual symptoms were persistent baseline symptoms suggesting an ongoing illness severity. Also, the necessity to re-evaluate the consensus criteria questioning the status of remission in these patients is also pointed out."],["dc.description.sponsorship","German Federal Ministry for Education and research BMBF [01 GI 0233]"],["dc.identifier.doi","10.1007/s00406-014-0528-2"],["dc.identifier.isi","000350305500003"],["dc.identifier.pmid","25261210"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37822"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1433-8491"],["dc.relation.issn","0940-1334"],["dc.title","What are residual symptoms in schizophrenia spectrum disorder? Clinical description and 1-year persistence within a naturalistic trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]