Now showing 1 - 3 of 3
  • 2016Journal Article Research Paper
    [["dc.bibliographiccitation.firstpage","94"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Human Brain Mapping"],["dc.bibliographiccitation.lastpage","121"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Cabral-Calderin, Yuranny"],["dc.contributor.author","Weinrich, Christiane Anne"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Poland, Eva"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Wilke, Melanie"],["dc.date.accessioned","2017-09-07T11:54:45Z"],["dc.date.available","2017-09-07T11:54:45Z"],["dc.date.issued","2016"],["dc.description.abstract","Transcranial alternating current stimulation (tACS) has emerged as a promising tool for manipulating ongoing brain oscillations. While previous studies demonstrated frequency-specific effects of tACS on diverse cognitive functions, its effect on neural activity remains poorly understood. Here we asked how tACS modulates regional fMRI blood oxygenation level dependent (BOLD) signal as a function of frequency, current strength, and task condition. TACS was applied over the posterior cortex of healthy human subjects while the BOLD signal was measured during rest or task conditions (visual perception, passive video viewing and motor task). TACS was applied in a blockwise manner at different frequencies (10, 16, 60 and 80 Hz). The strongest tACS effects on BOLD activity were observed with stimulation at alpha (10 Hz) and beta (16 Hz) frequency bands, while effects of tACS at the gamma range were rather modest. Specifically, we found that tACS at 16 Hz induced BOLD activity increase in fronto-parietal areas. Overall, tACS effects varied as a function of frequency and task, and were predominantly seen in regions that were not activated by the task. Also, the modulated regions were poorly predicted by current density modeling studies. Taken together, our results suggest that tACS does not necessarily exert its strongest effects in regions below the electrodes and that region specificity might be achieved with tACS due to varying susceptibility of brain regions to entrain to a given frequency. (C) 2015 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc."],["dc.identifier.doi","10.1002/hbm.23016"],["dc.identifier.fs","618728"],["dc.identifier.gro","3141752"],["dc.identifier.isi","000369150500007"],["dc.identifier.pmid","26503692"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14044"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/680"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10 / Funder: Hermann and Lilly Schilling Foundation"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1097-0193"],["dc.relation.issn","1065-9471"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Transcranial Alternating Current Stimulation Affects the BOLD Signal in a Frequency and Task-dependent Manner"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]
    Details DOI PMID PMC WOS
  • 2020Journal Article
    [["dc.bibliographiccitation.firstpage","102076"],["dc.bibliographiccitation.journal","NeuroImage: Clinical"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Miloserdov, Kristina"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Williams, Kathleen"],["dc.contributor.author","Weinrich, Christiane Anne"],["dc.contributor.author","Kagan, Igor"],["dc.contributor.author","Bürk, Katrin"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Wilke, Melanie"],["dc.date.accessioned","2020-12-10T15:20:31Z"],["dc.date.available","2020-12-10T15:20:31Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1016/j.nicl.2019.102076"],["dc.identifier.issn","2213-1582"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16784"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72695"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Aberrant functional connectivity of resting state networks related to misperceptions and intra-individual variability in Parkinson‘s disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]
    Details DOI
  • 2017Journal Article
    [["dc.bibliographiccitation.issue","124"],["dc.bibliographiccitation.journal","Journal of Visualized Experiments"],["dc.contributor.author","Williams, Kathleen A."],["dc.contributor.author","Cabral-Calderin, Yuranny"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Weinrich, Christiane Anne"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Wilke, Melanie"],["dc.date.accessioned","2018-10-10T09:02:41Z"],["dc.date.available","2018-10-10T09:02:41Z"],["dc.date.issued","2017"],["dc.description.abstract","Transcranial alternating current stimulation (tACS) is a promising tool for noninvasive investigation of brain oscillations. TACS employs frequency-specific stimulation of the human brain through current applied to the scalp with surface electrodes. Most current knowledge of the technique is based on behavioral studies; thus, combining the method with brain imaging holds potential to better understand the mechanisms of tACS. Because of electrical and susceptibility artifacts, combining tACS with brain imaging can be challenging, however, one brain imaging technique that is well suited to be applied simultaneously with tACS is functional magnetic resonance imaging (fMRI). In our lab, we have successfully combined tACS with simultaneous fMRI measurements to show that tACS effects are state, current, and frequency dependent, and that modulation of brain activity is not limited to the area directly below the electrodes. This article describes a safe and reliable setup for applying tACS simultaneously with visual task fMRI studies, which can lend to understanding oscillatory brain function as well as the effects of tACS on the brain."],["dc.fs.pkfprnr","60165"],["dc.identifier.doi","10.3791/55866"],["dc.identifier.fs","633451"],["dc.identifier.pmid","28605386"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15927"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1940-087X"],["dc.title","Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
    Details DOI PMID PMC