Dutschmann, Mathias

[["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The FASEB Journal"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Manzke, Till"],["dc.contributor.author","Kron, Martina"],["dc.contributor.author","Dutschmann, Mathias"],["dc.contributor.author","Richter, D."],["dc.date.accessioned","2018-11-07T11:17:10Z"],["dc.date.available","2018-11-07T11:17:10Z"],["dc.date.issued","2005"],["dc.format.extent","A657"],["dc.identifier.isi","000227610704502"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54748"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Federation Amer Soc Exp Biol"],["dc.publisher.place","Bethesda"],["dc.relation.conference","Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences"],["dc.relation.eventlocation","San Diego, CA"],["dc.relation.issn","0892-6638"],["dc.title","Expression patterns of 5-HT1A, 2A, 2B, 4(a) and 7 receptor isoforms in the respiratory network of rat"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","226"],["dc.bibliographiccitation.issue","5630"],["dc.bibliographiccitation.journal","Science"],["dc.bibliographiccitation.lastpage","229"],["dc.bibliographiccitation.volume","301"],["dc.contributor.author","Manzke, Till"],["dc.contributor.author","Guenther, U."],["dc.contributor.author","Ponimaskin, Evgeni G."],["dc.contributor.author","Haller, M."],["dc.contributor.author","Dutschmann, Mathias"],["dc.contributor.author","Schwarzacher, S."],["dc.contributor.author","Richter, Diethelm W."],["dc.date.accessioned","2018-11-07T10:37:41Z"],["dc.date.available","2018-11-07T10:37:41Z"],["dc.date.issued","2003"],["dc.description.abstract","Opiates are widely used analgesics in anesthesiology, but they have serious adverse effects such as depression of breathing. This is caused by direct inhibition of rhythm-generating respiratory neurons in the Pre-Boetzinger complex (PBC) of the brainstem. We report that serotonin 4(a) [5-HT4(a)] receptors are strongly expressed in respiratory PBC neurons and that their selective activation protects spontaneous respiratory activity. Treatment of rats with a 5-HT4 receptor specific agonist overcame fentanyl-induced respiratory depression and reestablished stable respiratory rhythm without loss of fentanyl's analgesic effect. These findings imply the prospect of a fine-tuned recovery from opioid-induced respiratory depression, through adjustment of intracellular adenosine 3', 5'-monophosphate levels through the convergent signaling pathways in neurons."],["dc.identifier.doi","10.1126/science.1084674"],["dc.identifier.isi","000184056200047"],["dc.identifier.pmid","12855812"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45628"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Assoc Advancement Science"],["dc.relation.issn","0036-8075"],["dc.title","5-HT4(a) receptors avert opioid-induced breathing depression without loss of analgesia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2331"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","The Journal of Physiology"],["dc.bibliographiccitation.lastpage","2343"],["dc.bibliographiccitation.volume","586"],["dc.contributor.author","Kron, Miriam"],["dc.contributor.author","Reuter, Julia"],["dc.contributor.author","Gerhardt, Ellen"],["dc.contributor.author","Manzke, Till"],["dc.contributor.author","Zhang, W."],["dc.contributor.author","Dutschmann, Mathias"],["dc.date.accessioned","2018-11-07T11:15:39Z"],["dc.date.available","2018-11-07T11:15:39Z"],["dc.date.issued","2008"],["dc.description.abstract","The Kolliker-Fuse nucleus (KF) contributes essentially to respiratory pattern formation and adaptation of breathing to afferent information. Systems physiology suggests that these KF functions depend on NMDA receptors (NMDA-R). Recent investigations revealed postnatal changes in the modulation of glutamatergic neurotransmission by brain-derived neurotrophic factor (BDNF) in the KF. Therefore, we investigated postnatal changes in NMDA-R subunit composition and postsynaptic modulation of NMDA-R-mediated currents by BDNF in KF slice preparations derived from three age groups (neonatal: postnatal day (P) 1-5; intermediate: P6-13; juvenile: P14-21). Immunohistochemistry showed a developmental up-regulation of the NR2D subunit. This correlated with a developmental increase in decay time of NMDA currents and a decline of desensitization in response to repetitive exogenous NMDA applications. Thus, developmental up-regulation of the NR2D subunit, which reduces the Mg2+ block of NMDA-R, causes these specific changes in NMDA current characteristics. This may determine the NMDA-R-dependent function of the mature KF in the control of respiratory phase transition. Subsequent experiments revealed that bath-application of BDNF progressively potentiated these repetitively evoked NMDA currents only in intermediate and juvenile age groups. Pharmacological inhibition of protein kinase C (PKC), as a downstream component of the BDNF-tyrosine kinase B receptor (trkB) signalling, prevented BDNF-induced potentiation of NMDA currents. BDNF-induced potentiation of NMDA currents in later developmental stages might be essential for synaptic plasticity during the adaptation of the breathing pattern in response to peripheral/central commands. The lack of plasticity in neonatal neurones strengthens the hypothesis that the respiratory network becomes permissive for activity-dependent plasticity with ongoing postnatal development."],["dc.identifier.doi","10.1113/jphysiol.2007.148916"],["dc.identifier.isi","000255497900011"],["dc.identifier.pmid","18339694"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54416"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.relation.issn","0022-3751"],["dc.title","Emergence of brain-derived neurotrophic factor-induced postsynaptic potentiation of NMDA currents during the postnatal maturation of the Kolliker-Fuse nucleus of rat"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The FASEB Journal"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Dutschmann, Mathias"],["dc.contributor.author","Simms, A."],["dc.contributor.author","Waki, Hidefumi"],["dc.contributor.author","Manzke, Till"],["dc.contributor.author","Pickering, A. E."],["dc.contributor.author","Richter, D."],["dc.contributor.author","Paton, J."],["dc.date.accessioned","2018-11-07T11:16:52Z"],["dc.date.available","2018-11-07T11:16:52Z"],["dc.date.issued","2005"],["dc.format.extent","A603"],["dc.identifier.isi","000227610704253"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54693"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Federation Amer Soc Exp Biol"],["dc.publisher.place","Bethesda"],["dc.relation.conference","Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences"],["dc.relation.eventlocation","San Diego, CA"],["dc.relation.issn","0892-6638"],["dc.title","The role of 5-HT4a and 5-HT1A receptor subtypes for recovery from opioid induced cardiovascular depression"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2611"],["dc.bibliographiccitation.issue","1529"],["dc.bibliographiccitation.journal","Philosophical Transactions of The Royal Society B Biological Sciences"],["dc.bibliographiccitation.lastpage","2623"],["dc.bibliographiccitation.volume","364"],["dc.contributor.author","Dutschmann, Mathias"],["dc.contributor.author","Waki, Hidefumi"],["dc.contributor.author","Manzke, Till"],["dc.contributor.author","Simms, A. E."],["dc.contributor.author","Pickering, A. E."],["dc.contributor.author","Richter, Diethelm W."],["dc.contributor.author","Paton, Julian F. R."],["dc.date.accessioned","2018-11-07T11:24:20Z"],["dc.date.available","2018-11-07T11:24:20Z"],["dc.date.issued","2009"],["dc.description.abstract","Serotonin receptor (5-HTR) agonists that target 5-HT(4(a))R and 5-HT(1A)R can reverse mu-opioid receptor (mu-OR)-evoked respiratory depression. Here, we have tested whether such rescuing by serotonin agonists also applies to the cardiovascular system. In working heart-brainstem preparations in situ, we have recorded phrenic nerve activity, thoracic sympathetic chain activity (SCA), vascular resistance and heart rate (HR) and in conscious rats, diaphragmatic electromyogram, arterial blood pressure (BP) and HR via radio-telemetry. In addition, the distribution of 5-HT(4(a))R and 5-HT(1A)R in ponto-medullary cardiorespiratory networks was identified using histochemistry. Systemic administration of the mu-OR agonist fentanyl in situ decreased HR, vascular resistance, SCA and phrenic nerve activity. Subsequent application of the 5-HT(1A)R agonist 8-OH-DPAT further enhanced bradycardia, but partially compensated the decrease in vascular resistance, sympathetic activity and restored breathing. By contrast, the 5-HT(4(a))R agonist RS67333 further decreased vascular resistance, HR and sympathetic activity, but partially rescued breathing. In conscious rats, administration of remifentanyl caused severe respiratory depression, a decrease in mean BP accompanied by pronounced bradyarrhythmia. 8-OH-DPAT restored breathing and prevented the bradyarrhythmia; however, BP and HR remained below baseline. In contrast, RS67333 further suppressed cardiovascular functions in vivo and only partially recovered breathing in some cases. The better recovery of mu-OR cardiorespiratory disturbance by 5-HT(1A)R than 5-HT(4(a))R is supported by the finding that 5-HT(1A)R was more densely expressed in key brainstem nuclei for cardiorespiratory control compared with 5-HT(4(a))R. We conclude that during treatment of severe pain, 5-HT(1A)R agonists may provide a useful tool to counteract opioid-mediated cardiorespiratory disturbances."],["dc.description.sponsorship","British Heart Foundation [RG/07/006/23634]; Wellcome Trust [074570]"],["dc.identifier.doi","10.1098/rstb.2009.0076"],["dc.identifier.isi","000268569000016"],["dc.identifier.pmid","19651661"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56379"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Royal Soc"],["dc.publisher.place","London"],["dc.relation.conference","Royal-Society Discussion Meeting on Brainstem - Neural Networks Vital for Life"],["dc.relation.eventlocation","Royal Soc, London, ENGLAND"],["dc.relation.issn","0962-8436"],["dc.title","The potency of different serotonergic agonists in counteracting opioid evoked cardiorespiratory disturbances"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The FASEB Journal"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Manzke, Till"],["dc.contributor.author","Gunther, U."],["dc.contributor.author","Dutschmann, Mathias"],["dc.contributor.author","Richter, D."],["dc.date.accessioned","2018-11-07T11:17:07Z"],["dc.date.available","2018-11-07T11:17:07Z"],["dc.date.issued","2005"],["dc.format.extent","A657"],["dc.identifier.isi","000227610704501"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54737"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Federation Amer Soc Exp Biol"],["dc.publisher.place","Bethesda"],["dc.relation.conference","Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences"],["dc.relation.eventlocation","San Diego, CA"],["dc.relation.issn","0892-6638"],["dc.title","The role of 5-HT 1A, 2A, 2B and 7 receptor isoforms for recovery from opioid induced respiratory depression in rat"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The FASEB Journal"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Kron, Martina"],["dc.contributor.author","Manzke, Till"],["dc.contributor.author","Dutschmann, Mathias"],["dc.date.accessioned","2018-11-07T11:17:00Z"],["dc.date.available","2018-11-07T11:17:00Z"],["dc.date.issued","2005"],["dc.format.extent","A651"],["dc.identifier.isi","000227610704472"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54715"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Federation Amer Soc Exp Biol"],["dc.publisher.place","Bethesda"],["dc.relation.conference","Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences"],["dc.relation.eventlocation","San Diego, CA"],["dc.relation.issn","0892-6638"],["dc.title","Developmental changes of BDNF (brain derived neurotrophic factor) and tyrosine kinase receptor B (trkB) expression in the rat respiratory network"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The FASEB Journal"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Dutschmann, Mathias"],["dc.contributor.author","Waki, Hidefumi"],["dc.contributor.author","Manzke, Till"],["dc.contributor.author","Pickering, A. E."],["dc.contributor.author","Richter, D."],["dc.contributor.author","Paton, J."],["dc.date.accessioned","2018-11-07T10:07:40Z"],["dc.date.available","2018-11-07T10:07:40Z"],["dc.date.issued","2006"],["dc.format.extent","A375"],["dc.identifier.isi","000236206503122"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39324"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Federation Amer Soc Exp Biol"],["dc.publisher.place","Bethesda"],["dc.relation.conference","Experimental Biology 2006 Meeting"],["dc.relation.eventlocation","San Francisco, CA"],["dc.relation.issn","0892-6638"],["dc.title","5-HT1A receptor agonist 8-OH-DPAT reliably recovered opioid induced cardio-respiratory disturbances in conscious rats."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2589"],["dc.bibliographiccitation.issue","1529"],["dc.bibliographiccitation.journal","Philosophical Transactions of The Royal Society B Biological Sciences"],["dc.bibliographiccitation.lastpage","2602"],["dc.bibliographiccitation.volume","364"],["dc.contributor.author","Manzke, Till"],["dc.contributor.author","Dutschmann, Mathias"],["dc.contributor.author","Schlaf, Gerald"],["dc.contributor.author","Moerschel, Michael"],["dc.contributor.author","Koch, Uwe R."],["dc.contributor.author","Ponimaskin, Evgeni G."],["dc.contributor.author","Bidon, Olivier"],["dc.contributor.author","Lalley, Peter M."],["dc.contributor.author","Richter, Diethelm W."],["dc.date.accessioned","2018-11-07T11:24:20Z"],["dc.date.available","2018-11-07T11:24:20Z"],["dc.date.issued","2009"],["dc.description.abstract","The cellular effects of serotonin (5-HT), a neuromodulator with widespread influences in the central nervous system, have been investigated. Despite detailed knowledge about the molecular biology of cellular signalling, it is not possible to anticipate the responses of neuronal networks to a global action of 5-HT. Heterogeneous expression of various subtypes of serotonin receptors (5-HTR) in a variety of neurons differently equipped with cell-specific transmitter receptors and ion channel assemblies can provoke diverse cellular reactions resulting in various forms of network adjustment and, hence, motor behaviour. Using the respiratory network as a model for reciprocal synaptic inhibition, we demonstrate that 5-HT(1A)R modulation primarily affects inhibition through glycinergic synapses. Potentiation of glycinergic inhibition of both excitatory and inhibitory neurons induces a functional reorganization of the network leading to a characteristic change of motor output. The changes in network operation are robust and help to overcome opiate-induced respiratory depression. Hence, 5-HT(1A)R activation stabilizes the rhythmicity of breathing during opiate medication of pain."],["dc.identifier.doi","10.1098/rstb.2009.0068"],["dc.identifier.isi","000268569000014"],["dc.identifier.pmid","19651659"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6127"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56378"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Royal Soc"],["dc.publisher.place","London"],["dc.relation.conference","Royal-Society Discussion Meeting on Brainstem - Neural Networks Vital for Life"],["dc.relation.eventlocation","Royal Soc, London, ENGLAND"],["dc.relation.issn","0962-8436"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Serotonin targets inhibitory synapses to induce modulation of network functions"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

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