Nitsche, Michael A.

[["dc.bibliographiccitation.firstpage","10701"],["dc.bibliographiccitation.issue","32"],["dc.bibliographiccitation.journal","Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","10709"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Fresnoza, Shane"],["dc.contributor.author","Stiksrud, Elisabeth"],["dc.contributor.author","Klinker, Florian"],["dc.contributor.author","Liebetanz, David"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Kuo, Min-Fang"],["dc.contributor.author","Nitsche, Michael A."],["dc.date.accessioned","2018-11-07T09:36:45Z"],["dc.date.available","2018-11-07T09:36:45Z"],["dc.date.issued","2014"],["dc.description.abstract","The neuromodulator dopamine plays an important role in synaptic plasticity. The effects depend on receptor subtypes, affinity, concentration level, and the kind of neuroplasticity induced. In animal experiments, dopamine D-2-like receptor stimulation revealed partially antagonistic effects on plasticity, which might be explained by dosage dependency. In humans, D-2 receptor block abolishes plasticity, and the D-2/D-3, but predominantly D-3, receptor agonist ropinirol has a dosage-dependent nonlinear affect on plasticity. Here we aimed to determine the specific affect of D-2 receptor activation on neuroplasticity in humans, because physiological effects of D-2 and D-3 receptors might differ. Therefore, we combined application of the selective D-2 receptor agonist bromocriptine (2.5, 10, and 20 mg or placebo medication) with anodal and cathodal transcranial direct current stimulation (tDCS), which induces nonfocal plasticity, and with paired associative stimulation (PAS) generating a more focal kind of plasticity in the motor cortex of healthy humans. Plasticity was monitored by transcranial magnetic stimulation-induced motor-evoked potential amplitudes. For facilitatory tDCS, bromocriptine prevented plasticity induction independent from drug dosage. However, its application resulted in an inverted U-shaped dose-response curve on inhibitory tDCS, excitability-diminishing PAS, and to a minor degree on excitability-enhancing PAS. These data support the assumption that modulation of D-2-like receptor activity exerts a nonlinear dose-dependent effect on neuroplasticity in the human motor cortex that differs from predominantly D-3 receptor activation and that the kind of plasticity-induction procedure is relevant for its specific impact."],["dc.description.sponsorship","German Research Foundation [NI 683/6-1]"],["dc.identifier.doi","10.1523/JNEUROSCI.0832-14.2014"],["dc.identifier.isi","000341017300023"],["dc.identifier.pmid","25100602"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32687"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc Neuroscience"],["dc.relation.issn","0270-6474"],["dc.title","Dosage-Dependent Effect of Dopamine D-2 Receptor Activation on Motor Cortex Plasticity in Humans"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","55"],["dc.bibliographiccitation.journal","Epilepsia"],["dc.bibliographiccitation.lastpage","56"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Klinker, Florian"],["dc.contributor.author","Hering, Diana"],["dc.contributor.author","Koch, R."],["dc.contributor.author","Nitsche, M. A."],["dc.contributor.author","Potschka, Heidrun"],["dc.contributor.author","Loscher, W."],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Tergau, Frithjof"],["dc.contributor.author","Liebetanz, David"],["dc.date.accessioned","2018-11-07T11:06:29Z"],["dc.date.available","2018-11-07T11:06:29Z"],["dc.date.issued","2007"],["dc.identifier.isi","000246578400172"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52321"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.publisher.place","Oxford"],["dc.relation.conference","5th Joint Meeting of the German, Austrian, and Swiss Sections of the International League Against Epilepsy"],["dc.relation.eventlocation","Basle, SWITZERLAND"],["dc.relation.issn","0013-9580"],["dc.title","Anticonvulsive aftereffects of cathodal transcranial direct current stimulation (tDCS) in the rat transcranial ramp model of focal epilepsy"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2220"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Clinical Neurophysiology"],["dc.bibliographiccitation.lastpage","2222"],["dc.bibliographiccitation.volume","114"],["dc.contributor.author","Nitsche, M. A."],["dc.contributor.author","Liebetanz, David"],["dc.contributor.author","Lang, N."],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Tergau, Frithjof"],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T10:34:56Z"],["dc.date.available","2018-11-07T10:34:56Z"],["dc.date.issued","2003"],["dc.identifier.doi","10.1016/S1388-2457(03)00235-9"],["dc.identifier.isi","000186563700026"],["dc.identifier.pmid","14580622"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/44984"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ireland Ltd"],["dc.relation.issn","1388-2457"],["dc.title","Safety criteria for transcranial direct current stimulation (tDCS) in humans"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3109"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Neurophysiology"],["dc.bibliographiccitation.lastpage","3117"],["dc.bibliographiccitation.volume","97"],["dc.contributor.author","Nitsche, M. A."],["dc.contributor.author","Doemkes, S."],["dc.contributor.author","Karakose, T."],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Liebetanz, David"],["dc.contributor.author","Lang, N."],["dc.contributor.author","Tergau, Frithjof"],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T11:03:39Z"],["dc.date.available","2018-11-07T11:03:39Z"],["dc.date.issued","2007"],["dc.description.abstract","Transcranial DC stimulation (tDCS) induces stimulation polarity-dependent neuroplastic excitability shifts in the human brain. Because it accomplishes long-lasting effects and its application is simple, it is used increasingly. However, one drawback is its low focality, caused by 1) the large stimulation electrode and 2) the functionally effective reference electrode, which is also situated on the scalp. We aimed to increase the focality of tDCS, which might improve the interpretation of the functional effects of stimulation because it will restrict its effects to more clearly defined cortical areas. Moreover, it will avoid unwanted reversed effects of tDCS under the reference electrode, which is of special importance in clinical settings, when a homogeneous shift of cortical excitability is needed. Because current density (current strength/electrode size) determines the efficacy of tDCS, increased focality should be accomplished by 1) reducing stimulation electrode size, but keeping current density constant; or 2) increasing reference electrode size under constant current strength. We tested these hypotheses for motor cortex tDCS. The results show that reducing the size of the motor cortex DC-stimulation electrode focalized the respective tDCS-induced excitability changes. Increasing the size of the frontopolar reference electrode rendered stimulation over this cortex functionally inefficient, but did not compromise the tDCS-generated motor cortical excitability shifts. Thus tDCS-generated modulations of cortical excitability can be focused by reducing the size of the stimulation electrode and by increasing the size of the reference electrode. For future applications of tDCS, such paradigms may help to achieve more selective tDCS effects."],["dc.identifier.doi","10.1152/jn.01312.2006"],["dc.identifier.isi","000247929900048"],["dc.identifier.pmid","17251360"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51664"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Physiological Soc"],["dc.relation.issn","0022-3077"],["dc.title","Shaping the effects of transcranial direct current stimulation of the human motor cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1573"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Neuropsychopharmacology"],["dc.bibliographiccitation.lastpage","1578"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Nitsche, M. A."],["dc.contributor.author","Jaussi, W."],["dc.contributor.author","Liebetanz, David"],["dc.contributor.author","Lang, N."],["dc.contributor.author","Tergau, Frithjof"],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T10:46:59Z"],["dc.date.available","2018-11-07T10:46:59Z"],["dc.date.issued","2004"],["dc.description.abstract","D-Cycloserine (CYC), a partial N-methyl-D-aspartate (NMDA) agonist, has been shown to improve cognitive functions in humans. However, the neurophysiological basis of this effect is unclear so far, We studied the impact of this drug on long-lasting after-effects of transcranial direct current (tDCS)-generated motor cortical excitability shifts, as revealed by transcranial magnetic stimulation-elicited motor-evoked potentials. While anodal tDCS enhances motor cortical excitability, cathodal tDCS diminishes it. Both effects seem to be NMDA receptor dependent. D-CYC selectively potentiated the duration of motor cortical excitability enhancements induced by anodal tDCS. D-CYC alone did not modulate excitability. The potency of this drug to consolidate neuronal excitability enhancements, most probably by stabilizing the strengthening of NMDA receptors, which is a probable neurophysiological derivate of learning processes, makes it an interesting substance to improve cognitive functions."],["dc.identifier.doi","10.1038/sj.npp.1300517"],["dc.identifier.isi","000222941200019"],["dc.identifier.pmid","15199378"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47862"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","0893-133X"],["dc.title","Consolidation of human motor cortical neuroplasticity by D-cycloserine"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1141"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Brain Stimulation"],["dc.bibliographiccitation.lastpage","1142"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Jackson, Mark P."],["dc.contributor.author","Bikson, Marom"],["dc.contributor.author","Liebetanz, David"],["dc.contributor.author","Nitsche, Michael"],["dc.date.accessioned","2020-12-10T14:22:47Z"],["dc.date.available","2020-12-10T14:22:47Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1016/j.brs.2017.08.004"],["dc.identifier.issn","1935-861X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71735"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","How to consider animal data in tDCS safety standards"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","462"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Experimental Neurology"],["dc.bibliographiccitation.lastpage","466"],["dc.bibliographiccitation.volume","204"],["dc.contributor.author","Fregni, Felipe"],["dc.contributor.author","Liebetanz, David"],["dc.contributor.author","Monte-Silva, Katia K."],["dc.contributor.author","Oliveira, Manuella B."],["dc.contributor.author","Santos, Angela A."],["dc.contributor.author","Nitsche, Michael A."],["dc.contributor.author","Pascual-Leone, Alvaro"],["dc.contributor.author","Guedes, Rubem C. A."],["dc.date.accessioned","2018-11-07T11:04:25Z"],["dc.date.available","2018-11-07T11:04:25Z"],["dc.date.issued","2007"],["dc.description.abstract","We have recently shown that two techniques of brain stimulation - repetitive electrical stimulation (ES) (that mimics transcranial magnetic stimulation) and transcranial direct current stimulation (tDCS) - modify the velocity of cortical spreading depression (CSD) significantly. Herein we aimed to study the effects of these two techniques combined on CSD. Thirty-two Wistar rats were divided into four groups according to the treatment: sham tDCS/sham ES, sham tDCS/1 Hz ES, anodal tDCS/1 Hz ES, cathodal tDCS/1 Hz ES. Our findings show that 1 Hz ES reduced CSD velocity, and this effect was modified by either anodal or cathodal tDCS. Anodal tDCS induced larger effects than cathodal tDCS. Hereby CSD velocity was actually increased significantly after anodal tDCS/1 Hz ES. Our results show that combining two techniques of brain stimulation can modify significantly the effects of ES alone on cortical excitability as measured by the neurophysiological parameter of cortical spreading depression and therefore provide important insights into the effects of this new approach of brain stimulation on cortical activity. (c) 2006 Elsevier Inc. All rights reserved."],["dc.description.sponsorship","NHLBI NIH HHS [K30 HL04095-03]"],["dc.identifier.doi","10.1016/j.expneurol.2006.09.019"],["dc.identifier.isi","000245086100047"],["dc.identifier.pmid","17113079"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51841"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","0014-4886"],["dc.title","Effects of transcranial direct current stimulation coupled with repetitive electrical stimulation on cortical spreading depression"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2122"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Neuropsychologia"],["dc.bibliographiccitation.lastpage","2128"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Kuo, Min-Fang"],["dc.contributor.author","Unger, Mandy"],["dc.contributor.author","Liebetanz, David"],["dc.contributor.author","Lang, Nicolas"],["dc.contributor.author","Tergau, Frithjof"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Nitsche, Michael A."],["dc.date.accessioned","2018-11-07T11:20:28Z"],["dc.date.available","2018-11-07T11:20:28Z"],["dc.date.issued","2008"],["dc.description.abstract","Neuroplasticity is the adaptive modification of network connectivity in response to environmental demands and has been identified as a major physiological correlate of learning. Since unrestricted neuroplastic modifications of network connectivity will result in a cle-stabilization of the system, metaplastic modification rules have been proposed for keeping plastic connectivity changes within a useful dynamic range. In this connection, the modification threshold to achieve synaptic strengthening is thought to correlate negatively with the history of activity of the respective neurons, i.e. high previous activity enhances the threshold for synaptic strengthening and vice versa. However, the relevance of metaplasticity for actual learning processes has not been tested so far. We reduced or enhanced motor cortex excitability before performance of the serial reaction time task (SRTT), a sequential motor learning paradigm, and a reaction time task (RTT) by transcranial direct current stimulation (tDCS). If homeostatic rules apply, excitability-diminishing cathodal tDCS should improve subsequent motor learning, especially if combined with the partial NMDA receptor-agoniSt D-cycloserine, which selectively enhances efficacy of active receptors, while excitability-enhancing anodal tDCS should reduce it. Only the results for anodal tDCS, when combined with D-cycloserine, were in accordance with the rules of homeostatic plasticity. We conclude that homeostatic plasticity, as tested here, has a limited influence on implicit sequential motor learning. (C) 2008 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.neuropsychologia.2008.02.023"],["dc.identifier.isi","000257530800002"],["dc.identifier.pmid","18394661"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55544"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","0028-3932"],["dc.title","Limited impact of homeostatic plasticity on motor learning in humans"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1029"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Neurological Research"],["dc.bibliographiccitation.lastpage","1037"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Wrede, Arne"],["dc.contributor.author","Schulz-Schaeffer, Walter J."],["dc.contributor.author","Taghizadeh-Waghefi, Ali"],["dc.contributor.author","Nitsche, Michael A."],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Liebetanz, David"],["dc.date.accessioned","2018-11-07T09:17:09Z"],["dc.date.available","2018-11-07T09:17:09Z"],["dc.date.issued","2013"],["dc.description.abstract","Objective: Transcranial direct current stimulation (tDCS) induces polarity-specific changes of cerebral blood flow (CBF). To determine whether these changes are focally limited or if they incorporate large cortical regions and thus have the potential for a therapeutic application, we investigated the effects of cathodal tDCS on CBF in an established tDCS rat model with particular attention to the spatial extension in CBF changes using laser Doppler blood perfusion imaging (LDI). Methods: Twenty-one Sprague Dawley rats received a single 15-minute session of cathodal tDCS at current intensities of 200, 400, 600, or 700 mu A applied over electrode contact areas (ECA) of 3.5, 7.0, 10.5, or 14.0 mm(2). One animal died prior to the stimulation. Cerebral blood flow was measured prior and after tDCS with LDI in three defined regions of interest (ROI) over the stimulated left hemisphere (region anterior to ECA - ROI 1, ECA - ROI 2, region posterior to ECA - ROI 3). Results: A regional decrease in CBF was measured after cathodal tDCS, the extent of the decrease depending on the current density applied. The most effective and spatially limited reduction in CBF (up to 50%, lasting as long as 90 minutes) was found after the application of 600 mu A over an ECA of 10.5 mm(2). This significant reduction in CBF even lasted up to 90 minutes in distant cortical areas (ROI 1 and 3) that were not directly related to the ECA (ROI 2). Discussion: Cathodal tDCS induces a regional, long-lasting, reversible decrease in CBF that is not limited to the region to which tDCS is applied."],["dc.identifier.doi","10.1179/1743132813Y.0000000248"],["dc.identifier.isi","000328144300006"],["dc.identifier.pmid","23899548"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28094"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Maney Publishing"],["dc.relation.issn","1743-1328"],["dc.relation.issn","0161-6412"],["dc.title","Cathodal transcranial direct current stimulation induces regional, long-lasting reductions of cortical blood flow in rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","986"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Brain Stimulation"],["dc.bibliographiccitation.lastpage","987"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Bikson, Marom"],["dc.contributor.author","Grossman, Pnina"],["dc.contributor.author","Zannou, Adantchede Louis"],["dc.contributor.author","Kronberg, Greg"],["dc.contributor.author","Truong, Dennis"],["dc.contributor.author","Boggio, Paulo"],["dc.contributor.author","Brunoni, Andre R."],["dc.contributor.author","Charvet, Leigh"],["dc.contributor.author","Fregni, Felipe"],["dc.contributor.author","Fritsch, Brita"],["dc.contributor.author","Gillick, Bernadette"],["dc.contributor.author","Hamilton, Roy H."],["dc.contributor.author","Hampstead, Benjamin M."],["dc.contributor.author","Kirton, Adam"],["dc.contributor.author","Knotkova, Helena"],["dc.contributor.author","Liebetanz, David"],["dc.contributor.author","Liu, Anli"],["dc.contributor.author","Loo, Colleen"],["dc.contributor.author","Nitsche, Michael A."],["dc.contributor.author","Reis, Janine"],["dc.contributor.author","Richardson, Jessica D."],["dc.contributor.author","Rotenberg, Alexander"],["dc.contributor.author","Turkeltaub, Peter E."],["dc.contributor.author","Woods, Adam J."],["dc.date.accessioned","2020-12-10T14:22:47Z"],["dc.date.available","2020-12-10T14:22:47Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1016/j.brs.2017.06.007"],["dc.identifier.issn","1935-861X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71734"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Response to letter to the editor: Safety of transcranial direct current stimulation: Evidence based update 2016"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]