Luther, Stefan

[["dc.bibliographiccitation.artnumber","e13449"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","19"],["dc.bibliographiccitation.journal","Physiological Reports"],["dc.bibliographiccitation.lastpage","12"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Mayer, Andreas"],["dc.contributor.author","Bittihn, Philip"],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2019-02-27T14:36:42Z"],["dc.date.available","2019-02-27T14:36:42Z"],["dc.date.issued","2017"],["dc.description.abstract","Spatiotemporal dynamics in cardiac tissue emerging from the coupling of individual cardiomyocytes underlie the heart's normal rhythm as well as undesired and possibly life‐threatening arrhythmias. While single cells and their transmembrane currents have been studied extensively, systematically investigating spatiotemporal dynamics is complicated by the nontrivial relationship between single‐cell and emergent tissue properties. Mathematical models have been employed to bridge this gap and contribute to a deepened understanding of the onset, development, and termination of arrhythmias. However, no such tissue‐level model currently exists for neonatal mice. Here, we build on a recent single‐cell model of neonatal mouse cardiomyocytes by Wang and Sobie (Am. J. Physiol. Heart Circ. Physiol. 294:H2565) to predict properties that are commonly used to gauge arrhythmogenicity of cardiac substrates. We modify the model to yield well‐defined behavior for common experimental protocols and construct a spatially extended version to study emergent tissue dynamics. We find a complex action potential duration (APD) restitution behavior characterized by a nonmonotonic dependence on pacing frequency. Electrotonic coupling in tissue leads not only to changes in action potential morphology but can also induce spatially concordant and discordant alternans not observed in the single‐cell model. In two‐dimensional tissue, our results show that the model supports stable functional reentry, whose frequency is in good agreement with that observed in adult mice. Our results can be used to further constrain and validate the mathematical model of neonatal mouse cardiomyocytes with future experiments."],["dc.identifier.doi","10.14814/phy2.13449"],["dc.identifier.pmid","28989116"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57649"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/186"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.issn","2051-817X"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.rights","CC BY 4.0"],["dc.title","Complex restitution behavior and reentry in a cardiac tissue model for neonatal mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2221"],["dc.bibliographiccitation.issue","1918"],["dc.bibliographiccitation.journal","Philosophical Transactions of the Royal Society of London. A, Mathematical, Physical and Engineering Sciences"],["dc.bibliographiccitation.lastpage","2236"],["dc.bibliographiccitation.volume","368"],["dc.contributor.author","Bittihn, Philip"],["dc.contributor.author","Squires, Amgad"],["dc.contributor.author","Luther, Gisa"],["dc.contributor.author","Bodenschatz, Eberhard"],["dc.contributor.author","Krinsky, Valentin"],["dc.contributor.author","Parlitz, Ulrich"],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2018-11-07T08:43:15Z"],["dc.date.available","2018-11-07T08:43:15Z"],["dc.date.issued","2010"],["dc.description.abstract","Life-threatening cardiac arrhythmias are associated with the existence of stable and unstable spiral waves. Termination of such complex spatio-temporal patterns by local control is substantially limited by anchoring of spiral waves at natural heterogeneities. Far-field pacing (FFP) is a new local control strategy that has been shown to be capable of unpinning waves from obstacles. In this article, we investigate in detail the FFP unpinning mechanism for a single rotating wave pinned to a heterogeneity. We identify qualitatively different phase regimes of the rotating wave showing that the concept of vulnerability is important but not sufficient to explain the failure of unpinning in all cases. Specifically, we find that a reduced excitation threshold can lead to the failure of unpinning, even inside the vulnerable window. The critical value of the excitation threshold (below which no unpinning is possible) decreases for higher electric field strengths and larger obstacles. In contrast, for a high excitation threshold, the success of unpinning is determined solely by vulnerability, allowing for a convenient estimation of the unpinning success rate. In some cases, we also observe phase resetting in discontinuous phase intervals of the spiral wave. This effect is important for the application of multiple stimuli in experiments."],["dc.identifier.doi","10.1098/rsta.2010.0038"],["dc.identifier.isi","000276266400007"],["dc.identifier.pmid","20368243"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19914"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Royal Soc"],["dc.relation.issn","1364-503X"],["dc.title","Phase-resolved analysis of the susceptibility of pinned spiral waves to far-field pacing in a two-dimensional model of excitable media"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","103012"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","New Journal of Physics"],["dc.bibliographiccitation.volume","10"],["dc.contributor.affiliation","Bittihn, Philip;"],["dc.contributor.affiliation","Luther, Gisela;"],["dc.contributor.affiliation","Bodenschatz, Eberhard;"],["dc.contributor.affiliation","Krinsky, Valentin;"],["dc.contributor.affiliation","Parlitz, Ulrich;"],["dc.contributor.affiliation","Luther, Stefan;"],["dc.contributor.author","Bittihn, Philip"],["dc.contributor.author","Luther, Gisela"],["dc.contributor.author","Bodenschatz, Eberhard"],["dc.contributor.author","Krinsky, Valentin"],["dc.contributor.author","Parlitz, Ulrich"],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2018-11-07T11:10:06Z"],["dc.date.available","2018-11-07T11:10:06Z"],["dc.date.issued","2008"],["dc.date.updated","2022-02-09T13:17:44Z"],["dc.description.abstract","Removing anchored spirals from obstacles is an important step in terminating cardiac arrhythmia. Conventional anti-tachycardia pacing (ATP) has this ability, but only under very restrictive conditions. In a generic model of excitable media, we demonstrate that for unpinning spiral waves from obstacles this profound limitation of ATP can be overcome by far field pacing (FFP). More specifically, an argument is presented for why FFP includes and thus can only extend the capabilities of ATP in the configurations considered. By numerical simulations, we show that in the model there exists a parameter region in which unpinning is possible by FFP but not by ATP. The relevance of this result regarding clinical applications is discussed."],["dc.identifier.doi","10.1088/1367-2630/10/10/103012"],["dc.identifier.eissn","1367-2630"],["dc.identifier.fs","441448"],["dc.identifier.isi","000259958200001"],["dc.identifier.ppn","583657737"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/4322"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53145"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Iop Publishing Ltd"],["dc.relation.issn","1367-2630"],["dc.relation.orgunit","Fakultät für Physik"],["dc.rights","Goescholar"],["dc.rights.uri","https://goedoc.uni-goettingen.de/licenses"],["dc.title","Far field pacing supersedes anti-tachycardia pacing in a generic model of excitable media"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","043012"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","New Journal of Physics"],["dc.bibliographiccitation.lastpage","7"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Shajahan, T. K."],["dc.contributor.author","Berg, Sebastian"],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Krinski, Valentin"],["dc.contributor.author","Bittihn, Philip"],["dc.date.accessioned","2019-02-27T14:16:19Z"],["dc.date.available","2019-02-27T14:16:19Z"],["dc.date.issued","2016"],["dc.description.abstract","Spiral waves in cardiac tissue can pin to tissue heterogeneities and form stable pinned waves. These waves can be unpinned by electric stimuli applied close to the pinning center during the vulnerable window of the spiral. Using a phase transition curve (PTC), we quantify the response of a pinned wave in a cardiac monolayer to secondary excitations generated electric field pulses. The PTC can be used to construct a one-dimensional map that faithfully predicts the pinned wave’s response to periodic field stimuli. Based on this 1D map, we predict that pacing at a frequency greater than the spiral frequency, over drive pacing, leads to phase locking of the spiral to the stimulus, which hinders unpinning. In contrast, under drive pacing can lead to scanning of the phase window of the spiral, which facilitates unpinning. The predicted mechanisms of phase scanning and phase locking are experimentally tested and confirmed in the same monolayers that were used to obtain the PTC. Our results have the potential to help choose optimal parameters for low energy antifibrillation pacing schemes."],["dc.identifier.doi","10.1088/1367-2630/18/4/043012"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57648"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/168"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.issn","1367-2630"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.rights","CC BY 3.0"],["dc.title","Scanning and resetting the phase of a pinned spiral wave using periodic far field pulses"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","153a"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Biophysical Journal"],["dc.bibliographiccitation.lastpage","154a"],["dc.bibliographiccitation.volume","104"],["dc.contributor.author","Bittihn, Philip"],["dc.contributor.author","Hörning, Marcel"],["dc.contributor.author","Hornung, Daniel"],["dc.contributor.author","Fenton, Flavio H."],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2022-03-01T11:44:57Z"],["dc.date.available","2022-03-01T11:44:57Z"],["dc.date.issued","2013"],["dc.identifier.doi","10.1016/j.bpj.2012.11.869"],["dc.identifier.pii","S0006349512021157"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103171"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.issn","0006-3495"],["dc.title","Electric-Field-Based Control Strategies for Cardiac Tissue"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","294"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Circulation Research"],["dc.bibliographiccitation.lastpage","304"],["dc.bibliographiccitation.volume","108"],["dc.contributor.author","Petitprez, Severine"],["dc.contributor.author","Zmoos, Anne-Flore"],["dc.contributor.author","Ogrodnik, Jakob"],["dc.contributor.author","Balse, Elise"],["dc.contributor.author","Raad, Nour"],["dc.contributor.author","El-Haou, Said"],["dc.contributor.author","Albesa, Maxime"],["dc.contributor.author","Bittihn, Philip"],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Lehnart, Stephan E."],["dc.contributor.author","Hatem, Stephane N."],["dc.contributor.author","Coulombe, Alain"],["dc.contributor.author","Abriel, Hugues"],["dc.date.accessioned","2018-11-07T08:59:18Z"],["dc.date.available","2018-11-07T08:59:18Z"],["dc.date.issued","2011"],["dc.description.abstract","Rationale: The cardiac sodium channel Na(v)1.5 plays a key role in excitability and conduction. The 3 last residues of Na(v)1.5 (Ser-Ile-Val) constitute a PDZ-domain binding motif that interacts with the syntrophin-dystrophin complex. As dystrophin is absent at the intercalated discs, Na(v)1.5 could potentially interact with other, yet unknown, proteins at this site. Objective: The aim of this study was to determine whether Na(v)1.5 is part of distinct regulatory complexes at lateral membranes and intercalated discs. Methods and Results: Immunostaining experiments demonstrated that Na(v)1.5 localizes at lateral membranes of cardiomyocytes with dystrophin and syntrophin. Optical measurements on isolated dystrophin-deficient mdx hearts revealed significantly reduced conduction velocity, accompanied by strong reduction of Na(v)1.5 at lateral membranes of mdx cardiomyocytes. Pull-down experiments revealed that the MAGUK protein SAP97 also interacts with the SIV motif of Na(v)1.5, an interaction specific for SAP97 as no pull-down could be detected with other cardiac MAGUK proteins (PSD95 or ZO-1). Furthermore, immunostainings showed that Na(v)1.5 and SAP97 are both localized at intercalated discs. Silencing of SAP97 expression in HEK293 and rat cardiomyocytes resulted in reduced sodium current (I-Na) measured by patch-clamp. The I-Na generated by Na(v)1.5 channels lacking the SIV motif was also reduced. Finally, surface expression of Na(v)1.5 was decreased in silenced cells, as well as in cells transfected with SIV-truncated channels. Conclusions: These data support a model with at least 2 coexisting pools of Na(v)1.5 channels in cardiomyocytes: one targeted at lateral membranes by the syntrophin-dystrophin complex, and one at intercalated discs by SAP97. (Circ Res. 2011;108:294-304.)"],["dc.identifier.doi","10.1161/CIRCRESAHA.110.228312"],["dc.identifier.gro","3142408"],["dc.identifier.isi","000286930500006"],["dc.identifier.pmid","21164104"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7040"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23858"],["dc.language.iso","en"],["dc.notes.intern","lifescience updates Crossref Import"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.eissn","1524-4571"],["dc.relation.issn","0009-7330"],["dc.relation.issn","0009-7330"],["dc.relation.issn","1524-4571"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Mayer, Andreas"],["dc.contributor.author","Bittihn, Philip"],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2022-05-13T09:13:29Z"],["dc.date.available","2022-05-13T09:13:29Z"],["dc.date.issued","2017-10-09"],["dc.identifier.doi","10.6084/m9.figshare.5353573"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/107858"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/219"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.title","Dataset for: Complex restitution behavior and reentry in a cardiac tissue model for neonatal mice"],["dc.type","research_data"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","235"],["dc.bibliographiccitation.issue","7355"],["dc.bibliographiccitation.journal","Nature"],["dc.bibliographiccitation.lastpage","U152"],["dc.bibliographiccitation.volume","475"],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Fenton, Flavio H."],["dc.contributor.author","Kornreich, Bruce G."],["dc.contributor.author","Squires, Amgad"],["dc.contributor.author","Bittihn, Philip"],["dc.contributor.author","Hornung, Daniel"],["dc.contributor.author","Zabel, Markus"],["dc.contributor.author","Flanders, James"],["dc.contributor.author","Gladuli, Andrea"],["dc.contributor.author","Campoy, Luis"],["dc.contributor.author","Cherry, Elizabeth M."],["dc.contributor.author","Luther, Gisa"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Krinsky, Valentin I."],["dc.contributor.author","Pumir, Alain"],["dc.contributor.author","Gilmour, Robert F. Jr."],["dc.contributor.author","Bodenschatz, Eberhard"],["dc.date.accessioned","2017-09-07T11:44:07Z"],["dc.date.available","2017-09-07T11:44:07Z"],["dc.date.issued","2011"],["dc.description.abstract","Controlling the complex spatio-temporal dynamics underlying life-threatening cardiac arrhythmias such as fibrillation is extremely difficult, because of the nonlinear interaction of excitation waves in a heterogeneous anatomical substrate(1-4). In the absence of a better strategy, strong, globally resetting electrical shocks remain the only reliable treatment for cardiac fibrillation(5-7). Here we establish the relationship between the response of the tissue to an electric field and the spatial distribution of heterogeneities in the scale-free coronary vascular structure. We show that in response to a pulsed electric field, E, these heterogeneities serve as nucleation sites for the generation of intramural electrical waves with a source density rho(E) and a characteristic time, tau, for tissue depolarization that obeys the power law tau proportional to E(alpha). These intramural wave sources permit targeting of electrical turbulence near the cores of the vortices of electrical activity that drive complex fibrillatory dynamics. Weshow in vitro that simultaneous and direct access to multiple vortex cores results in rapid synchronization of cardiac tissue and therefore, efficient termination of fibrillation. Using this control strategy, we demonstrate low-energy termination of fibrillation in vivo. Our results give new insights into the mechanisms and dynamics underlying the control of spatio-temporal chaos in heterogeneous excitable media and provide new research perspectives towards alternative, life-saving low-energy defibrillation techniques."],["dc.identifier.doi","10.1038/nature10216"],["dc.identifier.gro","3142697"],["dc.identifier.isi","000292690500052"],["dc.identifier.pmid","21753855"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/130"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","0028-0836"],["dc.title","Low-energy control of electrical turbulence in the heart"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","093931"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Chaos: An Interdisciplinary Journal of Nonlinear Science"],["dc.bibliographiccitation.lastpage","14"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Bittihn, Philip"],["dc.contributor.author","Berg, Sebastian"],["dc.contributor.author","Parlitz, Ulrich"],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2019-02-26T16:35:12Z"],["dc.date.available","2019-02-26T16:35:12Z"],["dc.date.issued","2017"],["dc.description.abstract","Self-organized activation patterns in excitable media such as spiral waves and spatio-temporal chaos underlie dangerous cardiac arrhythmias. While the interaction of single spiral waves with different types of heterogeneity has been studied extensively, the effect of heterogeneity on fully developed spatio-temporal chaos remains poorly understood. We investigate how the complexity and stability properties of spatio-temporal chaos in the Bär–Eiswirth model of excitable media depend on the heterogeneity of the underlying medium. We employ different measures characterizing the chaoticity of the system and find that the spatial arrangement of multiple discrete lower excitability regions has a strong impact on the complexity of the dynamics. Varying the number, shape, and spatial arrangement of the heterogeneities, we observe strong emergent effects ranging from increases in chaoticity to the complete cessation of chaos, contrasting the expectation from the homogeneous behavior. The implications of our findings for the development and treatment of arrhythmias in the heterogeneous cardiac muscle are discussed. Understanding the mechanisms that govern the onset, development, and termination of cardiac arrhythmias is essential to develop and further refine novel strategies for controlling them. However, cardiac tissue is inherently heterogeneous, and heterogeneity might be exacerbated in diseased hearts. In a generic model of excitable media, we investigate how patches of lower excitability change the characteristics of spatio-temporal chaos, which is related to lethal cardiac fibrillation. Surprisingly, the presence of multiple discrete heterogeneities may lead to the complete cessation of chaos, even though lower excitability increases complexity in a homogeneous medium. In other cases, the complexity of spatio-temporal chaos increases beyond the values expected from homogeneous behavior. Our results show that spatial variations in local parameters may have truly emergent effects and information about the distribution of natural heterogeneity in the cardiac muscle as well as the spatial scale and strength of pathological heterogeneities is an indispensable prerequisite for understanding the stability properties of cardiac arrhythmias and developing control strategies tailored to specific types of dynamics."],["dc.identifier.doi","10.1063/1.4999604"],["dc.identifier.pmid","28964139"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57628"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/184"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.issn","1054-1500"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.title","Emergent dynamics of spatio-temporal chaos in a heterogeneous excitable medium"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","118106"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Physical Review Letters"],["dc.bibliographiccitation.volume","109"],["dc.contributor.author","Bittihn, Philip"],["dc.contributor.author","Hoerning, Marcel"],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2018-11-07T09:05:53Z"],["dc.date.available","2018-11-07T09:05:53Z"],["dc.date.issued","2012"],["dc.description.abstract","Understanding the interaction of electric fields with the complex anatomy of biological excitable media is key to optimizing control strategies for spatiotemporal dynamics in those systems. On the basis of a bidomain description, we provide a unified theory for the electric-field-induced depolarization of the substrate near curved boundaries of generalized shapes, resulting in the localized recruitment of control sites. Our findings are confirmed in experiments on cardiomyocyte cell cultures and supported by two-dimensional numerical simulations on a cross section of a rabbit ventricle."],["dc.identifier.doi","10.1103/PhysRevLett.109.118106"],["dc.identifier.isi","000308736000017"],["dc.identifier.pmid","23005683"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7959"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25428"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Physical Soc"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/241526/EU//EUTRIGTREAT"],["dc.relation.issn","0031-9007"],["dc.relation.orgunit","Fakultät für Physik"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","Negative Curvature Boundaries as Wave Emitting Sites for the Control of Biological Excitable Media"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]