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Weber, Alexandra Kristina
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Weber, Alexandra Kristina
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Weber, Alexandra Kristina
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Weber, Kristina
Weber, K.
Weber, Alexandra K.
Weber, A. K.
Now showing 1 - 10 of 18
2013Journal Article [["dc.bibliographiccitation.artnumber","091112"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Applied Physics Letters"],["dc.bibliographiccitation.volume","102"],["dc.contributor.author","Joly, P."],["dc.contributor.author","Petrarca, M."],["dc.contributor.author","Vogel, A."],["dc.contributor.author","Pohl, T."],["dc.contributor.author","Nagy, T."],["dc.contributor.author","Jusforgues, Q."],["dc.contributor.author","Simon, P."],["dc.contributor.author","Kasparian, J."],["dc.contributor.author","Weber, K."],["dc.contributor.author","Wolf, J.-P."],["dc.date.accessioned","2018-11-07T09:27:10Z"],["dc.date.available","2018-11-07T09:27:10Z"],["dc.date.issued","2013"],["dc.description.abstract","We compare laser-induced condensation by UV laser pulses of femtosecond, sub-picosecond, and nanosecond duration between each other, as well as with respect to near-infrared (NIR) (800 nm) ultrashort laser pulses. Particle nucleation by UV pulses is so efficient that their growth beyond several hundreds of nm is limited by the local concentration of water vapour molecules. Furthermore, we evidence a dual mechanism: While condensation induced by ultrashort UV pulses rely on nitrogen photo-oxidative chemistry like in the NIR, nanosecond laser-induced condensation occurs without NO2 production, evidencing the domination of a mechanism distinct from that previously identified in the femtosecond regime. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4794416]"],["dc.description.sponsorship","European Research Council"],["dc.identifier.doi","10.1063/1.4794416"],["dc.identifier.isi","000316085200012"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30469"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Inst Physics"],["dc.relation.issn","0003-6951"],["dc.title","Laser-induced condensation by ultrashort laser pulses at 248 nm"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details DOI WOS2014Journal Article [["dc.bibliographiccitation.firstpage","57"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","European Archives of Psychiatry and Clinical Neuroscience"],["dc.bibliographiccitation.lastpage","66"],["dc.bibliographiccitation.volume","265"],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.contributor.author","Weber, Kristina"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Diekhof, Esther"],["dc.contributor.author","Keil, Maria"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2017-09-07T11:47:50Z"],["dc.date.available","2017-09-07T11:47:50Z"],["dc.date.issued","2014"],["dc.description.abstract","Depression is a debilitating psychiatric disorder characterized among other aspects by the inability to properly experience or respond to reward. However, it remains unclear whether patients with depression present impaired reward system due to abnormal modulatory mechanisms. We investigated the activation of the nucleus accumbens (NAcc), a crucial region involved in reward processing, with functional magnetic resonance imaging using the desire-reason-dilemma paradigm. This task allows tracking the activity of the NAcc during the acceptance or the rejection of previously conditioned reward stimuli. Patients were assigned into subgroups of lower (LA) or higher (HA) NAcc activation according to beta weights. LA patients presented significant hypoactivation in the ventral tegmental area in addition to bilateral ventral striatum, confirming impairments in the bottom-up input to the NAcc. Conversely, HA patients presented significant hyperactivation in prefrontal areas such as the rostral anterior cingulate cortex and the anterior ventral prefrontal cortex in addition to bilateral ventral striatum, suggesting disturbances in the top-down regulation of the NAcc. Demographic and clinical differences explaining the abnormal co-activations of midbrain and prefrontal regions were not identified. Therefore, we provide evidence for dysfunctional bottom-up processing in one potential neurobiological subtype of depression (LA) and dysfunctional top-down modulation in another subtype (HA). We suggest that the midbrain and prefrontal regions are more specific pathophysiological substrates for each depression subtype. Above all, our results encourage the segregation of patients by similar dysfunctional mechanisms of the dopaminergic system, which would finally contribute to disentangle more specific pathogeneses and guide the development of more personalized targets for future therapies."],["dc.identifier.doi","10.1007/s00406-014-0552-2"],["dc.identifier.gro","3150742"],["dc.identifier.pmid","25327829"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7532"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","0940-1334"],["dc.title","Dissociating pathomechanisms of depression with fMRI: bottom-up or top-down dysfunctions of the reward system"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]Details DOI PMID PMC2012Conference Abstract [["dc.bibliographiccitation.journal","The International Journal of Neuropsychopharmacology"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Vieker, Henning"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Fanelli, A."],["dc.contributor.author","Jakob, K."],["dc.contributor.author","Petrovic, A."],["dc.contributor.author","Weber, K."],["dc.contributor.author","Keil, M."],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Falkai, Peter Gaston"],["dc.date.accessioned","2018-11-07T09:10:04Z"],["dc.date.available","2018-11-07T09:10:04Z"],["dc.date.issued","2012"],["dc.format.extent","214"],["dc.identifier.isi","000209062500785"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26410"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.issn","1469-5111"],["dc.relation.issn","1461-1457"],["dc.title","Imaging endophenotypic biomarkers for schizophrenic and affective psychoses in key neural circuits"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details WOS2000Journal Article Editorial Contribution (Editorial, Introduction, Epilogue) [["dc.bibliographiccitation.firstpage","1527"],["dc.bibliographiccitation.issue","11-12"],["dc.bibliographiccitation.journal","Journal of Structural Geology"],["dc.bibliographiccitation.lastpage","1529"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Leiss, Bernd"],["dc.contributor.author","Ullemeyer, K."],["dc.contributor.author","Weber, K."],["dc.date.accessioned","2018-11-07T08:34:10Z"],["dc.date.available","2018-11-07T08:34:10Z"],["dc.date.issued","2000"],["dc.identifier.doi","10.1016/S0191-8141(00)00113-9"],["dc.identifier.isi","000165521400001"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17755"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0191-8141"],["dc.relation.orgunit","Abteilung Strukturgeologie und Geodynamik"],["dc.title","Introduction to the special issue: Textures and physical properties of rocks"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","editorial_ja"],["dspace.entity.type","Publication"]]Details DOI WOS2011Conference Abstract [["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Pharmacopsychiatry"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.contributor.author","Zvonik, Kerstin"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Weber, K."],["dc.contributor.author","Petrovic, A."],["dc.contributor.author","Henseler, Ilona"],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Melcher, T."],["dc.contributor.author","Keil, M."],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Falkai, Peter Gaston"],["dc.date.accessioned","2018-11-07T08:52:00Z"],["dc.date.available","2018-11-07T08:52:00Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.1055/s-0031-1292483"],["dc.identifier.isi","000296086300067"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22064"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.publisher.place","Stuttgart"],["dc.relation.conference","27th Symposium of the AGNP"],["dc.relation.eventlocation","Munich, GERMANY"],["dc.relation.issn","0176-3679"],["dc.title","Multi-functional MRI studies of disordered brain circuits in schizophrenic and affective psychoses"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details DOI WOS2002Journal Article Research Paper [["dc.bibliographiccitation.firstpage","787"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Geology"],["dc.bibliographiccitation.lastpage","790"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Liu, J. L."],["dc.contributor.author","Walter, Jens M."],["dc.contributor.author","Weber, K."],["dc.date.accessioned","2018-11-07T10:04:59Z"],["dc.date.available","2018-11-07T10:04:59Z"],["dc.date.issued","2002"],["dc.description.abstract","Postmetamorphic carbonate fault rocks from the Damara orogen, Namibia, show the following features: (1) obvious contrasts between centimeter-scale grains in the clasts and nanometer- to micrometer-scale grains in the matrix, and between macroscopic cataclastic and microscopic mylonitic microstructures; (2) coexistence of tangled dislocations and organized dislocation walls; (3) occurrence of subgrains along margins of clasts and their transition into dynamically recrystallized grains in the matrix; and (4) new grains in grain sizes of a few nanometers to 3 mum in diameter. The coexistence of brittle and ductile microstructures is attributed to comprehensive intragranular twinning, and kinking, fracturing, and subsequent dislocation remobilization or reorganization and recrystallization. Fracturing is triggered by dislocation pileups due to dynamic loading, twinning, and kinking. It also generates free dislocations and tangled dislocations. Fractures provide fluid paths, increase fluid-rock interfaces, and enhance the possibility of fluid-rock interaction. Fracturing is subsequently accommodated by low-temperature plasticity that is attributed to hydrolytic weakening, i.e., fluid-enhanced recovery and dynamic recrystallization due to the infiltration of fluids into the deforming grains. During hydrolytic weakening, remobilized free dislocations and tangled dislocations climb toward incoherent boundary-like fractures. The dislocations are reorganized into dislocation walls that commonly constitute parts of subgrains developing into new grains. We conclude that: (1) fluids may increase the rate of dislocation glide and dislocation climb and may also enhance the recovery of strain-hardened rocks to accommodate fracturing processes in calcite marbles at low temperatures; and (2) calcite marble may have low-temperature plasticity and may undergo crystal plastic deformation due to hydrolytic weakening at shallow crustal levels."],["dc.identifier.doi","10.1130/0091-7613(2002)030<0787:FELTPO>2.0.CO;2"],["dc.identifier.isi","000177937900006"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38806"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0091-7613"],["dc.relation.orgunit","Abteilung Strukturgeologie und Geodynamik"],["dc.title","Fluid-enhanced low-temperature plasticity of calcite marble"],["dc.title.subtitle","Microstructures and mechanisms"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]Details DOI WOS2003Journal Article [["dc.bibliographiccitation.firstpage","307"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Molecular Biology"],["dc.bibliographiccitation.lastpage","319"],["dc.bibliographiccitation.volume","333"],["dc.contributor.author","Karabinos, A."],["dc.contributor.author","Schulze, E."],["dc.contributor.author","Schunemann, J."],["dc.contributor.author","Parry, DAD"],["dc.contributor.author","Weber, K."],["dc.date.accessioned","2018-11-07T10:35:28Z"],["dc.date.available","2018-11-07T10:35:28Z"],["dc.date.issued","2003"],["dc.description.abstract","The in vitro polymerization and tissue-specific expression patterns of the four essential intermediate filament (IF) proteins (A1, A2, A3, B1) and the non-essential IF protein A4 were analyzed. Recombinant B1, used as a probe in blot overlay assays of the 11 Caenorhabditis elegans IF proteins, reacted strongly with proteins A1 to A4, indicating a heterotypic interaction. Obligate heteropolymeric filament assembly in vitro was confirmed by electron microscopy. Protein B1 formed long IF when mixed with an equimolar amount of A1, A2 or A3. Developmentally regulated coexpression of 131 and one or more members of the A family was found with GFP-promoter reporters. This coexpression pattern argues for a heteropolymer system in vivo. One or both splice variants of the B1 gene are always coexpressed in a tissue-specific manner with at least one member of the A family in hypodermis, pharynx, pharyngeal-intestinal valve, excretory cells, uterus, vulva and rectum. Interestingly, while the intestine normally lacks a B1/A pair, the dauer larva shows intestinal B1 and A4. These results are in line with similar postembryonic phenotypes of the hypodermis induced by RNA interference (RNAi) of genes B1, A2 and A3. Similarly, defects of the pharynx and its A1-GFP containing tonofilaments observed in the postembryonic B1 RNAi phenotype are consistent with the coexpression of B1 and A1 in the marginal cells. Thus RNAi analyses provide independent evidence for the existence of the B1/A obligate heteropolymer system in vivo. Proteins A1 and B1 have a similar and rather slow turnover rate in photobleaching experiments of the pharynx tonofilaments. (C) 2003 Published by Elsevier Ltd."],["dc.identifier.doi","10.1016/j.jmb.2003.08.041"],["dc.identifier.isi","000185852000007"],["dc.identifier.pmid","14529618"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45103"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Ltd Elsevier Science Ltd"],["dc.relation.issn","0022-2836"],["dc.title","In vivo and in vitro evidence that the four essential intermediate filament (IF) proteins A1, A2, A3 and B1 of the nematode Caenorhabditis elegans form an obligate heteropolymeric IF system"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details DOI PMID PMC WOS2000Journal Article Research Paper [["dc.bibliographiccitation.firstpage","1531"],["dc.bibliographiccitation.issue","11-12"],["dc.bibliographiccitation.journal","Journal of Structural Geology"],["dc.bibliographiccitation.lastpage","1540"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Leiss, Bernd"],["dc.contributor.author","Ullemeyer, K."],["dc.contributor.author","Weber, K."],["dc.contributor.author","Brokmeier, H. G."],["dc.contributor.author","Bunge, H. J."],["dc.contributor.author","Drury, M."],["dc.contributor.author","Faul, U."],["dc.contributor.author","Fueten, F."],["dc.contributor.author","Frischbutter, A."],["dc.contributor.author","Klein, Hannah"],["dc.contributor.author","Kuhs, W."],["dc.contributor.author","Launeau, P."],["dc.contributor.author","Lloyd, G. E."],["dc.contributor.author","Prior, D. J."],["dc.contributor.author","Scheffzuk, C."],["dc.contributor.author","Weiss, T."],["dc.contributor.author","Walther, K."],["dc.contributor.author","Wenk, H. R."],["dc.date.accessioned","2018-11-07T08:34:39Z"],["dc.date.available","2018-11-07T08:34:39Z"],["dc.date.issued","2000"],["dc.identifier.doi","10.1016/S0191-8141(00)00114-0"],["dc.identifier.isi","000165521400002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17866"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0191-8141"],["dc.relation.orgunit","Abteilung Strukturgeologie und Geodynamik"],["dc.title","Recent developments and goals in texture research of geological materials - Preface"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]Details DOI WOS2000Journal Article [["dc.bibliographiccitation.firstpage","285"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","The Plant Journal"],["dc.bibliographiccitation.lastpage","296"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Hausler, R. E."],["dc.contributor.author","Baur, B."],["dc.contributor.author","Scharte, J."],["dc.contributor.author","Teichmann, Thomas"],["dc.contributor.author","Eicks, M."],["dc.contributor.author","Fischer, K. L."],["dc.contributor.author","Flugge, U. I."],["dc.contributor.author","Schubert, S."],["dc.contributor.author","Weber, A."],["dc.contributor.author","Fischer, K."],["dc.date.accessioned","2018-11-07T08:50:05Z"],["dc.date.available","2018-11-07T08:50:05Z"],["dc.date.issued","2000"],["dc.description.abstract","The inducible crassulacean acid metabolism (CAM) plant Mesembryanthemum crystallinum accumulates malic acid during the night and converts it to starch during the day via a pathway that, because it is located in different subcellular compartments, depends on specific metabolite transport across membranes. The chloroplast glucose transporter (pGlcT) and three members of the phosphate translocator (PT) family were isolated. After induction of CAM, transcript amounts of the phosphoenolpyruvate (PEP) phosphate translocator (PPT) and the glucose-g-phosphate (Glc6P) phosphate translocator (GPT) genes were increased drastically, while triose phosphate (TP) phosphate translocator (TPT) and the pGlcT transcripts remained unchanged. PPT- and GPT-specific transcripts and transporter activities exhibited a pronounced diurnal variation, displaying the highest amplitude in the light. pGlcT transcripts were elevated towards the end of the light period and at the beginning of the dark period. These findings, combined with diurnal variations of enzyme activities and metabolite contents, helped to elucidate the roles of the PPT, GPT, TPT and pGlcT in CAM. The main function of the PPT is the daytime export from the stroma of PEP generated by pyruvate orthophosphate:dikinase (PPDK). The increased transport activity of GPT in the light suggests a higher requirement for Glc6P import for starch synthesis rather than starch mobilization. Most likely, Glc6P rather than 3-phosphoglycerate or triose phosphates is the main substrate for daytime starch biosynthesis in M. crystallinum plants in which CAM has been induced (CAM-induced), similar to non-green plastids. In the dark, starch is mobilized both phosphorylytically and amylolytically and the products are exported by the GPT, TPT and pGlcT. The transport activities of all three phosphate translocators and the transcript amounts of the pGlcT adapt to changing transport requirements in order to maintain high metabolic fluxes during the diurnal CAM cycle."],["dc.identifier.doi","10.1046/j.1365-313x.2000.00876.x"],["dc.identifier.isi","000165518700001"],["dc.identifier.pmid","11069702"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21614"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1365-313X"],["dc.relation.issn","0960-7412"],["dc.title","Plastidic metabolite transporters and their physiological functions in the inducible crassulacean acid metabolism plant Mesembryanthemum crystallinum"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details DOI PMID PMC WOS2002Conference Paper [["dc.bibliographiccitation.artnumber","PII S0040-1951(02)00047-1"],["dc.bibliographiccitation.firstpage","75"],["dc.bibliographiccitation.issue","1-4"],["dc.bibliographiccitation.journal","Tectonophysics"],["dc.bibliographiccitation.lastpage","92"],["dc.bibliographiccitation.volume","349"],["dc.contributor.author","Raab, M. J."],["dc.contributor.author","Brown, R. W."],["dc.contributor.author","Gallagher, K."],["dc.contributor.author","Carter, A."],["dc.contributor.author","Weber, K."],["dc.date.accessioned","2018-11-07T10:29:54Z"],["dc.date.available","2018-11-07T10:29:54Z"],["dc.date.issued","2002"],["dc.description.abstract","Namibia's passive continental margin records a long history of tectonic activity since the Proterozoic. The orogenic belt produced during the collision of the Congo and Kalahari Cratons in the Early Proterozoic led to a zone of crustal weakness,,which became the preferred location for tectonism during the Phanerozoic. The Pan-African Damara mobile belt forms this intraplate boundary in Namibia and its tectonostratigraphic zones are defined by ductile shear zones, where the most prominent is described as the Omaruru Lineament-Waterberg Thrust (OML-WT), The prominance of the continental margin escarpment is diminished in the area of the Central and Northern Zone of the Damara belt where the shear zones are located. This area has been targeted with a set of 66 outcrop samples over a 550-km-long, 60-km-broad coast-parallel transect from the top of the escarpment in the south across the Damara sector to the Kamanjab Inlier in the north. Apatite fission track age and length data from all samples reveal a regionally consistent cooling event. Thermal histories derived by forward modelling bracket this phase of accelerated cooling in the Late Cretaceous. Maximum palaeotemperatures immediately prior to the onset of cooling range from ca. 120 to ca. 60 degreesC with the maximum occurring directly south of the Omaruru Lineament. Because different palaeo-temperatures indicate different burial depth at a given time, the amount of denudation can be estimated and used to constrain vertical displacements of the continental crust. We interpret this cooling pattern as the geomorphic response to reactivation of basement structures caused by a change in spreading geometry in the South Atlantic and South Vest Indian Oceans. (C) 2002 Elsevier Science B.V All rights reserved."],["dc.identifier.doi","10.1016/S0040-1951(02)00047-1"],["dc.identifier.isi","000176453000006"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43742"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.publisher.place","Amsterdam"],["dc.relation.conference","9th International Conference on Fission Track Dating and Thermochronology"],["dc.relation.eventlocation","LOME, AUSTRALIA"],["dc.relation.issn","0040-1951"],["dc.title","Late Cretaceous reactivation of major crustal shear zones in northern Namibia: constraints from apatite fission track analysis"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details DOI WOS