Now showing 1 - 3 of 3
  • 2022Journal Article Research Paper
    [["dc.bibliographiccitation.firstpage","3935"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","International Journal of Molecular Sciences"],["dc.bibliographiccitation.volume","23"],["dc.contributor.affiliation","Dias, Mariana Santana; 1Intermediate Laboratory of Gene Therapy and Viral Vectors, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil; mdias@biof.ufrj.br (M.S.D.); hilda@biof.ufrj.br (H.P.-S.)"],["dc.contributor.affiliation","Luo, Xiaoyue; 2Department of Neurology, University Medical Center Göttingen, 37077 Göttingen, Germany; xiaoyue.luo@med.uni-goettingen.de"],["dc.contributor.affiliation","Ribas, Vinicius Toledo; 3Laboratory of Neurobiology, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil; ribasvt@ufmg.br"],["dc.contributor.affiliation","Petrs-Silva, Hilda; 1Intermediate Laboratory of Gene Therapy and Viral Vectors, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil; mdias@biof.ufrj.br (M.S.D.); hilda@biof.ufrj.br (H.P.-S.)"],["dc.contributor.affiliation","Koch, Jan Christoph; 2Department of Neurology, University Medical Center Göttingen, 37077 Göttingen, Germany; xiaoyue.luo@med.uni-goettingen.de"],["dc.contributor.author","Dias, Mariana Santana"],["dc.contributor.author","Luo, Xiaoyue"],["dc.contributor.author","Ribas, Vinicius Toledo"],["dc.contributor.author","Petrs-Silva, Hilda"],["dc.contributor.author","Koch, Jan Christoph"],["dc.date.accessioned","2022-05-02T08:09:37Z"],["dc.date.available","2022-05-02T08:09:37Z"],["dc.date.issued","2022"],["dc.date.updated","2022-09-03T21:04:55Z"],["dc.description.abstract","Glaucoma is a neurodegenerative disease that affects the retinal ganglion cells (RGCs) and leads to progressive vision loss. The first pathological signs can be seen at the optic nerve head (ONH), the structure where RGC axons leave the retina to compose the optic nerve. Besides damage of the axonal cytoskeleton, axonal transport deficits at the ONH have been described as an important feature of glaucoma. Axonal transport is essential for proper neuronal function, including transport of organelles, synaptic components, vesicles, and neurotrophic factors. Impairment of axonal transport has been related to several neurodegenerative conditions. Studies on axonal transport in glaucoma include analysis in different animal models and in humans, and indicate that its failure happens mainly in the ONH and early in disease progression, preceding axonal and somal degeneration. Thus, a better understanding of the role of axonal transport in glaucoma is not only pivotal to decipher disease mechanisms but could also enable early therapies that might prevent irreversible neuronal damage at an early time point. In this review we present the current evidence of axonal transport impairment in glaucomatous neurodegeneration and summarize the methods employed to evaluate transport in this disease."],["dc.description.abstract","Glaucoma is a neurodegenerative disease that affects the retinal ganglion cells (RGCs) and leads to progressive vision loss. The first pathological signs can be seen at the optic nerve head (ONH), the structure where RGC axons leave the retina to compose the optic nerve. Besides damage of the axonal cytoskeleton, axonal transport deficits at the ONH have been described as an important feature of glaucoma. Axonal transport is essential for proper neuronal function, including transport of organelles, synaptic components, vesicles, and neurotrophic factors. Impairment of axonal transport has been related to several neurodegenerative conditions. Studies on axonal transport in glaucoma include analysis in different animal models and in humans, and indicate that its failure happens mainly in the ONH and early in disease progression, preceding axonal and somal degeneration. Thus, a better understanding of the role of axonal transport in glaucoma is not only pivotal to decipher disease mechanisms but could also enable early therapies that might prevent irreversible neuronal damage at an early time point. In this review we present the current evidence of axonal transport impairment in glaucomatous neurodegeneration and summarize the methods employed to evaluate transport in this disease."],["dc.identifier.doi","10.3390/ijms23073935"],["dc.identifier.pii","ijms23073935"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/107420"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-561"],["dc.relation.eissn","1422-0067"],["dc.rights","CC BY 4.0"],["dc.title","The Role of Axonal Transport in Glaucoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]
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  • 2016Journal Article Discussion
    [["dc.bibliographiccitation.firstpage","1245"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Neural Regeneration Research"],["dc.bibliographiccitation.lastpage","1246"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Ribas, Vinicius T."],["dc.contributor.author","Lingor, Paul"],["dc.date.accessioned","2018-11-07T10:10:44Z"],["dc.date.available","2018-11-07T10:10:44Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.4103/1673-5374.189184"],["dc.identifier.isi","000384146000018"],["dc.identifier.pmid","27651770"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14216"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39915"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Medknow Publications & Media Pvt Ltd"],["dc.relation.issn","1876-7958"],["dc.relation.issn","1673-5374"],["dc.rights","CC BY-NC-SA 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-sa/3.0"],["dc.title","Calcium channel inhibition-mediated axonal stabilization improves axonal regeneration after optic nerve crush"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]
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  • 2021Journal Article Research Paper
    [["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Cell Death & Disease"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Ribas, Vinicius Toledo"],["dc.contributor.author","Vahsen, Björn Friedhelm"],["dc.contributor.author","Tatenhorst, Lars"],["dc.contributor.author","Estrada, Veronica"],["dc.contributor.author","Dambeck, Vivian"],["dc.contributor.author","Almeida, Raquel Alves"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Michel, Uwe"],["dc.contributor.author","Koch, Jan Christoph"],["dc.contributor.author","Müller, Hans Werner"],["dc.contributor.author","Lingor, Paul"],["dc.date.accessioned","2021-04-14T08:28:39Z"],["dc.date.available","2021-04-14T08:28:39Z"],["dc.date.issued","2021"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.1038/s41419-021-03503-3"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82673"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2041-4889"],["dc.relation.orgunit","Abteilung Neurobiologie"],["dc.rights","CC BY 4.0"],["dc.title","AAV-mediated inhibition of ULK1 promotes axonal regeneration in the central nervous system in vitro and in vivo"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]
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