Dutschmann, Mathias

[["dc.bibliographiccitation.firstpage","185"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Pflügers Archiv - European Journal of Physiology"],["dc.bibliographiccitation.lastpage","195"],["dc.bibliographiccitation.volume","457"],["dc.contributor.author","Funke, Frank"],["dc.contributor.author","Mueller, Michael"],["dc.contributor.author","Dutschmann, Mathias"],["dc.date.accessioned","2018-11-07T11:10:46Z"],["dc.date.available","2018-11-07T11:10:46Z"],["dc.date.issued","2008"],["dc.description.abstract","Recent studies showed that respiratory rhythm generation depends on oscillators located in the pre-Botzinger complex (pre-BotC) and the parafacial respiratory group (pFRG). To study inhibitory synaptic interactions between these two oscillators, we developed a rostrally tilted transversal slice preparation, which preserves these regions. The onset of rhythmic mass activity in the retrotrapezoid nucleus (RTN)/pFRG preceded that of the pre-BotC. Blockade of glycinergic and gamma-aminobutyric acidic inhibition synchronized preBotC and RTN/pFRG activity and significantly increased preBotC burst frequency, amplitude, and duration. Population imaging revealed recruitment of inspiratory-like neurones, while expiratory-like neurones lost their phasic activity. The reconfiguration after disinhibition reveals: (1) synaptic inhibition of the pre-BotC arising from the RTN/pFRG, (2) excitatory drive from the RTN/pFRG that triggers the pre-BotC burst. Our findings support the view that these synaptic interactions in vitro relate to the initiation of the inspiratory phase or to the steering of the expiratory-inspiratory phase transition in vivo."],["dc.identifier.doi","10.1007/s00424-008-0509-2"],["dc.identifier.isi","000259373000016"],["dc.identifier.pmid","18458944"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/3069"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53280"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0031-6768"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Reconfiguration of respiratory-related population activity in a rostrally tilted transversal slice preparation following blockade of inhibitory neurotransmission in neonatal rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2589"],["dc.bibliographiccitation.issue","1529"],["dc.bibliographiccitation.journal","Philosophical Transactions of The Royal Society B Biological Sciences"],["dc.bibliographiccitation.lastpage","2602"],["dc.bibliographiccitation.volume","364"],["dc.contributor.author","Manzke, Till"],["dc.contributor.author","Dutschmann, Mathias"],["dc.contributor.author","Schlaf, Gerald"],["dc.contributor.author","Moerschel, Michael"],["dc.contributor.author","Koch, Uwe R."],["dc.contributor.author","Ponimaskin, Evgeni G."],["dc.contributor.author","Bidon, Olivier"],["dc.contributor.author","Lalley, Peter M."],["dc.contributor.author","Richter, Diethelm W."],["dc.date.accessioned","2018-11-07T11:24:20Z"],["dc.date.available","2018-11-07T11:24:20Z"],["dc.date.issued","2009"],["dc.description.abstract","The cellular effects of serotonin (5-HT), a neuromodulator with widespread influences in the central nervous system, have been investigated. Despite detailed knowledge about the molecular biology of cellular signalling, it is not possible to anticipate the responses of neuronal networks to a global action of 5-HT. Heterogeneous expression of various subtypes of serotonin receptors (5-HTR) in a variety of neurons differently equipped with cell-specific transmitter receptors and ion channel assemblies can provoke diverse cellular reactions resulting in various forms of network adjustment and, hence, motor behaviour. Using the respiratory network as a model for reciprocal synaptic inhibition, we demonstrate that 5-HT(1A)R modulation primarily affects inhibition through glycinergic synapses. Potentiation of glycinergic inhibition of both excitatory and inhibitory neurons induces a functional reorganization of the network leading to a characteristic change of motor output. The changes in network operation are robust and help to overcome opiate-induced respiratory depression. Hence, 5-HT(1A)R activation stabilizes the rhythmicity of breathing during opiate medication of pain."],["dc.identifier.doi","10.1098/rstb.2009.0068"],["dc.identifier.isi","000268569000014"],["dc.identifier.pmid","19651659"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6127"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56378"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Royal Soc"],["dc.publisher.place","London"],["dc.relation.conference","Royal-Society Discussion Meeting on Brainstem - Neural Networks Vital for Life"],["dc.relation.eventlocation","Royal Soc, London, ENGLAND"],["dc.relation.issn","0962-8436"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Serotonin targets inhibitory synapses to induce modulation of network functions"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]