Hess, Clemens Friedrich

[["dc.bibliographiccitation.artnumber","PII S0167-8140(02)00471-6"],["dc.bibliographiccitation.firstpage","83"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Radiotherapy and Oncology"],["dc.bibliographiccitation.lastpage","87"],["dc.bibliographiccitation.volume","63"],["dc.contributor.author","Weiss, Elisabeth"],["dc.contributor.author","Eberlein, Klaus"],["dc.contributor.author","Pradier, Olivier"],["dc.contributor.author","Schmidberger, Heinz"],["dc.contributor.author","Hess, Clemens F"],["dc.date.accessioned","2021-06-01T10:50:10Z"],["dc.date.available","2021-06-01T10:50:10Z"],["dc.date.issued","2002"],["dc.description.abstract","Background and purpose: The intention of this prospective study is to assess the influence of different patient positionings and the use of belly boards on the coverage of the uterus by standard radiation fields. Material and methods: In 21 women with carcinoma of the uterine cervix magnetic resonance imaging (MRI) scans in prone patient position with and without belly board and computed tomography (CT) scans in supine position were analysed after superimposing standard pelvic box fields. Further, all patients underwent a second MRI field control in prone position with belly board to detect intraindividual variations in the uterus position during treatment. Results: Standard portals did not completely cover the uterus in supine position in 7/21 (33%), in prone position with belly board in 7/21 (33%) and without belly board in 5/21 (24%). Insufficient uterine coverage was found only in the anteroposterior direction. The mean y distance ( standard deviation) between the field borders of the lateral portals and the uterus was in supine position anteriorly 3.4 cm (+/-2.2 cm) and posteriorly 1.8 cm (+/-1.3 cm), in prone position with belly board anteriorly 2.2 cm (+/-2.7 cm) and posteriorly 2.6 cm (+/-1.6 cm), prone without belly board anteriorly 3.3 cm (+/-2.4 cm) and posteriorly 1.9 cm (+/-1.1 cm). The difference was statistically significant between supine and prone position with belly board and between prone position with and without belly board. Repeated MRI controls during therapy showed no significant changes compared to the MRIs at the beginning of therapy. Conclusions: The use of standard radiation fields results in a high percentage of geographical misfits. Three-dimensional treatment planning is a prerequisite for adequate uterus coverage. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved."],["dc.identifier.doi","10.1016/S0167-8140(01)00471-6"],["dc.identifier.isi","000177128000010"],["dc.identifier.pmid","12065107"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86555"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ireland Ltd"],["dc.relation.issn","0167-8140"],["dc.title","The impact of patient positioning on the adequate coverage of the uterus in the primary irradiation of cervical carcinoma: a prospective analysis using magnetic resonance imaging"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1008"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","International Journal of Radiation Oncology*Biology*Physics"],["dc.bibliographiccitation.lastpage","1019"],["dc.bibliographiccitation.volume","67"],["dc.contributor.author","Fietkau, Rainer"],["dc.contributor.author","Roedel, Claus"],["dc.contributor.author","Hohenberger, Werner"],["dc.contributor.author","Raab, Rudolf"],["dc.contributor.author","Hess, Clemens"],["dc.contributor.author","Liersch, Torsten"],["dc.contributor.author","Becker, Heinz"],["dc.contributor.author","Wittekind, Christian"],["dc.contributor.author","Hutter, Matthias"],["dc.contributor.author","Hager, Eva"],["dc.contributor.author","Karstens, Johann"],["dc.contributor.author","Ewald, Hermann"],["dc.contributor.author","Christen, Norbert"],["dc.contributor.author","Jagoditsch, Michael"],["dc.contributor.author","Martus, Peter"],["dc.contributor.author","Sauer, Rolf"],["dc.date.accessioned","2018-11-07T11:04:07Z"],["dc.date.available","2018-11-07T11:04:07Z"],["dc.date.issued","2007"],["dc.description.abstract","Purpose: The impact of the delivery of radiotherapy (RT) on treatment results in rectal cancer patients is unknown. Methods and Materials: The data from 788 patients with rectal cancer treated within the German CAO/AIO/ARO-94 phase III trial were analyzed concerning the impact of the delivery of RT (adequate RT: minimal radiation RT dose delivered, 4300 cGy for neoadjuvant RT or 4700 cGy for adjuvant RT; completion of RT in < 44 days for neoadjuvant RT or < 49 days for adjuvant RT) in different centers on the locoregional recurrence rate (LRR) and disease-free survival (DFS) at 5 years. The LRR, DFS, and delivery of RT were analyzed as endpoints in multivariate analysis. Results: A significant difference was found between the centers and the delivery of RT. The overall delivery of RT was a prognostic factor for the LRR (no RT, 29.6% +/- 7.8%; inadequate RT, 21.2% +/- 5.6%; adequate RT, 6.8% +/- 1.4%; p = 0.0001) and DFS (no RT, 55.1% +/- 9.1%; inadequate RT, 57.4% +/- 6.3%; adequate RT, 69.1% +/- 2.3%; p = 0.02). Postoperatively, delivery of RT was a prognostic factor for LRR on multivariate analysis (together with pathologic stage) but not for DFS (independent parameters, pathologic stage and age). Preoperatively, on multivariate analysis, pathologic stage, but not delivery of RT, was an independent prognostic parameter for LRR and DFS (together with adequate chemotherapy). On multivariate analysis, the treatment center, treatment schedule (neoadjuvant vs. adjuvant RT), and gender were prognostic parameters for adequate RT. Conclusion: Delivery of RT should be regarded as a prognostic factor for LRR in rectal cancer and is influenced by the treatment center, treatment schedule, and patient gender. (c) 2007 Elsevier Inc."],["dc.identifier.doi","10.1016/j.ijrobp.2006.10.020"],["dc.identifier.isi","000245021100008"],["dc.identifier.pmid","17197130"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51762"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.publisher.place","New york"],["dc.relation.conference","25th Congress of the European-Society-for-Therapeutic-Radiology-and-Oncology"],["dc.relation.eventlocation","Leipzig, GERMANY"],["dc.relation.issn","0360-3016"],["dc.title","Rectal cancer delivery of radiotherapy in adequate time and with adequate dose is influenced by treatment center, treatment schedule, and gender and is prognostic parameter for local control: Results of study CAO/ARO/AIO-94"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","148"],["dc.bibliographiccitation.issue","938"],["dc.bibliographiccitation.journal","British Journal of Radiology"],["dc.bibliographiccitation.lastpage","157"],["dc.bibliographiccitation.volume","79"],["dc.contributor.author","Hille, Andrea"],["dc.contributor.author","Tows, N."],["dc.contributor.author","Hess, C. F."],["dc.date.accessioned","2018-11-07T10:20:56Z"],["dc.date.available","2018-11-07T10:20:56Z"],["dc.date.issued","2006"],["dc.description.abstract","The purpose of the current study was to quantitatively assess differences between irradiation techniques on normal tissue exposure in different clinical target volumes (CTVs) in irradiation of prostate cancer. 14 patients with prostate cancer undergoing external beam radiotherapy were investigated. The prostate and prostate + proximal/entire seminal vesicles were delineated as CTVs. A three-field and two different four-field plans were generated and compared concerning rectum, bladder and femoral head dose-volume histograms (DVHs). The exposure of the rectum exposed to 40-60 Gy was significantly lower for all CTVs with the three-field technique compared with both four-field techniques. The exposure of the rectum to 70 Gy was significantly lower for all CTVs with the weighted four-field technique compared with the unweighted four-field and three-field techniques. The weighted four-field technique was worst in bladder dose sparing for the three CTVs. Comparing the threefield and the unweighted four-field technique for irradiation of the prostate and prostate + entire seminal vesicles, no technique provided a clear advantage or disadvantage in bladder dose sparing. For irradiation of the prostate + proximal seminal vesicles the unweighted four-field technique provided the best bladder dose sparing. Concerning the exposure of the femoral heads, the three-field technique was significantly worse for the three CTVs compared with both four-field techniques. No difference was found between the unweighted and the weighted four-field techniques. in conclusion, none of the studied techniques consistently proved superior in different CTVs in prostate cancer irradiation with respect to sparing all organs at risk. The absolute differences between the three techniques were small and the clinical relevance of these findings is uncertain."],["dc.identifier.doi","10.1259/bjr/10206556"],["dc.identifier.isi","000235734900009"],["dc.identifier.pmid","16489196"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41980"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","British Inst Radiology"],["dc.relation.issn","0007-1285"],["dc.title","A comparison of three-field and four-field techniques in different clinical target volumes in prostate cancer irradiation using dose volume histograms: a prospective three-dimensional analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","667"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.lastpage","672"],["dc.bibliographiccitation.volume","179"],["dc.contributor.author","Schmidberger, Heinz"],["dc.contributor.author","Rave-Fraenk, Margret"],["dc.contributor.author","Kim, S."],["dc.contributor.author","Hille, Andrea"],["dc.contributor.author","Pradier, Olivier"],["dc.contributor.author","Hess, C. F."],["dc.date.accessioned","2018-11-07T10:36:01Z"],["dc.date.available","2018-11-07T10:36:01Z"],["dc.date.issued","2003"],["dc.description.abstract","Background: Chemotherapy-induced mucositis can be related to a decrease in oral neutrophils. We tested the relationship between radiation-induced mucositis and oral neutrophil counts. Patients and Methods: Oral neutrophil counts were obtained for ten patients with head and neck cancer who received radiotherapy of the pharynx and oral cavity. Four patients received additional chemotherapy (5-FU, Mitomycin). Counts were obtained before and during treatment; four healthy volunteers were included in the study as well. For evaluation, a quantitative mouth rinse assay, including neutrophil-staining with acridin-orange, was applied. Results: We observed large inter-individual variations with respect to neutrophil counts for patients and control persons (Table 1). During treatment (irradiation or chemoirradiation), large intra-individual variations were seen additionally (Figure 1). We found a correlation between neutrophil counts and clinical reaction grade. Neutrophil counts increased with increasing mucositis (Figure 2). This increase was more pronounced for patients treated with chemoirradiation compared to radiation alone. Treatment breaks at weekends had no clear influence on neutrophil counts. Conclusions: We observed a weak correlation between neutrophil counts and clinical reaction grade. However, the variations in neutrophil counts are too large to utilize this parameter as a surrogate for clinical mucositis grading. The assumption that a decrease in oral neutrophils is associated with radiation-induced mucositis was clearly negated."],["dc.identifier.doi","10.1007/s00066-003-1121-1"],["dc.identifier.isi","000185950700002"],["dc.identifier.pmid","14566474"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45227"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.relation.issn","0179-7158"],["dc.title","Radiation-induced mucositis and neutrophil granulocytes in oral mucosa"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.volume","183"],["dc.contributor.author","Christiansen, H."],["dc.contributor.author","Guerleyen, Hakan"],["dc.contributor.author","Rave-Fraenk, Margret"],["dc.contributor.author","Dudas, Jozsef"],["dc.contributor.author","Hess, C. F."],["dc.contributor.author","Ramadori, Giuliano"],["dc.contributor.author","Saile, Bernhard"],["dc.date.accessioned","2018-11-07T11:02:14Z"],["dc.date.available","2018-11-07T11:02:14Z"],["dc.date.issued","2007"],["dc.format.extent","49"],["dc.identifier.isi","000247071800131"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51329"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.conference","13th Congress of the Deutschen-Gesellschaft-fur-Radioonkologie"],["dc.relation.eventlocation","Hannover, GERMANY"],["dc.relation.issn","0179-7158"],["dc.title","Radiation-induced reduced expression of Hsp27 in in vitro liver macrophages leads to apoptosis and release of TNF-alpha"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","15"],["dc.bibliographiccitation.journal","Journal of Clinical Oncology"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Sauer, R."],["dc.contributor.author","Liersch, Thorsten"],["dc.contributor.author","Merkel, S."],["dc.contributor.author","Becker, H."],["dc.contributor.author","Hohenberger, Werner"],["dc.contributor.author","Witzigmann, Helmut"],["dc.contributor.author","Hess, C. F."],["dc.contributor.author","Fietkau, Rainer"],["dc.contributor.author","Wittekind, Christian"],["dc.contributor.author","Roedel, Claus"],["dc.date.accessioned","2018-11-07T08:56:08Z"],["dc.date.available","2018-11-07T08:56:08Z"],["dc.date.issued","2011"],["dc.identifier.isi","000208880300290"],["dc.identifier.pmid","28020337"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23066"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Clinical Oncology"],["dc.publisher.place","Alexandria"],["dc.relation.issn","1527-7755"],["dc.relation.issn","0732-183X"],["dc.title","Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: Results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.volume","185"],["dc.contributor.author","Wagner, D. M."],["dc.contributor.author","Anton, M."],["dc.contributor.author","Hess, C. F."],["dc.contributor.author","Vorwerk, Hilke"],["dc.date.accessioned","2018-11-07T08:29:41Z"],["dc.date.available","2018-11-07T08:29:41Z"],["dc.date.issued","2009"],["dc.format.extent","88"],["dc.identifier.isi","000268225500216"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16710"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.conference","15th Annual Conference of the Deutschen-Gesellschaft-fur-Radioonkologie"],["dc.relation.eventlocation","Bremen, GERMANY"],["dc.relation.issn","0179-7158"],["dc.title","In vivo alanine/electron spin resonance (ESR) dosimetry in radiotherapy in patients with head and neck tumor"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","127"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.lastpage","133"],["dc.bibliographiccitation.volume","185"],["dc.contributor.author","Vorwerk, Hilke"],["dc.contributor.author","Liersch, Thorsten"],["dc.contributor.author","Rothe, Hilka"],["dc.contributor.author","Ghadimi, Michael B."],["dc.contributor.author","Christiansen, Hans"],["dc.contributor.author","Hess, Clemens Friedrich"],["dc.contributor.author","Hermann, Robert Michael"],["dc.date.accessioned","2018-11-07T08:33:20Z"],["dc.date.available","2018-11-07T08:33:20Z"],["dc.date.issued","2009"],["dc.description.abstract","In locally advanced rectal cancer, neoadjuvant radiochemotherapy is indicated. To improve target volume definition for radiotherapy planning, the potential of implanted gold markers in the tumor region was evaluated. In nine consecutive patients, two to three gold markers were implanted in the tumor region during rigid rectoscopy. Computed tomography scans were performed during treatment planning. All electronic portal imaging devices (EPIDs) recorded during treatment series were analyzed. All patients underwent complete tumor resection with meticulous histopathologic examination. The gold markers could easily be implanted into the mesorectal tissue at the caudal tumor border without any complications. They were helpful in identifying the inferior border of the planning target volume in order to spare normal tissue (in particular anal structures). No significant shift of the markers was found during the course of therapy. Marker matching of the EPIDs did not improve patient positioning in comparison to bone structure matching. The former position of at least one marker could be identified in all patients during histopathologic examination. The use of gold marker enables a more precise definition of the target volume for radiotherapy in patients with rectal cancer. This could eventually allow a better protection of anal structures of patients with a tumor localization a parts per thousand yen 5 cm cranial of the anal sphincter. The implantation of the gold markers improved communication between the surgeon, the radiooncologist and the pathologist resulting in intensified exchange of relevant informations."],["dc.description.sponsorship","German scientific community"],["dc.identifier.doi","10.1007/s00066-009-1928-5"],["dc.identifier.isi","000263686200007"],["dc.identifier.pmid","19241000"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17553"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.relation.issn","0179-7158"],["dc.title","Goldmarker zur Tumorlokalisation und Zielvolumendefinition bei der Strahlentherapie des Rektumkarzinoms"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.volume","180"],["dc.contributor.author","Weiss, Elisabeth"],["dc.contributor.author","Siekmeyer, B."],["dc.contributor.author","Pradier, Olivier"],["dc.contributor.author","Schmidberger, Heinz"],["dc.contributor.author","Hess, C. F."],["dc.date.accessioned","2018-11-07T10:48:47Z"],["dc.date.available","2018-11-07T10:48:47Z"],["dc.date.issued","2004"],["dc.format.extent","62"],["dc.identifier.isi","000221877000240"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48277"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.conference","10th Annual Congress of the Deutschen-Gesellschaft-fur-Radioonkologie"],["dc.relation.eventlocation","Erfurt, GERMANY"],["dc.relation.issn","0179-7158"],["dc.title","Effective follow-up management in high risk radiotherapy patients"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Radiotherapy and Oncology"],["dc.bibliographiccitation.volume","73"],["dc.contributor.author","Pradier, Olivier"],["dc.contributor.author","Christiansen, H."],["dc.contributor.author","Lederer, K."],["dc.contributor.author","Hille, Andrea"],["dc.contributor.author","Hess, C. F."],["dc.contributor.author","Schmidberger, Heinz"],["dc.date.accessioned","2018-11-07T10:45:26Z"],["dc.date.available","2018-11-07T10:45:26Z"],["dc.date.issued","2004"],["dc.format.extent","S351"],["dc.identifier.isi","000226237701326"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47500"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Ireland Ltd"],["dc.publisher.place","Clare"],["dc.relation.conference","23rd Annual Meeting of the European-Society-for-Therapeutic-Radiology-and-Oncology (ESTRO 23)"],["dc.relation.eventlocation","Amsterdam, NETHERLANDS"],["dc.relation.issn","0167-8140"],["dc.title","A phase I study of fludarabine combined with radiotherapy in patients with locally advanced NSCLC lung carcinoma"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]