Hess, Clemens Friedrich

[["dc.bibliographiccitation.firstpage","127"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.lastpage","133"],["dc.bibliographiccitation.volume","185"],["dc.contributor.author","Vorwerk, Hilke"],["dc.contributor.author","Liersch, Thorsten"],["dc.contributor.author","Rothe, Hilka"],["dc.contributor.author","Ghadimi, Michael B."],["dc.contributor.author","Christiansen, Hans"],["dc.contributor.author","Hess, Clemens Friedrich"],["dc.contributor.author","Hermann, Robert Michael"],["dc.date.accessioned","2018-11-07T08:33:20Z"],["dc.date.available","2018-11-07T08:33:20Z"],["dc.date.issued","2009"],["dc.description.abstract","In locally advanced rectal cancer, neoadjuvant radiochemotherapy is indicated. To improve target volume definition for radiotherapy planning, the potential of implanted gold markers in the tumor region was evaluated. In nine consecutive patients, two to three gold markers were implanted in the tumor region during rigid rectoscopy. Computed tomography scans were performed during treatment planning. All electronic portal imaging devices (EPIDs) recorded during treatment series were analyzed. All patients underwent complete tumor resection with meticulous histopathologic examination. The gold markers could easily be implanted into the mesorectal tissue at the caudal tumor border without any complications. They were helpful in identifying the inferior border of the planning target volume in order to spare normal tissue (in particular anal structures). No significant shift of the markers was found during the course of therapy. Marker matching of the EPIDs did not improve patient positioning in comparison to bone structure matching. The former position of at least one marker could be identified in all patients during histopathologic examination. The use of gold marker enables a more precise definition of the target volume for radiotherapy in patients with rectal cancer. This could eventually allow a better protection of anal structures of patients with a tumor localization a parts per thousand yen 5 cm cranial of the anal sphincter. The implantation of the gold markers improved communication between the surgeon, the radiooncologist and the pathologist resulting in intensified exchange of relevant informations."],["dc.description.sponsorship","German scientific community"],["dc.identifier.doi","10.1007/s00066-009-1928-5"],["dc.identifier.isi","000263686200007"],["dc.identifier.pmid","19241000"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17553"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.relation.issn","0179-7158"],["dc.title","Goldmarker zur Tumorlokalisation und Zielvolumendefinition bei der Strahlentherapie des Rektumkarzinoms"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S479"],["dc.bibliographiccitation.journal","Radiotherapy and Oncology"],["dc.bibliographiccitation.lastpage","S480"],["dc.bibliographiccitation.volume","81"],["dc.contributor.author","Rave-Fraenk, Margret"],["dc.contributor.author","Guerleyen, Hakan"],["dc.contributor.author","Christiansen, H."],["dc.contributor.author","Thello, K."],["dc.contributor.author","Dudas, Jozsef"],["dc.contributor.author","Hermann, Robert Michael"],["dc.contributor.author","Hess, C. F."],["dc.contributor.author","Ramadori, Giuliano"],["dc.contributor.author","Saile, Bernhard"],["dc.date.accessioned","2018-11-07T09:13:58Z"],["dc.date.available","2018-11-07T09:13:58Z"],["dc.date.issued","2006"],["dc.identifier.isi","000242719101490"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27292"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Ireland Ltd"],["dc.publisher.place","Clare"],["dc.relation.conference","Conference of the Spanish-Portuguese-and -Latin-American-Association"],["dc.relation.eventlocation","Leipzig, GERMANY"],["dc.relation.issn","0167-8140"],["dc.title","Irradiation leads to sensitization of hepatocytes to TNF-alpha- mediated apoptosis by upregulation of IKB expression"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","189"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Radiology"],["dc.bibliographiccitation.lastpage","197"],["dc.bibliographiccitation.volume","242"],["dc.contributor.author","Christiansen, Hans"],["dc.contributor.author","Sheikh, Nadeem"],["dc.contributor.author","Saile, Bernhard"],["dc.contributor.author","Reuter, Felix"],["dc.contributor.author","Rave-Frank, Margret"],["dc.contributor.author","Hermann, Robert Michael"],["dc.contributor.author","Dudas, Jozsef"],["dc.contributor.author","Hille, Andrea"],["dc.contributor.author","Hess, Clemens Friedrich"],["dc.contributor.author","Ramadori, Giuliano"],["dc.date.accessioned","2018-11-07T11:07:32Z"],["dc.date.available","2018-11-07T11:07:32Z"],["dc.date.issued","2007"],["dc.description.abstract","Purpose: To prospectively analyze hepcidin, hemojuvelin and ferro-portin-1 expression after x-irradiation or rat liver and isolated rat hepacocytes. Materials and Methods: The treatment of the rats and this study were improved by the local committee and the public authority on animal welfare. Rat livers in vivo and isolated rat hepatocytes in vitro were irradiated. The total number of rats in this study was 43. RNA extracted from livers (1, 3, 6, 12, 24, and 48 hours after irradiation) and from hepatocytes (1, 3, 6, 12, and 24 hours after irradiation) was analyzed with real-time polymerase chain reaction and Northern blot. Cytokines and prohepcidin in serum of irradiated rats were quantitatively detected with enzyme-linked immunosorbent assay. Sham-irradiated animals served as controls in all experiments. Differences between sham-irradiated and irradiated data groups were tested with anaylsis of variance and Dunnett post hoc test. Results: In vivo, a significant radiation-induced increase of hepcidin (P = .034), interleukin (IL) 1 beta (P = .008), IL-6 (P < .011), and tumor necrosis factor alpha (TNF-alpha) (P = .047) expression could be detected within the first 48 hours after irradiation. Expression of hemojuvelin (P = .008) and ferro-portin-1 (P = .002) was significantly decreased. Serum iron levels were decreased because of irradiation (P < .058); prohepcidin serum levels were increased (P = .05). In rat hepatocytes in vitro, hepcidin RNA levels were significantly downregulated after irradiation (P < .001). Incubation of irradiated hepatocytes with IL-1 beta, IL-6, or TNNF-alpha led to upregulation of hepcidin expression in vitro up to 6 hours after irradiation, with subsequent significant down-regulation for incubation with IL-1 beta (P < .001). Hemojuvelin expression behaved in a way opposite to that of hepcidin. Conclusion: x-Irradiation of the liver, induced changes of hepcidin gene expression that are probably induced by acute phase mediators produced within the liver, itself."],["dc.identifier.doi","10.1148/radiol.2421060083"],["dc.identifier.isi","243842500024"],["dc.identifier.pmid","17090718"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52584"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Radiological Soc North America"],["dc.relation.issn","0033-8419"],["dc.title","x-irradiation in rat liver: Consequent upregulation of hepcidin and downregulation of hemojuvelin and ferroportin-1 gene expression"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","375"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Endocrine Related Cancer"],["dc.bibliographiccitation.lastpage","388"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Schmidberger, Heinz"],["dc.contributor.author","Hermann, Robert Michael"],["dc.contributor.author","Hess, C. F."],["dc.contributor.author","Emons, G."],["dc.date.accessioned","2018-11-07T10:36:25Z"],["dc.date.available","2018-11-07T10:36:25Z"],["dc.date.issued","2003"],["dc.description.abstract","Adjuvant radiotherapy and adjuvant endocrine therapy are commonly given to patients with invasive breast cancer or with ductal carcinoma in situ (DCIS). Although both therapies have been well established through a number of randomized studies, little is known about a possible interaction of both treatment modalities if they are given simultaneously. A number of in vitro studies have indicated that tamoxifen treatment might reduce the intrinsic radiosensitivity of MCF-7 breast cancer cells. Conversely, estradiol treatment increases the intrinsic radiosensitivity of MCF-7 cells. In one available animal study, an antagonistic effect of tamoxifen and ionizing radiation (XRT) could not be observed. Retrospective analyses of randomized clinical studies have not indicated an antagonistic effect of tamoxifen on the effectiveness of XRT since local control has been consistently higher when XRT was combined with tamoxifen, compared with treatment with XRT alone, regardless of whether tamoxifen was started simultaneously with radiotherapy or after completion of radiotherapy. Currently there are no clinical data available that would suggest an adverse effect of adjuvant tamoxifen treatment started prior to or simultaneously with radiotherapy in breast cancer or DCIS. However, since an antagonistic effect of tamoxifen and simultaneous chemotherapy has been reported recently, the issue of simultaneous versus sequential radiation and tamoxifen treatment in breast cancer should be addressed in further studies."],["dc.identifier.doi","10.1677/erc.0.0100375"],["dc.identifier.isi","000185849300003"],["dc.identifier.pmid","14503914"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45321"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc Endocrinology"],["dc.relation.issn","1351-0088"],["dc.title","Interactions between radiation and endocrine therapy in breast cancer"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.volume","181"],["dc.contributor.author","Christiansen, H."],["dc.contributor.author","Hermann, Robert Michael"],["dc.contributor.author","Hille, Andrea"],["dc.contributor.author","Schmidberger, Heinz"],["dc.contributor.author","Martin, A."],["dc.contributor.author","Nitsche, M."],["dc.contributor.author","Hess, C. F."],["dc.contributor.author","Pradier, Olivier"],["dc.date.accessioned","2018-11-07T11:06:37Z"],["dc.date.available","2018-11-07T11:06:37Z"],["dc.date.issued","2005"],["dc.format.extent","24"],["dc.identifier.isi","000229590600085"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52360"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.conference","11th Annual Congress of the German-Society-for-Radiooncology"],["dc.relation.eventlocation","Karlsruhe, GERMANY"],["dc.relation.issn","0179-7158"],["dc.title","Mitomycin-C duration infusion in primary radiochemotherapy of advanced inoperable head and neck tumours - Results of a Phase I study"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","817"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Cancer/Radiothérapie"],["dc.bibliographiccitation.lastpage","821"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Nitsche, M."],["dc.contributor.author","Horstmann, Olaf"],["dc.contributor.author","Christiansen, H."],["dc.contributor.author","Hermann, Robert Michael"],["dc.contributor.author","Hess, C. F."],["dc.contributor.author","Becker, H."],["dc.contributor.author","Pradier, Olivier"],["dc.contributor.author","Schmidberger, Heinz"],["dc.date.accessioned","2018-11-07T11:08:24Z"],["dc.date.available","2018-11-07T11:08:24Z"],["dc.date.issued","2008"],["dc.description.abstract","Background. - Recent Studies give rise to the hypothesis, that adjuvant chemoradioimmunotherapy with 5-fluorouracil (5-FU), cisplatin and interferon-alpha (IFN-alpha) might be a possible new treatment of pancreatic cancer in resected patients. We report the up-to-now experience at our institution. Patients and methods. - Eleven patients with histological diagnosis of localized carcinoma of the pancreas (n = 7) or periampullary (n =4) were prospectively analyzed. Four patients were deemed unresectable because of local invasion of adjacent organs (neoadjuvant setting) and seven patients underwent curative resection (adjuvant setting). Eight patients were classified as T3 carcinomas and three T4 carcinomas. Fifty-five per cent (6/11) of the patients presented with positive lymph node involvement. One histological Grade I, six Grade II and three Grade III were detected. External conformal irradiation to a total dose of 50.4 Gy with 1.8 Gy per day was delivered. All patients received a concomitant chemotherapy with continuous 5-FU 200 mg/m(2) per day on 28 treatment days and intravenous bolus cisplatin 30 mg/m(2) per week (Day 2, 9, 16, 23, 30). A recombinant r-IFN-alpha was administered on three days weekly during Week one to five of the radiotherapy course as subcutanous injections with 3 3 Mio. I.U. weekly. Results. - The four-year overall Survival rate for all patients was 55%. In the neoadjuvant group, three of four patients died due to progressive disease; in the adjuvant group, combined chemoradioimmunotherapy lead to controlled disease in five of seven patients. The overall toxicity was well-managed. Conclusion. - Our data strengthens the hypothesis of concomitant chemoradioimmunotherapy with 5-FU, IFN-alpha and cisplatin as a possible new treatment of pancreatic cancer in resected patients. (C) 2008 Elsevier Masson SAS. All rights reserved."],["dc.identifier.doi","10.1016/j.canrad.2008.09.009"],["dc.identifier.isi","000262218600009"],["dc.identifier.pmid","18996727"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52769"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier"],["dc.relation.issn","1278-3218"],["dc.title","Chemoradioimmunotherapy with 5-fluorouracil, cisplatin and interferon-alpha in pancreatic and periampullary cancer: Results of a feasibility study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.volume","186"],["dc.contributor.author","Hennies, Steffen"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Herrmann, M. K. A."],["dc.contributor.author","Rave-Fraenk, Margret"],["dc.contributor.author","Jung, K."],["dc.contributor.author","Strehle, J."],["dc.contributor.author","Ghadimi, B. Michael"],["dc.contributor.author","Hess, C. F."],["dc.contributor.author","Christiansen, H."],["dc.contributor.author","Hermann, Robert Michael"],["dc.date.accessioned","2018-11-07T08:43:03Z"],["dc.date.available","2018-11-07T08:43:03Z"],["dc.date.issued","2010"],["dc.format.extent","24"],["dc.identifier.isi","000278071200058"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19860"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.conference","16th Annual Meeting of the German-Society-of-Radio-Oncology"],["dc.relation.eventlocation","Magdeburg, GERMANY"],["dc.relation.issn","0179-7158"],["dc.title","Hormone status and quality of life in men after multimodal curative therapy (neoadjuvant chemoradiotherapy, TME and adjuvant chemotherapy) locally advanced rectum."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","162"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Radiation Research"],["dc.bibliographiccitation.lastpage","169"],["dc.bibliographiccitation.volume","169"],["dc.contributor.author","Moriconi, Federico"],["dc.contributor.author","Christiansen, Hans"],["dc.contributor.author","Raddatz, Dirk"],["dc.contributor.author","Dudas, Joszef"],["dc.contributor.author","Hermann, Robert Michael"],["dc.contributor.author","Rave-Fraenk, Mararet"],["dc.contributor.author","Sheikh, Nadeem"],["dc.contributor.author","Saile, Bernhard"],["dc.contributor.author","Hess, Clemens Friedrich"],["dc.contributor.author","Ramadori, Giuliano"],["dc.date.accessioned","2018-11-07T11:18:56Z"],["dc.date.available","2018-11-07T11:18:56Z"],["dc.date.issued","2008"],["dc.description.abstract","The aim of the study was to analyze the effect of a single irradiation on chemokine gene expression in the rat liver and in isolated rat hepatocytes. RNA extracted from livers and from hepatocytes within the first 48 h after irradiation was analyzed by real-time PCR and the Northern blot assay. The chemokine concentrations in the serum of irradiated rats were measured quantitatively by ELISA. A significant radiation-induced increase of CINC1, IP10, MCP1, MIP3 alpha, MIP3 beta, MIG and ITAC gene expression could be detected at the RNA level in the liver. CINC1, MCP1 and IP10 serum levels were significantly increased. In rat hepatocytes in vitro, only MIP3a showed a radiation-induced increase in expression, while CINC1, IP10, MIP3 beta, MIG, MIP1 alpha, ITAC and SDF1 RNA levels were significantly down-regulated. However, incubation of irradiated hepatocytes in vitro with either TNF-alpha, IL1 beta, or IL6 plus TNF-alpha led to up-regulation of MCP1, IP10 and MCP1 or CINC1 and MIP3 beta, respectively. Irradiation of the liver induces up-regulation of the genes of the main proinflammatory chemokines, probably through the action of locally synthesized proinflammatory cytokines. The reason for the lack of liver inflammation in this model has still to be clarified. (C) 2008 by Radiation Research Society."],["dc.identifier.doi","10.1667/RR1006.1"],["dc.identifier.isi","000252633000004"],["dc.identifier.pmid","18220462"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55150"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Radiation Research Soc"],["dc.relation.issn","0033-7587"],["dc.title","Effect of radiation on gene expression of rat liver chemokines: In vivo and in vitro studies"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Radiotherapy and Oncology"],["dc.bibliographiccitation.volume","70"],["dc.contributor.author","Hermann, Robert Michael"],["dc.contributor.author","Christiansen, H."],["dc.contributor.author","Schmidberger, Heinz"],["dc.contributor.author","Hess, C. F."],["dc.contributor.author","Pradier, Olivier"],["dc.date.accessioned","2018-11-07T10:51:37Z"],["dc.date.available","2018-11-07T10:51:37Z"],["dc.date.issued","2004"],["dc.format.extent","211"],["dc.identifier.doi","10.1016/j.radonc.2003.11.011"],["dc.identifier.isi","000220394500018"],["dc.identifier.pmid","15028413"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48933"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ireland Ltd"],["dc.relation.issn","0167-8140"],["dc.title","Comment on ' Dieckmann K, Georg D, Zehetmayer M, Bogner J, Georgopoulos M, Potter R LINAC based stereotactic radiotherapy of uveal melanoma: 4 years clinical experience' [Radiother oncol 2003; 67 : 199-206]"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.volume","185"],["dc.contributor.author","Wagner, D. M."],["dc.contributor.author","Anton, M."],["dc.contributor.author","Selbach, Hans-Joachim"],["dc.contributor.author","Hackel, Thomas"],["dc.contributor.author","Hermann, Robert Michael"],["dc.contributor.author","Hess, C. F."],["dc.contributor.author","Vorwerk, Hilke"],["dc.date.accessioned","2018-11-07T08:29:40Z"],["dc.date.available","2018-11-07T08:29:40Z"],["dc.date.issued","2009"],["dc.format.extent","20"],["dc.identifier.isi","000268225500042"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16703"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.conference","15th Annual Conference of the Deutschen-Gesellschaft-fur-Radioonkologie"],["dc.relation.eventlocation","Bremen, GERMANY"],["dc.relation.issn","0179-7158"],["dc.title","In vivo alanin/electron spin resonance (ESR) dosimetry in the urethra during (192)lr HDR brachtherapy in patients with prostate carcinoma: a phantom study"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]