Saul, Dominik

[["dc.bibliographiccitation.journal","Facial Plastic Surgery & Aesthetic Medicine"],["dc.contributor.author","Hawellek, Thelonius"],["dc.contributor.author","Beil, Frank Timo"],["dc.contributor.author","Hischke, Sandra"],["dc.contributor.author","Saul, Dominik"],["dc.contributor.author","Hoffmann, Daniel Bernd"],["dc.contributor.author","Kleiss, Sebastian"],["dc.contributor.author","Rolvien, Tim"],["dc.contributor.author","Ries, Christian"],["dc.contributor.author","Püschel, Klaus"],["dc.contributor.author","Frosch, Stephan"],["dc.contributor.author","Hubert, Jan"],["dc.date.accessioned","2021-12-01T09:23:50Z"],["dc.date.available","2021-12-01T09:23:50Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1089/fpsam.2021.0063"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94768"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.relation.eissn","2689-3622"],["dc.relation.issn","2689-3614"],["dc.rights.uri","https://www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/"],["dc.title","Costal Cartilage Calcification: Prevalence, Amount, and Structural Pattern in the General Population and Its Association with Age: A Cadaveric Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","705"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Calcified Tissue International"],["dc.bibliographiccitation.lastpage","719"],["dc.bibliographiccitation.volume","102"],["dc.contributor.author","Saul, D."],["dc.contributor.author","Harlas, B."],["dc.contributor.author","Ahrabi, A."],["dc.contributor.author","Kosinsky, R. L."],["dc.contributor.author","Hoffmann, D. B."],["dc.contributor.author","Wassmann, M."],["dc.contributor.author","Wigger, R."],["dc.contributor.author","Böker, K. O."],["dc.contributor.author","Sehmisch, S."],["dc.contributor.author","Komrakova, M."],["dc.date.accessioned","2020-06-10T14:22:48Z"],["dc.date.available","2020-06-10T14:22:48Z"],["dc.date.issued","2017"],["dc.description.abstract","Osteoporosis is often accompanied by sarcopenia. The effect of strontium ranelate (SR) on muscle tissue has not been investigated sufficiently. In this study, the effect of different SR treatments on muscle was studied. Additionally, the lumbar vertebrae were analyzed. Three-month-old female rats were divided into five groups (n = 12): Group 1: untreated (NON-OVX); Group 2: ovariectomized and left untreated (OVX); Group 3: SR after OVX until the study ended (13 weeks, SR prophylaxis and therapy = pr+th); Group 4: OVX and SR for 8 weeks (SR prophylaxis = pr); Group 5: SR for 5 weeks from the 8 week after OVX (SR therapy = SR th). SR was applied in food (630 mg/kg body weight). The size of muscle fibers, capillary density, metabolic enzymes, and mRNA expression were assessed in soleus, gastrocnemius, and longissimus muscles. The vertebral bodies underwent micro-CT, biomechanical, and ashing analyses. In general, SR did not alter the muscle histological parameters. The changes in fiber size and capillary ratio were related to the body weight. Myostatin mRNA was decreased in Sr pr+th; protein expression was not changed. SR th led to increase in mRNA expression of vascular endothelial growth factor (Vegf-B). In lumbar spine, SR pr+th enhanced biomechanical properties, bone mineral density, trabecular area, density, and thickness and cortical density. The reduced calcium/phosphate ratio in the SR pr+th group indicates the replacement of calcium by strontium ions. SR has no adverse effects on muscle tissue and it shows a favorable time-dependent effect on vertebrae. A functional analysis of muscles could verify these findings."],["dc.identifier.doi","10.1007/s00223-017-0374-0"],["dc.identifier.pmid","29242963"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66222"],["dc.language.iso","en"],["dc.relation.eissn","1432-0827"],["dc.relation.issn","0171-967X"],["dc.title","Effect of Strontium Ranelate on the Muscle and Vertebrae of Ovariectomized Rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","994"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Orthopaedic Surgery"],["dc.bibliographiccitation.lastpage","1002"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Saul, Dominik"],["dc.contributor.author","Riekenberg, Juliane"],["dc.contributor.author","Ammon, Jan C."],["dc.contributor.author","Hoffmann, Daniel B."],["dc.contributor.author","Sehmisch, Stephan"],["dc.date.accessioned","2020-06-08T13:10:10Z"],["dc.date.available","2020-06-08T13:10:10Z"],["dc.date.issued","2019"],["dc.description.abstract","Objective Investigation of the treatment of femur fractures and the type of femur fracture‐associated complications regarding timing of surgery and length of hospital stay. Methods In this retrospective cohort study, a total of 358 hip fractures were evaluated retrospectively from 1 January 2008 until 31 December 2010 at a level I trauma center in Germany. Inclusion criteria was age >18 years and a proximal femur fracture. Both sexes were evaluated. Mean age was 75.5 years, most patients were female (63.7%). Intervention was the operative treatment of proximal femur fracture. Outcome parameters were time until surgery, complications, reoperations, mortality, and length of hospital stay. Results Among the proximal femur fractures (n = 358), 46.6% were pertrochanteric, 11.2% subtrochanteric, and 42.2% femoral neck fractures. Operation upon hip fractures was managed regularly within 24 hours of injury (73%; mean for femoral neck: 28.3 hrs.; mean for pertrochanteric fractures: 21.4 hrs.; mean for subtrochanteric fractures: 19.5 hrs.). Delayed treatment, as well as implantation of hip total endoprosthesis (TEP), increased the overall length of hospital stay (15.4 vs 17.6 days; 18.1 vs 15.8 days). Accordingly, surgical procedures performed within 24 hours of injury resulted in a shorter hospital residence. Longest delay of operation was measured for hip fractures (28.3 hrs.). In 351 patients, secondary injuries were detected in 94 individuals (26%), with fractures being the most common secondary injury (n = 40). We recorded postoperative complications of nonsurgical and surgical origin, and 33.6% of our patient cohort displayed complications. Complications were distributed among 118 patients. There was no significant difference in complications regarding the time of operation, with most nonsurgical and surgical complications appearing within 24 hours after operation (n = 110 vs n = 31). Nonsurgical complications, such as anemia (n = 49) and electrolyte imbalances (n = 30), were observed more frequently than surgical complications (n = 107 vs n = 34); however, these complications were reduced by delay in surgery (82.0% in 6–24 hrs. vs 74.2% in ≥24 hrs.). Anticoagulant therapy and age did not affect postoperative complications. The hospital mortality of patients was 6.2%. Follow‐up was restrained to ambulatory visits in the clinic. Conclusions Surgical management of hip fractures performed within 24 hours of injury minimizes hospital stay. We did not detect significant differences in the spectrum or number of complications regarding delay of surgery. Surgical complications mainly occur with rapid primary care, and medical complications can be reduced by more intensive preparation of patient and operation procedures."],["dc.identifier.doi","10.1111/os.12524"],["dc.identifier.isi","WOS:000488199600001"],["dc.identifier.pmid","31568676"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16519"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66198"],["dc.identifier.url","https://publons.com/publon/28102254/"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","John Wiley \\u0026 Sons Australia, Ltd"],["dc.relation.eissn","1757-7861"],["dc.relation.issn","1757-7853"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Hip Fractures: Therapy, Timing, and Complication Spectrum"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","243"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Bone and Mineral Metabolism"],["dc.bibliographiccitation.lastpage","255"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Hoffmann, D. B."],["dc.contributor.author","Komrakova, M."],["dc.contributor.author","Pflug, S."],["dc.contributor.author","Oertzen, M. von"],["dc.contributor.author","Saul, D."],["dc.contributor.author","Weiser, L."],["dc.contributor.author","Walde, T. A."],["dc.contributor.author","Wassmann, M."],["dc.contributor.author","Schilling, A. F."],["dc.contributor.author","Lehmann, W."],["dc.contributor.author","Sehmisch, S."],["dc.date.accessioned","2020-06-15T13:52:01Z"],["dc.date.available","2020-06-15T13:52:01Z"],["dc.date.issued","2018"],["dc.description.abstract","We investigated the combinatorial effects of whole-body vertical vibration (WBVV) with the primarily osteoanabolic parathyroid hormone (PTH) and the mainly antiresorptive strontium ranelate (SR) in a rat model of osteoporosis. Ovariectomies were performed on 76 three-month-old Sprague-Dawley rats (OVX, n = 76; NON-OVX, n = 12). After 8 weeks, the ovariectomized rats were divided into 6 groups. One group (OVX + PTH) received daily injections of PTH (40 µg/kg body weight/day) for 6 weeks. Another group (OVX + SR) was fed SR-supplemented chow (600 mg/kg body weight/day). Three groups (OVX + VIB, OVX + PTH + VIB, and OVX + SR + VIB) were treated with WBVV twice a day at 70 Hz for 15 min. Two groups (OVX + PTH + VIB, OVX + SR + VIB) were treated additionally with PTH and SR, respectively. The rats were killed at 14 weeks post-ovariectomy. The lumbar vertebrae and femora were removed for biomechanical and morphological assessment. PTH produced statistically significant improvements in biomechanical and structural properties, including bone mineral density (BMD) and trabecular bone quality. In contrast, SR treatment exerted mild effects, with significant effects in cortical thickness only. SR produced no significant improvement in biomechanical properties. WBVV as a single or an adjunctive therapy produced no significant improvements. In conclusion, vibration therapy administered as a single or dual treatment had no significant impact on bones affected by osteoporosis. PTH considerably improved bone quality in osteoporosis cases and is superior to treatment with SR."],["dc.identifier.doi","10.1007/s00774-018-0929-9"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66263"],["dc.language.iso","en"],["dc.relation.issn","0914-8779"],["dc.title","Evaluation of Ostarine as a Selective Androgen Receptor Modulator in a Rat Model of Postmenopausal Osteoporosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","4"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nutrition & Metabolism"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Saul, Dominik"],["dc.contributor.author","Weber, Marie"],["dc.contributor.author","Zimmermann, Marc Hendrik"],["dc.contributor.author","Kosinsky, Robyn Laura"],["dc.contributor.author","Hoffmann, Daniel Bernd"],["dc.contributor.author","Menger, Björn"],["dc.contributor.author","Taudien, Stefan"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Komrakova, Marina"],["dc.contributor.author","Sehmisch, Stephan"],["dc.date.accessioned","2019-07-09T11:49:50Z"],["dc.date.accessioned","2020-06-09T07:03:29Z"],["dc.date.available","2019-07-09T11:49:50Z"],["dc.date.available","2020-06-09T07:03:29Z"],["dc.date.issued","2019"],["dc.description.abstract","Background Osteoporosis is one of the world’s major medical burdens in the twenty-first century. Pharmaceutical intervention currently focusses on decelerating bone loss, but phytochemicals such as baicalein, which is a lipoxygenase inhibitor, may rescue bone loss. Studies evaluating the effect of baicalein in vivo are rare. Methods We administered baicalein to sixty-one three-month-old female Sprague-Dawley rats. They were divided into five groups, four of which were ovariectomized (OVX) and one non-ovariectomized (NON-OVX). Eight weeks after ovariectomy, bilateral tibial osteotomy with plate osteosynthesis was performed and bone formation quantified. Baicalein was administered subcutaneously using three doses (C1: 1 mg/kg BW; C2: 10 mg/kg BW; and C3: 100 mg/kg BW) eight weeks after ovariectomy for four weeks. Finally, femora and tibiae were collected. Biomechanical tests, micro-CT, ashing, histological and gene expression analyses were performed. Results Biomechanical properties were unchanged in tibiae and reduced in femora. In tibiae, C1 treatment enhanced callus density and cortical width and decreased callus area. In the C3 group, callus formation was reduced during the first 3 weeks after osteotomy, correlating to a higher mRNA expression of Osteocalcin, Tartrate-resistant acid phosphatase and Rankl. In femora, baicalein treatments did not alter bone parameters. Conclusions Baicalein enhanced callus density and cortical width but impaired early callus formation in tibiae. In femora, it diminished the biomechanical properties and calcium-to-phosphate ratio. Thus, it is not advisable to apply baicalein to treat early bone fractures. To determine the exact effects on bone healing, further studies in which baicalein treatments are started at different stages of healing are needed."],["dc.identifier.doi","10.1186/s12986-018-0327-2"],["dc.identifier.pmid","30651746"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15789"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59640"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66212"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1743-7075"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Effect of the Lipoxygenase Inhibitor Baicalein on Bone Tissue and Bone Healing in Ovariectomized Rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","31"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Bone and Mineral Metabolism"],["dc.bibliographiccitation.lastpage","39"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Hoffmann, D. B."],["dc.contributor.author","Sehmisch, S."],["dc.contributor.author","Hofmann, A. M."],["dc.contributor.author","Eimer, C."],["dc.contributor.author","Komrakova, M."],["dc.contributor.author","Saul, D."],["dc.contributor.author","Wassmann, M."],["dc.contributor.author","Stürmer, K. M."],["dc.contributor.author","Tezval, M."],["dc.date.accessioned","2018-10-08T06:30:06Z"],["dc.date.accessioned","2020-06-15T06:44:32Z"],["dc.date.available","2018-10-08T06:30:06Z"],["dc.date.available","2020-06-15T06:44:32Z"],["dc.date.issued","2016"],["dc.description.abstract","We investigated the combinatorial effects of whole-body vertical vibration (WBVV) with the primarily osteoanabolic parathyroid hormone (PTH) and the mainly antiresorptive strontium ranelate (SR) in a rat model of osteoporosis. Ovariectomies were performed on 76 three-month-old Sprague-Dawley rats (OVX, n = 76; NON-OVX, n = 12). After 8 weeks, the ovariectomized rats were divided into 6 groups. One group (OVX + PTH) received daily injections of PTH (40 µg/kg body weight/day) for 6 weeks. Another group (OVX + SR) was fed SR-supplemented chow (600 mg/kg body weight/day). Three groups (OVX + VIB, OVX + PTH + VIB, and OVX + SR + VIB) were treated with WBVV twice a day at 70 Hz for 15 min. Two groups (OVX + PTH + VIB, OVX + SR + VIB) were treated additionally with PTH and SR, respectively. The rats were killed at 14 weeks post-ovariectomy. The lumbar vertebrae and femora were removed for biomechanical and morphological assessment. PTH produced statistically significant improvements in biomechanical and structural properties, including bone mineral density (BMD) and trabecular bone quality. In contrast, SR treatment exerted mild effects, with significant effects in cortical thickness only. SR produced no significant improvement in biomechanical properties. WBVV as a single or an adjunctive therapy produced no significant improvements. In conclusion, vibration therapy administered as a single or dual treatment had no significant impact on bones affected by osteoporosis. PTH considerably improved bone quality in osteoporosis cases and is superior to treatment with SR."],["dc.identifier.doi","10.1007/s00774-016-0736-0"],["dc.identifier.pmid","26825660"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66239"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1435-5604"],["dc.title","Comparison of parathyroid hormone and strontium ranelate in combination with whole-body vibration in a rat model of osteoporosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","400"],["dc.bibliographiccitation.journal","Frontiers in Endocrinology"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Saul, Dominik"],["dc.contributor.author","Geisberg, Laura Katharina"],["dc.contributor.author","Gehle, Torben"],["dc.contributor.author","Hoffmann, Daniel Bernd"],["dc.contributor.author","Tezval, Mohammad"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Komrakova, Marina"],["dc.date.accessioned","2019-07-16T08:32:27Z"],["dc.date.accessioned","2020-06-10T14:24:58Z"],["dc.date.available","2019-07-16T08:32:27Z"],["dc.date.available","2020-06-10T14:24:58Z"],["dc.date.issued","2019"],["dc.description.abstract","Objective: In aging population, postmenopausal osteoporosis and decline of musculoskeletal function, referred to as \"frailty syndrome\" lead to loss of bone and muscle, causing falls, and fall-related injuries. To limit the impact of this portentous duo, simultaneous treatment of both is needed. Urocortin (UCN) has been reported to improve osteoporotic bone properties while its effect on muscle has not been addressed yet. Design and Methods: We aimed to investigate the effect of urocortin in vivo on skeletal muscle structure in osteopenic rats. Sixty Sprague-Dawley rats were divided into five groups: four were ovariectomized (OVX) and one underwent sham operation (SHAM). One ovariectomized group was left untreated (OVX), while one was treated with urocortin s.c. in 3 μg/kg body weight (bw) (OVX+UCN low), one with 30 μg/kg (OVX+UCN high), while one group was treated with estradiol orally (OVX+E: 0.2 mg/kg bw), each for 35 days. Mm. gastrocnemius, longissimus, and soleus were isolated and capillary density as well as diameters of type I and II fibers were measured. In addition, we examined the effect of UCN on tibia using biomechanical, micro-CT and ashing analysis and investigated the blood serum. Results: We demonstrated a positive effect of UCN on M. soleus, in which fiber diameter was positively influenced. The biomechanical and structural parameters of bone were not changed in UCN treated rats. The higher cholesterol, glucose and triglyceride levels in the \"UCN high\" group raise concern about this treatment. Conclusions: Our results portray urocortin as a substance that can be assessed for future therapeutic treatments of estrogen deficiency. New and Noteworthy: Urocortin has a positive effect on M. soleus (diameter). Urocortin raises serum cholesterol and triglyceride levels. Bone tissue was not affected by UCN."],["dc.identifier.doi","10.3389/fendo.2019.00400"],["dc.identifier.isi","WOS:000473058700001"],["dc.identifier.pmid","31293517"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16282"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61553"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66223"],["dc.identifier.url","https://publons.com/publon/28102255/"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1664-2392"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Changes in Musculoskeletal System and Metabolism in Osteoporotic Rats Treated With Urocortin"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","100234"],["dc.bibliographiccitation.journal","Bone Reports"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Hoffmann, Daniel Bernd"],["dc.contributor.author","Popescu, Christian"],["dc.contributor.author","Komrakova, Marina"],["dc.contributor.author","Welte, Lena"],["dc.contributor.author","Saul, Dominik"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Hawellek, Thelonius"],["dc.contributor.author","Beil, Frank Timo"],["dc.contributor.author","Dakna, Mohammed"],["dc.contributor.author","Sehmisch, Stephan"],["dc.date.accessioned","2020-06-15T14:01:09Z"],["dc.date.available","2020-06-15T14:01:09Z"],["dc.date.issued","2020"],["dc.description.abstract","Introduction We evaluated the prevalence and influence of chronic hyponatremia in patients with low energy trauma. We also investigated the influence of medication and diseases on hyponatremia. Material and methods This retrospective study included 314 cases of proximal femoral fracture due to low energy trauma. Patients were treated in the University Medical Center Goettingen within 3 years. Hyponatremia was defined as serum sodium <135 mmol/L at admission. Results Overall, 15.6% of patients in the low energy trauma group had hyponatremia. Among patients older than 80 years, women showed distinctly higher rates of hyponatremia (female: 16.4%; male: 5.9%). In contrast only 4.7% of patients who underwent elective hip arthroplasty showed hyponatremia. Patients on sartanes and aldosterone antagonists showed significantly higher rates of hyponatremia. Alcoholism was significantly associated with hyponatremia. Conclusions We confirmed a high prevalence of chronic hyponatremia in patients with fractures due to low energy trauma. Our data underscore chronic hyponatremia as a contributing factor to hip fractures. Women older than 80 have a higher risk of developing hyponatremia. Sartanes, aldosterone antagonists, and alcohol disease are associated with hyponatremia. Treating hyponatremia may decrease the risk of fracture after low energy trauma. Therefore, physicians of different specialties should focus on treatment of chronic hyponatremia to reduce the fracture rate associated with low energy trauma."],["dc.identifier.doi","10.1016/j.bonr.2019.100234"],["dc.identifier.pmid","31909095"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17137"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66267"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2352-1872"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Chronic hyponatremia in patients with proximal femoral fractures after low energy trauma: A retrospective study in a level-1 trauma center"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","118"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","European Journal of Applied Physiology"],["dc.bibliographiccitation.lastpage","130"],["dc.bibliographiccitation.volume","124"],["dc.contributor.author","Saul, D."],["dc.contributor.author","Ninkovic, M."],["dc.contributor.author","Komrakova, M."],["dc.contributor.author","Wolff, P."],["dc.contributor.author","Simka, P."],["dc.contributor.author","Gasimov, T."],["dc.contributor.author","Menger, B."],["dc.contributor.author","Hoffmann, D. B."],["dc.contributor.author","Rohde, V."],["dc.contributor.author","Sehmisch, S."],["dc.date.accessioned","2020-06-15T06:51:43Z"],["dc.date.available","2020-06-15T06:51:43Z"],["dc.date.issued","2017"],["dc.description.abstract","Estrogen deficiency and aging are associated with osteoporosis, impaired bone healing, and lower cognitive performance. Close functional and physical connections occur between bone and the central nervous system. An anti-inflammatory drug, zileuton (which is an inhibitor of arachidonate 5-lipoxygenase), is known to have a positive effect on bone tissue repair and brain ischemia. We studied the effect of zileuton on osteopenic bone and its healing and on the genes considered to be crucial for the cross talks between bone and brain. Three-month-old Sprague-Dawley rats were ovariectomized or left untreated. After 8 wk, bilateral metaphyseal tibia osteotomy with plate osteosynthesis was performed in all rats. Ovariectomized rats were fed with food containing zileuton (1, 10, or 100 mg/kg body wt) for 5 wk. In tibiae, bone volume, callus and cortical volume, and gene expression of osteocalcin and alkaline phosphatase were enhanced by zileuton (10 or 100 mg); biomechanical properties and bone density were not changed. In femur, zileuton enlarged cortical volume distal and trabecular volume proximal, decreasing their density. The expression level of brain Sema3a, known to regulate bone mass positively, was downregulated after ovariectomy. In contrast, bone Sema4d, a negative regulator of bone mass, was upregulated in the tibia callus after ovariectomy, whereas zileuton treatment (10 or 100 mg) resulted in reverse effects. Here, we describe for the first time the expression of Rbbp4 mRNA and its increase in tibia after ovariectomy. Zileuton caused downregulation of Rbbp4 in the hippocampus and had an effect on bone healing, changed the expression of genes involved in cross talk between bones and brain, and may be a potent drug for further examination in estrogen deficiency-related dysfunction(s)."],["dc.identifier.doi","10.1152/japplphysiol.01126.2016"],["dc.identifier.pmid","28860177"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66241"],["dc.language.iso","en"],["dc.relation.eissn","1522-1601"],["dc.relation.issn","8750-7587"],["dc.title","Effect of zileuton on osteoporotic bone and its healing, expression of bone and brain genes in rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Journal of Nutrition and Metabolism"],["dc.bibliographiccitation.lastpage","14"],["dc.bibliographiccitation.volume","2016"],["dc.contributor.author","Saul, D."],["dc.contributor.author","Kling, J. H."],["dc.contributor.author","Kosinsky, R. L."],["dc.contributor.author","Hoffmann, D. B."],["dc.contributor.author","Komrakova, M."],["dc.contributor.author","Wick, M."],["dc.contributor.author","Menger, B."],["dc.contributor.author","Sehmisch, S."],["dc.date.accessioned","2019-07-09T11:43:04Z"],["dc.date.accessioned","2020-06-15T07:13:16Z"],["dc.date.available","2019-07-09T11:43:04Z"],["dc.date.available","2020-06-15T07:13:16Z"],["dc.date.issued","2016"],["dc.description.abstract","Sarcopenia, a loss of muscle mass accompanying osteoporosis, leads to falls and fall-related injuries. Baicalein, as a phytochemical agent, has an antioxidative and anti-inflammatory effect inmuscle. In this study, sixty-one female SpragueDawley rats were divided into five groups: four groups were ovariectomized (OVX) and one control group was nonovariectomized (NON-OVX). Eight weeks after ovariectomy, three disparate concentrations (1mg/kg body weight (BW), 10mg/kg BW, and 100mg/kg BW) of baicalein were applied subcutaneously daily in three OVX groups. Mm. soleus, gastrocnemius, and longissimus were extracted; their diameter, area, relation to body, andmuscleweights aswell as number of capillaries per fibrewere recorded. InMm. soleus and gastrocnemius, the baicalein effect (increasing number of capillaries per fibre) was proportional to the dose applied.The fibre diameters and area under baicalein treatment were significantly greater compared to OVX and NON-OVX groups. In M. longissimus, we observed a shift to type IIa fibres. Serum creatine kinase levels were significantly lower in highest baicalein concentration group.We conclude that baicalein can stimulate angiogenesis, though not fibre type-specific, in skeletal muscle and reduce the estrogen-related loss of fibre diameter and area in the skeletal muscle in rats.Therefore, a protective effect of baicalein on muscle cells can be assumed."],["dc.identifier.doi","10.1155/2016/3703216"],["dc.identifier.pmid","28050282"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14099"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58815"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66246"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","2090-0732"],["dc.relation.issn","2090-0724"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Effect of the Lipoxygenase Inhibitor Baicalein on Muscles in Ovariectomized Rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]