Luther, Stefan

[["dc.bibliographiccitation.firstpage","279"],["dc.bibliographiccitation.lastpage","294"],["dc.bibliographiccitation.seriesnr","20"],["dc.contributor.author","Krinsky, Valentin I."],["dc.contributor.author","Biktashev, Vadim N."],["dc.contributor.author","Otani, Niels F."],["dc.contributor.author","Luther, Stefan"],["dc.contributor.editor","Aranson, Igor S."],["dc.contributor.editor","Pikovsky, Arkady"],["dc.contributor.editor","Rulkov, Nikolai F."],["dc.contributor.editor","Tsimring, Lev S."],["dc.date.accessioned","2019-02-05T14:12:54Z"],["dc.date.available","2019-02-05T14:12:54Z"],["dc.date.issued","2017"],["dc.description.abstract","Methods for termination of three-dimensional electrical vortices in the heart are needed for development of patient-friendly cardiac defibrillation techniques (Nature 475, 235, 2011). The defibrillation technique used today is the delivery of a high-energy electric shock (360 J, 1 kV, 30 A, 12 ms, when applied externally) often associated with severe side effects. Developing low-energy defibrillation methods are hampered by two problems: the unknown locations of the cores of the vortices, and the unpredictable phases of the vortex waves rotating around these cores. The first problem has been resolved through the use of electric field pulses to excite the cores of all pinned vortices simultaneously. Approaches to solve the second problem are being developed. One of them is based on the phase scanning of all pinned vortices in parallel to hit the critical time window (“Vulnerable Window”, VW) of every pinned vortex. We investigate the related physical mechanisms and describe problems created by scanning. We describe also a mechanism by which a 3-dim scroll vortex may be terminated with a VW of the full 2π radians. It makes knowledge of the wave phase no longer required. We describe a mechanism terminating also a free (not pinned) vortex, when the vortex’s core passes not very far from a defect. About 500 experiments with termination of vortices during ventricular fibrillation in pig isolated hearts confirm that pinned vortices, hidden from direct observation, are significant in fibrillation. These results form a physical basis needed for creation of new effective methods for termination vortices underlying fibrillation."],["dc.identifier.doi","10.1007/978-3-319-53673-6_17"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57522"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/166"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.publisher","Springer"],["dc.publisher.place","Cham, Switzerland"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | A02: Bedeutung des Phosphatase-Inhibitors-1 für die SR-spezifische Modulation der Beta- adrenozeptor-Signalkaskade"],["dc.relation","SFB 1002 | A03: Bedeutung CaMKII-abhängiger Mechanismen für die Arrhythmogenese bei Herzinsuffizienz"],["dc.relation.crisseries","Nonlinear Systems and Complexity"],["dc.relation.doi","10.1007/978-3-319-53673-6"],["dc.relation.isbn","978-3-319-53672-9"],["dc.relation.isbn","978-3-319-53673-6"],["dc.relation.ispartof","Advances in Dynamics, Patterns, Cognition. Challenges in Complexity"],["dc.relation.ispartofseries","Nonlinear Systems and Complexity; 20"],["dc.relation.issn","2195-9994"],["dc.relation.issn","2196-0003"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.title","Vortices Termination in the Cardiac Muscle"],["dc.type","book_chapter"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]