Stürmer, Klaus Michael

[["dc.bibliographiccitation.firstpage","521"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Der Unfallchirurg"],["dc.bibliographiccitation.lastpage","527"],["dc.bibliographiccitation.volume","110"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Hingelbaum, S."],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Roessler, M."],["dc.contributor.author","Stuermer, Klaus-Michael"],["dc.date.accessioned","2018-11-07T11:02:18Z"],["dc.date.available","2018-11-07T11:02:18Z"],["dc.date.issued","2007"],["dc.description.abstract","Background. The anatomic region on the lateral cortex of the ileum, where a palpable \"groove\" is formed by angulations of the lateral cortex of the iliac wing, is recommended as the insertion point for the pelvic emergency clamp by many authors. In our opinion this technique often leads to an incomplete closure of the anterior pelvic ring as well as to bacterial contamination of the access for the sacroiliac joint screw fixation and is accompanied by a risk for nerve and vessel injuries. To reduce these risks the pelvic clamp was placed at a supra-acetabular location. The goal of our study was to report on our experiences with the supra-acetabular position of the pelvic emergency clamp and to compare our results with the current literature. Material and method. From September 1998 to February 2006 the pelvic emergency clamp was applied in 15 polytraumatized patients (9 male, 6 female), with a mean age of 46 years (19-93) and a mean injury severity score (ISS) of 40 points (25-66) with mechanically and hemodynamically unstable pelvic ring fractures. According to the AO classification the injury pattern was type B2 in four cases, type B3 in one case, type C1 in seven cases, type C2 in two cases and type C3 in one case. The pelvic clamp was percutaneously applied 2-3 cm cranial to the acetabular roof. The duration from hospital admission until the pelvic emergency clamp was applied amounted to an average of 54 min (15-150); the procedure itself was performed in all cases in less than 15 min. The mean Hb at arrival in the emergency department was 7.4 (2.4-13.8) mg/dl and the mean systolic blood pressure 69 (0-130) mmHg. Results. In 14 patients a complete closure of the anterior and posterior pelvic ring could be achieved; in 1 patient an overcompression of the anterior pelvic ring was observed. Four patients died due to massive bleeding. Three patients with isolated pelvic ring fractures became hemodynamically stable within 20 min after treatment with the supra-acetabular pelvic clamp. Nine patients needed additional emergency surgery because of intracerebral, intrathoracic or intra-abdominal injuries. On average in the first 6 h, 36.7 (9-175) units of erythrocyte concentrates and 34.5 (4-200) units of fresh frozen plasma were transfused. Conclusions. The supra-acetabular pelvic clamp leads to a homogeneous force distribution to the pelvic ring and enables complete closure of the anterior and posterior pelvic ring in unstable pelvic fractures. Reduction of the intrapelvic volume and compression of the posterior pelvic ring can thus be achieved. Risks for intrapelvic perforation or injuries of vessels and nerves are low. No bacterial contamination of the access for the sacroiliac screw fixation occurs. To avoid overcompression of the unstable pelvic ring, manual or radiological control of the closure of the ventral pelvic ring is necessary."],["dc.identifier.doi","10.1007/s00113-007-1228-4"],["dc.identifier.isi","000247257500005"],["dc.identifier.pmid","17318312"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51348"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0177-5537"],["dc.title","The supra-acetabular pelvic clamp. Emergency treatment for unstable pelvic ring fractures"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","261"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","ACTA ORTHOPAEDICA BELGICA"],["dc.bibliographiccitation.lastpage","265"],["dc.bibliographiccitation.volume","74"],["dc.contributor.author","Balcarek, Peter"],["dc.contributor.author","Sawallich, Tobias"],["dc.contributor.author","Losch, Andreas"],["dc.contributor.author","Stuermer, Klaus Michael"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.date.accessioned","2018-11-07T11:16:16Z"],["dc.date.available","2018-11-07T11:16:16Z"],["dc.date.issued","2008"],["dc.description.abstract","Loss of knee extension after reconstruction of the anterior cruciate ligament may occur due to a neo-proliferative fibrous nodule located anterolateral to the tibial tunnel, termed cyclops syndrome. This nodule occurs usually within the early postoperative period and results in diminished knee extension due to impingement on the intercondylar notch. We report a case of a 24-year-old female patient with an uncommon delayed-onset loss of knee extension due to a cyclops syndrome four years after anterior cruciate ligament reconstruction."],["dc.identifier.isi","000256232500019"],["dc.identifier.pmid","18564486"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54545"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Acta Medica Belgica"],["dc.relation.issn","0001-6462"],["dc.title","Delayed cyclops syndrome : Symptomatic extension block four years after anterior cruciate ligament reconstruction"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","91"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Technology and Health Care"],["dc.bibliographiccitation.lastpage","102"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Floerkemeier, Thilo"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Wachowski, Martin"],["dc.contributor.author","Kubein-Meesenburg, Dietmar"],["dc.contributor.author","Gezzi, Riccardo"],["dc.contributor.author","Fanghaenel, Jochen"],["dc.contributor.author","Stuermer, Klaus Michael"],["dc.contributor.author","Naegerl, Hans"],["dc.date.accessioned","2018-11-07T09:02:04Z"],["dc.date.available","2018-11-07T09:02:04Z"],["dc.date.issued","2011"],["dc.description.abstract","After total knee replacement the persistence of pain represents a significant problem. In this study, a novel knee arthroplasty (Aequos G1 knee arthroplasty) is investigated that was designed to replicate main features of human knee morphology to reduce the periodically occurring pain after knee replacement. Previous work showed theoretically that this arthroplasty design may reconstruct the four-bar linkage mechanism as it occurs in human knee by contriving a convex lateral tibial compartment and a sagittal offset of the centre of the medial and lateral femur condyles - inducing a roll-back mechanism as it exists in human. The aim of this study was to determine whether this potential roll-back mechanism can be confirmed by in-vivo measurements. This retrospective study showed that the patellar tendon angle decreases during flexion of 0.21 degrees per degree of flexion on average in the 16 knees studied. This amount is similar to physiological knee kinematics and in contrast to existing results in the literature after implantation of conventional total knee replacements which lack physiological knee kinematics. The results suggest that physiological motion after implantation of the Aequos G1 knee arthroplasty occurs during loaded motion up to approximately 45 degrees knee flexion."],["dc.identifier.doi","10.3233/THC-2011-0616"],["dc.identifier.isi","000208598900003"],["dc.identifier.pmid","21422533"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24586"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Ios Press"],["dc.relation.issn","0928-7329"],["dc.title","Physiologically shaped knee arthroplasty induces natural roll-back"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Cytotherapy"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Hingelbaum, S."],["dc.contributor.author","Drengk, Anja"],["dc.contributor.author","Jennissen, H. P."],["dc.contributor.author","Chatzinikolaidou, M."],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.contributor.author","Stuermer, Klaus-Michael"],["dc.date.accessioned","2018-11-07T10:32:54Z"],["dc.date.available","2018-11-07T10:32:54Z"],["dc.date.issued","2006"],["dc.format.extent","8"],["dc.identifier.isi","000239337800021"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/44468"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Taylor & Francis As"],["dc.publisher.place","Oslo"],["dc.relation.issn","1465-3249"],["dc.title","BMP-2 and cell-coated titanium implants accelerate healing of osteochondral defects in a sheep model"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","214"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Cells Tissues Organs"],["dc.bibliographiccitation.lastpage","227"],["dc.bibliographiccitation.volume","170"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Barvencik, F."],["dc.contributor.author","Lohmann, Christoph H."],["dc.contributor.author","Viereck, Volker"],["dc.contributor.author","Siggelkow, Heide"],["dc.contributor.author","Breme, J."],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Sturmer, K. M."],["dc.date.accessioned","2018-11-07T10:32:53Z"],["dc.date.available","2018-11-07T10:32:53Z"],["dc.date.issued","2002"],["dc.description.abstract","The goal of this study was to characterize growth, mineralization and bone formation of osteoblast-like cells in titanium pore channels of defined diameter. Titanium implants with continuous drill channels of diameters of 300, 400, 500, 600 and 1,000 mum were inserted into human osteoblast-like cell cultures. The ingrowth of the cells into the drill channels was investigated by transmitted-light microscopy and scanning electron microscopy. Immunofluorescence and histological analysis of 15-channel sections of each diameter were used to investigate the growth behavior and the matrix protein patterns. Mineralization was evidenced by Alizarin red staining and high-resolution microradiography. The ingrowth of human osteoblast-like cells in the drill channels occurred in a sequence of four characteristic stages. In stage 1, osteoblast precursor cells adhered to the wall of the channel and migrated three-dimensionally into the channel by forming foot-like protoplasmic processes. For all 15 sample drill channels that were investigated, the cell ingrowth over 20 days amounted on average to 793 mum (+/- 179) into 600-mum-diameter channels, where they migrated significantly faster than in all the other channels. In stage 2, approximately on day 5-7, the osteoblast-like cells began to anchor on the substrate wall by matrix proteins and to build up a dense network of matrix proteins in the drill channel. The mineralization of the extracellular matrix, while depending on cell stimulation, was initiated in stage 3, on average after 4 weeks. In drill channels of a diameter of 1,000 mum the cell growth was incomplete and no mineralization was found by radiological assessment. Starting in week 6, in the drill channels of diameters ranging from 300 to 600 mum, the network of extracellular matrix proteins and osteoblast-like cells began to form an osteon-like structure. Neither the highly developed migration behavior of osteoblastic cells nor the reorganization from a fiber-like matrix to a lamellar structure have so far been described for cell cultures."],["dc.identifier.doi","10.1159/000047925"],["dc.identifier.isi","000174840400002"],["dc.identifier.pmid","11919409"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/44464"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","1422-6405"],["dc.title","Migration, matrix production and lamellar bone formation of human osteoblast-like cells in porous titanium implants"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","850"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Planta Medica"],["dc.bibliographiccitation.lastpage","857"],["dc.bibliographiccitation.volume","76"],["dc.contributor.author","Kolios, Leila"],["dc.contributor.author","Schumann, Jacob"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Rack, Thomas"],["dc.contributor.author","Tezval, Mohammed"],["dc.contributor.author","Seidlova-Wuttke, Dana"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Stuermer, Klaus Michael"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.date.accessioned","2018-11-07T08:43:01Z"],["dc.date.available","2018-11-07T08:43:01Z"],["dc.date.issued","2010"],["dc.description.abstract","Osteoporosis and its accompanying, predominantly metaphyseal, fractures are a major health problem. Black cohosh (Cimicifuga racemosa) and estrogen positively influence osteoporotic bone. Both substances may improve fracture healing in early osteoporosis as well. In 48 twelve-week-old ovariectomized or, respectively, sham-operated (SHAM) rats, a standardized metaphyseal tibia osteotomy with bridging T-plate fixation was performed. During the healing process of 35 days, rats received soy-free (SHAM, osteopenic C), estrogen-(E) or Cimicifuga racemosa-(CR) supplemented diets. After sacrifice, the callus formation was analyzed with regard to biomechanical quality, morphology, quantity, time course of new bone built and gene expression. CR induced a high rate of metaphyseal callus formation. The biomechanical properties and the amount of new callus formation indicated that fracture healing was still in progress. Therefore, gene expression of osteoblasts was comparatively high. Body weight and the trabecular structure were influenced little by CR. Estrogen improved the biomechanical properties of the callus. Resistance to microfracturing was significantly enhanced in the E group and even superior to SHAM. Remodeling of the callus formation had already begun. The trabecular network and the typical endosteal fracture healing were especially improved. Osteoporotic metaphyseal fracture healing was improved by estrogen more than by Cimicifuga racemosa. The process of fracture healing occurred nearly physiologically. The generation of callus formation was supported by Cimicifuga racemosa as well, but the five-week duration of application was too short for Cimicifuga racemosa to show its complete potential. Already-initiated Cimicifuga racemosa therapy for menopausal symptoms could be continued during fracture healing without hesitation."],["dc.description.sponsorship","DFG [STU 478/2-1]"],["dc.identifier.doi","10.1055/s-0029-1240798"],["dc.identifier.isi","000279668400002"],["dc.identifier.pmid","20104444"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19846"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0032-0943"],["dc.title","Effects of Black Cohosh (Cimicifuga racemosa) and Estrogen on Metaphyseal Fracture Healing in the Early Stage of Osteoporosis in Ovariectomized Rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","415"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","European Journal of Radiology"],["dc.bibliographiccitation.lastpage","420"],["dc.bibliographiccitation.volume","79"],["dc.contributor.author","Balcarek, Peter"],["dc.contributor.author","Walde, Tim Alexander"],["dc.contributor.author","Frosch, Stephan"],["dc.contributor.author","Schüttrumpf, Jan P."],["dc.contributor.author","Wachowski, Martin M."],["dc.contributor.author","Stürmer, Klaus M."],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.date.accessioned","2021-06-01T10:49:35Z"],["dc.date.available","2021-06-01T10:49:35Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.1016/j.ejrad.2010.06.042"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86346"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","0720-048X"],["dc.title","Patellar dislocations in children, adolescents and adults: A comparative MRI study of medial patellofemoral ligament injury patterns and trochlear groove anatomy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","176"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Der Unfallchirurg"],["dc.bibliographiccitation.lastpage","184"],["dc.bibliographiccitation.volume","112"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Naegerl, H."],["dc.contributor.author","Kubein-Meesenburg, Dietmar"],["dc.contributor.author","Doerner, Jochen"],["dc.contributor.author","Dathe, H."],["dc.contributor.author","Hellerer, O."],["dc.contributor.author","Dumont, C."],["dc.contributor.author","Stuermer, Klaus-Michael"],["dc.date.accessioned","2018-11-07T08:33:22Z"],["dc.date.available","2018-11-07T08:33:22Z"],["dc.date.issued","2009"],["dc.description.abstract","The human medial tibial plateau is concave, whereas the lateral tibial plateau is convex. In a normal knee, the convex femoral condyles roll and glide on the tibia during the standing phase of walking. The designs of most commercially available knee prostheses do not take this morphological feature into consideration. The novel design of the AEQUOS G1 knee replacement prosthesis is based on the natural anatomy of the knee joint, with a convex lateral tibia plateau and a sagittal offset of the medial and lateral compartments. Following extensive development and testing, initial clinical results of the AEQUOS G1 prosthesis in a mulitcenter study are presented. From Mai 2005 to March 2007, 158 patients in 4 clinics underwent total knee arthroplasty with the AEQUOS G1 and agreed to participate in the study. Patients were evaluated preoperatively and at 3, 6 and 12 months of follow-up using a standardized protocol that included the American Knee Society Score (AKSS), the Oxford Knee Score (OKS) and the Visual Analog Scale (VAS) for pain. After 3 months, 151 patients appeared for follow up appointments, after 6 months, 134, and after 12 months, 127. The mean range of motion preoperatively was 97.0A degrees (+/- 19.9A degrees) and 107.5A degrees (+/- 15.9A degrees) 12 months after surgery. The AKSS, as well as the modified OKS, significantly improved (p < 0.0001) from preoperative scores of 98.8 (+/- 35.8) and 37.3 (+/- 6.9) points, respectively, to 165.8 (+/- 34.1) and 21.9 (+/- 7.8) points, preoperatively, and 12 months postoperatively. The VAS score significantly decreased (p < 0.001) from 7.4 (+/- 1.8) points preoperatively to 1.9 (+/- 2.2) points 12 months postoperatively. One implant was revised because of arthrofibrosis and another due to patellar luxation. Two patients required revision because their implants revealed malalignement with ligamentous instability. No infections, aseptic loosening or other implant-specific complications were observed at this early follow-up. Good clinical results were observed at early follow-up with the AEQUOS G1 knee arthroplasty. However, longer follow-up is necessary for a general evaluation of the implant."],["dc.identifier.doi","10.1007/s00113-008-1551-4"],["dc.identifier.isi","000263300400006"],["dc.identifier.pmid","19212737"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17560"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0177-5537"],["dc.title","A new total knee arthroplasty with physiologically shaped surfaces Part 2: First clinical results"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","367"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Der Unfallchirurg"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","106"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Knopp, W."],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Langer, C."],["dc.contributor.author","Sturmer, K. M."],["dc.date.accessioned","2018-11-07T10:39:29Z"],["dc.date.available","2018-11-07T10:39:29Z"],["dc.date.issued","2003"],["dc.description.abstract","The treatment of comminuted fractures of the radial head with concomitant injuries of the ulnar complex by resection of the radial head usually does not provide satisfactory long-term results. Other than joint instability in the elbow and a limited range of motion, radius proximalisation in the sense of ulnocarpal impingement, osteoarthritis and pain in the elbow have been described. Between 1995 and 1997, 11 radial head prostheses were implanted in ten patients who had sustained a comminuted fracture of the radial head with concomitant injury to the ulnar complex. A follow-up survey was conducted with the patients on average 5 years after the injury. Eight patients with nine implants participated in the follow-up, one patient had died and another refused to participate but declared that he did not suffer from any impairment. According to the Morrey score, two of the results were found to be very good,five to be good, one to be fair and one to be poor. Despite the severe injuries sustained by the elbow, neither joint instability in the elbow nor proximalisation of the radius, cubitus valgus, ulnar nerve syndrome, nor loosening of the prosthesis were found in any of the patients. In the event of comminuted fractures of the radial head which are impossible to reconstruct by osteosynthesis and which occur with concomitant ulnar ligamentous or osseous injury, the implantation of a prosthesis is preferred over the resection of the head of the radius."],["dc.identifier.doi","10.1007/s00113-003-0573-1"],["dc.identifier.isi","000183518200002"],["dc.identifier.pmid","12750809"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46061"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0177-5537"],["dc.title","A bipolar radial head prosthesis after comminuted radial head fractures: indications, treatment and outcome after 5 years"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1796"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Phytotherapy Research"],["dc.bibliographiccitation.lastpage","1806"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Kolios, Leila"],["dc.contributor.author","Daub, Florian"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Tezval, Mohammed"],["dc.contributor.author","Stuermer, Klaus Michael"],["dc.contributor.author","Wuttke, Wolfgang"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.date.accessioned","2018-11-07T08:36:30Z"],["dc.date.available","2018-11-07T08:36:30Z"],["dc.date.issued","2010"],["dc.description.abstract","The healing of predominantly metaphyseal fractures in postmenopausal osteoporosis is delayed and comparatively poor. Due to the potential side effects of HRT, natural alternatives are appealing. The aim of this study was to determine whether Cimicifuga racemosa extract BNO 1055 improves metaphyseal fracture healing in severe osteopenic bone in rats. Thirty-three 12-week-old female rats developed severe osteopenia during 10 weeks after ovariectomy. After metaphyseal tibial-osteotomy and standardized T-plate-osteosynthesis, the healing periods in ovariectomized rats (C), 17-beta-estradiol (E) and Cimicifuga racemosa (CR) supplemented diets were assessed for 35 days. Changes in callus morphology were evaluated qualitatively by biomechanical testing and quantitatively in microradiographies and fluorochrome-labeled histological sections. The CR-supplementation slightly improved callus quality and trabecular bone formation. It significantly enhanced the endosteal callus density compared to C group (CI.Dn.e C: 59.08 +/- 21.89, E: 45.95 +/- 18.39, CR: 60.85 +/- 18.66 ), though most of the other morphological parameters examined showed no improvement. The time course of fracture healing did not change due to CR. Estrogen-supplementation enhanced the biomechanical properties of the fracture site. Trabecular bone was improved indicating the physiological endosteal healing process. The CR-supplementation did not exhibit positive effects in severe (senile) osteopenic fracture healing as seen in early (postmenopausal) osteoporosis in rats. Callus formation was slightly improved under CR. Estrogen improved fracture healing in severe osteopenic bone, while the extent of callus formation played a minor role. Copyright (C) 2010 John Wiley & Sons, Ltd."],["dc.description.sponsorship","DFG [STU 478/2-1]"],["dc.identifier.doi","10.1002/ptr.3176"],["dc.identifier.isi","000285679200008"],["dc.identifier.pmid","20564511"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18326"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0951-418X"],["dc.title","Absence of Positive Effect of Black Cohosh (Cimicifuga racemosa) on Fracture Healing in Osteopenic Rodent Model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]