Stürmer, Klaus Michael

[["dc.bibliographiccitation.firstpage","850"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Planta Medica"],["dc.bibliographiccitation.lastpage","857"],["dc.bibliographiccitation.volume","76"],["dc.contributor.author","Kolios, Leila"],["dc.contributor.author","Schumann, Jacob"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Rack, Thomas"],["dc.contributor.author","Tezval, Mohammed"],["dc.contributor.author","Seidlova-Wuttke, Dana"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Stuermer, Klaus Michael"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.date.accessioned","2018-11-07T08:43:01Z"],["dc.date.available","2018-11-07T08:43:01Z"],["dc.date.issued","2010"],["dc.description.abstract","Osteoporosis and its accompanying, predominantly metaphyseal, fractures are a major health problem. Black cohosh (Cimicifuga racemosa) and estrogen positively influence osteoporotic bone. Both substances may improve fracture healing in early osteoporosis as well. In 48 twelve-week-old ovariectomized or, respectively, sham-operated (SHAM) rats, a standardized metaphyseal tibia osteotomy with bridging T-plate fixation was performed. During the healing process of 35 days, rats received soy-free (SHAM, osteopenic C), estrogen-(E) or Cimicifuga racemosa-(CR) supplemented diets. After sacrifice, the callus formation was analyzed with regard to biomechanical quality, morphology, quantity, time course of new bone built and gene expression. CR induced a high rate of metaphyseal callus formation. The biomechanical properties and the amount of new callus formation indicated that fracture healing was still in progress. Therefore, gene expression of osteoblasts was comparatively high. Body weight and the trabecular structure were influenced little by CR. Estrogen improved the biomechanical properties of the callus. Resistance to microfracturing was significantly enhanced in the E group and even superior to SHAM. Remodeling of the callus formation had already begun. The trabecular network and the typical endosteal fracture healing were especially improved. Osteoporotic metaphyseal fracture healing was improved by estrogen more than by Cimicifuga racemosa. The process of fracture healing occurred nearly physiologically. The generation of callus formation was supported by Cimicifuga racemosa as well, but the five-week duration of application was too short for Cimicifuga racemosa to show its complete potential. Already-initiated Cimicifuga racemosa therapy for menopausal symptoms could be continued during fracture healing without hesitation."],["dc.description.sponsorship","DFG [STU 478/2-1]"],["dc.identifier.doi","10.1055/s-0029-1240798"],["dc.identifier.isi","000279668400002"],["dc.identifier.pmid","20104444"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19846"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0032-0943"],["dc.title","Effects of Black Cohosh (Cimicifuga racemosa) and Estrogen on Metaphyseal Fracture Healing in the Early Stage of Osteoporosis in Ovariectomized Rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","235"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Planta Medica"],["dc.bibliographiccitation.lastpage","240"],["dc.bibliographiccitation.volume","76"],["dc.contributor.author","Tezval, Mohammad"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Seidlova-Wuttke, Dana"],["dc.contributor.author","Rack, Thomas"],["dc.contributor.author","Kolios, Leila"],["dc.contributor.author","Wuttke, Wolfgang"],["dc.contributor.author","Stuermer, Klaus Michael"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.date.accessioned","2018-11-07T08:46:36Z"],["dc.date.available","2018-11-07T08:46:36Z"],["dc.date.issued","2010"],["dc.description.abstract","The isoflavonoids found in soy have attracted great interest as dietary phytoestrogens that might be effective for postmenopausal hormone replacement therapy. Special attention has been devoted to the hormonal effects of various isoflavonoids, like genistein (GEN) and daidzein's (DAID) potent metabolite, equol (EQ). Here we aimed to investigate the short-term effects of genistein and equol on the proximal femur of ovariectomized (OVX) rats. Forty-eight, 3-month-old female Sprague-Dawley rats were ovarectomized; after eight weeks the bilateral osteotomy and osteosynthesis (OS) of their tibiae was performed and the rats were randomly divided into the following four groups: OVX control group (C), treated with estradiol-17beta (E2) -benzoate (E; daily intake 0.086 mg/d per animal), genistein (GEN; daily intake 12.7 mg/d per animal) and equol (EQ; daily intake 4.65 mg/d per animal). At 5 weeks postoperatively (OS), the breaking test was performed on the trochanteric region of femur. Additionally, histomorphometric assessment, and trabecular and cortical bone microstructure analyses were performed. The relative gain of body weight (BW) in the EQ (24%) group was significantly (p < 0.05) lower than in the C (33%) and GEN (30%) groups. After treatment for 5 weeks, the maximal load (F(max)) and yield load (yL) were higher (p < 0.05 for the weight-adapted results) in the E (188.4 N resp. 113.1 N) and EQ (177.3 N resp. 112 N) groups as compared to C (162.8 N resp. 109.1 N) and GEN (165.7 N resp. 108.8 N). In the histomorphometric tests the E-(trabecular area (Tb.Ar) = 74.93%, trabecular nodes/mm(2) (N.Nd/mm(2)) = 48.65) and EQ-treated (Tb.Ar = 63.13%, N.Nd/mm(2) = 43.72) animals showed significant improvement with regard to Tb.Ar and trabecular connectivity (N.Nd./mm(2)) in comparison to C (Tb.Ar = 46.84, N.Nd/mm(2) = 31.86) and GEN (Tb.Ar = 48.22%, N.Nd/mm(2) = 34.15). There were no differences in relative cortical width (Ct.Wi) among the four groups. The treatment with EQ resulted in improved biomechanical and histomorphometric properties as compared to the treatment with GEN. Thus, of the studied substances, EQ seems to be a possible alternative to hormone replacement therapy, but further studies are needed."],["dc.description.sponsorship","DFG [STU 478/2-1]"],["dc.identifier.doi","10.1055/s-0029-1186136"],["dc.identifier.isi","000274392700005"],["dc.identifier.pmid","19764010"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20732"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0032-0943"],["dc.title","Changes in the Histomorphometric and Biomechanical Properties of the Proximal Femur of Ovariectomized Rat after Treatment with the Phytoestrogens Genistein and Equol"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1796"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Phytotherapy Research"],["dc.bibliographiccitation.lastpage","1806"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Kolios, Leila"],["dc.contributor.author","Daub, Florian"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Tezval, Mohammed"],["dc.contributor.author","Stuermer, Klaus Michael"],["dc.contributor.author","Wuttke, Wolfgang"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.date.accessioned","2018-11-07T08:36:30Z"],["dc.date.available","2018-11-07T08:36:30Z"],["dc.date.issued","2010"],["dc.description.abstract","The healing of predominantly metaphyseal fractures in postmenopausal osteoporosis is delayed and comparatively poor. Due to the potential side effects of HRT, natural alternatives are appealing. The aim of this study was to determine whether Cimicifuga racemosa extract BNO 1055 improves metaphyseal fracture healing in severe osteopenic bone in rats. Thirty-three 12-week-old female rats developed severe osteopenia during 10 weeks after ovariectomy. After metaphyseal tibial-osteotomy and standardized T-plate-osteosynthesis, the healing periods in ovariectomized rats (C), 17-beta-estradiol (E) and Cimicifuga racemosa (CR) supplemented diets were assessed for 35 days. Changes in callus morphology were evaluated qualitatively by biomechanical testing and quantitatively in microradiographies and fluorochrome-labeled histological sections. The CR-supplementation slightly improved callus quality and trabecular bone formation. It significantly enhanced the endosteal callus density compared to C group (CI.Dn.e C: 59.08 +/- 21.89, E: 45.95 +/- 18.39, CR: 60.85 +/- 18.66 ), though most of the other morphological parameters examined showed no improvement. The time course of fracture healing did not change due to CR. Estrogen-supplementation enhanced the biomechanical properties of the fracture site. Trabecular bone was improved indicating the physiological endosteal healing process. The CR-supplementation did not exhibit positive effects in severe (senile) osteopenic fracture healing as seen in early (postmenopausal) osteoporosis in rats. Callus formation was slightly improved under CR. Estrogen improved fracture healing in severe osteopenic bone, while the extent of callus formation played a minor role. Copyright (C) 2010 John Wiley & Sons, Ltd."],["dc.description.sponsorship","DFG [STU 478/2-1]"],["dc.identifier.doi","10.1002/ptr.3176"],["dc.identifier.isi","000285679200008"],["dc.identifier.pmid","20564511"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18326"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0951-418X"],["dc.title","Absence of Positive Effect of Black Cohosh (Cimicifuga racemosa) on Fracture Healing in Osteopenic Rodent Model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S168"],["dc.bibliographiccitation.journal","Phytotherapy Research"],["dc.bibliographiccitation.lastpage","S174"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Sehmisch, Stefan"],["dc.contributor.author","Erren, Matthias"],["dc.contributor.author","Kolios, Leila"],["dc.contributor.author","Tezval, Mohammed"],["dc.contributor.author","Seidlova-Wuttke, Dana"],["dc.contributor.author","Wuttke, Wolfgang"],["dc.contributor.author","Stuermer, Klaus-Michael"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.date.accessioned","2018-11-07T08:43:00Z"],["dc.date.available","2018-11-07T08:43:00Z"],["dc.date.issued","2010"],["dc.description.abstract","Phytoestrogens might be an alternative medication in prophylaxis and treatment of osteoporosis. In this study, the osteoprotective effects of genistein (GEN) and equol (EQO) were evaluated. After ovariectomy, 44 rats received soy-free food (Control, C) and developed substantial osteoporosis over the course of two months. After that period, the rats were divided into different groups and fed estradiol (E), GEN or EQO for 35 days. To analyze the osteoprotective effects of the tested substances, bone biomechanical properties and histomorphometric changes of the lumbar vertebrae were evaluated. In analyzing the vertebral body compression strength, we found that the EQO (103.8%) and GEN (96.8%) groups reached similar levels relative to the E group, while the C group reached 77.7% of the biomechanical properties of the E group. EQO was significantly superior to C. The histomorphometric evaluation demonstrated an increased number of nodes in EQO- and E-treated rats compared to GEN- and C-treated rats. E led to an improvement of cortical as well as trabecular bone, an advantage that was only partly seen in the other groups. Treatment with phytoestrogens induced improved bone quality. EQO and GEN might be alternatives for hormone replacement therapy, although further studies are needed to elucidate possible side effects. Copyright (C) 2009 John Wiley & Sons, Ltd."],["dc.identifier.doi","10.1002/ptr.3060"],["dc.identifier.isi","000279801000008"],["dc.identifier.pmid","20013821"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19842"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","John Wiley & Sons Ltd"],["dc.relation.issn","0951-418X"],["dc.title","Effects of Isoflavones Equol and Genistein on Bone Quality in a Rat Osteopenia Model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","E358"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Plastic Reconstructive & Aesthetic Surgery"],["dc.bibliographiccitation.lastpage","E363"],["dc.bibliographiccitation.volume","63"],["dc.contributor.author","Kolios, Leila"],["dc.contributor.author","Striepling, Enno E."],["dc.contributor.author","Kolios, G."],["dc.contributor.author","Rudolf, K.-D."],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Doerges, J."],["dc.contributor.author","Stuermer, Klaus-Michael"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.date.accessioned","2018-11-07T08:44:41Z"],["dc.date.available","2018-11-07T08:44:41Z"],["dc.date.issued","2010"],["dc.description.abstract","Nitric acid burn traumata often occur in the chemical industry. A few publications addressing this topic can be found in the medical database, and there are no reports about these traumata in children. A total of 24 patients, average 16.6 years of age, suffering from nitric acid traumata were treated. Wound with I degrees burns received open therapy with panthenol-containing creams. Wound of II degrees and higher were initially treated by irrigation with sterile isotonic saline solution and then by covering with silver-sulphadiazine dressing. Treatment was changed on the second day to fluid-absorbent foam bandages for superficial wounds (up to IIa degrees depth) and occlusive, antiseptic moist bandages in combination with enzymatic substances for IIb degrees-III degrees burns. After the delayed demarcation, necrectomy and mesh-graft transplantation were performed. All wounds healed adequately. Chemical burn traumata with nitric acid lead to specific yellow- to brown-stained wounds with slower accumulation of eschar and slower demarcation compared with thermal burns. Remaining wound eschar induced no systemic inflammation reaction. After demarcation, skin transplantation can be performed on the wounds, as is commonly done. The distinguishing feature of nitric-acid-induced chemical burns is the difficulty in differentiation and classification of burn depth. An immediate lavage should be followed by silver sulphadiazine treatment. Thereafter, fluid-absorbent foam bandages or occlusive, antiseptic moist bandages should be used according to the burn depth. Slow demarcation caused a delay in performing surgical treatments. (C) 2009 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.bjps.2009.09.001"],["dc.identifier.isi","000275814800028"],["dc.identifier.pmid","19875347"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20255"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.relation.issn","1748-6815"],["dc.title","The Nitric acid burn trauma of the skin"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","480"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Bone"],["dc.bibliographiccitation.lastpage","492"],["dc.bibliographiccitation.volume","47"],["dc.contributor.author","Komrakova, Marina"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.contributor.author","Werner, Carsten"],["dc.contributor.author","Wicke, Michael"],["dc.contributor.author","Kolios, Leila"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Tezval, Mohammad"],["dc.contributor.author","Daub, Florian"],["dc.contributor.author","Martens, Timo"],["dc.contributor.author","Witzenhausen, Peter"],["dc.contributor.author","Dullin, Christian"],["dc.contributor.author","Stuermer, Klaus-Michael"],["dc.date.accessioned","2018-11-07T08:39:33Z"],["dc.date.available","2018-11-07T08:39:33Z"],["dc.date.issued","2010"],["dc.description.abstract","Three experiments were conducted to investigate the effect of intermittent administration of parathyroid hormone (PTH) (1-34) applied at different regimes on fracture healing and muscle in healthy and ovariectomized (Ovx at 3 months of age) rats. Five-month old rats underwent bilateral transverse metaphyseal osteotomy of tibia and were divided into groups (12 rats each). In Exp 1, Ovx rats were either treated with PTH (7x/w, 1-35d), with oral estradiol-17 beta-benzoate (0.4 mg/kg BW, 1-35d) or untreated. In Exp. 2, there were 3 groups: healthy untreated or treated with PTH (5x/w, 1-35d or 7-35d). In Exp. 3, there were 7 groups: healthy, Ovx, \"healthy PTH 5x/w 7-35d\", \"Ovx PTH 5x/w 7-35d, 14-35d or 14-28d\", \"Ovx PTH every other day 7-35d\". Single dosage of PTH was 40 mu g/kg BW. After 35 days of healing one tibia was analyzed by computed tomographical, biomechanical, histological analyses. The other tibia was used in analyses of Alp, Oc, Trap 1, Igf-1, Rank1, Opg genes (Exp.2, 3). Serum Oc and Alp were measured. Body, uterus weight was recorded. M. gastrocnemius was analyzed for weight (Exp. 2), fiber size and mitochondria] respiratory activity (MRA) (Exp.3). Estrogen enhanced uterus weight, prevented body increase, however, did not improve bone healing in Ovx rats (Exp. 1). PTH administration from days 1 and 7 improved bone parameters in all rats regardless of the application frequency (7, 5x/w or every other day) (Exp. 1, stiffness Ovx: 118 + 13 N/mm, Ovx PTH: 250+/-20 N/mm) being more effective in healthy rats (Exp. 3, stiffness improvement Healthy: 59 to 174 N/mm, Ovx: 52 to 98 N/mm). Serum Oc level was elevated in PTH treated rats. Application from day 14 proved to be less effective (Exp. 3). PTH had no effect (P>0.05) on body, uterus and muscle weight, muscle fiber size, MRA and expression of bone markers. PTH promoted bone healing in Ovx and healthy rats, when it is applied during early stage of healing without having any adverse systemic effect. In perspective, PTH may represent a treatment for enhancement of fracture healing. The findings need to be confirmed by follow-up studies on other animals. (C) 2010 Elsevier Inc. All rights reserved."],["dc.description.sponsorship","DFG [STU 478/3-1]"],["dc.identifier.doi","10.1016/j.bone.2010.05.013"],["dc.identifier.isi","000281464200003"],["dc.identifier.pmid","20580683"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19023"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","8756-3282"],["dc.title","Effect of human parathyroid hormone hPTH (1-34) applied at different regimes on fracture healing and muscle in ovariectomized and healthy rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","459"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Planta Medica"],["dc.bibliographiccitation.lastpage","465"],["dc.bibliographiccitation.volume","75"],["dc.contributor.author","Kolios, Leila"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Daub, Florian"],["dc.contributor.author","Rack, Thomas"],["dc.contributor.author","Tezval, Mohammed"],["dc.contributor.author","Stuermer, Klaus Michael"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.date.accessioned","2018-11-07T08:31:25Z"],["dc.date.available","2018-11-07T08:31:25Z"],["dc.date.issued","2009"],["dc.description.abstract","Healing of predominantly metaphyseal fractures in postmenopausal osteoporosis is delayed and comparatively poor. Hormone replacement therapy could improve fracture healing, but, because of its potential side effects, natural alternatives are more appealing. The aim of this study was to determine if the soy metabolite equol and the native isoflavone genistein, in comparison to 17 beta-estradiol, improve metaphyseal fracture healing in ovariectomy-induced osteoporotic bone of the rat. Forty-eight 12-week-old female rats developed severe osteoporosis ten weeks after ovariectomy. After metaphyseal tibial osteotomy and standardized stable internal fixation, changes in callus morphology were evaluated biomechanically, qualitatively and quantitatively in fluorochrome-labeled histological sections and microradiographs in ovariectomized rats (C) and under standardized 17 beta-estradiol (E), equol (EQ) and genistein (G) supplemented rats over a period of five weeks. Estrogen and equol were able to improve the elasticity of callus formation significantly in postmenopausal osteoporotic bone (stiffness of C: 121.40 +/- 47.08 N/mm, E: 147.90 +/- 39.38 N/mm, EQ: 167.8 +/- 59.90 N/mm). The effects of estrogen were more anabolic than those of equol and were visible in changes to the trabecular bone (N.Nd of E: 6.47 +/- 7.68, EQ: 4.25 +/- 3.96). However, in terms of the whole body, equol seemed to induce less of an adverse reaction than estrogen (body weight of C: 342.20 +/- 19.91 g, E: 280.25 +/- 12.05 g, EQ: 308.75 +/- 24.28 g). Genistein as an osteoclast inhibitor influenced callus stiffness (G: 144.50 +/- 61.52 N/mm) and negatively impacted trabecular structure (N.Nd of G: 0.59 +/- 1.01) in severely osteoporotic bones. Estrogen and equol were able to improve fracture healing in ovariectomy-induced osteoporotic bones, and the extent of callus formation played only a minor role. Genistein rather negatively influenced fracture healing. The metaphyseal osteotomy model in ovariectomized rats allows an accurate study of the therapeutic effects of antiosteoporotic substances on the fracture healing process."],["dc.description.sponsorship","DFG [STU 478/2-1]"],["dc.identifier.doi","10.1055/s-0029-1185380"],["dc.identifier.isi","000265486100001"],["dc.identifier.pmid","19241330"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17117"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0032-0943"],["dc.title","Equol but not Genistein Improves Early Metaphyseal Fracture Healing in Osteoporotic Rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]