Nawrot, Martin Paul

[["dc.bibliographiccitation.artnumber","ENEURO.0549-20.2021"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","eNeuro"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Springer, Magdalena"],["dc.contributor.author","Nawrot, Martin Paul"],["dc.date.accessioned","2022-08-19T11:49:40Z"],["dc.date.available","2022-08-19T11:49:40Z"],["dc.date.issued","2021"],["dc.description.abstract","Extinction learning, the ability to update previously learned information by integrating novel contradictory information, is of high clinical relevance for therapeutic approaches to the modulation of maladaptive memories. Insect models have been instrumental in uncovering fundamental processes of memory formation and memory update. Recent experimental results in Drosophila melanogaster suggest that, after the behavioral extinction of a memory, two parallel but opposing memory traces coexist, residing at different sites within the mushroom body (MB). Here, we propose a minimalistic circuit model of the Drosophila MB that supports classical appetitive and aversive conditioning and memory extinction. The model is tailored to the existing anatomic data and involves two circuit motives of central functional importance. It employs plastic synaptic connections between Kenyon cells (KCs) and MB output neurons (MBONs) in separate and mutually inhibiting appetitive and aversive learning pathways. Recurrent modulation of plasticity through projections from MBONs to reinforcement-mediating dopaminergic neurons (DAN) implements a simple reward prediction mechanism. A distinct set of four MBONs encodes odor valence and predicts behavioral model output. Subjecting our model to learning and extinction protocols reproduced experimental results from recent behavioral and imaging studies. Simulating the experimental blocking of synaptic output of individual neurons or neuron groups in the model circuit confirmed experimental results and allowed formulation of testable predictions. In the temporal domain, our model achieves rapid learning with a step-like increase in the encoded odor value after a single pairing of the conditioned stimulus (CS) with a reward or punishment, facilitating single-trial learning."],["dc.identifier.doi","10.1523/ENEURO.0549-20.2021"],["dc.identifier.pmid","33785523"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113054"],["dc.identifier.url","https://for2705.de/literature/publications/27"],["dc.language.iso","en"],["dc.relation","FOR 2705: Dissection of a Brain Circuit: Structure, Plasticity and Behavioral Function of the Drosophila Mushroom Body"],["dc.relation","FOR 2705 | TP 4: From molecular computation to adaptive behavior: Across level modeling of memory computation in the mushroom bodies"],["dc.relation.issn","2373-2822"],["dc.relation.workinggroup","RG Nawrot"],["dc.title","A Mechanistic Model for Reward Prediction and Extinction Learning in the Fruit Fly"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Jürgensen, Anna-Maria"],["dc.contributor.author","Khalili, Afshin"],["dc.contributor.author","Chicca, Elisabetta"],["dc.contributor.author","Indiveri, Giacomo"],["dc.contributor.author","Nawrot, Martin Paul"],["dc.date.accessioned","2022-08-19T12:43:01Z"],["dc.date.available","2022-08-19T12:43:01Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1101/2021.06.29.450278"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113076"],["dc.identifier.url","https://for2705.de/literature/publications/40"],["dc.relation","FOR 2705: Dissection of a Brain Circuit: Structure, Plasticity and Behavioral Function of the Drosophila Mushroom Body"],["dc.relation.workinggroup","RG Gerber"],["dc.relation.workinggroup","RG Nawrot"],["dc.title","A neuromorphic model of olfactory processing and sparse coding in the Drosophila larva brain"],["dc.type","preprint"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Strube-Bloss, Martin Fritz"],["dc.contributor.author","D’Albis, Tiziano"],["dc.contributor.author","Menzel, Randolf"],["dc.contributor.author","Nawrot, Martin Paul"],["dc.date.accessioned","2022-08-19T12:39:09Z"],["dc.date.available","2022-08-19T12:39:09Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1101/2020.12.30.424797"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113074"],["dc.identifier.url","https://for2705.de/literature/publications/32"],["dc.relation","FOR 2705: Dissection of a Brain Circuit: Structure, Plasticity and Behavioral Function of the Drosophila Mushroom Body"],["dc.relation.workinggroup","RG Nawrot"],["dc.title","Single neuron activity predicts behavioral performance of individual animals during memory retention"],["dc.type","preprint"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Sakagiannis, Panagiotis"],["dc.contributor.author","Aguilera, Miguel"],["dc.contributor.author","Nawrot, Martin Paul"],["dc.date.accessioned","2022-08-19T12:30:53Z"],["dc.date.available","2022-08-19T12:30:53Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1101/2020.09.19.304774"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113072"],["dc.identifier.url","https://for2705.de/literature/publications/29"],["dc.relation","FOR 2705: Dissection of a Brain Circuit: Structure, Plasticity and Behavioral Function of the Drosophila Mushroom Body"],["dc.relation","FOR 2705 | TP 4: From molecular computation to adaptive behavior: Across level modeling of memory computation in the mushroom bodies"],["dc.relation.workinggroup","RG Nawrot"],["dc.title","A plausible mechanism for Drosophila larva intermittent behavior"],["dc.type","preprint"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Rapp, Hannes"],["dc.contributor.author","Nawrot, Martin Paul"],["dc.date.accessioned","2022-08-19T12:41:23Z"],["dc.date.available","2022-08-19T12:41:23Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1101/2020.04.05.026203"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113075"],["dc.identifier.url","https://for2705.de/literature/publications/37"],["dc.relation","FOR 2705: Dissection of a Brain Circuit: Structure, Plasticity and Behavioral Function of the Drosophila Mushroom Body"],["dc.relation","FOR 2705 | TP 4: From molecular computation to adaptive behavior: Across level modeling of memory computation in the mushroom bodies"],["dc.relation.workinggroup","RG Nawrot"],["dc.title","Neural computation underlying rapid learning and dynamic memory recall for sensori-motor control in insects"],["dc.type","preprint"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","498"],["dc.bibliographiccitation.issue","4-6"],["dc.bibliographiccitation.journal","Journal of Physiology-Paris"],["dc.bibliographiccitation.lastpage","506"],["dc.bibliographiccitation.volume","98"],["dc.contributor.author","Mehring, Carsten"],["dc.contributor.author","Nawrot, Martin Paul"],["dc.contributor.author","de Oliveira, Simone Cardoso"],["dc.contributor.author","Vaadia, Eilon"],["dc.contributor.author","Schulze-Bonhage, Andreas"],["dc.contributor.author","Aertsen, Ad"],["dc.contributor.author","Ball, Tonio"],["dc.date.accessioned","2022-10-06T13:33:13Z"],["dc.date.available","2022-10-06T13:33:13Z"],["dc.date.issued","2004"],["dc.identifier.doi","10.1016/j.jphysparis.2005.09.016"],["dc.identifier.pii","S0928425705000173"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115574"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0928-4257"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Comparing information about arm movement direction in single channels of local and epicortical field potentials from monkey and human motor cortex"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Rapp, Hannes"],["dc.contributor.author","Nawrot, Martin Paul"],["dc.contributor.author","Stern, Merav"],["dc.date.accessioned","2022-08-19T12:25:07Z"],["dc.date.available","2022-08-19T12:25:07Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1101/662932"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113069"],["dc.identifier.url","https://for2705.de/literature/publications/5"],["dc.relation","FOR 2705: Dissection of a Brain Circuit: Structure, Plasticity and Behavioral Function of the Drosophila Mushroom Body"],["dc.relation","FOR 2705 | TP 4: From molecular computation to adaptive behavior: Across level modeling of memory computation in the mushroom bodies"],["dc.relation.workinggroup","RG Nawrot"],["dc.title","Numerical cognition based on precise counting with a single spiking neuron"],["dc.type","preprint"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Springer, Magdalena"],["dc.contributor.author","Nawrot, Martin Paul"],["dc.date.accessioned","2022-08-19T12:45:57Z"],["dc.date.available","2022-08-19T12:45:57Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1101/2020.12.03.409490"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113078"],["dc.identifier.url","https://for2705.de/literature/publications/45"],["dc.relation","FOR 2705: Dissection of a Brain Circuit: Structure, Plasticity and Behavioral Function of the Drosophila Mushroom Body"],["dc.relation","FOR 2705 | TP 4: From molecular computation to adaptive behavior: Across level modeling of memory computation in the mushroom bodies"],["dc.relation.workinggroup","RG Nawrot"],["dc.title","A mechanistic model for reward prediction and extinction learning in the fruit fly"],["dc.type","preprint"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Sakagiannis, Panagiotis"],["dc.contributor.author","Jürgensen, Anna-Maria"],["dc.contributor.author","Nawrot, Martin Paul"],["dc.date.accessioned","2022-08-19T12:44:17Z"],["dc.date.available","2022-08-19T12:44:17Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1101/2021.07.07.451470"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113077"],["dc.identifier.url","https://for2705.de/literature/publications/41"],["dc.relation","FOR 2705: Dissection of a Brain Circuit: Structure, Plasticity and Behavioral Function of the Drosophila Mushroom Body"],["dc.relation","FOR 2705 | TP 4: From molecular computation to adaptive behavior: Across level modeling of memory computation in the mushroom bodies"],["dc.relation.workinggroup","RG Nawrot"],["dc.title","A realistic locomotory model of Drosophila larva for behavioral simulations"],["dc.type","preprint"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","288"],["dc.bibliographiccitation.lastpage","299"],["dc.contributor.author","Sakagiannis, Panagiotis"],["dc.contributor.author","Aguilera, Miguel"],["dc.contributor.author","Nawrot, Martin Paul"],["dc.contributor.editor","Vouloutsi, Vasiliki"],["dc.contributor.editor","Mura, Anna"],["dc.contributor.editor","Tauber, Falk"],["dc.contributor.editor","Speck, Thomas"],["dc.contributor.editor","Prescott, Tony J."],["dc.contributor.editor","Verschure, Paul F. M. J."],["dc.date.accessioned","2022-08-19T12:16:10Z"],["dc.date.available","2022-08-19T12:16:10Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/978-3-030-64313-3_28"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113064"],["dc.identifier.url","https://for2705.de/literature/publications/47"],["dc.publisher","Springer"],["dc.publisher.place","Cham"],["dc.relation","FOR 2705: Dissection of a Brain Circuit: Structure, Plasticity and Behavioral Function of the Drosophila Mushroom Body"],["dc.relation","FOR 2705 | TP 4: From molecular computation to adaptive behavior: Across level modeling of memory computation in the mushroom bodies"],["dc.relation.conference","9th International Conference, Living Machines 2020"],["dc.relation.eventend","2020-07-30"],["dc.relation.eventlocation","Freiburg"],["dc.relation.eventstart","2020-07-28"],["dc.relation.isbn","978-3-030-64312-6"],["dc.relation.isbn","978-3-030-64313-3"],["dc.relation.ispartof","Biomimetic and Biohybrid Systems"],["dc.relation.workinggroup","RG Nawrot"],["dc.title","A Plausible Mechanism for Drosophila Larva Intermittent Behavior"],["dc.type","conference_paper"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]