Große, Lena

[["dc.bibliographiccitation.firstpage","816"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Applied Microbiology and Biotechnology"],["dc.bibliographiccitation.lastpage","822"],["dc.bibliographiccitation.volume","72"],["dc.contributor.author","Wang, L."],["dc.contributor.author","Grosse, T."],["dc.contributor.author","Stevens, H."],["dc.contributor.author","Brinkhoff, T."],["dc.contributor.author","Simon, M."],["dc.contributor.author","Liang, L."],["dc.contributor.author","Bitzer, J."],["dc.contributor.author","Bach, G."],["dc.contributor.author","Zeeck, Axel"],["dc.contributor.author","Tokuda, H."],["dc.contributor.author","Lang, S."],["dc.date.accessioned","2018-11-07T09:08:24Z"],["dc.date.available","2018-11-07T09:08:24Z"],["dc.date.issued","2006"],["dc.description.abstract","The new marine Halomonas sp. strain GWS-BW-H8hM (DSM 17996) was found to produce 3-(4'-hydroxyphenyl)-4-phenylpyrrole-2,5-dicarboxylic acid (HPPD-1) and 3,4-bis(4'-hydroxy- phenyl)pyrrole-2,5-dicarboxylic acid (HPPD-2). In initial cultivations using marine broth, only low contents of these compounds have been isolated. Improving the conditions and growing the strain on artificial seawater supplemented with tryptone 10 g l(-1), yeast extract 5 g l(-1), L-tyrosine 0.6 g l(-1), glycine 1 g l(-1), and glucose 6 g l(-1), the growth-associated HPPD-1 and HPPD-2 production of a 40-l batch cultivation reached the amounts of 47 mg l(-1)supercript stop and 116 mg l(-1), respectively, after 65 h. Both compounds showed potent anti-tumor-promoting activities."],["dc.identifier.doi","10.1007/s00253-006-0370-1"],["dc.identifier.isi","000240809600027"],["dc.identifier.pmid","16642332"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26023"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0175-7598"],["dc.title","Bioactive hydroxyphenylpyrrole-dicarboxylic acids from a new marine Halomonas sp.: production and structure elucidation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","86"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","The Journal of Antibiotics"],["dc.bibliographiccitation.lastpage","92"],["dc.bibliographiccitation.volume","59"],["dc.contributor.author","Bitzer, J."],["dc.contributor.author","Grosse, T."],["dc.contributor.author","Wang, L."],["dc.contributor.author","Lang, S."],["dc.contributor.author","Beil, W."],["dc.contributor.author","Zeeck, Axel"],["dc.date.accessioned","2018-11-07T10:22:55Z"],["dc.date.available","2018-11-07T10:22:55Z"],["dc.date.issued","2006"],["dc.description.abstract","The addition of anthranilic acid to the culture medium of the marine derived Halomonas sp. strain GWS-BW-H8hM completely altered the secondary metabolite pattern relative to the standard conditions. The red-orange color of the culture filtrate extract was the result of the production of 2-aminophenoxazin-3-one (1), chandrananimycin C (5) and three new derivatives of 1 with a previously unknown substitution pattern: 2-amino-, 2-amino-S-benzoyl-, and 2-amino-8-(4-hydroxybenzoyl)-6-hydroxyphenoxazin-3 -one (2 similar to 4). The compounds were determined to have antibacterial and cytotoxic activities; a mode of action other than DNA intercalation is discussed."],["dc.identifier.isi","000235791600003"],["dc.identifier.pmid","16629408"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42357"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Japan Antibiotics Research Assoc"],["dc.relation.issn","0021-8820"],["dc.title","New aminophenoxazinones from a marine Halomonas sp.: Fermentation, structure elucidation, and biological activity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]