Hünlich, Mark

[["dc.bibliographiccitation.firstpage","286"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","EuroIntervention"],["dc.bibliographiccitation.lastpage","293"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Puls, Miriam"],["dc.contributor.author","Korte, Kerstin Pia"],["dc.contributor.author","Bleckmann, Annalen"],["dc.contributor.author","Huenlich, Mark"],["dc.contributor.author","Danner, Bernhard"],["dc.contributor.author","Schoendube, Friedrich"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Jacobshagen, Claudius"],["dc.contributor.author","Schillinger, Wolfgang"],["dc.date.accessioned","2021-06-01T10:48:55Z"],["dc.date.available","2021-06-01T10:48:55Z"],["dc.date.issued","2017"],["dc.description.abstract","AIMS: The objective of this study was to examine the impact of guideline-defined subtypes of severe aortic stenosis (AS) on long-term outcomes after TAVI. METHODS AND RESULTS: Four hundred (400) consecutive patients who underwent TAVI (203 transapical, 197 transfemoral) at our institution 8/2008-3/2013 were followed systematically (for up to seven years). One hundred and forty-seven (147) individuals suffered from NEF-HG AS (LV-EF ≥50%, high Pmean ≥40 mmHg), 63 from LEF-HG AS (LV-EF <50%, high gradient), 77 from PLF-LG AS (LV-EF ≥50%, low gradient, stroke volume index [SVI] <35 ml/m²), and 81 from LEF-LG AS (LV-EF <50%, low gradient). LEF-LG status was associated with the highest all-cause and cardiovascular mortality and MACCE rate, whereas NEF-HG patients exhibited the best outcome (i.e., median survival 5.1 years in NEF-HG vs. 1.3 years in LEF-LG, p=0.0006; or vs. 3.3 years in PLF-LG, p=0.02). In multivariate analysis, LEF-LG status emerged as the outcome predictor with the highest hazard ratio for all-cause mortality (HR 2.86, p=0.003), cardiovascular mortality (HR 6.53, p<0.0001), and MACCE (HR 2.44, p=0.007), whereas neither baseline EF nor SVI <35 ml/m² independently predicted these endpoints. CONCLUSIONS: These findings suggest that an assessment of LV-EF alone for outcome prediction after TAVI is inadequate; it is the guideline-defined subtype of AS that determines outcome."],["dc.identifier.doi","10.4244/EIJ-D-16-00801"],["dc.identifier.gro","3142338"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86102"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","final"],["dc.relation.issn","1774-024X"],["dc.title","Long-term outcomes after TAVI in patients with different types of aortic stenosis: the conundrum of low flow, low gradient and low ejection fraction"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","107"],["dc.bibliographiccitation.journal","International Journal of Cardiology"],["dc.bibliographiccitation.lastpage","111"],["dc.bibliographiccitation.volume","220"],["dc.contributor.author","Tichelbäcker, Tobias"],["dc.contributor.author","Puls, Miriam"],["dc.contributor.author","Jacobshagen, Claudius"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Schillinger, Wolfgang"],["dc.contributor.author","Huenlich, Mark"],["dc.contributor.author","Schroeter, Marco Robin"],["dc.date.accessioned","2017-09-07T11:44:37Z"],["dc.date.available","2017-09-07T11:44:37Z"],["dc.date.issued","2016"],["dc.description.abstract","Background: Percutaneous mitral valve repair using MitraClip (R) (MC) is a well-established method for a subset of patients with severe mitral regurgitation (MR) and high risk for surgical intervention. Amplatzer (R) Cardiac Plug (ACP) occludes left atrial appendage and allows the discontinuation of oral anticoagulation and prevention of thromboembolic stroke. Due to the need for femoral and transseptal access in both procedures, a single approach could lead to minor risk of further complications and shorter cumulative intervention time. Methods: We systematically analysed all four patients who underwent a combined procedure with MC and ACP in our heart-centre. All procedures were performed under fluoroscopic as well as echocardiographic guidance, and follow-up controls in a midterm period were carried out. Results: In all patients (2 male/female; age 73-88 years), MC (1-2 Clips) and ACP (size 18-28mm) were successfully implanted in one procedure (mean total time: 114 +/- 17 min). At least moderate MR was achieved and two patients had no complications and therefore were discharged early. In a third patient, a dislocation of ACP occurred 2 h after the implantation. The oldest patient developed a respiratory insufficiency due to cardiac decompensation and further complications. Conclusion: A combination of MC and ACP in a single procedure was feasible in this first case series of patients without a significant extension of procedure time. However, it might be important to select patients carefully. The location of optimal transseptal puncture may be challenging in regard to ACP placement, even in experienced hands and subsequent complications can occur. (C) 2016 Elsevier Ireland Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.ijcard.2016.06.170"],["dc.identifier.gro","3141615"],["dc.identifier.isi","000381582000019"],["dc.identifier.pmid","27389439"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/1456"],["dc.notes.intern","WoS Import 2017-03-10 / Funder: Abbott Vascular; St. Jude Medical"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Elsevier Ireland Ltd"],["dc.relation.eissn","1874-1754"],["dc.relation.issn","0167-5273"],["dc.title","MitraClip (R) and Amplatzer (R) cardiac plug implantation in a single procedure: A reasonable approach?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Seidler, Tim"],["dc.contributor.author","Huenlich, Mark"],["dc.contributor.author","Puls, Miriam"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Jacobshagen, Claudius"],["dc.date.accessioned","2018-11-07T10:10:31Z"],["dc.date.available","2018-11-07T10:10:31Z"],["dc.date.issued","2016"],["dc.format.extent","945"],["dc.identifier.isi","000383869504531"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39871"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.eventlocation","Rome, ITALY"],["dc.relation.issn","1522-9645"],["dc.relation.issn","0195-668X"],["dc.title","Outcome of interventional treatment for access site complications in transfemoral aortic valve implantation"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Der Internist"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Puls, Miriam"],["dc.contributor.author","Sobisiak, Bettina"],["dc.contributor.author","von der Ehe, Katrin"],["dc.contributor.author","Bleckmann, Annalen"],["dc.contributor.author","Huenlich, Mark"],["dc.contributor.author","Jacobshagen, Claudius"],["dc.contributor.author","Schillinger, Wolfgang"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.date.accessioned","2018-11-07T10:15:53Z"],["dc.date.available","2018-11-07T10:15:53Z"],["dc.date.issued","2016"],["dc.format.extent","S14"],["dc.identifier.isi","000375417500022"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40912"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.issn","1432-1289"],["dc.relation.issn","0020-9554"],["dc.title","The demographic Change requires Innovations- Appropriate Patient Selection for catheter supported Heart Valve Interventions in multi morbid Patient Cohort with high Average Age"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Schillinger, Wolfgang"],["dc.contributor.author","Tichelbaecker, Tobias"],["dc.contributor.author","Huenlich, Mark"],["dc.contributor.author","Puls, Miriam"],["dc.contributor.author","Rueter, Karin"],["dc.contributor.author","Seipelt, Ralf G."],["dc.contributor.author","Hasenfuß, Gerd"],["dc.date.accessioned","2018-11-07T09:07:30Z"],["dc.date.available","2018-11-07T09:07:30Z"],["dc.date.issued","2012"],["dc.format.extent","974"],["dc.identifier.isi","000308012407112"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25810"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.eventlocation","Munchen, GERMANY"],["dc.relation.issn","0195-668X"],["dc.title","Determinants for survival and hospitalisation because of congestive heart failure after percutaneous mitral valve repair"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1407"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","EuroIntervention"],["dc.bibliographiccitation.lastpage","1417"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Puls, Miriam"],["dc.contributor.author","Tichelbäcker, Tobias"],["dc.contributor.author","Bleckmann, Annalen"],["dc.contributor.author","Huenlich, Mark"],["dc.contributor.author","von der Ehe, Katrin"],["dc.contributor.author","Beuthner, Bo Eric"],["dc.contributor.author","Rueter, Karin"],["dc.contributor.author","Beißbarth, Tim"],["dc.contributor.author","Seipelt, Ralf"],["dc.contributor.author","Schoendube, Friedrich"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Schillinger, Wolfgang"],["dc.date.accessioned","2017-09-07T11:46:19Z"],["dc.date.available","2017-09-07T11:46:19Z"],["dc.date.issued","2014"],["dc.description.abstract","Aims: MitraClip implantation is evolving as a potential alternative treatment to conventional surgery in high-risk patients with significant mitral regurgitation (MR). However, outcome predictors are under-investigated. The aim of this study was to identify predictors of midterm mortality and heart failure rehospitalisation after percutaneous mitral valve repair with MitraClip. Methods and results: A total of 150 consecutive patients were followed for a median of 463 days. Survival analyses were performed for baseline characteristics, risk scores and failure of acute procedural success (APS) defined as persisting MR grade 3+ or 4+. Univariate significant risk stratifiers were tested in multivariate analyses using a Cox proportional hazards model. Overall survival was 96% at 30 days, 79.5% at 12 months, and 62% at two years. Multivariate analysis identified APS failure (HR 2.13, p=0.02), NYHA Class IV at baseline (HR 2.11, p=0.01) and STS score >= 12 (HR 2.20, p<0.0001) as significant independent predictors of all-cause mortality, and APS failure (HR 2.31, p=0.01) and NYHA Class IV at baseline (HR 1.89, p=0.03) as significant independent predictors of heart failure rehospitalisation. Furthermore, a post-procedural significant decrease in hospitalisation rate could only be observed after successful interventions (0.89 +/- 1.07 per year before vs. 0.54 +/- 0.96 after implantation, p=0.01). Patients with severely dilated and overloaded ventricles who did not meet EVEREST II eligibility criteria were at higher risk of APS failure. Conclusions: The failure of acute procedural success proved to have the most important impact on outcome after MitraClip implantation."],["dc.identifier.doi","10.4244/EIJV9I12A238"],["dc.identifier.gro","3142144"],["dc.identifier.isi","000337011100009"],["dc.identifier.pmid","24972141"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/5033"],["dc.notes.intern","WoS Import 2017-03-10 / Funder: Abbott Vascular"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Europa Edition"],["dc.relation.eissn","1969-6213"],["dc.relation.issn","1774-024X"],["dc.title","Failure of acute procedural success predicts adverse outcome after percutaneous edge-to-edge mitral valve repair with MitraClip"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","7973165"],["dc.bibliographiccitation.journal","BioMed Research International"],["dc.bibliographiccitation.volume","2018"],["dc.contributor.author","Hünlich, Mark"],["dc.contributor.author","Lubos, Edith"],["dc.contributor.author","Beuthner, Bo Eric"],["dc.contributor.author","Puls, Miriam"],["dc.contributor.author","Bleckmann, Annalen"],["dc.contributor.author","Beißbarth, Tim"],["dc.contributor.author","Tichelbäcker, Tobias"],["dc.contributor.author","Rudolph, Volker"],["dc.contributor.author","Baldus, Stephan"],["dc.contributor.author","Schäfer, Ulrich"],["dc.contributor.author","Treede, Hendrik"],["dc.contributor.author","Bardeleben, Ralph Stephan von"],["dc.contributor.author","Blankenberg, Stefan"],["dc.contributor.author","Schillinger, Wolfgang"],["dc.date.accessioned","2020-03-27T08:24:13Z"],["dc.date.available","2020-03-27T08:24:13Z"],["dc.date.issued","2018"],["dc.description.abstract","Positive results of MitraClip in terms of improvement in clinical and left ventricular parameters have been described in detail. However, long-term effects on secondary pulmonary hypertension were not investigated in a larger patient cohort to date. 70 patients with severe mitral regurgitation, additional pulmonary hypertension, and right heart failure as a result of left heart disease were treated in the heart centers Hamburg and Göttingen. Immediately after successful MitraClip implantation, a reduction of the RVOT diameter from 3.52 cm to 3.44 cm was observed reaching a statistically significant value of 3.39 cm after 12 months. In contrast, there was a significant reduction in the velocity of the tricuspid regurgitation (TR) from 4.17 m/s to 3.11 m/s, the gradient of the TR from 48.5 mmHg to 39.3 mmHg, and the systolic pulmonary artery pressure (PAPsyst) from 58.6 mmHg to 50.0 mmHg. This decline continued in the following months (Vmax TR 3.09 m/s, peak TR 38.6 mmHg, and PAPsyst 47.4 mmHg). The tricuspid annular plane systolic excursion (TAPSE) increased from 16.5 mm to 18.9 mm after 12 months. MitraClip implantation improves pulmonary artery pressure, tricuspid regurgitation, and TAPSE after 12 months. At the same time, there is a decrease in the RVOT diameter without significant changes in other right ventricular and right atrial dimensions."],["dc.identifier.doi","10.1155/2018/6817832"],["dc.identifier.pmid","29725600"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/63379"],["dc.language.iso","en"],["dc.relation.eissn","2314-6141"],["dc.relation.issn","2314-6133"],["dc.title","Acute and Long-Term Hemodynamic Effects of MitraClip Implantation on a Preexisting Secondary Right Heart Failure"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","945"],["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.lastpage","946"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Kalbacher, D."],["dc.contributor.author","Tigges, E."],["dc.contributor.author","Puls, Miriam"],["dc.contributor.author","Huenlich, Mark"],["dc.contributor.author","Thomas, Christoph"],["dc.contributor.author","Reichenspurner, Hermann"],["dc.contributor.author","Blankenberg, Stefan"],["dc.contributor.author","Schaefer, U."],["dc.contributor.author","Schillinger, Wolfgang"],["dc.contributor.author","Lubos, Edith"],["dc.date.accessioned","2018-11-07T10:10:30Z"],["dc.date.available","2018-11-07T10:10:30Z"],["dc.date.issued","2016"],["dc.identifier.isi","000383869504532"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39868"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.conference","Congress of the European-Society-of-Cardiology (ESC)"],["dc.relation.eventlocation","Rome, ITALY"],["dc.relation.issn","1522-9645"],["dc.relation.issn","0195-668X"],["dc.title","Impact of acute and chronic renal injury in patients undergoing MitraClip implantation: retrospective data analysis from two German high-volume centers"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Catheterization and Cardiovascular Interventions"],["dc.bibliographiccitation.volume","96"],["dc.contributor.author","Puls, Miriam"],["dc.contributor.author","Huenlich, Mark"],["dc.contributor.author","Boekstegers, Peter"],["dc.contributor.author","Lubos, Edith"],["dc.contributor.author","Bardeleben, Ralph S."],["dc.contributor.author","May, Andreas E."],["dc.contributor.author","Nickenig, Georg"],["dc.contributor.author","Baldus, Stefan"],["dc.contributor.author","Sievert, Horst"],["dc.contributor.author","Ouarrak, Taoufik"],["dc.contributor.author","Senges, Jochen"],["dc.contributor.author","Schillinger, Wolfgang"],["dc.date.accessioned","2020-12-10T14:05:45Z"],["dc.date.available","2020-12-10T14:05:45Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1002/ccd.v96.3"],["dc.identifier.eissn","1522-726X"],["dc.identifier.issn","1522-1946"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/69642"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Implantation of one versus two MitraClips in the German TRAMI registry: Is more always better?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S47"],["dc.bibliographiccitation.journal","Der Internist"],["dc.bibliographiccitation.lastpage","S48"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Beuthner, B."],["dc.contributor.author","Lubos, Edith"],["dc.contributor.author","Bleckmann, Annalen"],["dc.contributor.author","Baldus, S."],["dc.contributor.author","Schaefer, U."],["dc.contributor.author","von Bardeleben, R."],["dc.contributor.author","Schillinger, Wolfgang"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Puls, Miriam"],["dc.contributor.author","Huenlich, Mark"],["dc.date.accessioned","2018-11-07T10:15:49Z"],["dc.date.available","2018-11-07T10:15:49Z"],["dc.date.issued","2016"],["dc.identifier.isi","000375417500092"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40893"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.issn","1432-1289"],["dc.relation.issn","0020-9554"],["dc.title","Acute and long-term hemodynamic Effects of a MitraClip-Implantation on a pre-existing secondary Right Heart Failure"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]