Laatsch, Hartmut G.

[["dc.bibliographiccitation.firstpage","3109"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Marine Drugs"],["dc.bibliographiccitation.lastpage","3123"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Abou-El-Wafa, Ghada S. E."],["dc.contributor.author","Shaaban, Mohamed"],["dc.contributor.author","Shaaban, Khaled Attia"],["dc.contributor.author","El-Naggar, Mohamed E. E."],["dc.contributor.author","Maier, Armin"],["dc.contributor.author","Fiebig, Heinz-Herbert"],["dc.contributor.author","Laatsch, Hartmut"],["dc.date.accessioned","2018-11-07T09:20:08Z"],["dc.date.available","2018-11-07T09:20:08Z"],["dc.date.issued","2013"],["dc.description.abstract","Two new diterpenoids, pachydictyol B (1a/1b) and C (2), were isolated from the dichloromethane extract of the marine brown alga, Dictyota dichotoma, collected from the Red Sea coast of Egypt, along with the known metabolites, pachydictyol A (3a), dictyol E (4), cis-africanan-1-ol (5a), fucosterol (6), tetrahydrothiophen-1,1-dioxide and poly--hydroxybutyric acid. GC-MS analysis of the nonpolar fractions also indicated the presence of -bourbonene and nonanal, along with three hydrocarbons and five fatty acids or their simple derivatives, respectively. GC-MS analysis of the unsaponifiable algal petroleum ether extract revealed the presence of a further eight compounds, among them 2,2,6,7-tetramethyl-10-oxatricyclo[4.3.0.1(1,7)]decan-5-one (7), N-(4-bromo-n-butyl)-piperidin-2-one (8) and tert-hexadecanethiol. Structures 1-6 were assigned by 1D and 2D NMR, mass spectra (EI, CI, HREI and HRESI) and by comparison with data from related structures. The crude algal extract was potently active against the breast carcinoma tumor cell line, MCF7 (IC50 = 0.6 mu g mL(-1)); pachydictyol B (1a) and dictyol E (4) showed weak antimicrobial properties, and the other compounds were inactive. Pachydictyols B (1a) and C (2) demonstrated a weak and unselective cytotoxicity against twelve human tumor cell lines with a mean IC50 of >30.0 mu M."],["dc.description.sponsorship","German Academic Exchange Service (DAAD)"],["dc.identifier.doi","10.3390/md11093109"],["dc.identifier.isi","000328621900001"],["dc.identifier.pmid","23975221"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10028"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28807"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mdpi Ag"],["dc.relation.issn","1660-3397"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Pachydictyols B and C: New Diterpenes from Dictyota dichotoma Hudson"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","35"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Marine Drugs"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Shaaban, Mohamed"],["dc.contributor.author","Abou-El-Wafa, Ghada S. E."],["dc.contributor.author","Golz, Christopher"],["dc.contributor.author","Laatsch, Hartmut"],["dc.date.accessioned","2021-04-14T08:29:39Z"],["dc.date.available","2021-04-14T08:29:39Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.3390/md19010035"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82956"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.publisher","MDPI"],["dc.relation.eissn","1660-3397"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.title","New Haloterpenes from the Marine Red Alga Laurencia papillosa: Structure Elucidation and Biological Activity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","579"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Applied Biochemistry and Biotechnology"],["dc.bibliographiccitation.lastpage","593"],["dc.bibliographiccitation.volume","162"],["dc.contributor.author","Elleuch, Lobna"],["dc.contributor.author","Shaaban, Mohamed"],["dc.contributor.author","Smaoui, Slim"],["dc.contributor.author","Mellouli, Lotfi"],["dc.contributor.author","Karray-Rebai, Ines"],["dc.contributor.author","Fguira, Lilia Fourati-Ben"],["dc.contributor.author","Shaaban, Khaled Attia"],["dc.contributor.author","Laatsch, Hartmut"],["dc.date.accessioned","2018-11-07T08:39:27Z"],["dc.date.available","2018-11-07T08:39:27Z"],["dc.date.issued","2010"],["dc.description.abstract","During our search for Streptomyces spp. as new producers of bioactive secondary metabolites, the ethyl acetate extract of the new terrestrial Streptomyces isolate TN262 delivered eight antimicrobially active compounds. They were identified as 1-acetyl-beta-carboline (1), tryptophol (2), cineromycin B (3), 2,3-dihydrocineromycin B (4), cyclo-(tyrosylprolyl) (5), 3-(hydroxyacetyl)-indole (6), brevianamide F (7), and cis-cyclo-(l-prolyl-l-leucyl) (8). Three further metabolites were detected in the unpolar fractions using GC-MS and tentatively assigned as benzophenone (9), N-butyl-benzenesulfonamide (10), and hexanedioic acid-bis-(2-ethylhexyl) ester (11). This last compound is known as plasticizer derivatives, but it has never been described from natural sources. In this article, we describe the identification of the new Streptomyces sp. isolate TN262 using its cultural characteristics, the nucleotide sequence of the corresponding 16S rRNA gene and the phylogenetic analysis, followed by optimization, large-scale fermentation, isolation of the bioactive constituents, and determination of their structures. The biological activity of compounds (2), (3), (4), and those of the unpolar fractions was addressed as well."],["dc.description.sponsorship","Tunisian-Egyptian project \"MELLOULI/SHAABAN\""],["dc.identifier.doi","10.1007/s12010-009-8808-4"],["dc.identifier.isi","000277282500023"],["dc.identifier.pmid","19842066"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6828"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19001"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Humana Press Inc"],["dc.relation.issn","0273-2289"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Bioactive Secondary Metabolites from a New Terrestrial Streptomyces sp TN262"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]