Stürmer, Klaus Michael

[["dc.bibliographiccitation.firstpage","317"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Cells Tissues Organs"],["dc.bibliographiccitation.lastpage","326"],["dc.bibliographiccitation.volume","189"],["dc.contributor.author","Drengk, Anja"],["dc.contributor.author","Zapf, Antonia"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.contributor.author","Stuermer, Klaus Michael"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.date.accessioned","2018-11-07T08:34:01Z"],["dc.date.available","2018-11-07T08:34:01Z"],["dc.date.issued","2009"],["dc.description.abstract","Background/Aims: Autologous chondrocyte (CC) transplantation has the disadvantages of requiring two surgical interventions and in vitro expansion of cells, implying the risk of cellular dedifferentiation. Our clinical aim is to develop a one-step procedure for autologous CC transplantation, i.e. harvesting, isolation and reimplantation of CC performed in one single surgical procedure. Platelet-rich plasma (PRP) is a source of autologous growth factors reported to have mitogenic effects. The objective of this study was to test the influence of PRP as an autologous scaffold on freshly isolated CC and mesenchymal stem cells (MSC). Methods: CC and MSC were subjected to two- or three-dimensional (3D) growth systems, either with or without PRP. Chondrogenic differentiation was determined via quantification of collagen type II mRNA and immunohistochemical staining. Results: We observed a proliferative effect for MSCs exposed to PRP in monolayer culture and an increase in the expression of chondrogenic markers when cells are exposed to a 3D environment. CCs exposed to PRP show a decrease in the chondrogenic phenotype with increasing proliferative activity. Conclusion: PRP has a proliferative effect on CCs and MSCs. In a one-step procedure for autologous CC transplantation, this might be an advantage over other scaffold materials, but confirmation in in vivo studies is required. Copyright (C) 2008 S. Karger AG, Basel"],["dc.identifier.doi","10.1159/000151290"],["dc.identifier.isi","000265178600002"],["dc.identifier.pmid","18689989"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9312"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17722"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","1422-6405"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Influence of Platelet-Rich Plasma on Chondrogenic Differentiation and Proliferation of Chondrocytes and Mesenchymal Stem Cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","673"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Knee Surgery Sports Traumatology Arthroscopy"],["dc.bibliographiccitation.lastpage","680"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Balcarek, Peter"],["dc.contributor.author","Kuhn, Anke"],["dc.contributor.author","Weigel, Arwed"],["dc.contributor.author","Walde, Tim Alexander"],["dc.contributor.author","Ferlemann, Keno G."],["dc.contributor.author","Stuermer, Klaus-Michael"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.date.accessioned","2018-11-07T08:43:40Z"],["dc.date.available","2018-11-07T08:43:40Z"],["dc.date.issued","2010"],["dc.description.abstract","The purpose of this study was to analyze the impact of monopolar radiofrequency energy treatment on subchondral bone viability. The femoral grooves of six chinchilla bastard rabbits were exposed bilaterally to monopolar radiofrequency energy for 2, 4 and 8 s, creating a total of 36 defects. An intravital fluorescence bone-labeling technique characterized the process of subchondral bone mineralization within the 3 months following exposure to radiofrequency energy and was analyzed by widefield epifluorescence optical sectioning microscopy using an ApoTome. After 2 s of radiofrequency energy exposure, regular fluorescence staining of the subchondral bone was evident in all samples when compared to untreated areas. The depth of osteonecrosis after 4 and 8 s of radiofrequency energy treatment averaged 126 and 942 A mu m at 22 days (P < .05; P < .01). The 4 s treatment group showed no osteonecrosis after 44 days whereas the depth of osteonecrosis extended from 519 A mu m at 44 days (P < .01), to 281 A mu m at 66 days (P < .01) and to 133 A mu m at 88 days (P < .05) after 8 s of radiofrequency energy application. Though radiofrequency energy may induce transient osteonecrosis in the superficial zone of the subchondral bone, the results of this study suggest that post-arthroscopic osteonecrosis appears to be of only modest risk given the current clinical application in humans."],["dc.identifier.doi","10.1007/s00167-009-0949-z"],["dc.identifier.isi","000276722900019"],["dc.identifier.pmid","19838673"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/4232"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20025"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0942-2056"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Impact of monopolar radiofrequency energy on subchondral bone viability"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2251"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Knee Surgery Sports Traumatology Arthroscopy"],["dc.bibliographiccitation.lastpage","2256"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Frosch, Stephan"],["dc.contributor.author","Rittstieg, Anne"],["dc.contributor.author","Balcarek, Peter"],["dc.contributor.author","Walde, Tim Alexander"],["dc.contributor.author","Schuettrumpf, Jan Philipp"],["dc.contributor.author","Wachowski, Martin Michael"],["dc.contributor.author","Stuermer, Klaus-Michael"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.date.accessioned","2018-11-07T09:04:12Z"],["dc.date.available","2018-11-07T09:04:12Z"],["dc.date.issued","2012"],["dc.description.abstract","The aim of this study was to evaluate the clinical outcome and differences in anterior-posterior laxity of ACL reconstruction using a bioabsorbable interference screw for femoral graft fixation when compared to femoral bioabsorbable cross pin fixation. Clinical outcome was evaluated among 59 patients 1 year after arthroscopic ACL reconstruction with hamstrings graft in a prospective, non-randomised study. In 31 cases, femoral fixation of the graft was performed using a bioabsorbable interference screw. In 28 cases, two bioabsorbable cross pins were used for femoral fixation. Patients were evaluated using Tegner, Lysholm and Marshall scores, the visual analogue scale for pain and KT-1000 arthrometer measurement. No significant difference (P a parts per thousand yen 0.05) was observed at follow-up for the knee scores. The average Tegner score was 5.83 points (+/- 2.00) for the interference screw fixation and 5.83 points (+/- 1.24) for the cross pin fixation; the average Lysholm score was 93.58 (+/- 5.79) to 92.72 (+/- 6.34) points; and the average Marshall score 46.72 (+/- 2.4) to 47.30 (+/- 2.35) points. No significant difference was found for the visual analogue scale for pain. KT-1000 arthrometer measurement revealed a significant (P < 0.05) difference in the mean side-to-side anterior translation at all applied forces. At 67 N, the mean difference was 1.53 mm (+/- 1.24) in the interference screw group and 0.47 mm (+/- 1.18) in the cross pin group (P < 0.05). At 89 N, the mean differences were 1.85 mm (+/- 1.29) versus 0.59 mm (+/- 1.59), respectively, (P < 0.05), and maximum manual displacements were 2.02 mm (+/- 1.26) versus 1.22 mm (1.18; P < 0.05). In ACL reconstruction with hamstrings graft, similar clinical results are obtained for the use of bioabsorbable cross pins when compared to bioabsorbable interference screws for femoral fixation. Cross pin fixation was superior with regard to the anteroposterior laxity as measured with KT-1000."],["dc.identifier.doi","10.1007/s00167-011-1875-4"],["dc.identifier.isi","000310223100018"],["dc.identifier.pmid","22290125"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8788"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25063"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0942-2056"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Bioabsorbable interference screw versus bioabsorbable cross pins: influence of femoral graft fixation on the clinical outcome after ACL reconstruction"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","147"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Journal of Trauma and Emergency Surgery"],["dc.bibliographiccitation.lastpage","152"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Rack, Thomas"],["dc.contributor.author","Dumont, Clemens"],["dc.contributor.author","Tezval, Mohammad"],["dc.contributor.author","Stuermer, Klaus Michael"],["dc.date.accessioned","2018-11-07T08:31:04Z"],["dc.date.available","2018-11-07T08:31:04Z"],["dc.date.issued","2009"],["dc.description.abstract","Rigid plate osteosynthesis with compression is still the treatment of choice for forearm fractures to gain anatomic reposition, provide proper rotation and avoid a bridging callus. Due to necessary operative dissection there is a serious risk for infection and malunion. Based on good clinical results with elastic bridge plating at femur, humerus and tibia, this technique was also started to be used for forearm fractures in our clinic in 1995. In a prospective study, 86 of 124 consecutive patients at the age of 35.2 +/- 14.7 years with 129 diaphyseal fractures of the radius or ulna (AO: 37 type A, 36 type B, 13 type C) were analyzed between January 1998 and December 2003. All fractures were stabilized by bridge plating. Radiographic union and clinical outcome were documented. Of the 129, 122 diaphyseal fractures (94.5%) healed within 10.2 +/- 3.4 weeks without complications (no nerve lesions, nonunion, synostosis callus). One re-osteosynthesis, one secondary lag screw, and five cancellous bone grafts were necessary before final healing. About 79.1% of the patients had a perfect clinical outcome; 17.4% had additional severe injuries of the same arm. Bridge plating, without interfragmentary compression is a reliable surgical procedure even for forearm fractures with low risk of infection and nonunion."],["dc.identifier.doi","10.1007/s00068-008-8002-3"],["dc.identifier.isi","000265340900011"],["dc.identifier.pmid","26814768"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5045"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17036"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.relation.issn","1863-9933"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","The Elastic Bridge Plating of the Forearm Fracture: A Prospective Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2542"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Biomaterials"],["dc.bibliographiccitation.lastpage","2549"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Drengk, Anja"],["dc.contributor.author","Krause, Petra"],["dc.contributor.author","Viereckc, V."],["dc.contributor.author","Miosge, Nicolai"],["dc.contributor.author","Werner, C."],["dc.contributor.author","Schild, Detlev"],["dc.contributor.author","Sturmer, E. K."],["dc.contributor.author","Sturmer, K. M."],["dc.date.accessioned","2018-11-07T10:00:31Z"],["dc.date.available","2018-11-07T10:00:31Z"],["dc.date.issued","2006"],["dc.description.abstract","The goal of the present study was to evaluate the partial surface replacement of the knee with stem cell-coated titanium implants and to provide a basis for a successful treatment of large osteochondral defects. Mesenchymal stem cells (MSCs) were isolated from bone marrow aspirates of adult sheep. Round titanium implants with a diameter of 2 x 7.3 mm were seeded with autologous MSC and inserted into an osteochondral defect in the medial femoral condyle. As controls, defects received either an uncoated implant or were left untreated. Nine animals with 18 defects were sacrificed after 6 months. Histological evaluation was performed by intravital polychrome fluorescent labelling, intravital perfusion with Indian ink, microradiographs and differential staining with toluidine blue. The quality of regenerated cartilage was assessed by in situ hybridization of collagen type II and immunohistochemistry of collagen types I and II. In 50% of the cases, defects treated with MSC-coated implants showed a complete regeneration of the subchondral bone layer. In these cases collagen type II and only traces of collagen type I were detected. A high level of collagen type II mRNA expression compared to articular cartilage indicates regenerating hyaline-like cartilage. A total of 50% of MSC-coated and uncoated implants failed to osseointegrate and formation of fibrocartilage was observed. Untreated defects as well as defects treated with uncoated implants demonstrated incomplete healing of subchondral bone and formation of fibrous cartilage. A modified histological score according to Wakitani significantly demonstrated better results for cell-coated implants (8.8 +/- 6.4) than for uncoated implants (5.5 +/- 3.9) and for untreated defects (2.8 +/- 2.5). Our results demonstrate that, in a significant number of cases, a partial joint resurfacing of the knee with stem cell-coated titanium implants occur. A slow bone and cartilage regeneration and an incomplete healing in half of the MSC-coated implants are limitations of the presented method. To improve our approach and optimize the experimental parameters, further investigations are needed prior to clinical application. (c) 2005 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.biomaterials.2005.11.034"],["dc.identifier.isi","000235722100004"],["dc.identifier.pmid","16368134"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7753"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37824"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.relation.issn","0142-9612"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Stem cell-coated titanium implants for the partial joint resurfacing of the knee"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","163"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Langenbeck s Archives of Surgery"],["dc.bibliographiccitation.lastpage","172"],["dc.bibliographiccitation.volume","395"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.contributor.author","Sehmisch, Stefan"],["dc.contributor.author","Rack, Thomas"],["dc.contributor.author","Wenda, E."],["dc.contributor.author","Seidlova-Wuttke, Dana"],["dc.contributor.author","Tezval, Mohammed"],["dc.contributor.author","Wuttke, Wolfgang"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Stuermer, Klaus-Michael"],["dc.date.accessioned","2018-11-07T08:46:24Z"],["dc.date.available","2018-11-07T08:46:24Z"],["dc.date.issued","2010"],["dc.description.abstract","Background Fracture healing in osteoporosis is delayed. Quality and speed of fracture healing in osteoporotic fractures are crucial with regard to the outcome of patients. The question arises whether established antiosteoporotic drugs can further improve fracture healing. Materials and methods Osteoporosis manifests predominantly in the metaphyseal bone. Nevertheless, an established metaphyseal fracture model is lacking. A standardized metaphyseal fracture-healing model with stable plate fixation was developed for rat tibiae. The healing process was analyzed by biomechanical, gene expression, and histomorphometric methods in ovariectomized (OVX) and sham-operated rats (SHAM), compared to standardized estrogen (E)- and raloxifene (R)-supplemented diets. Results Estrogen and raloxifene improved the biomechanical properties of bone healing compared to OVX (Yield load: SHAM = 63.1 +/- 20.8N, E = 60.8 +/- 17.9 N, R = 44.7 +/- 17.5 N, OVX = 32.5 +/- 22.0 N). Estrogen vs OVX was significant based on a denser trabecular network. Raloxifenegreatly induced total callus formation (R = 5.3 +/- 0.9 mm(2), E = 4.7 +/- 0.5 mm(2), SHAM = 4.51 +/- 0.61 mm(2), OVX = 4.1 +/- 0.6 mm(2)), whereas estrogen mainly enhanced new endosteal bone formation. There was no correlation between the gene expression (osteocalcin, collagen1 alpha 1, IGF-1, tartrate-resistant phosphatase) in the callus and the morphology and quality of callus formation. Conclusion Raloxifene and estrogen improve fracture healing in osteoporotic bone significantly with regard to callus formation, resistance, and elasticity. The biomechanically stable metaphyseal osteotomy model with T-plate fixation presented here has proven to be appropriate to investigate fracture healing in osteoporosis."],["dc.identifier.doi","10.1007/s00423-008-0436-x"],["dc.identifier.isi","000274652000011"],["dc.identifier.pmid","19048282"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/4034"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20682"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1435-2443"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Estrogen and raloxifene improve metaphyseal fracture healing in the early phase of osteoporosis. A new fracture-healing model at the tibia in rat"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","59"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Acta Orthopaedica"],["dc.bibliographiccitation.lastpage","64"],["dc.bibliographiccitation.volume","83"],["dc.contributor.author","Ruebenhagen, Rene"],["dc.contributor.author","Schuettrumpf, Jan Philipp"],["dc.contributor.author","Stuermer, Klaus Michael"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.date.accessioned","2018-11-07T09:13:51Z"],["dc.date.available","2018-11-07T09:13:51Z"],["dc.date.issued","2012"],["dc.description.abstract","Background and purpose Little is known about biochemical mediators that correlate with the initiation and progression of knee osteoarthritis (OA). We therefore valuated the roles of cytokines and metalloenzymes in knee OA in relation to OA grading, age, and BMI. Patients and methods A multiplex ELISA-based immunoassay (Luminex technology) was used to measure biochemical mediators in the synovial fluid (SF) of 82 patients undergoing knee surgery. All patients were classified according to age, BMI, and OA grade. 24 patients had no signs of OA (knee reconstruction surgeries). The mediators that were tested for included interleukins (IL-1Ra, IL-6, IL-7, and IL-18), chemokines (CCL2 (MCP1), CCL3 (MIP-1(sic)), and CXCL8 (IL-8)), growth factors (HGF and VEGF), and matrix metalloproteinases (MMP-1, MMP-2, MMP-9, and MMP-13). Results There was a correlation between IL-7 levels in SF and age (p < 0.01). The 11 highest IL-7 levels were seen in patients who were aged between 59 and 72 but had different OA grades. In contrast, all patients who had severe OA in all 3 knee compartments (pan-OA) had only low or medium IL-7 levels. There was a negative correlation between MMP-1 levels in synovial fluid and grade of OA (p < 0.001). Correlation studies between pairs of mediators revealed two groups of mediators that are important in OA progression, dominated by MCP-1 and IL-1Ra. Interpretation IL-7 levels in SF are elevated in elderly people suffering from OA of different grades, but they are depressed in patients with severe 3-compartment OA, possibly due to widely impaired chondrocytes embedded in the affected cartilage tissue. The observed decrease in MMP-1 levels in SF, which is dependent on the severity of OA, may be caused by deterioration of superficial cartilage layers during progression of OA."],["dc.identifier.doi","10.3109/17453674.2011.645195"],["dc.identifier.isi","000300022600011"],["dc.identifier.pmid","22206448"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9974"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27262"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Informa Healthcare"],["dc.relation.issn","1745-3674"],["dc.rights","CC BY-NC-ND 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/3.0"],["dc.title","Interleukin-7 levels in synovial fluid increase with age and MMP-1 levels decrease with progression of osteoarthritis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1756"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","The American journal of sports medicine"],["dc.bibliographiccitation.lastpage","1761"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Balcarek, Peter"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Stürmer, Klaus Michael"],["dc.date.accessioned","2019-07-09T11:53:48Z"],["dc.date.available","2019-07-09T11:53:48Z"],["dc.date.issued","2011-08-01"],["dc.description.abstract","BACKGROUND: A lateralized tibial tubercle may be a relevant anatomic factor in patients with patellar instability and can be used as an indication for a distal realignment procedure. However, parameter values for the tibial tuberosity-trochlear groove (TT-TG) distance in the young patient have not been defined. It also remains to be determined how this parameter contributes to patellar instability in the growing knee joint. PURPOSE: The purpose of this study was to evaluate the value of the TT-TG distance in patellar instability in the young athlete. STUDY DESIGN: Case control study; Level of evidence, 3. METHODS: Knee magnetic resonance images were collected from 109 patients with lateral patellar instability and from 136 control subjects. Student t test and multiple logistic regression analysis were used to compare the absolute and relative values of the TT-TG distance between patients and controls. The relative value was defined as the ratio between the TT-TG distance and the total width of the distal femur. RESULTS: The TT-TG distance (absolute and relative to femur width) differed significantly between patients with patellar dislocation and the control group (both P < .01). The TT-TG distances were on average 4 mm larger in patients with patellar dislocation; TT-TG distance divided by femur width was on average 5% larger in patients with patellar dislocation. Multiple logistic regression analysis confirmed the TT-TG distance as a significant risk factor for patellar dislocation (P = .04), but showed no significant interaction with patient age or femur width (P = .95 and P = .15, respectively). CONCLUSION: A lateralized tibial tubercle is a relevant anatomic factor in the young athlete and in the adult patient with lateral patellar instability. Its parameter values and its influence on patellar dislocation are independent of patient age and should therefore be evaluated as in adults."],["dc.identifier.doi","10.1177/0363546511404883"],["dc.identifier.fs","578191"],["dc.identifier.pmid","21566067"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8057"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60499"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1552-3365"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.mesh","Adolescent"],["dc.subject.mesh","Adult"],["dc.subject.mesh","Aging"],["dc.subject.mesh","Case-Control Studies"],["dc.subject.mesh","Child"],["dc.subject.mesh","Female"],["dc.subject.mesh","Humans"],["dc.subject.mesh","Joint Instability"],["dc.subject.mesh","Male"],["dc.subject.mesh","Middle Aged"],["dc.subject.mesh","Patellar Dislocation"],["dc.subject.mesh","Patellofemoral Joint"],["dc.subject.mesh","Tibia"],["dc.subject.mesh","Young Adult"],["dc.title","Value of the tibial tuberosity-trochlear groove distance in patellar instability in the young athlete."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]