Hess, Clemens Friedrich

[["dc.bibliographiccitation.firstpage","455"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Radiotherapy and Oncology"],["dc.bibliographiccitation.lastpage","460"],["dc.bibliographiccitation.volume","91"],["dc.contributor.author","Vorwerk, Hilke"],["dc.contributor.author","Beckmann, Gabriele"],["dc.contributor.author","Bremer, Michael"],["dc.contributor.author","Degen, Maria"],["dc.contributor.author","Dietl, Barbara"],["dc.contributor.author","Fietkau, Rainer"],["dc.contributor.author","Gsaenger, Tammo"],["dc.contributor.author","Hermann, Robert Michael"],["dc.contributor.author","Herrmann, Markus Karl Alfred"],["dc.contributor.author","Hoeller, Ulrike"],["dc.contributor.author","van Kampen, Michael"],["dc.contributor.author","Koerber, Wolfgang"],["dc.contributor.author","Maier, Burkhard"],["dc.contributor.author","Martin, Thomas"],["dc.contributor.author","Metz, Michael"],["dc.contributor.author","Richter, Ronald"],["dc.contributor.author","Siekmeyer, Birgit"],["dc.contributor.author","Steder, Martin"],["dc.contributor.author","Wagner, Daniela"],["dc.contributor.author","Hess, Clemens Friedrich"],["dc.contributor.author","Weiss, Elisabeth"],["dc.contributor.author","Christiansen, Hans"],["dc.date.accessioned","2018-11-07T08:29:37Z"],["dc.date.available","2018-11-07T08:29:37Z"],["dc.date.issued","2009"],["dc.description.abstract","Purpose: Differences in the delineation of the gross target volume (GTV) and planning target volume (PTV) in patients with non-small-cell lung cancer are considerable. The focus of this work is on the analysis of observer-related reasons while controlling for other variables. Methods: In three consecutive patients, eighteen physicians from fourteen different departments delineated the GTV and M in CT-slices using a detailed instruction for target delineation. Differences in the volumes, the delineated anatomic lymph node compartments and differences in every delineated pixel of the contoured volumes in the CT-slices (pixel-by-pixel-analysis) were evaluated for different groups: ten radiation oncologists from ten departments (ROs), four haematologic oncologists and chest physicians from four departments (HOs) and five radiation oncologists from one department (RO1D). Results: Agreement (overlap >= 70% of the contoured pixels) for the GTV and PTV delineation was found in 16.3% and 23.7% (ROs), 30.4% and 38.6% (HOs) and 32.8% and 35.9% (RO1D), respectively. Conclusion: A large interobserver variability in the PTV and much more in the GTV delineation were observed in spite of a detailed instruction for delineation. The variability was smallest for group RO1D where due to repeated discussions and uniform teaching a better agreement was achieved. (C) 2009 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 91 (2009) 455-460"],["dc.identifier.doi","10.1016/j.radonc.2009.03.014"],["dc.identifier.isi","000266749200028"],["dc.identifier.pmid","19339069"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6276"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16693"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Ireland Ltd"],["dc.relation.issn","0167-8140"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","The delineation of target volumes for radiotherapy of lung cancer patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","85"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Radiation and Environmental Biophysics"],["dc.bibliographiccitation.lastpage","94"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Guerleyen, Hakan"],["dc.contributor.author","Christiansen, Hans"],["dc.contributor.author","Tello, Khodr"],["dc.contributor.author","Dudas, Joszef"],["dc.contributor.author","Hermann, Robert Michael"],["dc.contributor.author","Rave-Fraenk, Margret"],["dc.contributor.author","Hess, Clemens Friedrich"],["dc.contributor.author","Ramadori, Giuliano"],["dc.contributor.author","Saile, Bernhard"],["dc.date.accessioned","2018-11-07T08:33:19Z"],["dc.date.available","2018-11-07T08:33:19Z"],["dc.date.issued","2009"],["dc.description.abstract","This study aimed to reveal the pathophysiological signalling responsible for radiation-induced sensitization of hepatocytes to TNF-alpha-mediated apoptosis. I kappa B was upregulated in irradiated hepatocytes. Administration of I kappa B antisense oligonucleotides prior to irradiation inhibited occurrence of apoptosis after TNF-alpha administration. Caspases-8, -9 and -3 activities were increased in irradiated hepatocytes and downregulation of apoptosis by I kappa B antisense oligonucleotides was mediated by suppression of caspases-9 and -3 activation but not of caspase-8 activation, suggesting that radiation-induced sensitization of hepatocytes to TNF-alpha-mediated apoptosis additionally requires changes upstream of caspase-8 activation. Herein, upregulation of FLIP may play a crucial role. Cleavage of bid, upregulation of bax, downregulation of bcl-2 and release of cytochrome c after TNF-alpha-administration depend on radiation-induced upregulation of I kappa B, thus demonstrating an apoptosis permitting effect of I kappa B."],["dc.description.sponsorship","Deutsche Krebshilfe [106760]"],["dc.identifier.doi","10.1007/s00411-008-0200-1"],["dc.identifier.isi","000262316300009"],["dc.identifier.pmid","18956207"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/3523"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17548"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-2099"],["dc.relation.issn","0301-634X"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Irradiation leads to sensitization of hepatocytes to TNF-alpha-mediated apoptosis by upregulation of I kappa B expression"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","961"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Journal of Cancer Research and Clinical Oncology"],["dc.bibliographiccitation.lastpage","967"],["dc.bibliographiccitation.volume","135"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Overbeck, Tobias R."],["dc.contributor.author","Roedel, Ralf M. W."],["dc.contributor.author","Hermann, Robert Michael"],["dc.contributor.author","Herrmann, Markus Karl Alfred"],["dc.contributor.author","Kertesz, Tereza"],["dc.contributor.author","Vorwerk, Hilke"],["dc.contributor.author","Hille, Andrea"],["dc.contributor.author","Matthias, Christoph"],["dc.contributor.author","Hess, Clemens Friedrich"],["dc.contributor.author","Christiansen, Hans"],["dc.date.accessioned","2018-11-07T08:28:13Z"],["dc.date.available","2018-11-07T08:28:13Z"],["dc.date.issued","2009"],["dc.description.abstract","To evaluate toxicity of radiochemotherapy schedule using daily-low-dose-cisplatin in radiochemotherapy of locally-advanced head-and-neck-cancer (HNSCC). From October 2003 to October 2006, 50 patients with HNSCC (stage III/IVA/IVB) were treated. In 32 patients, surgery and adjuvant radiotherapy(64 Gy), in 18 patients definitive radiotherapy(70 Gy) was performed. Low-dose-cisplatin was applied concomitantly (6 mg/m(2)/every radiotherapy-day). Acute toxicity a parts per thousand yengrade 3 was observed in 22 patients (11 patients mucositis/dysphagia, 7 hematologic toxicity, 4 mucositis/dysphagia/hematologic toxicity). 90% of our patients received > 80% of the planned cumulative chemotherapy dose, 94% the intended dose of radiotherapy. After median follow-up of 24.2 months, 3-year overall survival and loco-regional control rates were 67.1 and 78%. During follow-up, chronic toxicity a parts per thousand yengrade 3 (xerostomia, subcutaneous fibrosis, or lymphedema) was observed in nine patients. We found chemoradiation with daily-low-dose-cisplatin to be feasible with advantage of low acute and chronic toxicity. Therefore, use of low-dose-cisplatin should be evaluated in future clinical trials."],["dc.identifier.doi","10.1007/s00432-008-0532-x"],["dc.identifier.isi","000266477900012"],["dc.identifier.pmid","19107519"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/3539"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16373"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-1335"],["dc.relation.issn","0171-5216"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Toxicity of daily low dose cisplatin in radiochemotherapy for locally advanced head and neck cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]