Welz, Christian

[["dc.bibliographiccitation.firstpage","1631"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Head & Neck"],["dc.bibliographiccitation.lastpage","1638"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Weiss, Bernhard G."],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Wolff, Hendrik A."],["dc.contributor.author","Schneider, Simon"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Steiner, Wolfgang"],["dc.contributor.author","Welz, Christian"],["dc.date.accessioned","2020-12-10T14:06:36Z"],["dc.date.available","2020-12-10T14:06:36Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1002/hed.v39.8"],["dc.identifier.issn","1043-3074"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/69956"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Transoral laser microsurgery for treatment for hypopharyngeal cancer in 211 patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","963"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Head & Neck"],["dc.bibliographiccitation.lastpage","972"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Baumeister, Philipp"],["dc.contributor.author","Baumüller, Konstantin"],["dc.contributor.author","Harréus, Ulrich"],["dc.contributor.author","Reiter, Maximilian"],["dc.contributor.author","Welz, Christian"],["dc.date.accessioned","2020-12-10T14:06:36Z"],["dc.date.available","2020-12-10T14:06:36Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1002/hed.v40.5"],["dc.identifier.issn","1043-3074"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/69957"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Evaluation of margins in head and neck squamous cell carcinoma from the surgeon's perspective"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2201"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Anticancer Research"],["dc.bibliographiccitation.lastpage","2210"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Hagemann, Jan"],["dc.contributor.author","Jacobi, Christian"],["dc.contributor.author","Hahn, Moritz"],["dc.contributor.author","Schmid, Vanessa"],["dc.contributor.author","Welz, Christian"],["dc.contributor.author","Schwenk-Zieger, Sabina"],["dc.contributor.author","Stauber, Roland"],["dc.contributor.author","Baumeister, Philipp"],["dc.contributor.author","Becker, Sven"],["dc.date.accessioned","2018-11-07T10:24:11Z"],["dc.date.available","2018-11-07T10:24:11Z"],["dc.date.issued","2017"],["dc.description.abstract","Background/Aim: Chemo-radiation currently serves as first-line therapy of advanced and recurrent head and neck cancer, while new chemotherapy regimens are emerging. However, response rates to any treatment are difficult to predict and underlie broad variation. This study shows the development of a standardized, high-throughput in vitro assay to assess patients' individual response to therapy regimens as a future tool for personalized tumor therapy. Materials and Methods: Viability and proliferation analyses after chemo +/- radiation treatment of single spheroids (low adhesion plates/Hanging Drop (HD)) were generated from head and neck squamous cell carcinoma (HNSCC) cell lines and primary human cells from fresh tumor specimens. Results: All cell lines showed reliable growth in all cell culture methods. The spheroids showed significant delay of growth and/or necrosis compared to control groups when exposed to current standard chemotherapeutic regimens. Single 3D spheroids ready for therapy susceptibility testing could be generated from actual tumor specimens after enzymatic and mechanical separation. Conclusion: In its current form, this single spheroid-based in vitro assay was able to test individual therapy susceptibility to current standard therapy regimens or, potentially, for testing new targeted drugs in HNSCC treatment. With recent discoveries regarding tumor heterogeneity and individual mutation status, a reliable assay is a prerequisite for personalized therapy in head and neck cancer."],["dc.description.sponsorship","Universitat Munchen"],["dc.identifier.doi","10.21873/anticanres.11555"],["dc.identifier.isi","000402173300005"],["dc.identifier.pmid","28476783"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42610"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Int Inst Anticancer Research"],["dc.relation.issn","1791-7530"],["dc.relation.issn","0250-7005"],["dc.title","Spheroid-based 3D Cell Cultures Enable Personalized Therapy Testing and Drug Discovery in Head and Neck Cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e1711"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Plastic & Reconstructive Surgery"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Spiegel, Jennifer L."],["dc.contributor.author","Pilavakis, Yiannis"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Welz, Christian"],["dc.date.accessioned","2020-12-10T18:19:54Z"],["dc.date.available","2020-12-10T18:19:54Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1097/GOX.0000000000001711"],["dc.identifier.issn","2169-7574"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75416"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Shoulder Morbidity in Patients after Head and Neck Reconstruction with the Pedicled Supraclavicular Island Flap"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","294"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Auris Nasus Larynx"],["dc.bibliographiccitation.lastpage","301"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Becker, Sven"],["dc.contributor.author","Zimmermann, Julia L."],["dc.contributor.author","Baumeister, Philipp"],["dc.contributor.author","Brunner, Theresa F."],["dc.contributor.author","Shimizu, Tetsuji"],["dc.contributor.author","Li, Yang-Fang"],["dc.contributor.author","Morfill, Gregor E."],["dc.contributor.author","Harréus, Ulrich"],["dc.contributor.author","Welz, Christian"],["dc.date.accessioned","2020-12-10T14:22:24Z"],["dc.date.available","2020-12-10T14:22:24Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.anl.2018.07.008"],["dc.identifier.issn","0385-8146"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71598"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Effects of cold atmospheric plasma (CAP) on bacteria and mucosa of the upper aerodigestive tract"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","878"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Otolaryngology–Head and Neck Surgery"],["dc.bibliographiccitation.lastpage","881"],["dc.bibliographiccitation.volume","158"],["dc.contributor.author","Baumeister, Philipp"],["dc.contributor.author","Welz, Christian"],["dc.contributor.author","Jacobi, Christian"],["dc.contributor.author","Reiter, Maximilian"],["dc.date.accessioned","2020-12-10T18:38:24Z"],["dc.date.available","2020-12-10T18:38:24Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1177/0194599817750354"],["dc.identifier.eissn","1097-6817"],["dc.identifier.issn","0194-5998"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77301"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Is Perineural Invasion of Head and Neck Squamous Cell Carcinomas Linked to Tobacco Consumption?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","343"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Environmental Pathology, Toxicology and Oncology"],["dc.bibliographiccitation.lastpage","354"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Welz, Christian"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Schwenk-Zieger, Sabina"],["dc.contributor.author","Becker, Sven"],["dc.contributor.author","Stucke, Vincent"],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Baumeister, Philipp"],["dc.date.accessioned","2020-12-10T18:42:45Z"],["dc.date.available","2020-12-10T18:42:45Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1615/JEnvironPatholToxicolOncol.v35.i4"],["dc.identifier.issn","0731-8898"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78070"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Cytotoxic and Genotoxic Effects of Electronic Cigarette Liquids on Human Mucosal Tissue Cultures of the Oropharynx"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2311"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","European Archives of Oto-Rhino-Laryngology"],["dc.bibliographiccitation.lastpage","2318"],["dc.bibliographiccitation.volume","276"],["dc.contributor.author","Spiegel, Jennifer L."],["dc.contributor.author","Pilavakis, Yiannis"],["dc.contributor.author","Weiss, Bernhard G."],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Welz, Christian"],["dc.date.accessioned","2020-12-10T14:10:30Z"],["dc.date.available","2020-12-10T14:10:30Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00405-019-05478-6"],["dc.identifier.eissn","1434-4726"],["dc.identifier.issn","0937-4477"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70779"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Quality of life in patients after reconstruction with the supraclavicular artery island flap (SCAIF) versus the radial free forearm flap (RFFF)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1997"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","European Archives of Oto-Rhino-Laryngology"],["dc.bibliographiccitation.lastpage","2004"],["dc.bibliographiccitation.volume","274"],["dc.contributor.author","Weiss, Bernhard G."],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Pilavakis, Yiannis"],["dc.contributor.author","Wolff', Hendrik A."],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Welz, Christian"],["dc.contributor.author","Steiner, Wolfgang"],["dc.date.accessioned","2018-11-07T10:25:34Z"],["dc.date.available","2018-11-07T10:25:34Z"],["dc.date.issued","2017"],["dc.description.abstract","For the treatment of T1b glottic carcinoma, different treatment options, such as transoral laser microsurgery, open surgical techniques, and primary radiotherapy, are under discussion. In this context, the aim of the present study was to describe oncologic results and complication rates of transoral laser microsurgery in treatment of T1b glottic carcinoma. This is a retrospective unicenter chart review of patients treated at an academic tertiary referral center between 1986 and 2006. Fifty-one previously untreated T1b cases were exclusively treated by transoral laser microsurgery and included into this study, 47 were male, and 4 were female. The main outcome measures included local control rate and complications, overall, disease specific, and recurrence-free survival. The median follow-up period was 98 months. The 5-year local control rate was 90.2%; larynx preservation rate was 92.2%. No intra- or postoperative complications, such as wound infections, postoperative bleeding, hematoma, edema, and fistula development, were observed. A single patient required revision surgery due to synechia. Five-year survival rates were: overall 84.7%, disease specific 97.7%, and recurrence free 72.4%. Our data support the conclusion that transoral laser microsurgery is a considerable treatment option in T1b glottic carcinoma. The oncologic outcome was at least comparable to other treatment options, while the perioperative morbidity and complication rate were lower."],["dc.identifier.doi","10.1007/s00405-016-4432-4"],["dc.identifier.isi","000399177000028"],["dc.identifier.pmid","28028607"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42879"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Springer"],["dc.relation.issn","1434-4726"],["dc.relation.issn","0937-4477"],["dc.title","Transoral laser microsurgery for T1b glottic cancer: review of 51 cases"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2432"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Cancers"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Kugler, Philipp"],["dc.contributor.author","Becker, Sven"],["dc.contributor.author","Welz, Christian"],["dc.contributor.author","Wiesmann, Nadine"],["dc.contributor.author","Sax, Jonas"],["dc.contributor.author","Buhr, Christoph R."],["dc.contributor.author","Thoma, Markus H."],["dc.contributor.author","Brieger, Juergen"],["dc.contributor.author","Eckrich, Jonas"],["dc.date.accessioned","2022-06-01T09:39:56Z"],["dc.date.available","2022-06-01T09:39:56Z"],["dc.date.issued","2022"],["dc.description.abstract","Cold atmospheric plasma (CAP) has demonstrated promising anti-cancer effects in numerous in vitro and in vivo studies. Despite their relevance for the treatment of solid tumors, effects of CAP on tumor vasculature and microcirculation have only rarely been investigated. Here, we report the reduction of vessel density and an increase in vascular permeability and tumor cell apoptosis after CAP application. Solid tumors in the chorioallantoic membrane of chicken embryos were treated with CAP and evaluated with respect to effects of CAP on embryo survival, tumor size, and tumor morphology. Furthermore, intratumoral blood vessel density, apoptotic cell death and the tumor-associated microcirculation were investigated and compared to sham treatment. Treatment with CAP significantly reduced intratumoral vessel density while increasing the rate of intratumoral apoptosis in solid tumors. Furthermore, CAP treatment increased vascular permeability and attenuated the microcirculation by causing vessel occlusions in the tumor-associated vasculature. These effects point out the potential of CAP as a promising and yet underrated therapeutic modality for addressing the tumor vasculature in the treatment of solid tumors."],["dc.identifier.doi","10.3390/cancers14102432"],["dc.identifier.pii","cancers14102432"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/108597"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-572"],["dc.relation.eissn","2072-6694"],["dc.title","Cold Atmospheric Plasma Reduces Vessel Density and Increases Vascular Permeability and Apoptotic Cell Death in Solid Tumors"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]