Luther, Stefan

[["dc.bibliographiccitation.firstpage","51"],["dc.bibliographiccitation.journal","Progress in Biophysics and Molecular Biology"],["dc.bibliographiccitation.lastpage","60"],["dc.bibliographiccitation.volume","144"],["dc.contributor.author","Schlick, Susanne F."],["dc.contributor.author","Spreckelsen, Florian"],["dc.contributor.author","Tiburcy, Malte"],["dc.contributor.author","Iyer, Lavanya M."],["dc.contributor.author","Meyer, Tim"],["dc.contributor.author","Zelarayan, Laura C."],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Parlitz, Ulrich"],["dc.contributor.author","Zimmermann, Wolfram-Hubertus"],["dc.contributor.author","Rehfeldt, Florian"],["dc.date.accessioned","2020-12-10T15:20:42Z"],["dc.date.available","2020-12-10T15:20:42Z"],["dc.date.issued","2019"],["dc.description.abstract","Cardiomyocyte and stroma cell cross-talk is essential for the formation of collagen-based engineered heart muscle, including engineered human myocardium (EHM). Fibroblasts are a main component of the myocardial stroma. We hypothesize that fibroblasts, by compacting the surrounding collagen network, support the self-organization of cardiomyocytes into a functional syncytium. With a focus on early self-organization processes in EHM, we studied the molecular and biophysical adaptations mediated by defined populations of fibroblasts and embryonic stem cell-derived cardiomyocytes in a collagen type I hydrogel. After a short phase of cell-independent collagen gelation (30 min), tissue compaction was progressively mediated by fibroblasts. Fibroblast-mediated tissue stiffening was attenuated in the presence of cardiomyocytes allowing for the assembly of stably contracting, force-generating EHM within 4 weeks. Comparative RNA-sequencing data corroborated that fibroblasts are particularly sensitive to the tissue compaction process, resulting in the fast activation of transcription profiles, supporting heart muscle development and extracellular matrix synthesis. Large amplitude oscillatory shear (LAOS) measurements revealed nonlinear strain stiffening at physiological strain amplitudes (>2%), which was reduced in the presence of cells. The nonlinear stress-strain response could be characterized by a mathematical model. Collectively, our study defines the interplay between fibroblasts and cardiomyocytes during human heart muscle self-organization in vitro and underscores the relevance of fibroblasts in the biological engineering of a cardiomyogenesis-supporting viscoelastic stroma. We anticipate that the established mathematical model will facilitate future attempts to optimize EHM for in vitro (disease modelling) and in vivo applications (heart repair)."],["dc.identifier.doi","10.1016/j.pbiomolbio.2018.11.011"],["dc.identifier.pmid","30553553"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72769"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/248"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C04: Fibroblasten-Kardiomyozyten Interaktion im gesunden und erkrankten Herzen: Mechanismen und therapeutische Interventionen bei Kardiofibroblastopathien"],["dc.relation","SFB 1002 | S01: In vivo und in vitro Krankheitsmodelle"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.relation.workinggroup","RG Tiburcy (Stem Cell Disease Modeling)"],["dc.relation.workinggroup","RG Zelarayán-Behrend (Developmental Pharmacology)"],["dc.relation.workinggroup","RG Zimmermann (Engineered Human Myocardium)"],["dc.rights","CC BY 4.0"],["dc.title","Agonistic and antagonistic roles of fibroblasts and cardiomyocytes on viscoelastic stiffening of engineered human myocardium"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","093701"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Chaos: An Interdisciplinary Journal of Nonlinear Science"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Cherry, Elizabeth M."],["dc.contributor.author","Fenton, Flavio H."],["dc.contributor.author","Krogh-Madsen, Trine"],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Parlitz, Ulrich"],["dc.date.accessioned","2020-12-10T18:12:37Z"],["dc.date.available","2020-12-10T18:12:37Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1063/1.5003940"],["dc.identifier.eissn","1089-7682"],["dc.identifier.issn","1054-1500"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74442"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Introduction to Focus Issue: Complex Cardiac Dynamics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","063040"],["dc.bibliographiccitation.journal","New Journal of Physics"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Stein, Sebastian"],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Parlitz, Ulrich"],["dc.date.accessioned","2018-11-07T10:22:28Z"],["dc.date.available","2018-11-07T10:22:28Z"],["dc.date.issued","2017"],["dc.description.abstract","We investigate a system of two viscoelastically coupled, modified Van der Pol oscillators to compare their synchronization properties due to elastic and viscoelastic coupling. We show that viscoelastic coupling leads to in-phase synchronization while elastic coupling favours anti-phase synchronization. To study the impact of symmetry and nonlinearity, the restoring forces in the Van der Pol oscillators are extended to include nonlinear and asymmetric components. If the asymmetry, or rather the nonlinearity, of the restoring forces exceeds a certain threshold, only in-phase synchronized motion is found to be stable. Another important finding is that chaotic solutions can only be found if the restoring forces are asymmetric and the coupling incorporates viscosity."],["dc.description.sponsorship","German Research Foundation (DFG) [SFB 937]"],["dc.identifier.doi","10.1088/1367-2630/aa6d4a"],["dc.identifier.isi","000404761900003"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14652"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42284"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Iop Publishing Ltd"],["dc.relation.haserratum","/handle/2/74922"],["dc.relation.issn","1367-2630"],["dc.relation.orgunit","Fakultät für Physik"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0/"],["dc.title","Impact of viscoelastic coupling on the synchronization of symmetric and asymmetric self-sustained oscillators"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","157"],["dc.bibliographiccitation.lastpage","158"],["dc.contributor.author","Schlemmer, Alexander"],["dc.contributor.author","Zwirnmann, Henning"],["dc.contributor.author","Zabel, Markus"],["dc.contributor.author","Parlitz, Ulrich"],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2019-02-26T15:08:20Z"],["dc.date.available","2019-02-26T15:08:20Z"],["dc.date.issued","2014"],["dc.description.abstract","We evaluate several machine learning algorithms in the context of long-term prediction of cardiac diseases. Results from applying K Nearest Neighbors Classifiers (KNN), Support Vector Machines (SVM) and Random Forests (RF) to data from a cardiological long-term study suggests that multivariate methods can significantly improve classification results. SVMs were found to yield the best results in Matthews Correlation Coefficient and are most stable with respect to a varying number of features."],["dc.identifier.doi","10.1109/ESGCO.2014.6847567"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57623"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/53"],["dc.language.iso","en"],["dc.notes.status","fcwi"],["dc.publisher","IEEE"],["dc.publisher.place","Piscataway, NJ"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.conference","8th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO)"],["dc.relation.eventend","2014-05-28"],["dc.relation.eventlocation","Trento, Italy"],["dc.relation.eventstart","2014-05-25"],["dc.relation.isbn","978-1-4799-3969-5"],["dc.relation.isbn","978-1-4799-3968-8"],["dc.relation.isbn","978-1-4799-3970-1"],["dc.relation.ispartof","2014 8th Conference of the European Study Group on Cardiovascoular Oscillations (ESGCO 2014)"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.title","Evaluation of Machine Learning Methods for the Long-Term Prediction of Cardiac Diseases"],["dc.type","conference_paper"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2221"],["dc.bibliographiccitation.issue","1918"],["dc.bibliographiccitation.journal","Philosophical Transactions of the Royal Society of London. A, Mathematical, Physical and Engineering Sciences"],["dc.bibliographiccitation.lastpage","2236"],["dc.bibliographiccitation.volume","368"],["dc.contributor.author","Bittihn, Philip"],["dc.contributor.author","Squires, Amgad"],["dc.contributor.author","Luther, Gisa"],["dc.contributor.author","Bodenschatz, Eberhard"],["dc.contributor.author","Krinsky, Valentin"],["dc.contributor.author","Parlitz, Ulrich"],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2018-11-07T08:43:15Z"],["dc.date.available","2018-11-07T08:43:15Z"],["dc.date.issued","2010"],["dc.description.abstract","Life-threatening cardiac arrhythmias are associated with the existence of stable and unstable spiral waves. Termination of such complex spatio-temporal patterns by local control is substantially limited by anchoring of spiral waves at natural heterogeneities. Far-field pacing (FFP) is a new local control strategy that has been shown to be capable of unpinning waves from obstacles. In this article, we investigate in detail the FFP unpinning mechanism for a single rotating wave pinned to a heterogeneity. We identify qualitatively different phase regimes of the rotating wave showing that the concept of vulnerability is important but not sufficient to explain the failure of unpinning in all cases. Specifically, we find that a reduced excitation threshold can lead to the failure of unpinning, even inside the vulnerable window. The critical value of the excitation threshold (below which no unpinning is possible) decreases for higher electric field strengths and larger obstacles. In contrast, for a high excitation threshold, the success of unpinning is determined solely by vulnerability, allowing for a convenient estimation of the unpinning success rate. In some cases, we also observe phase resetting in discontinuous phase intervals of the spiral wave. This effect is important for the application of multiple stimuli in experiments."],["dc.identifier.doi","10.1098/rsta.2010.0038"],["dc.identifier.isi","000276266400007"],["dc.identifier.pmid","20368243"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19914"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Royal Soc"],["dc.relation.issn","1364-503X"],["dc.title","Phase-resolved analysis of the susceptibility of pinned spiral waves to far-field pacing in a two-dimensional model of excitable media"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","305a"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Biophysical Journal"],["dc.bibliographiccitation.volume","102"],["dc.contributor.author","Kohl, Tobias"],["dc.contributor.author","Parlitz, Ulrich"],["dc.contributor.author","Lauterbach, Marcel"],["dc.contributor.author","Minh Tuan, Hoang-Trong"],["dc.contributor.author","Williams, George S.B."],["dc.contributor.author","Westphal, Volker"],["dc.contributor.author","Jafri, M. Saleet"],["dc.contributor.author","Lederer, W.J."],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Hell, Stefan W."],["dc.contributor.author","Lehnart, Stephan E."],["dc.date.accessioned","2022-03-01T11:44:54Z"],["dc.date.available","2022-03-01T11:44:54Z"],["dc.date.issued","2012"],["dc.identifier.doi","10.1016/j.bpj.2011.11.1683"],["dc.identifier.pii","S0006349511030311"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103157"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.issn","0006-3495"],["dc.title","STED Nanoscopy of Cardiac RyR2 Clusters and Sub-Structure Analysis After Myocardial Infarction"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2409"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Biophysical Journal"],["dc.bibliographiccitation.lastpage","2419"],["dc.bibliographiccitation.volume","117"],["dc.contributor.author","Cosi, Filippo G."],["dc.contributor.author","Giese, Wolfgang"],["dc.contributor.author","Neubert, Wilhelm"],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Chamakuri, Nagaiah"],["dc.contributor.author","Parlitz, Ulrich"],["dc.contributor.author","Falcke, Martin"],["dc.date.accessioned","2020-12-10T14:22:46Z"],["dc.date.available","2020-12-10T14:22:46Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.bpj.2019.09.023"],["dc.identifier.issn","0006-3495"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17130"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71727"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.relation.orgunit","Fakultät für Physik"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0/"],["dc.title","Multiscale Modeling of Dyadic Structure-Function Relation in Ventricular Cardiac Myocytes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1561"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Physiological Measurement"],["dc.bibliographiccitation.lastpage","1575"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Schlemmer, Alexander"],["dc.contributor.author","Baig, T."],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Parlitz, Ulrich"],["dc.date.accessioned","2020-12-10T18:15:46Z"],["dc.date.available","2020-12-10T18:15:46Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1088/1361-6579/aa7be0"],["dc.identifier.eissn","1361-6579"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74950"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Detection and characterization of intermittent complexity variations in cardiac arrhythmia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Spreckelsen, Florian"],["dc.contributor.author","Rüchardt, Baltasar"],["dc.contributor.author","Lebert, Jan"],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Parlitz, Ulrich"],["dc.contributor.author","Schlemmer, Alexander"],["dc.date.accessioned","2022-05-13T10:05:43Z"],["dc.date.available","2022-05-13T10:05:43Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.20944/preprints202004.0035.v1"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/107869"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/352"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.title","Guidelines for a Standardized File Structure for Scientific Data"],["dc.type","preprint"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","042920"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Physical Review. E"],["dc.bibliographiccitation.volume","92"],["dc.contributor.author","Spreckelsen, Florian"],["dc.contributor.author","Hornung, Daniel"],["dc.contributor.author","Steinbock, Oliver"],["dc.contributor.author","Parlitz, Ulrich"],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2018-11-07T09:50:03Z"],["dc.date.available","2018-11-07T09:50:03Z"],["dc.date.issued","2015"],["dc.description.abstract","Scroll waves in a three-dimensional medium with negative filament tension may break up and display spatiotemporal chaos. The presence of heterogeneities can influence the evolution of the medium, in particular scroll waves may pin to such heterogeneities. We show that as a result the medium may be stabilized by heterogeneities of a suitably chosen geometry. Thin rodlike heterogeneities suppress otherwise developing spatiotemporal chaos and additionally clear out already existing chaotic excitation patterns."],["dc.identifier.doi","10.1103/PhysRevE.92.042920"],["dc.identifier.isi","000363242700008"],["dc.identifier.pmid","26565317"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35630"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/95"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.issn","2470-0053"],["dc.relation.issn","2470-0045"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.title","Stabilization of three-dimensional scroll waves and suppression of spatiotemporal chaos by heterogeneities"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","overview_ja"],["dspace.entity.type","Publication"]]