Gold, Ralf

[["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Journal of Neuroimmunology"],["dc.bibliographiccitation.volume","154"],["dc.contributor.author","Stasiolek, Mariusz"],["dc.contributor.author","Bayas, A."],["dc.contributor.author","Kruse, Niels"],["dc.contributor.author","Toyka, Klaus V."],["dc.contributor.author","Gold, Ralf"],["dc.contributor.author","Selmaj, K."],["dc.date.accessioned","2018-11-07T10:46:03Z"],["dc.date.available","2018-11-07T10:46:03Z"],["dc.date.issued","2004"],["dc.format.extent","158"],["dc.identifier.isi","000224003200531"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47653"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.publisher.place","Amsterdam"],["dc.relation.conference","7th International Congress of the International-Society-of-Neuroimmunology"],["dc.relation.eventlocation","Venice, ITALY"],["dc.relation.issn","0165-5728"],["dc.title","Multiple sclerosis: impaired phenotype and maturation of plasmacytoid dendritic cells"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1009"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Der Nervenarzt"],["dc.bibliographiccitation.lastpage","1021"],["dc.bibliographiccitation.volume","76"],["dc.contributor.author","Gold, Ralf"],["dc.contributor.author","Bayas, A."],["dc.contributor.author","Toyka, Klaus V."],["dc.date.accessioned","2018-11-07T11:12:22Z"],["dc.date.available","2018-11-07T11:12:22Z"],["dc.date.issued","2005"],["dc.description.abstract","The group of autoimmune neuropathies includes the Guillain-Barre syndrome, chronic inflammatory demyelinating polyneuritis, multifocal motor neuropathy, neuropathies associated with monoclonal gammopathies, and vasculitic neuropathies. This educational review first addresses diagnostic pathways that facilitate more rational diagnostic decisions. Many therapies are effective for treating immune neuropathies. Unfortunately, none of the available therapies are specific. In the acute phase, glucocorticosteroids, plasmapheresis, and intravenous immunoglobulins play key roles. The list of long-term therapies includes azathioprine, cyclosporine, cyclophosphamide, and immunoglobulins. The therapeutic mechanisms involved are not clear for most of these compounds. Modem immunotherapy has to consider medical aspects, available therapeutic evidence, and long-term economic burden."],["dc.identifier.doi","10.1007/s00115-005-1942-5"],["dc.identifier.isi","000231649800014"],["dc.identifier.pmid","16080020"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53648"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0028-2804"],["dc.title","Autoimmune neuropathien - Current aspects of immunopathologic diagnostics and therapy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1236"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","1237"],["dc.bibliographiccitation.volume","253"],["dc.contributor.author","Schneider-Gold, Christiane"],["dc.contributor.author","Wessig, Carsten"],["dc.contributor.author","Hoepker, Martin"],["dc.contributor.author","Erdlenbruch, Bernhard"],["dc.contributor.author","Gold, Ralf"],["dc.contributor.author","Toyka, Klaus V."],["dc.date.accessioned","2018-11-07T09:21:23Z"],["dc.date.available","2018-11-07T09:21:23Z"],["dc.date.issued","2006"],["dc.identifier.doi","10.1007/s00415-006-0150-y"],["dc.identifier.isi","000241113100021"],["dc.identifier.pmid","16598612"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29091"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.relation.issn","0340-5354"],["dc.title","Pregnancy and delivery of a healthy baby in autoimmune Lambert-Eaton myasthenic syndrome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","MULTIPLE SCLEROSIS"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Stasiolek, Mariusz"],["dc.contributor.author","Bayas, A."],["dc.contributor.author","Kruse, Niels"],["dc.contributor.author","Toyka, Klaus V."],["dc.contributor.author","Gold, Ralf"],["dc.contributor.author","Selmaj, K."],["dc.date.accessioned","2018-11-07T10:56:30Z"],["dc.date.available","2018-11-07T10:56:30Z"],["dc.date.issued","2005"],["dc.format.extent","S121"],["dc.identifier.isi","000232249900443"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50026"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Hodder Arnold, Hodder Headline Plc"],["dc.publisher.place","London"],["dc.relation.conference","21st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis/10th Annual Meeting of Rehabilitation in MS"],["dc.relation.eventlocation","Thessaloniki, GREECE"],["dc.relation.issn","1352-4585"],["dc.title","Impaired reaction of plasmacytoid dendritic cells to toll-like receptor 7 and 9 ligands in MS patients"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","39"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Clinical & Experimental Immunology"],["dc.bibliographiccitation.lastpage","44"],["dc.bibliographiccitation.volume","142"],["dc.contributor.author","Hofstetter, Harald H."],["dc.contributor.author","Mossner, Rotraut"],["dc.contributor.author","Lesch, K. P."],["dc.contributor.author","Linker, Ralf Andreas"],["dc.contributor.author","Toyka, Klaus V."],["dc.contributor.author","Gold, Ralf"],["dc.date.accessioned","2018-11-07T10:55:12Z"],["dc.date.available","2018-11-07T10:55:12Z"],["dc.date.issued","2005"],["dc.description.abstract","Serotonin (5-hydroxytryptamine, 5-HT) is one of the most extensively studied neurotransmitters of the central nervous system. It also has been identified in constituents of the immune system. Therefore serotonin has been suggested to serve as a mediator of bidirectional interactions between the nervous system and the immune system. We investigated this interaction in experimental autoimmune encephalomyelitis (EAE), a well-defined animal model of autoimmune disease of the central nervous system (CNS) mimicking features of the human disease multiple sclerosis. EAE was induced by immunization with the autoantigens myelin basic protein (MBP) or the immunodominant peptide of myelin oligodendrocyte glycoprotein (MOG) spanning amino acids 35-55 (MOGp 35-55). We studied EAE in knockout (KO) mice lacking the 5-HT transporter (5-HTT) on a C57.BL/6 background, in comparison with wild-type C57.BL/6 animals. After immunization with MOGp 35-55, or with rat MBP, the disease courses of the 5-HTT knockout mice were attenuated as compared to wildtype control mice. This difference was more pronounced in female animals. To dissect potential immune mechanisms underlying this phenomenon, histological studies of the CNS and cytokine measurements in mononuclear cells from the spleens of 5-HTT KO mice and wild-type controls were performed. We found a reduction of the inflammatory infiltrate in the CNS and of the neuroantigen-specific production of IFN-gamma in splenocytes, again accompanied by a gender difference. These findings suggest a potential role of extracellular 5-HT homeostasis in the fine-tuning of neuroantigen-specific immune responses."],["dc.identifier.doi","10.1111/j.1365-2249.2005.02901.X"],["dc.identifier.isi","000231824900005"],["dc.identifier.pmid","16178854"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49732"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.relation.issn","0009-9104"],["dc.title","Absence of reuptake of serotonin influences susceptibility to clinical autoimmune disease and neuroantigen-specific interferon-gamma production in mouse EAE"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1406"],["dc.bibliographiccitation.issue","9468"],["dc.bibliographiccitation.journal","The Lancet"],["dc.bibliographiccitation.lastpage","1411"],["dc.bibliographiccitation.volume","365"],["dc.contributor.author","Sommer, C."],["dc.contributor.author","Weishaupt, Andreas"],["dc.contributor.author","Brinkhoff, J."],["dc.contributor.author","Biko, L."],["dc.contributor.author","Wessig, C."],["dc.contributor.author","Gold, Ralf"],["dc.contributor.author","Toyka, Klaus V."],["dc.date.accessioned","2018-11-07T11:07:59Z"],["dc.date.available","2018-11-07T11:07:59Z"],["dc.date.issued","2005"],["dc.description.abstract","Background Stiff-person syndrome (SPS) with antibodies to amphiphysin is a paraneoplastic disorder of the central nervous system with a putative autoimmune pathogenesis. Proof of a causal role of the antibodies is still lacking for this and all other antibody-associated paraneoplastic syndromes of the central nervous system. Methods We obtained the plasma filtrate of a patient with breast cancer and SPS that responded to therapeutic plasmapheresis. The purified IgG fraction included high-titre antibodies to the synaptic protein amphiphysin. In a cotransfer design, this IgG fraction was injected intraperitoneally into female Lewis rats that had received encephalitogenic T-helper (Th) lymphocytes specific for myelin basic protein, to induce an immune-mediated leaky blood-brain barrier. The rats were followed up with behavioural tests, video photography, and electromyography. Findings The injection of the IgG fraction including antibodies to amphiphysin resulted in a dose-dependent stiffness with spasms resembling human SPS. Control IgG injected into rats that had received the same encephalitogenic Th cells had no effect. IgG binding was demonstrated in the central nervous system of rats that Showed signs of the disorder. Interpretation These experiments support the hypothesis of a pathogenetic role of antibodies to amphiphysin, thus adding paraneoplastic SPS to the group of antibody-mediated autoimmune disorders. Relevance to practice These findings provide a strong argument for a direct pathogenetic role of anti-amphiphysin in this type of SPS and support therapeutic attempts to eliminate these autoantibodies by plasmapheresis. The experimental approach used could help to elucidate the role of autoantibodies in other paraneoplastic syndromes, such as SPS with antibodies to glutamic acid decarboxylase, and others including anti-Hu-associated subacute cerebellar degeneration and limbic encephalitis."],["dc.identifier.doi","10.1016/S0140-6736(05)66376-3"],["dc.identifier.isi","000228401900029"],["dc.identifier.pmid","15836889"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52693"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","0140-6736"],["dc.title","Paraneoplastic stiff-person syndrome: passive transfer to rats by means of IgG antibodies to amphiphysin"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.volume","251"],["dc.contributor.author","Bayas, A."],["dc.contributor.author","Stasiolek, Mariusz"],["dc.contributor.author","Kruse, Niels"],["dc.contributor.author","Toyka, Klaus V."],["dc.contributor.author","Selmaj, K."],["dc.contributor.author","Gold, Ralf"],["dc.date.accessioned","2018-11-07T10:48:35Z"],["dc.date.available","2018-11-07T10:48:35Z"],["dc.date.issued","2004"],["dc.format.extent","43"],["dc.identifier.isi","000222500400152"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48231"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.publisher.place","Darmstadt"],["dc.relation.conference","14th Meeting of the European-Neurological-Society"],["dc.relation.eventlocation","Barcelona, SPAIN"],["dc.relation.issn","0340-5354"],["dc.title","Altered regulatory function of plasmacytoid dendritic cells in multiple sclerosis"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1604"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","1606"],["dc.bibliographiccitation.volume","254"],["dc.contributor.author","Chan, Andrew"],["dc.contributor.author","Lee, De-Hyung"],["dc.contributor.author","Linker, Ralf"],["dc.contributor.author","Mohr, Alexander"],["dc.contributor.author","Toyka, Klaus V."],["dc.contributor.author","Gold, Ralf"],["dc.date.accessioned","2018-11-07T10:57:12Z"],["dc.date.available","2018-11-07T10:57:12Z"],["dc.date.issued","2007"],["dc.identifier.doi","10.1007/s00415-007-0593-9"],["dc.identifier.isi","000251096000021"],["dc.identifier.pmid","17713826"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50186"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.relation.issn","0340-5354"],["dc.title","Rescue therapy with anti-CD20 treatment in neuroimmunologic breakthrough disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","123"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Cellular Immunology"],["dc.bibliographiccitation.lastpage","130"],["dc.bibliographiccitation.volume","237"],["dc.contributor.author","Hofstetter, Harald H."],["dc.contributor.author","Ibrahim, S. M."],["dc.contributor.author","Koczan, D."],["dc.contributor.author","Kruse, Niels"],["dc.contributor.author","Weishaupt, Andreas"],["dc.contributor.author","Toyka, Klaus V."],["dc.contributor.author","Gold, Ralf"],["dc.date.accessioned","2018-11-07T10:55:11Z"],["dc.date.available","2018-11-07T10:55:11Z"],["dc.date.issued","2005"],["dc.description.abstract","Experimental autoimmune encephalomyelitis (EAE) is widely regarded as an animal model of the human disease multiple sclerosis. A multitude of studies has investigated the neuroantigen-specific T-cell mediated cytokine pattern present in animals with EAE. In particular, the role of the so-called Th1- and Th2-cytokines has been addressed. In a recent study.. it has been demonstrated that IL-23 rather than IL-12 is critical for modulating the character of the developing immune response towards a proinflammatory response and leading to EAE. IL-17 is a crucial effector cytokine, whose production is specifically triggered by IL-23, and it has been shown to be an essential,,g inflammatory mediator in other autoimmune diseases and inflammatory conditions. This led us to investigate the role of IL-17 in EAE. Strong antigen-specific production of IL-17 was demonstrated both in peripheral immune organs and in the CNS in acute and chronic EAE, as demonstrated by ELISPOT and RT-PCR analysis. Therapeutic neutralization of IL-17 with IL-17-receptor-Fc-protein in acute EAE ameliorated clinical symptoms. Neutralization of IL-17 with a monoclonal antibody also ameliorated the disease course. We conclude that IL-17 is crucially involved in the cytokine network as an effector cytokine in EAE. (c) 2005 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.cellimm.2005.11.002"],["dc.identifier.isi","000235248700006"],["dc.identifier.pmid","16386239"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49727"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","0008-8749"],["dc.title","Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","267"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","278"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Reinhardt, M."],["dc.contributor.author","Hauff, Peter"],["dc.contributor.author","Linker, Ralf Andreas"],["dc.contributor.author","Briel, A."],["dc.contributor.author","Gold, Ralf"],["dc.contributor.author","Rieckmann, Peter"],["dc.contributor.author","Becker, G."],["dc.contributor.author","Toyka, Klaus V."],["dc.contributor.author","Maurer, M."],["dc.contributor.author","Schirner, M."],["dc.date.accessioned","2018-11-07T10:56:48Z"],["dc.date.available","2018-11-07T10:56:48Z"],["dc.date.issued","2005"],["dc.description.abstract","Molecular imaging requires, not only the identification of an appropriate marker, but also its quantitative analysis. We used the Sensitive Particle Acoustic Quantification (SPAQ) technology - a novel ultrasound technique - for detection and quantification of cell adhesion molecules in isolated tissue and in live animals. By conjugating gasfilled microparticles (MPs) with antibodies to intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1), we were able to depict and quantify ICAM-1 and VCAM-I in isolated brain and spinal cord from rats with autoimmune encephalomyelitis (EAE), an established inflammatory disease model of human multiple sclerosis (MS). Depiction and quantification of specific MPs were also feasible in living animals with AT-EAE with similar results. After treatment with methylprednisolone, the measured number of targeted anti-ICAM-1 and VCAM-1-MPs was significantly lower (P < 0.01) compared to untreated animals demonstrating the high sensitivity of this imaging technique. Depending on the antibody linked to the surface of the MPs, the technique can be used to quantify the expression of any accessible antigen expressed on the luminal surface of endothelial cells and is therefore a promising tool for the noninvasive and dynamic assessment of disease-related molecules. (c) 2005 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.neuroimage.2005.04.019"],["dc.identifier.isi","000231154900002"],["dc.identifier.pmid","15905104"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50101"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","1053-8119"],["dc.title","Ultrasound derived imaging and quantification of cell adhesion molecules in experimental autoimmune encephalomyelitis (EAE) by Sensitive Particle Acoustic Quantification (SPAQ)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]