Quintes, Susanne

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[["dc.bibliographiccitation.firstpage","7632"],["dc.bibliographiccitation.issue","22"],["dc.bibliographiccitation.journal","Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","7645"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Fuenfschilling, Ursula"],["dc.contributor.author","Jockusch, Wolf J."],["dc.contributor.author","Sivakumar, Nandhini"],["dc.contributor.author","Möbius, Wiebke"],["dc.contributor.author","Corthals, Kristina"],["dc.contributor.author","Li, Sai"],["dc.contributor.author","Quintes, Susanne"],["dc.contributor.author","Kim, Younghoon"],["dc.contributor.author","Schaap, Iwan Alexander Taco"],["dc.contributor.author","Rhee, Jeong-Seop"],["dc.contributor.author","Nave, Klaus-Armin"],["dc.contributor.author","Saher, Gesine"],["dc.date.accessioned","2018-11-07T09:10:14Z"],["dc.date.available","2018-11-07T09:10:14Z"],["dc.date.issued","2012"],["dc.description.abstract","Cholesterol is an essential membrane component enriched in plasma membranes, growth cones, and synapses. The brain normally synthesizes all cholesterol locally, but the contribution of individual cell types to brain cholesterol metabolism is unknown. To investigate whether cortical projection neurons in vivo essentially require cholesterol biosynthesis and which cell types support neurons, we have conditionally ablated the cholesterol biosynthesis in these neurons in mice either embryonically or postnatally. We found that cortical projection neurons synthesize cholesterol during their entire lifetime. At all stages, they can also benefit from glial support. Adult neurons that lack cholesterol biosynthesis are mainly supported by astrocytes such that their functional integrity is preserved. In contrast, microglial cells support young neurons. However, compensatory efforts of microglia are only transient leading to layer-specific neuronal death and the reduction of cortical projections. Hence, during the phase of maximal membrane growth and maximal cholesterol demand, neuronal cholesterol biosynthesis is indispensable. Analysis of primary neurons revealed that neurons tolerate only slight alteration in the cholesterol content and plasma membrane tension. This quality control allows neurons to differentiate normally and adjusts the extent of neurite outgrowth, the number of functional growth cones and synapses to the available cholesterol. This study highlights both the flexibility and the limits of horizontal cholesterol transfer in vivo and may have implications for the understanding of neurodegenerative diseases."],["dc.identifier.doi","10.1523/JNEUROSCI.1352-11.2012"],["dc.identifier.fs","596609"],["dc.identifier.isi","000304627100022"],["dc.identifier.pmid","22649242"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8454"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26441"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc Neuroscience"],["dc.relation.issn","0270-6474"],["dc.relation.orgunit","Fakultät für Physik"],["dc.title","Critical Time Window of Neuronal Cholesterol Synthesis during Neurite Outgrowth"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Glia"],["dc.bibliographiccitation.volume","65"],["dc.contributor.author","Brinkmann, Bastian G."],["dc.contributor.author","Kungl, Theresa"],["dc.contributor.author","Ebert, Matthias"],["dc.contributor.author","Wernick, S."],["dc.contributor.author","Quintes, Susanne"],["dc.contributor.author","Nave, K.-A."],["dc.contributor.author","Sereda, Michael W."],["dc.date.accessioned","2018-11-07T10:23:01Z"],["dc.date.available","2018-11-07T10:23:01Z"],["dc.date.issued","2017"],["dc.format.extent","E381"],["dc.identifier.isi","000403071700590"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42381"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wiley"],["dc.publisher.place","Hoboken"],["dc.relation.conference","13th European Meeting on Glial Cells in Health and Disease"],["dc.relation.eventlocation","Edinburgh, SCOTLAND"],["dc.relation.issn","1098-1136"],["dc.relation.issn","0894-1491"],["dc.title","Using mouse models of peripheral neuropathies to study the development of Schmidt-Lanterman incisures"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Glia"],["dc.bibliographiccitation.volume","63"],["dc.contributor.author","Brinkmann, Bastian G."],["dc.contributor.author","Quintes, Susanne"],["dc.contributor.author","Ebert, Matthias"],["dc.contributor.author","Keric, Naureen"],["dc.contributor.author","Matz, A."],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.contributor.author","Nave, K.-A."],["dc.contributor.author","Sereda, Michael W."],["dc.date.accessioned","2018-11-07T09:54:17Z"],["dc.date.available","2018-11-07T09:54:17Z"],["dc.date.issued","2015"],["dc.format.extent","E286"],["dc.identifier.isi","000356386700487"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36504"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","12th European Meeting on Glial Cell Function in Health and Disease"],["dc.relation.eventlocation","Bilbao, SPAIN"],["dc.relation.issn","1098-1136"],["dc.relation.issn","0894-1491"],["dc.title","A novel role for Endothelin receptor B signalling in the peripheral nervous system"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.firstpage","202"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Structural Biology"],["dc.bibliographiccitation.lastpage","212"],["dc.bibliographiccitation.volume","173"],["dc.contributor.author","Dučić, Tanja"],["dc.contributor.author","Quintes, Susanne"],["dc.contributor.author","Nave, Klaus-Armin"],["dc.contributor.author","Susini, Jean"],["dc.contributor.author","Rak, Margaret"],["dc.contributor.author","Tucoulou, Remi"],["dc.contributor.author","Alevra, Mihai"],["dc.contributor.author","Guttmann, Peter"],["dc.contributor.author","Salditt, Tim"],["dc.date.accessioned","2017-09-07T11:44:21Z"],["dc.date.available","2017-09-07T11:44:21Z"],["dc.date.issued","2011"],["dc.description.abstract","We report elemental mappings on the sub-cellular level of myelinated sciatic neurons isolated from wild type mice, with high spatial resolution. The distribution of P. S. Cl, Na, K, Fe, Mn, Cu was imaged in freeze-dried as well as cryo-preserved specimen, using the recently developed cryogenic sample environment at beamline ID21 at the European Synchrotron Radiation Facility (ESRF). In addition, synchrotron radiation based Fourier transform infrared (FTIR) spectromicroscopy was used as a chemically sensitive imaging method. Finally single fiber diffraction in highly focused hard X-ray beams, and soft X-ray microscopy and tomography in absorption contrast are demonstrated as novel techniques for the study of single nerve fibers. (C) 2010 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.jsb.2010.10.001"],["dc.identifier.gro","3142780"],["dc.identifier.isi","000286846700002"],["dc.identifier.pmid","20950687"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/221"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10 / Funder: DFG Research Center"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1047-8477"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.subject.gro","x-ray imaging"],["dc.subject.gro","x-ray scattering"],["dc.subject.gro","neuro biophysics"],["dc.title","Structure and composition of myelinated axons: A multimodal synchrotron spectro-microscopy study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","6094"],["dc.bibliographiccitation.issue","19"],["dc.bibliographiccitation.journal","Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","6104"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Saher, G."],["dc.contributor.author","Quintes, S."],["dc.contributor.author","Möbius, Wiebke"],["dc.contributor.author","Wehr, M. C."],["dc.contributor.author","Kramer-Albers, E.-M."],["dc.contributor.author","Brugger, B."],["dc.contributor.author","Nave, K.-A."],["dc.date.accessioned","2021-06-01T10:48:22Z"],["dc.date.available","2021-06-01T10:48:22Z"],["dc.date.issued","2009"],["dc.identifier.doi","10.1523/JNEUROSCI.0686-09.2009"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85911"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1529-2401"],["dc.relation.issn","0270-6474"],["dc.title","Cholesterol Regulates the Endoplasmic Reticulum Exit of the Major Membrane Protein P0 Required for Peripheral Myelin Compaction"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]